Mitochondria hold diverse and pivotal roles in fundamental processes that govern cell survival, differentiation, and death, in addition to organismal growth, maintenance, and aging. The mitochondrial protein import system is a major contributor to mitochondrial biogenesis and lies at the crossroads between mitochondrial and cellular homeostasis. Recent findings highlight the mitochondrial protein import system as a signaling hub, receiving inputs from other cellular compartments and adjusting its function accordingly. Impairment of protein import, in a physiological, or disease context, elicits adaptive (...) responses inside and outside mitochondria. In this review, we discuss recent developments, relevant to the mechanisms of mitochondrial protein import regulation, with a particular focus on quality control, proteostatic and metabolic cellular responses, triggered upon impairment of mitochondrial protein import. (shrink)

Socrates’ philosophy as expressed in its most general form manifests itself within the framework of questions of the type “What is F-ness?” The method is determinant in the way an asked question is handled and the character of the philosophy that is identified with it. This method is known as elenchus or the Socratic method. This study aims to generally explain what elenchus is and how it can be used. Plato and his dialogues are at the forefront of the sources (...) to look at for understanding the Socratic method. In particular, understanding the Socratic method will be studied through Plato’s early dialogues. In this context, while Plato’s dialogues and Socrates’ approach constitute one of the main pillars of this effort to understand, considering the sophists as another pillar is also thought to be necessary. Understanding the sophists that Socrates and Plato positioned themselves against, their philosophizing practices, and the methods that guide these practices is thought will make understanding the Socratic method easier. In this respect, the Socratic method will be evaluated in terms of its relationship with eristic, which is attributed to the sophists as their method. One of the main determinations of elenchus and eristic is that they result in aporia (expression of logical impasse). From this point of view, the study will explain the positions of these two methods and their attitudes toward aporia. (shrink)

Sie sind so verschieden, dass man sie nur unter der Kategorie ihrer ungewöhnlichen Grösse zusammenbringen kann: Hegel und Nietzsche.... Sie stimmen darin überein, dass Sokrates den Kern des griechischen Wesens verneint, ...

Zajímavě psaná odborná studie podrobným rozborem dochovaných svědectví o řeckém filosofu dokládá, že Sokrates "tak, jak žil a žije v obecném podvědomí, je vlastně postavou neskutečnou, nehistorickou, legendárně zidealizovanou", a že hlavní zásluhu na sokratovských legendách má jeho žák Plato.

Sokrates hat als Figur in der kaiserzeitlichen Philosophie nicht zuletzt auch bei der Auseinandersetzung mit dem Christentum eine Rolle gespielt. Dass dies auch für Aspekte der praktischen Ethik gilt, die mit seinem Namen verbunden werden, ist mit Blick auf die wachsende Jenseitsorientierung der kaiserzeitlichen, platonisch dominierten Philosophie bestritten worden. Michael Erler zeigt, dass die von Sokrates im Gorgias als 'wahre Politik' bezeichnete praktische Anwendung philosophischer Methoden gleichwohl auch im späteren Platonismus eine Rolle spielte und als Hilfestellung für das Leben im (...) Diesseits letztlich der Befreiung der Seele für das Jenseits diente."-- Back cover. (shrink)

In den platonischen Werken scheint die historische Figur des Sokrates besonders im Frühwerk omnipräsent. Die Dialogfigur Sokrates führt bei Platon die Auseinandersetzung mit den Sophisten. Einzelne Figuren der Sophistik, darunter Protagoras von Abdera, Gorgias von Leontinoi und Prodikos von Keos spielen dabei eine besonders prominente Rolle. Hinzu kommen als Vertreter der Sophistik u. a. Kallikles, Thrasymachos, Hippias, Kritias, Antiphon. Vor allem die frühe platonische Ethik steht ganz im Zeichen der Auseinandersetzung mit dem sophistischen Angriff auf die konventionelle Moralvorstellung sowie mit (...) dem Anspruch der Sophisten, Tugenden lehren zu können. (shrink)

45~ JOURNAL OF THE HISTORY OF PHILOSOPHY 34:3 JULY 1996 text" , and an element of "oralism" remains in all of Plato's written works. Nonetheless, Robb's "speculations" on the Platonic dialogues are certainly worth reading. Robb is quite aware that his book stirs up controversial issues, and some of these are briefly stated and discussed in his concluding chapter, "Homer, the Alphabet, and the Progress of Greek Literacy and Paideia." And yet in the very notions of "literacy" and "progress," some (...) weaknesses in Robb's work can be found. For example, as W. V. Harris observed in his Ancient Literacy , 3ft., there is no single definition of literacy or orality, and although Robb cites Harris's book , he takes no special account of it in attempting to define or characterize what he means by "orality" and "literacy." And in his zeal to provide a survey of the influence of alphabetic literacy on Plato, Robb perhaps oversimplifies the tension that existed between the spoken and written work in the ancient world. Much of Greek "literature" remains the product of literate, slave- owning, and well-educated authors, written for their peers. Robb suggests as much in his discussion of mousild and sunousia , and one might desire a "sociology" of ancient Athens, for example, in which economic status and.. (shrink)

Xenophon: Erinnerungen an Sokrates Edition Holzinger. Taschenbuch Berliner Ausgabe, 2015 Vollstandiger, durchgesehener Neusatz bearbeitet und eingerichtet von Michael Holzinger In der Ubersetzung von Otto Guthling erstmalig erschienen bei Reclam, Leipzig, 1883. Herausgeber der Reihe: Michael Holzinger Reihengestaltung: Viktor Harvion Umschlaggestaltung unter Verwendung des Bildes: Raphael, Wandfresko: Die Schule von Athen, Detail: Sokrates und Xenophon, 1509-1510 Gesetzt aus Minion Pro, 11 pt.

Keine ausführliche Beschreibung für "Sokrates und die alte Kirche" verfügbar.

The modern term >fascination fascination force divided self< allow to indicate them as prototypical descriptions of fascination. References to Plato by Marsilio Ficin and Friedrich Nietzsche expose the importance of Socrates in the conceptual history of fascination.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections (...) in the preservation process, and hope you enjoy this valuable book. (shrink)