AbstractmiRNA‐mediated gene repression and ubiquitin‐dependent processes are among the oldest and most versatile mechanisms that control multiple molecular pathways, rather than just protein turnover. These systems were discovered decades ago and have become among the most studied. All systems within cells are interconnected, and these two are no exception: the plethora of studies have demonstrated that the activity of the miRNAs system depends on players of the ubiquitin‐centered universe of processes, and vice versa. This review focuses on recent progress that (...) highlights that very similar mechanisms of regulation of miRNAs by ubiquitin‐related processes are likely to be found in distantly related species, including animals, plants, and viruses. Most of them occur through the ubiquitination of Argonaute proteins, but some of the other miRNA system factors are also regulated. This suggests that their regulatory relationships are either ancient evolutionary acquisitions or have arisen independently in different kingdoms. (shrink)

This book provides an introduction to literacy pedagogy within today's new media environment.

Ethics requires good science. Many scientists, government leaders, and industry representatives support tripling of global-nuclear-energy capacity on the grounds that nuclear fission is “carbon free” and “releases no greenhouse gases.” However, such claims are scientifically questionable (and thus likely to lead to ethically questionable energy choices) for at least 3 reasons. (i) They rely on trimming the data on nuclear greenhouse-gas emissions (GHGE), perhaps in part because flawed Kyoto Protocol conventions require no full nuclear-fuel-cycle assessment of carbon content. (ii) They (...) underestimate nuclear-fuel-cycle releases by erroneously assuming that mostly high-grade uranium ore, with much lower emissions, is used. (iii) They inconsistently compare nuclear-related GHGE only to those from fossil fuels, rather than to those from the best GHG-avoiding energy technologies. Once scientists take account of (i)–(iii), it is possible to show that although the nuclear fuel cycle releases (per kWh) much fewer GHG than coal and oil, nevertheless it releases far more GHG than wind and solar-photovoltaic. Although there may be other, ethical, reasons to support nuclear tripling, reducing or avoiding GHG does not appear to be one of them. (shrink)

The TRIM/RBCC proteins are defined by the presence of the tripartite motif composed of a RING domain, one or two B‐box motifs and a coiled‐coil region. These proteins are involved in a plethora of cellular processes such as apoptosis, cell cycle regulation and viral response. Consistently, their alteration results in many diverse pathological conditions. The highly conserved modular structure of these proteins suggests that a common biochemical function may underlie their assorted cellular roles. Here, we review recent data indicating (...) that some TRIM/RBCC proteins are implicated in ubiquitination and propose that this large protein family represents a novel class of ‘single protein RING finger’ ubiquitin E3 ligases. BioEssays 27:1147–1157, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

