The biological membranes of eukaryotic cells harbor sensitive surveillance systems to establish, sense, and maintain characteristic physicochemical properties that ultimately define organelle identity. They are fundamentally important for membrane homeostasis and play active roles in cellular signaling, protein sorting, and the formation of vesicular carriers. Here, we compare the molecular mechanisms of Mga2 and Ire1, two sensors involved in the regulation of fatty acid desaturation and the response to unfolded proteins and lipid bilayer stress in order to identify their commonalities (...) and specializations. We will speculate on the cellular significance of membrane property sensors in other organelles and discuss their putative mechanisms. Based on these findings, we propose membrane property sensors as an emerging class of proteins with wide implications for organelle communication and function. (shrink)

This paper deals with universes in explicit mathematics. After introducing some basic definitions, the limit axiom and possible ordering principles for universes are discussed. Later, we turn to least universes, strictness and name induction. Special emphasis is put on theories for explicit mathematics with universes which are proof-theoretically equivalent to Feferman's.

Plato's _Republic_ is one of the best-known and most widely-discussed texts in the history of philosophy. But how might we get to the heart of this work today, 2,500 years after its original composition? Alain Badiou breathes life into Plato's landmark text and revives its universality. Rather than producing yet another critical commentary, he has instead worked closely on the original Greek and, through spectacular changes, adapted it to our times. In this innovative reimagining of Plato's work, Badiou has removed (...) all references specific to ancient Greek society--from lengthy exchanges about moral courage in archaic poetry to political considerations mainly of interest to the aristocratic elite--and has expanded the range of cultural references. Here, philosophy is firing on all cylinders: Socrates and his companions are joined by Beckett, Pessoa, Freud, and Hegel, among others. Together these thinkers demonstrate that true philosophy endures, ready to absorb new horizons without changing its essence. Moreover, Badiou--who is also a dramatist--has transformed the Socratic dialogue into a genuine oratorial contest. In his version of the _Republic_, the interlocutors do much more than simply agree with Socrates. They argue, stand up to him, put him on the spot, and show thought in motion. In this work of dramatic scholarship and philosophy, we encounter a modern version of Plato's text that is alive, stimulating, and directly relevant to our own world. (shrink)

Vector models of language are based on the contextual aspects of words and how they co-occur in text. Truth conditional models focus on the logical aspects of language, the denotations of phrases, and their compositional properties. In the latter approach the denotation of a sentence determines its truth conditions and can be taken to be a truth value, a set of possible worlds, a context change potential, or similar. In this short paper, we develop a vector semantics for language based (...) on the simply typed lambda calculus. Our semantics uses techniques familiar from the truth conditional tradition and is based on a form of dynamic interpretation inspired by Heim's context updates. (shrink)

This contribution focuses on three aspects of Nietzsche’s art of living that have become relevant today especially in the United States (but not only here): first, regarding some facets of the economic-political conditions of any contemporary art of living; second, the widespread adoption of Nietzsche’s notion of self-overcoming and artistic self-design in entrepreneurship and individual’s lives; and third, how his notion of ‘incorporation’ has been further developed in current approaches to habit design. Eventually I will show via the example of (...) Anthony Robbins that some notions of Nietzsche’s art of living have become most popular outside of academia, namely in the commercial industries of what has been called ‘self-growth’ or ‘self-development.’. (shrink)

This essay investigates, via the concepts of the philosophy of orientation, Annie Duke’s decision-making theory in "Thinking in Bets" and scrutinizes as to what extent one can universalize the 'orientation skill' of decision-making with regard to our everyday and professional life.

