Glycosylation refers to the co‐ and post‐translational modification of protein and lipids by monosaccharides or oligosaccharide chains. The surface of mammalian cells is decorated by a heterogeneous and highly complex array of protein and lipid linked glycan structures that vary significantly between different cell types, raising questions about their roles in development and disease pathogenesis. This review will begin by focusing on recent findings that define roles for cell surface protein and lipid glycosylation in pluripotent stem cells and their functional (...) impact during normal development. Then, we will describe how patient derived induced pluripotent stem cells are being used to model human diseases such as congenital disorders of glycosylation. Collectively, these studies indicate that cell surface glycans perform critical roles in human development and disease. (shrink)

A first take, matured in later work, in modeling belief polarization.

Stephen J. Schulhofer, Unwanted Sex: The Culture of Intimidation and the Failure of Law Cambridge, MA: Harvard University Press, 1998, xii + 284 pp.

What is social constructionism? Is it a form of relativism that is essentially similar to cultural relativism and historical relativism? Is it a thesis about the contingency of knowledge? What is the point of saying constructionism is 'social'? Partly as a result of the fact that the term 'social construction' had its origins in sociology, in Berger and Luckmann's influential book The Social Construction of Reality, these simple 'philosophical' questions have not been systematically addressed. In this chapter I will (...) give a kind of genealogy of relativism in terms of which these questions may be posed. I will distinguish two historically important forms of relativism, which I will call cold and hot relativisms. Cold relativisms are those that appeal to notions like 'culture' and 'epoch'. Cultures and epochs are totalizing notions. But precisely because they are totalizing notions, change is difficult to account for. Hot relativisms are those, like Thomas Kuhn's (1964) model of scientific revolutions, in which change plays a more central and dramatic role. But change is a puzzle for Kuhn as well. (shrink)

I hope this book will inspire every reader to stop and consider things that are...so clearly meaningless that they never seemed worth a second thought.... Grass, the night sky, a postage stamp, a crack in the sidewalk, a shoulder. Ordinary objects of everyday life. But when we look at them--really look at them--what do we see? In the tradition of John Berger's bestselling Ways of Seeing,James Elkins'sHow to Use Your Eyesinvites us to look at--and maybe to see for first (...) time--the world around us, with breathtaking results. Here are the common artifacts of life, often misunderstood and largely ignored, brought into striking focus. A butterfly's wing pattern encodes its identity. A cloudless sky yields a precise sequence of colors at sunset. A bridge reveals the relationship of a population with its landscape. With the discerning eye of a painter and the zeal of a detective, Elkins also explores complicated things like mandalas,the periodic table, or a hieroglyph, remaking the world into a treasure box of observations--eccentric, ordinary, marvelous. How to Use Your Eyesis a thrilling read evocative of the work of Diane Ackerman and Stephen Jay Gould. It will transform your view of nature and the mind. (shrink)

Stephen Schiffer; XIII*—Contextualist Solutions to Scepticism, Proceedings of the Aristotelian Society, Volume 96, Issue 1, 1 June 1996, Pages 317–334, https://.

This book reformulates the sociological subdiscipline known as the sociology of knowledge. Knowledge is presented as more than ideology, including as well false consciousness, propaganda, science and art.

Stephen Gaukroger traces the development of Descartes's thought in the social, religious, and intellectual context of seventeenth‐century Europe. Gaukroger describes Descartes's upbringing and his education at the Jesuit La Flèche collège, and shows the role these played in the development of his ground‐breaking work in philosophy and science. The book details the effects of his relationships with others on his work, both through collaboration and through conflict. It discusses the history of the composition of his major works and details (...) their structure and content. It documents the correspondence, which played a major part in the development of his thinking, both before and after publication. The book concludes, as it begins, with his correspondence with Princess Elizabeth of Bohemia on the subject of the passions. (shrink)

These essays engage Jin Y. Park’s recent translation of the work of Kim Iryŏp, a Buddhist nun and public intellectual in early twentieth-century Korea. Park’s translation of Iryŏp’s Reflections of a Zen Buddhist Nun was the subject of two book panels at recent conferences: the first a plenary session at the annual meeting of the Society for Asian and Comparative Philosophy and the second at the Eastern Division of the American Philosophical Association on a group program session sponsored by the (...) International Society for Buddhist Philosophy. This exchange also includes a response from Park. (shrink)