In An Introduction to Non-Classical Logic: From If to Is Graham Priest presents branching rules in Free Logic, Variable Domain Modal Logic, and Intuitionist Logic. I propose a simpler, non-branching rule to replace Priest's rule for universal instantiation in Free Logic, a second, slightly modified version of this rule to replace Priest's rule for universal instantiation in Variable Domain Modal Logic, and third and fourth rules, further modifying the second rule, to replace Priest's branching universal and particular instantiation rules in (...) Intuitionist Logic. In each of these logics the proposed rule leads to tableaux with fewer branches. In Intuitionist logic, the proposed rules allow for the resolution of a particular problem Priest is grappling with throughout the chapter. In this paper, I demonstrate that the proposed rules can greatly simplify tableaux and argue that they should be used in place of the rules given by Priest. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Literature 25.1 (2001) 46-58 [Access article in PDF] In Defense of Trimming Eugene Goodheart I In The Education of Henry Adams, Adams disparages a class of English politicians as "trimmers." They are "the political economist, the anti-slavery and doctrinaire class, the followers of Tocqueville, and of John Stuart Mill. As a class, they were timid--and with good reason--and timidity, which is high wisdom in philosophy, sicklies the (...) whole cast of thought in action." 1 Timidity in action, but high wisdom in philosophy. Adams's ambivalent characterization is, relatively speaking, kind to the trimmer, for in the prevailing view he has a reputation for cowardice, lack of integrity, unprincipled behavior. Dante did not know the word, but the "neutrals" (in Sinclair's translation) whom the poet consigns to limbo have been retroactively called trimmers. Virgil regards them as beneath contempt: "Let us not talk of them; but look thou and pass." Sinclair explains why: "These innumerable seekers of safety first, and last, who take no risk either of suffering in a good cause or of scandal in a bad one, are here manifestly, nakedly, that which they were in life, the waste and rubbish of the universe, of no account to the world, unfit for Heaven and barely admitted to Hell. They have no need to die, for they 'never were alive'. They follow still, as they have always done, a meaningless, shifting banner that never stands for anything because it never stands at all, a cause which is no cause but the changing magnet of the day. Their pains are paltry and their tears and blood mere food for worms." 2The dictionary defines trimming as the "modif[ication] of one's attitude in order to stand well with opposite parties; also to accommodate oneself to the mood of the times," and gives 1685 as the date of provenance. By the late nineteenth century trimming becomes opportunism: [End Page 46] "to modify according to expediency." So it was something of a surprise to find a defense of trimming in Macaulay's famous History of England in his eulogy of one of Charles the Second's ministers, Viscount Halifax (Charles Savile). "Halifax," we learn, "was a trimmer on principle. He was also a trimmer by the constitution of his head and his heart." Macaulay sums up Halifax's defense in his essay "The Character of a Trimmer." "Everything good, he said, trims between extremes. The temperate zone trims between the climate in which men are roasted and the climate in which they are frozen. The English Church trims between the Anabaptist madness and the Papist lethargy. The English constitution trims between Turkish despotism and Polish anarchy. Virtue is nothing but a just temper between propensities any one of which, if indulged to excess, becomes vice." Behind trimming lies Aristotle's golden mean.What of the character of the trimmer? Macaulay provides an admirable and admiring portrait of Halifax. "His understanding was keen, sceptical, inexhaustibly fertile in distinctions and objections; his taste refined, his sense of the ludicrous exquisite; his temper placid and forgiving, but fastidious, and by no means prone either to malevolence or to enthusiastic admiration." Charming and agreeable, but where is the integrity or courage, attributes that we associate with character? He had nothing in common with those who fly from extreme to extreme, and regard the party which they have deserted with an animosity far exceeding that of consistent enemies. His place was on the debatable ground between the hostile divisions of the community.... The party to which he at any moment belonged was the party which, at that moment, he liked least, because it was the party of which at that moment he had the nearest view. He was therefore always severe upon his violent associates, and was always in friendly relations with his moderate opponents. Every faction in the day of its insolent and vindictive triumph incurred his censure; and every faction, when vanquished and persecuted, found in him a protector. To his lasting honor it must be mentioned that he attempted to save those victims whose fate... (shrink)

American Journal of Public Health Vol. 97.

Professor Matthew Kramer is one of the most important legal philosophers of our time - even if the label 'legal philosopher' does not do justice to the breadth of his work. This collection of essays brings together esteemed philosophers, as well as junior scholars, to critically assess Kramer's philosophy. The contributions focus on Kramer's work on legal philosophy, metaethics, normative ethics, and political philosophy. The volume is divided into six parts, each focusing on different aspect of Kramer's work. The first (...) part, Rights and Right-holding, contains five essays addressing Kramer's work on rights and right-holding, including the Hohfeldian analysis and the interest theory of right-holding. The four essays in the second part, General Jurisprudence, focus on Kramer's work in general jurisprudence, from the compatibility of legal positivism with universal legal error, to his robust defense of inclusive legal positivism, concluding with reflections on his writings on the rule of law. The third part, General Matters of Ethics, contains two essays addressing Kramer's metaethical work on moral realism as a moral doctrine. The fourth and fifth parts, Freedom and Liberalism, have four essays falling within political philosophy, probing Kramer's work on negative freedom and political liberalism, respectively. The sixth part, Applied Ethics, contains two essays on Kramer's work on capital punishment and freedom of expression. The collection is rounded off by reflections on, and replies to, the contributions by Kramer himself. (shrink)

In patients with pain characterized by a painful focus and allodynia, the painful symptoms arise from altered central processing that is initiated and subsequently maintained by persistent input from nociceptive afferents. Treatments directed at this normal consequence of persistent input are inherently limited. The most efficacious treatments will target the pathology, the various sources of ongoing nociceptor input. [blumberg et al.; coderre & katz; dickenson].