Standard approaches to proper names, based on Kripke's views, hold that the semantic values of expressions are (set-theoretic) functions from possible worlds to extensions and that names are rigid designators, i.e.\ that their values are \emph{constant} functions from worlds to entities. The difficulties with these approaches are well-known and in this paper we develop an alternative. Based on earlier work on a higher order logic that is \emph{truly intensional} in the sense that it does not validate the axiom scheme of (...) Extensionality, we develop a simple theory of names in which Kripke's intuitions concerning rigidity are accounted for, but the more unpalatable consequences of standard implementations of his theory are avoided. The logic uses Frege's distinction between sense and reference and while it accepts the rigidity of names it rejects the view that names have direct reference. Names have constant denotations across possible worlds, but the semantic value of a name is not determined by its denotation. (shrink)

Logic has its roots in the study of valid argument, but while traditional logicians worked with natural language directly, modern approaches first translate natural arguments into an artificial language. The reason for this step is that some artificial languages now have very well developed inferential systems. There is no doubt that this is a great advantage in general, but for the study of natural reasoning it is a drawback that the original linguistic forms get lost in translation. An alternative approach (...) would be to develop a general theory of the natural logic behind human reasoning and human information processing by studying formal logics that operate directly on linguistic representations. That this is possible we will try to make plausible in this paper. It will turn out that one level of representation, that of Logical Form, can meaningfully be identified with the language of an existing and well-understood logic, a restricted form of the theory of types. It is not difficult to devise inference systems for this language, and it is thus possible to study reasoning systems that are based directly on language. (shrink)

The ArgumentIn contrast to “socialist eugenics” as a set of ideas on how to deal with the biological problems of mankind, “proletarian race hygiene” placed its emphasis on the environmental components of human life. This mode of eugenics always assumed a change in living conditions, or social milieu, to be the key to human betterment. Its objective was a gradualist, thoroughgoing improvement of human working and living conditions in order to bring about a life of harmony, solidarity and equality. These (...) ideas can be traced back to phrenomesmerism at the beginning of the nineteenth century, and developed through a stage closely entwined with the Marxist thought of Daniels, Engels, Bebel, etc.. This tradition was picked up in the early twentieth century by the Austrian sociologist Goldscheid as well as by the developmental biologist Kammerer. These men extended these ideas and incorporated them into the framework of “proletarian race hygiene,” involving as key concepts what they called “human economy” and “organic technology.”. (shrink)

the world of phenomena is immensely large this means we can perceive only part of the world. We see, feel and hear parts of reality, not the whole of it, and it seems that a sentence containing a verb of perception like 'John sees a house burn' is most naturally treated as saying that the subject sees an incomplete world in which the embedded sentence is true (see Barwise (1981) for this analysis). But if we want to analyse perception verbs (...) thus, we must introduce some form of incompleteness into our formal system, the.. (shrink)

This collection is the first book-length analysis of the theoretical foundations of public debt sustainability concepts and their application to the empirical study of actual budgetary policies.

The present volume is devoted to the theme of Divine Father in Second Temple Jewish and early Christian tradition and in its ancient pagan contexts. It brings together proceedings of a conference under the same title, held in Gottingen in September 2011. Selected articles by well-known scholars focus on religious and philosophical concepts of divine parenthood in antiquity, from the Hebrew Bible and Second Temple Judaism (the Dead Sea Scrolls, Targums, Philo and Josephus) to the field of the New Testament. (...) In addition, the volume deals with the designation of deity as father or mother from the broad spectrum of ancient Egypt and classical antiquity (Homer, Hesiod, Plato, and its reception) to late antiquity (Plotinus and Porphyry).". (shrink)

This book aims to publish a complete and systematic exposition of Scholastic philosophy based upon the sound principles of Aristotle and Thomas Aquinas and bring it into contact with the facts of modern science. The considerations which have guided the author in its composition are chiefly two: he wished both to modernize and popularize the Philosophia Perennis. The book covers the topics: philosophy of nature, psychology, ontology and metaphysics and natural theology.

"Each nation can do well, as in the life of individuals, only if things go equally well in all of her neighboring nations; the life of sciences is similar to that of states whose interest demands that everything be in order within individual states as properly as their relations be in good order among themselves. Understanding this correctly, the most important carriers of mathematical thoughts have always shown great interest in the law and order in neighboring sciences and, above all (...) for the benefit of mathematics, have cultivated the relations to the neighboring sciences, in particular to physics and epistemology. The essence of these relations and the ground of their fertility will be made most distinct, I believe, if I sketch to you that general method of inquiry which appears to grow more and more significant in modern mathematics; the axiomatic method, I mean." (David Hilbert, 1917). (shrink)

The paper reproduces a hitherto unpublished report of 1902 by the mathematician of Göttingen, Felix Klein, to the Prussian ministry of education on his travels, in 1893 and 1896, to the United States. Introduction and commentary stress the relation of this document to the beginnings of German foreign cultural policy, in particular to the German-American professors' exchange program since 1905.

