We need to find a middle way between the exaggerated deference towards science characteristic of scientism, and the exaggerated suspicion characteristic of anti-scientific attitudes — to acknowledge that science is neither sacred nor a confidence trick. The Critical Commonsensist account of scientific evidence and scientific method offered here corrects the narrowly logical approach of the Old Deferentialists without succumbing to the New Cynics' sociologism or their factitious despair of the epistemic credentials of science.

The question of how actin filaments are attached to membranes is of central importance to an understanding of how actin gives rise to shape and movement in cells. A number of approaches to this question have been taken, but there have been few definitive answers. Some of the limitations of these approaches are discussed, as well as possible avenues for overcoming them.

Designing curricular experiences that make the usefulness of the liberal arts vividly clear as early as possible in an undergraduate's education is our collective responsibility. In this essay, I argue for providing that experience by employing a critical pedagogy of awakening (seeing), interdisciplinary understanding (knowing) and agency (doing), and I illustrate the use of this pedagogy with an example that brings philosophy "into the field" with biology.

In this APA blog, I appeal to two 2020 cases of algorithms gone wrong to motivate philosophical attention to algorithmic oppression. I offer a simple definition, then describe a few of the ways it is engendered. References and extends work by Safiya Noble, Cathy O'Neil, Ruha Benjamin, Virginia Eubanks, Sara Wachter-Boettcher, Michael Kearns & Aaron Roth.

Human genomics is a translational field spanning research, clinical care, public health, and direct-to-consumer testing. However, law differs across these domains on issues including liability, consent, promoting quality of analysis and interpretation, and safeguarding privacy. Genomic activities crossing domains can thus encounter confusion and conflicts among these approaches. This paper suggests how to resolve these conflicts while protecting the rights and interests of individuals sequenced. Translational genomics requires this more translational approach to law.

[opening paragraph]: Do you believe, deep down, that you exist? Do you feel as though `you' make the decisions and run `your' life? Above all do you think that `you' are conscious? If so, according to Guy Claxton's latest book, you have got it all wrong.

Drawing on John Dewey's discussion of habit in Human Nature and Conduct and Simone de Beauvoir's discussion of the “adventurer” in The Ethics of Ambiguity, I argue that while some of our relations with things and people may very well be instrumental, many take a different form in which it is our very setting, and not merely our attainment, of ends that is at stake. Moreover, the fullest realization of our freedom requires us to recognize not only that this different (...) form of relation, which is cooperative rather than controlling, exists but also that it is constitutive of, rather than in opposition to, our freedom. I conclude by briefly examining how our honest acknowledgment of a kind of powerlessness inherent to our powers, to our freedom, might change the way we interact with other things and other people. (shrink)

I begin with the story told by Herman Melville in his short novel, Billy Budd.The year is 1797. Britain is engaged in a long and bitter war against France, and the British war effort has been threatened by two naval mutinies: the Nore Mutiny and the mutiny at Spithead. The scene is His Majesty’s Ship, the Indomitable, and the central character is Billy Budd, sailor. Billy Budd is a young man of exceptional beauty, both physical and moral, whose only flaw (...) is a stammer. He is loved by all his fellow sailors except the master-at-arms, John Claggart. The incarnation of evil, Claggart recognises in Billy the incarnation of goodness, and is consumed by a jealousy which leads him to accuse Billy (falsely) of inciting the crew to mutiny. Alone with Claggart and the ship’s Captain, Edward Vere, Billy hears the lying charge against him. He is enraged, but his stammer prevents him from responding in words. He strikes Claggart, and the blow is fatal. Billy Budd, sailor, has killed the master-at-arms of one of His Majesty’s ships on active service, and the penalty for this is death. (shrink)

Is toleration a requirement of morality or a dictate of prudence? What limits are there to toleration? What is required of us if we are to promote a truly tolerant society? These themes--the grounds, limits, and requirements of toleration--are central to this book, which presents the W.B. Morrell Memorial Lectures on Toleration, given in 1986 at the University of York. Covering a wide range of practical and theoretical issues, the contributors--including F.A. Hayek, Maurice Cranston, and Karl Popper--consider the philosophical difficulties (...) inherent in the concept as well as the practical problems of implementing a policy of toleration. Although the contributors differ in their conclusions about the grounds of toleration, they all share a belief in the importance of the concept both historically and in modern society. (shrink)