This book is an uncompromising defense of legal positivism that insists on the separability of law and morality. After distinguishing among three facets of morality, Kramer explores a variety of ways in which law has been perceived as integrally connected to each of those facets. The book concludes with a detailed discussion of the obligation to obey the law--a discussion that highlights the strengths of legal positivism in the domain of political philosophy as much as in the domain of jurisprudence.

This third of three articles outlining a different approach to science/religion dialogue generally and to engagement between theology and the neurosciences specifically, gives a brief account of the model in practice. It begins by introducing the question to be investigated—whether the experience of relational connection can affect health outcomes by directly moderating immune function. Then, employing the same threefold heuristic of encounter, exchange, and expression used previously, it discusses how the transversal model set out in these articles has been used (...) to investigate this question and to develop a theoretical physiological model for the proposed link between relationality and health. (shrink)

Reviewed by Heli Tissari Reviewed by Heli Tissari Research Unit for Variation, Contacts and Change in English Department of Modern Languages University of Helsinki, Finland [email protected]...

On Jaina philosophy and doctrines; Sanskrit text with commentary and Gujarati translation.

The European Legacy, Volume 17, Issue 3, Page 400, June 2012.

Merck suppressed data on harmful effects of its drug Vioxx, and Guidant suppressed data on electrical flaws in one of its heart-defibrillator models. Both cases reveal how financial conflicts of interest can skew biomedical research. Such conflicts also occur in electric-utility-related research. Attempting to show that increased atomic energy can help address climate change, some industry advocates claim nuclear power is an inexpensive way to generate low-carbon electricity. Surveying 30 recent nuclear analyses, this paper shows that industry-funded studies appear to (...) fall into conflicts of interest and to illegitimately trim cost data in several main ways. They exclude costs of full-liability insurance, underestimate interest rates and construction times by using overnight costs, and overestimate load factors and reactor lifetimes. If these trimmed costs are included, nuclear-generated electricity can be shown roughly 6 times more expensive than most studies claim. After answering four objections, the paper concludes that, although there may be reasons to use reactors to address climate change, economics does not appear to be one of them. (shrink)

Annotation. "This trim publication satisfies a much-felt need among teachers of Indian philosophy, who badly want introductions to the several systems of classical Indian thought such as Professor Deutsch provides."--Journal of Asian Studies.

You'd never know Athens was locked in a life-or-death struggle from the tranquil and leisurely philosophical discussion that unfolds through the pages of the Republic...Plato's masterpiece continues to inform our questions and our thinking when it comes to being, truth, beauty, goodness, justice, community, the soul, and more." -From Dr. Littlejohn's Introduction. On the way back from a festival, Socrates is waylaid by some friends who compel him to go home with them. There he and his companions engage in a (...) long discussion about whether it is worse to suffer evil or to commit it. Far from being dry or abstract, Plato's dialogue is full of practical questions about the nature of justice, education, power, and virtue, and it ends with two of the most vivid myths ever devised by man. This Canon Classic is translated clearly by Benjamin Jowett, and unlike all other works of philosophy, it's actually fun to read. The Canon Classics series presents the most definitive works of Western literature in a colorful, well-crafted, and affordable way. Unlike many other thrift editions, our classics are printed on thicker text stock and feature individualized designs that prioritize readability by means of proper margins, leading, characters per line, font, trim size, etc. Each book's materials and layout combine to make the classics a simple and striking addition to classrooms and homes, ideal for introducing the best of literary culture and human experience to the next generation. This Worldview Edition features an introduction divided into sections on The World Around, About the Author, What Other Notables Said, Setting, Characters, & Plot Summary, Worldview Analysis, 21 Significant Questions & Answers, and Further Discussion & Review. (shrink)

Perfect Paperbount Trim: 6 X 9 Text throught No halftones, No bleeds Update Print/Year line to read for year 2001, 6th printing.