L. M. de Rijk supposed in 1982 that two anonymous logical tracts in the Viennese Codex 4698, fol. 18r–27v, may be the work of Martinus Anglicus to whom a tract on consequences and one on obligations are ascribed in that codex. The tract on supposition of which the Viennese codex hands down only a fragment of the beginning is contained completely in Hs I 613 of the Stadtbibliothek Mainz, fol. 20vb–21vb. This finding ensures the authorship of Martinus Anglicus and allows (...) to ascribe an Introduction into Logic in some seven parts to him. Martin’s tract on supposition and the more detailed one by Thomas Manlevelt show some resemblances in structure and content, the first being presumably the later one. This paper presents an edition of Martin’s Tractatus de suppositione from the Mainz manuscript and an introduction regarding the author and his work. (shrink)

Stephen Ingram defends a robustly realistic metaethical theory, based on the concept of normative arbitrariness, of which he provides the first in-depth analysis. He argues that, in order to capture the normative non-arbitrariness of moral choice, we must commit to the existence of robustly stance-independent, categorical, irreducibly normative, non-natural moral facts. Specifically, he identifies five ways in which a metaethical theory might fail to capture the non-arbitrariness of moral choice. The first involves claims about the bruteness of moral attitudes (...) or facts. The second involves claims about the privileging of some attitudes over others. The third involves the claim that some metaethical theories leave a normative deficit. The fourth involves a claim about our ownership over moral reality. And the fifth involves the claim that certain metaethical theories introduce a destabilising contingency into the moral domain. Ingram argues that robust realism is the theory that is best placed to avoid all five of these arbitrariness charges. He then goes on to show that, by exploring the nature of interpersonal moral dialogue, robust realists can defend epistemological and meta-semantic theories that are friendly to their view. Specifically, he defends a dualistic form of moral intuitionism on which some moral beliefs are justified on the basis of a priori intuitions, whilst others are justified on the basis of a posteriori moral experiences, and provides a theory of 'moral mental files' to explain how moral terms and concepts are able to refer to robust moral facts. (shrink)

Stephen Makin offers an account of indifference arguments and the pre-Socratic atomism underpinned by this sort of reasoning. Used by Parmenides, Democritus, Plato, Aristotle and Leibniz, as well as some contemporary philosophers, indifference arguments start from claims about a balance of reasons or an absence of asymmetries. While some provide plausible support for strong conclusion, others produce no conviction.

Berger and Whistler provide a ground-breaking account of Schelling's first controversy with his critic A.C.A. Eschenmayer in 1801, which focused on the philosophy of nature. They argue that key Schellingian concepts, such as identity, potency and abstraction, were first forged in his early debate with Eschenmayer.

Relationalism holds that perceptual experiences are relations between subjects and perceived objects. But much evidence suggests that perceptual states can be unconscious. We argue here that unconscious perception raises difficulties for relationalism. Relationalists would seem to have three options. First, they may deny that there is unconscious perception or question whether we have sufficient evidence to posit it. Second, they may allow for unconscious perception but deny that the relationalist analysis applies to it. Third, they may offer a relationalist explanation (...) of unconscious perception. We argue that each of these strategies is questionable. (shrink)

Berger, U., Total sets and objects in domain theory, Annals of Pure and Applied Logic 60 91-117. Total sets and objects generalizing total functions are introduced into the theory of effective domains of Scott and Ersov. Using these notions Kreisel's Density Theorem and the Theorem of Kreisel-Lacombe-Shoenfield are generalized. As an immediate consequence we obtain the well-known continuity of computable functions on the constructive reals as well as a domain-theoretic characterization of the Heriditarily Effective Operations.