The term “vagueness” describes a property of natural concepts, which normally have fuzzy boundaries, admit borderline cases, and are susceptible to Zeno's sorites paradox. We will discuss the psychology of vagueness, especially experiments investigating the judgment of borderline cases and contradictions. In the theoretical part, we will propose a probabilistic model that describes the quantitative characteristics of the experimental finding and extends Alxatib's and Pelletier's () theoretical analysis. The model is based on a Hopfield network for predicting truth values. Powerful (...) as this classical perspective is, we show that it falls short of providing an adequate coverage of the relevant empirical results. In the final part, we will argue that a substantial modification of the analysis put forward by Alxatib and Pelletier and its probabilistic pendant is needed. The proposed modification replaces the standard notion of probabilities by quantum probabilities. The crucial phenomenon of borderline contradictions can be explained then as a quantum interference phenomenon. (shrink)

_Heidegger's Hidden Sources_ documents for the first time Heidegger's remarkable debt to East Asian philosophy. In this groundbreaking study, Reinhard May shows conclusively that Martin Heidegger borrowed some of the major ideas of his philosophy - on occasion almost word for word - from German translations of Chinese Daoist and Zen Buddhist classics. The discovery of this astonishing appropriation of non-Western sources will have important consequences for future interpretations of Heidegger's work. Moreover, it shows Heidegger as a pioneer of (...) comparative philosophy and transcultural thinking. (shrink)

This book provides readers with in-depth insights into Corporate Social Responsibility and sustainability strategies, as well as their impacts on product and process innovation, business models and social innovation around the globe. It explains how resource issues, climate change, the impacts of pollution and economic activities, and emerging social challenges inevitably lead to changes in the business environment, cost structure and competitive advantage. Further, it highlights how these changes influence the process of innovation, and how companies can gain an edge (...) by integrating stakeholder groups in their innovation process, and by considering sustainability and the needs of society at large. The book reflects the immense strides made in recent years in the discussion about the relationship between business and society, and demonstrates the increasing impact on innovation management. (shrink)

In der Reihe werden herausragende monographische Interpretationen von Nietzsches Werk im Ganzen oder von spezifischen Themen und Aspekten aus unterschiedlichen wissenschaftlichen Perspektiven veröffentlicht, vor allem aus philosophischer, literatur- und kommunikationswissenschaftlicher, soziologischer und historischer Sicht. Die Publikationen repräsentieren den aktuellen Stand. Jeder Band ist peer-reviewed.

Carl Schmitt is one of the most widely read and influential German thinkers of the twentieth century. His fundamental works on friend and enemy, legality and legitimacy, dictatorship, political theology and the concept of the political are read today with great interest by everyone from conservative Catholic theologians to radical political thinkers on the left. In his private life, however, Schmitt was haunted by the demons of his wild anti-Semitism, his self-destructive and compulsive sexuality and his deep-seated resentment against the (...) complacency of bourgeois life. As a young man from a modest background, full of social envy, he succeeded in making his way to the top of the academic discipline of law in Germany through his exceptional intellectual prowess. And yet he never felt at home in the academic establishment and among those of high social standing. In his works, Schmitt unmasked the liberal Rechtsstaat as a constitutional façade and reflected on the legitimacy of dictatorship. When the Nazis seized power Schmitt was susceptible to their ideology. He broke with his Jewish friends, joined the Nazi Party in May 1933 and lent a helping hand to Hitler, thereby becoming deeply entangled with the regime. Schmitt was irrevocably compromised by his role as the ‘crown jurist’ of the Third Reich. But by 1936 he had already lost his influential position. After the war, he led a secluded life in his home town in the Sauerland and became a key background figure in the intellectual scene of postwar Germany. Reinhard Mehring’s outstanding biography is the most comprehensive work available on the life and work of Carl Schmitt. Based on thorough research and using new sources that were previously unavailable, Mehring portrays Schmitt as a Shakespearean figure at the centre of the German catastrophe. (shrink)