How do we acquire moral obligations to others? The most straightforward cases are those where we acquire obligations as the result of particular actions which we voluntarily perform. If I promise you that I will trim your hedge, I face a moral Obligation to uphold my promise, and in the absence of some morally significant countervailing reason, I should indeed cut your hedge. Moral obligations which arise as a result of wrongdoing, as a function of corrective justice, are typically (...) thought to be of a similar nature. (shrink)

Many people argue that uncertain science—or controversial policies based on science—can be clarified primarily by greater attention to social/political values influencing the science and by greater attention to the vested interests involved. This paper argues that while such clarification is necessary, it is not a sufficient condition for achieving better science and policy; indeed its importance may be overemphasized. Using a case study involving the current, highly politicized controversy over the shape of dose‐response curves for biological effects of ionizing radiation, (...) the paper argues that the conflict could be significantly resolved through specific methodological improvements in the areas of metascience and philosophy of science. These improvements focus on taking account, respectively, of scale, data trimming, aggregation, measurability, and simplicity. (shrink)

This article locates Weyl''s philosophy of mathematics and its relationship to his philosophy of science within the epistemological and ontological framework of Husserl''s phenomenology as expressed in the Logical Investigations and Ideas. This interpretation permits a unified reading of Weyl''s scattered philosophical comments in The Continuum and Space-Time-Matter. But the article also indicates that Weyl employed Poincaré''s predicativist concerns to modify Husserl''s semantics and trim Husserl''s ontology. Using Poincaré''s razor to shave Husserl''s beard leads to limitations on the least (...) upper bound theorem in the foundations of analysis and Dirichlet''s principle in the foundations of physics. Finally, the article opens the possibility of reading Weyl as a systematic thinker, that he follows Husserl''s so-called transcendental turn in the Ideas. This permits an even more unified reading of Weyl''s scattered philosophical comments. (shrink)

Abstract: It is the aim of this paper to establish a temporal and cultural link between entheogen-use1 in Classical mystery cults and their possible use in a segment of the early Christian Gnostic Church. As early Christianity was heavily influenced by the Classical world in which it first developed, it is essential to examine the evidence of entheogen-use within Classical mystery cults, and explore their possible influence on the development of Christian ritual. We will first present textual evidence from the (...) New Testament and Nag Hammadi Library (NHL) that indicate possible use of ritual entheogens. Next we will examine entheogen-use by some of the main religious sects of the ancient Mediterranean world as part of their liturgical practice between c. fifth century BCE and the third century CE. Then we will show that the different schools of philosophical thought examined were quite fluid, and that there was considerable overlap among schools with respect to several key philosophies and practices. Ultimately the subject of entheogen-use in the Classical world necessarily falls into the realm of plausible speculation mainly due to the lack of primary sources. However, should the entheogenic hypothesis2 prove to be correct, it promises to be quite useful in future research and in the translation of original documents. (shrink)

This essay juxtaposes the position in metaethics defended, expressivism with quasirealistic trimmings, with the ancient problem of relativism. It argues that, perhaps surprisingly, there is less of a problem of normative truth on this approach than on others. Because ethics is not in the business of representing aspects of the world, there is no way to argue for a plurality of moral truths, simply from the existence of a plurality of moral opinions. The essay also argues that other approaches, which (...) superficially seem better adapted to defending robust and substantive conceptions of moral truth, in fact face more danger from the threat of relativism. This is particularly so in the case of 'secondary quality' or 'response-dependent' approaches, but also in the case of certain kinds of constructivism. (shrink)