According to Rosenthal's higher-order thought (HOT) theory of consciousness, one is in a conscious mental state if and only if one is aware of oneself as being in that state via a suitable HOT. Several critics have argued that the possibility of so-called targetless HOTs—that is, HOTs that represent one as being in a state that does not exist—undermines the theory. Recently, Wilberg (2010) has argued that HOT theory can offer a straightforward account of such cases: since consciousness is a (...) property of mental state tokens, and since there are no states to exhibit consciousness, one is not in conscious states in virtue of targetless HOTs. In this paper, I argue that Wilberg's account is problematic and that Rosenthal's version of HOT theory, according to which a suitable HOT is both necessary and sufficient for consciousness, is to be preferred to Wilberg's account. I then argue that Rosenthal's account can comfortably accommodate targetless HOTs because consciousness is best understood as a property of individuals, not a property of states. (shrink)

I offer here a new hypothesis about the nature of implicit attitudes. Psy- chologists and philosophers alike often distinguish implicit from explicit attitudes by maintaining that we are aware of the latter, but not aware of the former. Recent experimental evidence, however, seems to challenge this account. It would seem, for example, that participants are frequently quite adept at predicting their own perfor- mances on measures of implicit attitudes. I propose here that most theorists in this area have nonetheless overlooked (...) a commonsense distinction regarding how we can be aware of attitudes, a difference that fundamentally distinguishes implicit and explicit attitudes. Along the way, I discuss the implications that this distinction may hold for future debates about and experimental investigations into the nature of implicit attitudes. (shrink)

According to what Birch (2022) calls the theory-heavy approach to investigating nonhuman-animal consciousness, we select one of the well-developed theories of consciousness currently debated within contemporary cognitive science and investigate whether animals exhibit the neural structures or cognitive abilities posited by that theory as sufficient for consciousness. Birch argues, however, that this approach is in general problematic because it faces what he dubs the dilemma of demandingness—roughly, that we cannot use theories that are based on the human case to assess (...) consciousness in nonhuman animals and vice versa. We argue here that, though this dilemma may problematize the application of many current accounts of consciousness to nonhuman animals, it does not challenge the use of standard versions of the higher-order thought theory (“HOTT”) of consciousness, according to which a creature is in a conscious mental state just in case it is aware of being in that state via a suitable higher-order thought (“HOT”). We show this in two ways. First, we argue that, unlike many extant theories of consciousness, HOTT is typically motivated by a commonsense, and more importantly, neutral condition on consciousness that applies to humans and animals alike. Second, we offer new empirical and theoretical reasons to think that many nonhuman animals possess the relevant HOTs necessary for consciousness. Considering these issues not only reveals the explanatory power of HOTT and some of its advantages over rival accounts, but also enables us to further extend and clarify the theory. (shrink)

While there seems to be much evidence that perceptual states can occur without being conscious, some theorists recently express scepticism about unconscious perception. We explore here two kinds of such scepticism: Megan Peters and Hakwan Lau's experimental work regarding the well-known problem of the criterion -- which seems to show that many purported instances of unconscious perception go unreported but are weakly conscious -- and Ian Phillips' theoretical consideration, which he calls the 'problem of attribution' -- the worry that many (...) purported examples of unconscious perception are not perceptual, but rather merely informational and subpersonal. We argue that these concerns do not undermine the evidence for unconscious perception and that this sceptical approach results in a dilemma for the sceptic, who must either deny that there is unconscious mentality generally or explain why perceptual states are unique in the mind such that they cannot occur unconsciously. Both options, we argue, are problematic. (shrink)

Perceptual experiences justify beliefs. A perceptual experience of a dog justifies the belief that there is a dog present. But there is much evidence that perceptual states can occur without being conscious, as in experiments involving masked priming. Do unconscious perceptual states provide justification as well? The answer depends on one’s theory of justification. While most varieties of externalism seem compatible with unconscious perceptual justification, several theories have recently afforded to consciousness a special role in perceptual justification. We argue that (...) such views face a dilemma: either consciousness should be understood in functionalist terms, in which case our best current theories of consciousness do not seem to imbue consciousness with any special epistemic features, or it should not, in which case it is mysterious why only conscious states are justificatory. We conclude that unconscious perceptual justification is quite plausible. (shrink)