Abstractβ1,4‐galactosyltransferase is unusual among the glycosyltransferases in that it is found in two subcellular compartments where it performs two distinct functions. In the trans‐Golgi complex, galactosyltransferase participates in oligosaccharide biosynthesis, as do the other glycosyltransferases. On the cell surface, however, galactosyltransferase associates with the cytoskeleton and functions as a receptor for extracellular oligosaccharide ligands. Although we now know much regarding galactosyltransferase function in these two compartments, little is known about how it is targeted to these different sites. By cloning the (...) galactosyltransferase gene products, certain features of the protein have been identified that may be critical for its expression on the cell surface or retention within the Golgi complex. This article discusses recent studies which suggest that a cytoplasmic sequence unique to one galactosyltransferase isoform is required for targeting a portion of this protein to the plasma membrane, enabling it to function as a cell adhesion molecule. These findings allow one to manipulate surface galactosyltransferase expression, either positively or negatively, and perturb galactosyltransferase‐dependent cellular interactions during fertilization and development. (shrink)

Recent studies of early development in a number of ivertebrate and vertebrate species have suggested that growth factors and their receptors may play important roles in differentiation as well as cell proliferation. In the mouse embryo, the expression of the receptors for insulin and insulin‐like growth factors I and II (IGF‐I and ‐II) are temporally regulated. The ontogeny of receptor and ligand expression within the insulin and IGF gene family suggests that the very earliest stages of mammalian embryogenesis may be (...) subject to regulation by autocrine and paracrine factors from maternal and embryonic sources. (shrink)

Ethics involves an organized, reasoned approach to gathering and processing data in order to arrive at decisions about what to do, what to value, and/or what virtues to cultivate. A model is proposed for conceptualizing this complex dynamic, which incorporates elements of both rule-and-principle ethics and the ethic of care. The model suggested here has two levels. The first level identifies the components that comprise philosophical reasoning; the second contextualizes and operationalizes the model in relation to the processor’s philosophical stance (...) on the nature of knowing. Three philosophical stances are identified and described: science-dominant, person-dominant, and science-person equilibrium. Physicians tend to process patients from first perspectives, nurses from second. Hence, health team collaboration in moral problem solving is critically important. (shrink)

The seventies period in Australia is often referred to as the “anything goes” decade. It is a label that gives a sense of the profusion of antiestablishment modes that emerged in response to calls for social and political change that reverberated around the globe around that time. As a time of immense change in the Australian art scene, the seventies would influence the development of art into the contemporary era. The period‟s diversity, though, has presented difficulty for Australian art historiography. (...) Despite the flowering of arts activity during the seventies era—and probably also because of it—the period remains largely unaccounted for by the Australian canon. In retrospect, the seventies can be seen as a period of crucial importance for Australia‟s embrace of contemporary art. Many of the tendencies currently identified with the contemporary era—its preoccupation with the present moment, awareness of the plurality of existence, rejection of hierarchies, resistance to hegemonic domination, and a sense of a global community—were inaugurated during the seventies period. Art-historically, however, it appears as a “gap” in the narration of Australian art‟s development which can be explained neither by the modernism which preceded it, nor by postmodernism. In Australia, the seventies saw a rash of new art “movements” emerge almost simultaneously. Feminist, Pop, Conceptual art, Performance, Protest, Craft, and Aboriginal art as fine art are some of the forms that emerged as part of the concerted questioning and revolt that were characteristic of the period. Art practice changed radically at this time—with challenges both to the art object mounted by conceptualism, and to its hierarchical traditions prompted by feminism and other historically marginalised groups. While no style dominated the period, most of the art-making shared tendencies and concerns, and was driven by a common vision that had its roots in the era‟s politically charged milieu. The focus of this paper is the importance for many artists of working collectively and collaboratively in their pursuit of a new cultural paradigm. Often it was only through joint endeavour that recognition of the multiple valid alternatives, through which many began to define themselves, was possible. However, the embrace of the idea of collective enterprise in itself also facilitated new ways to think about art and the manner and meaning of its production. The purpose here, therefore, is to draw attention to the important ways in which organisational collectivism and collaboration contributed to the seventies as a period of revolutionary transformation in art practice that would propel Australian art into the contemporary era. (shrink)

Human tool behavior is species-specific. It remains a diagnostic feature of humans, even when comparisons are made with closely related non-human primates. The archaeological record demonstrates both the deep antiquity of human tool behavior and its fundamental role in distinguishing human behavior from that of non-human primates.

Whether the mind is thought to be physical or non-physical, philosophers generally agree that there is an intimate connection between the mind and the self. Dualists have always maintained that the person is his mind and that he just happens to have a particular body. There has also been support for this in classical and contemporary literature on personal identity in the discussions of numerous hypothetical cases involving the transfer of “mental contents” from one body to another, often in the (...) form of “brain transplants”. In connection with each case the following question was raised: Does mental continuity guarantee that one will be the same person or is spatio-temporal continuity necessary? Most philosophers have thought that spatio-temporal continuity is not necessary, but that mental continuity is. Finally, very recently there has been much interest in two types of abnormal phenomena—the “split-brain” and multiple personalities—which give indications of there being more than one mental stream associated with a single body and, as a result, philosophers discussing these phenomena have thought that there is good reason to think of there being more than one self involved in such cases. (shrink)