Despite a widely agreed necessity for agroecological transition, there are various substantial constraints that hinder the adoption of alternative, more sustainable, practices. We employ the niche management concept to examine the initial phases of transition in the local wine-growing niche in Israel, or specifically, the replacement of herbicides with the use of cover-crops combined with the practice of mowing of herbaceous growth using specialized trimming machines. Our goal is to uncover the triggers, drivers and agents of change in farming practices (...) within the agroecological system in which it happened, despite entrenched, widely recognized risk perceptions among farmers. The problem-oriented research design revolved around a transdiciplinary team that included ecologists and social scientists. We identified three groups of frontrunners who initiated, developed and sustained the adoption of the more sustainable agricultural practices. The two-year study focused on interviewing vineyard farmers who were transitioning to cover crops, and this qualitative research was paralleled with continuous ecological monitoring. The farmers believed that the risks inherent in the new practice, if any, were preventable and manageable. The transdisciplinary research design, which integrated farmers into the social and ecological research process, further assisted in facilitating a transition by creating a forum for stimulating communication between diverse stakeholders during the transition, increasing trust between actors from the various sectors and identifying key issues of concern (e.g., risk and associated costs) to better align the motives of farmers, wine-makers, and ecologists. The research design may have also contributed to the adoption of a more holistic view of the agroecological system by various stakeholders and the belief that one cultivation method clearly benefits the system, particularly in the long-term. We therefore conclude with key-insights on the role of the research itself in agroecological transition processes. (shrink)

Analytic Philosophy, EarlyView. The method of paraphrasing away apparent ontological commitments is a familiar tool for trimming one's ontology. Even so, I argue that aiming to avoid commitment via paraphrase is unjustified. The reason is the standard motivations for paraphrase rest on implicit yet faulty principles regarding ontological categories and categorization- or so I argue. These results also provide indirect support for a permissivist approach to ontology.

In his story entitled "Toenails," the surgeon Richard Selzer (1982) warns readers that total immersion in medicine is wrongheaded. Rather, to ensure their own health, doctors should discover other passions that permit them periodically to disconnect from medical practice. Selzer's surgeon character devotes his Wednesday afternoons to the public library, where he joins "a subculture of elderly men and women who gather … to read or sleep beneath the world's newspapers" (p. 69). Among these often eccentric personages is Neckerchief, an (...) arthritic man in his 80s who suffers from severe foot pain. His toenails, never trimmed because of his inability to reach them, have grown so long that they curve beneath his toes and .. (shrink)

School climate is a multidimensional construct of the quality of a student’s academic environment, often subsuming dimensions such as safety, instructional practices, social relationships, school facilities, and school connectedness. Positive school climate has beneficial effects on a wide range of adjustment variables in youth, including academic achievement, mental health, school attendance and graduation, and school-based behavior. Studies regarding school climate assessment have burgeoned in recent years but remain marked by limited sample sizes, narrow developmental levels, restricted items, unclear psychometric strength (...) across multiple demographic groups, and lack of integration with key student education contextual factors such as academic mindset and social emotional learning. The present study evaluated a comprehensive measure of aspects of school climate, academic mindset, and social emotional learning in a sample of 105,379 diverse students (Mage = 13.47 years; SD = 2.47). The 9-factor structure of the School Climate and Academic Mindset Inventory was supported via confirmatory factor analysis. A trimmed model displayed adequate goodness-of-fit for males and females, younger age groups, and European American, biracial/multiracial, Hispanic, Native American, and Native Hawaiian/Pacific Islander students. The trimmed model was slightly less strong for older age groups as well as for African American and Asian American students. The scale may be useful for assessing school climate interventions, longitudinal climate patterns, and school-based algorithms of future performance, though additional validation of the scale remains necessary. (shrink)

This chapter explores the unifying themes of “the Pittsburgh School” of Sellars, Brandom, and McDowell: a social pragmatist account of intentionality, the rejection of the Myth of the Given, and the partial rehabilitation of Hegel for analytic philosophy. In addition this chapter also discusses three points of disagreement within the Pittsburgh School: whether or not we should posit sense-impressions, whether perceptual intentionality is world-relational, and whether the natural sciences have epistemic authority over other ways of thinking about nature. The chapter (...) concludes with a metaphilosophical concern about the status of a return to Hegel within analytic philosophy. Analytic philosophy follows an anti-Hegelian neo-Kantian institution of a divide between philosophy and the social and natural sciences. Hegel would reject such a divide, since he conceives of philosophy as investigating “shapes of a world” and not just “shapes of consciousness”. In these terms the Pittsburgh School marks a return to Hegel trimmed to suit the needs of analytic philosophy rather than questioning those needs. (shrink)