Leslie Stephen, author, literary critic, social commentator and the first editor of the Dictionary of National Biography, published his two-volume History of English Thought in the Eighteenth Century in 1876. This led him to further investigation and study of utilitarianism, whose proponents believed that human action should be guided by the principle of ensuring the happiness of the greatest number of people. While working on many other projects, especially the Dictionary, and haunted by domestic tragedy in the sudden death (...) of his second wife in 1895, Stephen struggled for two decades with this undertaking, calling it the 'utilitarian bog': the long-awaited three-volume work was finally published in 1900. Volume 1 gives the social and political context of the rise of utilitarianism and examines its leading theorist, Jeremy Bentham. (shrink)

Leslie Stephen was an English biographer, and a writer on philosophy, ethics and literature. He was educated at Eton, King's College, London, and then Trinity College in Cambridge, where he remained as a fellow and a tutor for his entire career. He was also a keen mountaineer, taking part in first ascents of nine peaks in the Alps. He served as the first editor of the Dictionary of National Biography and in 1871 he became editor of the Cornhill Magazine. (...) During his eleven-year tenure he wrote two successful books on ethics, of which this work, published in 1882, was one. It was widely adopted as a standard textbook on moral philosophy, and became one of the most influential publications on the ideas of evolutionary ethics that had been inspired by Darwin's theory of evolution by natural selection. (shrink)

Many have claimed that epistemic rationality sometimes requires us to have imprecise credal states (i.e. credal states representable only by sets of credence functions) rather than precise ones (i.e. credal states representable by single credence functions). Some writers have recently argued that this claim conflicts with accuracy-centered epistemology, i.e., the project of justifying epistemic norms by appealing solely to the overall accuracy of the doxastic states they recommend. But these arguments are far from decisive. In this essay, we prove some (...) new results, which show that there is little hope for reconciling the rationality of credal imprecision with accuracy-centered epistemology. (shrink)

It is often assumed that perceptual experience provides evidence about the external world. But much perception can occur unconsciously, as in cases of masked priming or blindsight. Does unconscious perception provide evidence as well? Many theorists maintain that it cannot, holding that perceptual experience provides evidence in virtue of its conscious character. Against such views, I challenge here both the necessity and, perhaps more controversially, the sufficiency of consciousness for perception to provide evidence about the external world. In addition to (...) motivating and defending the idea that unconscious perception can and does often provide evidence, I observe that whether or not perceptual phenomenology is relevant to the evidentiary status of perception depends on the nature of consciousness. And I argue that a well-supported theory of consciousness—higher-order thought theory—invites a striking conclusion: that perceptual phenomenology is not on its own sufficient to provide for evidence of the external world. (shrink)

Health disparities are primarily driven by structural inequality including systemic racism. Medical educators, led by the AAMC, have tended to minimize these core drivers of health disparities. Ins...

For over twenty years Douglas Berger has advanced research and reflection on Indian philosophical traditions from both classical and cross-cultural perspectives. This volume reveals the extent of his contribution by bringing together his perspectives on these classical Indian philosophies and placing them in conversation with Confucian, Chinese Buddhist and medieval Indian Sufi traditions. Delving into debates between Nyaya and Buddhist philosophers on consciousness and identity, the nature of Sankara's theory of the self, the precise character of Nagarjuna's idea of (...) emptiness, and the relationship between awareness and embodiment in the broad spectrum of Indian thought, chapters exhibit Berger's unusually broad range of expertise. They connect Chinese Confucian and Buddhist texts with classical Indian theories of ethics and consciousness, contrast the ideas of seminal European thinkers like Nietzsche and Derrida from prevailing themes in Buddhism, and shed light on the spiritual and political dimensions of the Mughal prince Dara Shukoh's immersion into Vedantic thought. Always approaching the arguments from an intercultural perspective, Berger shows how much relevance and resonance classical Indian thought has with ancient Confucian views of ethics, Chinese Buddhist depictions of consciousness and medieval Mughal conceptions of divinity. The result is a volume celebrating the rigor, vitality and intercultural resonance of India's rich philosophical heritage. (shrink)

In this book, Alan Berger further develops the new theory of reference -- as formulated by Kripke and Putnam -- applying it in novel ways to many philosophical problems concerning reference and existence. Berger argues that his notion of anaphoric background condition and anaphoric links within a linguistic community are crucial not only to a theory of reference, but to the analysis of these problems as well. The book is organized in three parts. In part I, Berger (...) distinguishes between two styles of rigid designation. Based on this distinction, he develops a theory of reference change for rigid designator terms and shows how this distinction sheds light on identity statements. In part II, he offers an account of belief attribution containing vacuous names within the belief context, of intentional identity statements, and of true negative existential statements. In part III, he analyzes anaphoric expressions and presents a formalization of anaphora and plural quantification. (shrink)

I motivate and defend a previously underdeveloped functionalist account of the metaphysics of color, a view that I call ‘quality-space functionalism’ about color. Although other theorists have proposed varieties of color functionalism, this view differs from such accounts insofar as it identifies and individuates colors by their relative locations within a particular kind of so-called ‘quality space’ that reflects creatures’ capacities to discriminate visually among stimuli. My arguments for this view of color are abductive: I propose that quality-space functionalism best (...) captures our commonsense conception of color, fits with many experimental findings, coheres with the phenomenology of color experience, and avoids many issues for standard theories of color such as color physicalism and color relationalism. (shrink)

I discuss here the nature of nonconscious mental states and the ways in which they may differ from their conscious counterparts. I first survey reasons to think that mental states can and often do occur without being conscious. Then, insofar as the nature of nonconscious mentality depends on how we understand the nature of consciousness, I review some of the major theories of consciousness and explore what restrictions they may place on the kinds of states that can occur nonconsciously. I (...) close with a discussion of what makes a state mental, if consciousness is not the mark of the mental. (shrink)

Representationalism holds that a perceptual experience's qualitative character is identical with certain of its representational properties. To date, most representationalists endorse atomistic theories of perceptual content, according to which an experience's content, and thus character, does not depend on its relations to other experiences. David Rosenthal, by contrast, proposes a view that is naturally construed as a version of representationalism on which experiences’ relations to one another determine their contents and characters. I offer here a new defense of this holistic (...) representationalism, arguing that some objections to atomistic views are best interpreted as supporting it. (shrink)

Society is a dialectical process: men produce society, which in turn produces them. Certain Marxist categories are especially useful for the sociology of knowledge, dealing with the relation between consciousness and society. Social structure is nothing but the result of human enterprise. Alienation-rupture between producer and product-leads to a false consciousness in neglecting the productive process. Reification, historically recurrent though not anthropologically necessary, while bestowing ontological status on social roles and institutions only sees society as producing men. Certain social conditions (...) encourage de-reification. Philosophy and sociology, superstructures rooted in intersubjectivity, must co-operate in pursuing the sociology of knowledge. (shrink)

Incapacitated adult patients are commonly divided into two groups for purposes of decision making; those with a surrogate and those without. Respectively, these groups are often referred to as represented and unrepresented, and the relative ethics of decision making between them raises two particular issues. The first issue involves the differential application of the best interests standard between groups. Second is the prevailing notion that representedness and unrepresentedness are categorical phenomena, though it is more aptly understood as a multidimensional and (...) continuous variable based on relational moral authority. This paper examines the nature of representedness as it relates to ethical norms of surrogate decision making. (shrink)

Sociological theories of space have so far not provided an in-depth analysis of online spaces. The paper addresses this issue by means of Löw’s relational theory of space. As this theory mainly focuses on material spaces, it is necessary to embrace the phenomenological perspective in order to apply it to the virtual realm. More recent phenomenological research has highlighted the ongoing mediatization or virtualization of the life-world. These theories, and presence research more generally, are useful for examining the layers of (...) virtual presence. This paper focuses on two emblematic types of spaces: multiplayer online role-playing games and Skype video chats. The first represents an online version of a Schutzian finite province of meaning, while Skyping is an example of how the paramount reality of everyday life expands into the virtual realm. Albeit differently, actors in both cases constitute hybrid, virtual-material spaces with various forms and degrees of virtual presence. User experiences in these spaces are in line with contemporary sociological diagnoses indicating the vanishing experience of living in space and the general tendency of late modernity to question previous social forms of modernity. (shrink)

Stephen Eric Bronner is a prolific author, activist, and one of America’s leading political thinkers. His new book presents bigotry as a systematic, all-encompassing mindset that has a special affinity for right-wing movements. In what will surely prove a seminal study, Bronner explores its appeal, the self-image it justifies, the interests it serves, and its complex connection with modernity. He reveals how prejudice shapes the conspiratorial and paranoid worldview of the true believer, the elitist, and the chauvinist. In the (...) process, it becomes apparent how the bigot hides behind mainstream conservative labels in order to support policies designed to disadvantage the targets of his contempt. Examining bigotry in its various dimensions—anthropological, historical, psychological, sociological, and political—Professor Bronner illustrates how the bigot’s intense hatred of “the other” is a direct reaction to social progress, liberal values, secularism, and an increasingly complex and diverse world. A sobering look at the bigot in the twenty-first century, this volume is essential for making sense of the dangers facing democracy now and in the future. (shrink)

Stephen R. L. Clark; XV*—God, Good and Evil, Proceedings of the Aristotelian Society, Volume 77, Issue 1, 1 June 1977, Pages 247–264, https://doi.org/10.1093/ar.

While Stephen Davies argues that a debate on cross-cultural aesthetics is possible if we adopt an attitude of mutual respect and forbearance, his fellow symposiasts shed light upon different aspects which merit a closer scrutiny in such a dialogue. Samer Akkach warns that an inclusivistic embrace of difference runs the risk of collapsing the very difference one sought to understand. Julie Nagam underscores that local knowledge carriers and/or the medium should be involved in such a cross-cultural exploration. Enrico Fongaro (...) searches for a way of experiencing cross-cultural art such that it can lead to a transformative experience Relatedly, Meilin Chinn uses the analogy of friendship to explore the edifying dimension of experiencing an art form. Lastly, John Powell studies whether Dickie’s Institutional Theory can be meaningfully used to identify works of art in Western and non-Western traditions. (shrink)

Downs, Stephen Many Catholics know that Vatican II advocated a more positive approach to other religions and belief systems, and called for dialogue with their adherents. But has any progress been made since then? Some will have heard of dialogue between Catholics and people of other faiths taking place. But what of the Catholic understanding of other faiths; has it changed or developed since Vatican II?

Stephen Gersh's Being Different: More Neoplatonism after Derrida continues his earlier project ) of reading the philosophy of late antiquity in a critical encounter with Jacques Derrida's deconstruction of Platonism.

Introduction Stephen Law, Think, FirstView Article.

Stephen Law follows THE PHILOSOPHY FILES with a second book of philosophical conundrums for teenagers. This time he asks such questions as Do Miracles Happen? Why Do These Words Mean Something? and Do I Know the Sun will Rise Tomorrow? You can dip into the arguments that interest you, in eight chapters where the themes are set up in witty scenarios and then debated. There are wacky thought experiments to work out and a variety of characters appear - some (...) of them Martians. As in THE PHILOSOPHY FILES, there are hundreds of lively cartoons running through the book. Stephen Law is a brilliant communicator with a passion to make young people think for themselves. As the GUARDIAN said: 'It's philosophy in action rather than philosophy in aspic... a real philosophy book for kids - which students and adults could enjoy too - finally exists'. (shrink)

Stephen Rainbow assesses the actual practice of green politics in New Zealand using a political and philosophical framework. He argues that the State should take responsibility for developing policies of sustainable development, and that green activists should be required to adopt achievable and credible strategies for change. Through a critique of current models of development and growth which rely on a narrow conception of economic realities, Rainbow suggests possible directions for the future. He bases his arguments on the common (...) belief that given New Zealand's geographical and social advantages, it is in a unique position to lead the world towards a green future. (shrink)

Stephen E. Smallman describes the process of new birth and what is common in all authentic conversion experiences--genuine faith in Jesus Christ as Lord and Savior. Spiritual Birthline testifies to new birth in all kinds of people, in all sorts of circumstances. It is helpful to those with a budding curiosity in God as well as to people interested in relational evangelism.