In this paper, we’ll present, explain, and defend a Christian ethic for sport that takes loving all individuals as the fundamental moral imperative. First, we’ll begin by taking a seeming detour through views about the morality of war. More specifically, we’ll consider realism, according to which, roughly, moral requirements and rules are suspended during war such that it is misguided to attempt to apply moral terms to acts performed within the context of war. Second, by paying attention to relevant surveys (...) and testimonies, we’ll see how this sort of realism seems to be prevalent within the sports world. We’ll see that a singular focus upon winning seems to cultivate this orientation toward realism and its corresponding relaxed attitude toward rule exploitation and violation and the imposition of harms upon one’s opponents. Third, we’ll present an argument from counterexamples against realism about war and then we’ll consider a structurally identical argument against realism in sport. Fourth, we’ll fill the resulting void by presenting, explaining, and defending the aforementioned Christian ethic for sport. Finally, we’ll apply our Christian ethic for sport, tracing some of its implications for fighting in the NHL, taunting and trash-talking, and telling the truth within gameplay. (shrink)

Aristotle listed moderation as one of the moral virtues. He also defined virtue as the mean between extremes, implying that moderation plays a vital role in all forms of moral excellence. But moderation's protean character—its vague and ill-defined omnipresence in judgment and action—makes it exceedingly difficult to grasp theoretically. At the same time, moderation seems to be the foundation of many contemporary democratic political regimes, because the competition between parties cannot properly function without compromise and bargaining. The success of representative (...) government and its institutions depends to a great extent on the virtue of moderation, yet the latter persists in being absent from both the conceptual discourse of many political philosophers and the campaign speeches of politicians fearful of losing elections if they are perceived as moderates. Aurelian Craiutu aims to resolve this paradox. Examining the writings of prominent twentieth-century thinkers such as Raymond Aron, Isaiah Berlin, Norberto Bobbio, Michael Oakeshott, and Adam Michnik, he addresses the following questions: What does it mean to be a moderate voice in political and public life? What are the virtues and limits of moderation? Can moderation be the foundation for a successful platform or party? Though critics maintain that moderation is merely a matter of background and personal temperament, Craiutu finds several basic norms that have consistently appeared in different national and political contexts. The authors studied in this book defended pluralism, of ideas, interests, and social forces, and sought to achieve a sound balance between them through political trimming. They shared a preoccupation with political evil and human dignity, but refused to see the world in Manichaean terms that divide it neatly into the forces of light and those of darkness. Faces of Moderation argues that moderation remains crucial for today's encounters with new forms of extremism and fundamentalism across the world. (shrink)

This paper discusses the political implications of the British military's Trauma Risk Management (TRiM) approach to personnel suffering from combat-related mental debilities such as post-traumatic stress disorder. Drawing on narratives that emerged from qualitative interviews with trained TRiM practitioners and military welfare workers, I tease out some of the assumptions and beliefs about mental health and mental illness that underpin this mental health intervention programme. I explore TRiM as a biopolitical strategy targeted towards the construction of a (...) particular conceptualisation of mental wellness and militarised masculine personhood. As a biopolitical strategy, I argue that TRiM plays an important role in the construction of ideas around mental well-being and mental frailty that best enable the operation of military power in the contemporary British context. I discuss the narrative of transformation in militarised models of masculinity that emerge from discussions of TRiM, and highlight the important political function that this plays in enabling and legitimating militarism. Finally, I draw attention to the ways in which the focus on individual and cultural factors, rather than war as the primary cause of difficulties for servicemen experiencing psychological distress, functions to neutralise the potential trouble that could be instigated for the British military by the bodies of servicemen psychologically damaged by their experiences of conflict. (shrink)

In this paper, we critically consider the analogy between “infodemic” and “pandemic”, i.e. the spread of fake news about COVID-19 as a medial virus and the infection with the biological virus itself from the perspective of cultural evolutionary theory (CET). After confronting three major shortcomings of the ‘infodemic’ concept, we use CET as a background framework to analyze this phenomenon. To do so, we summarize which bi-ases are crucial for transmission in terms of cultural selection and how transmission is restricted (...) by filter bubbles or echo chambers acting as TRIMS (transmission isolating mechanisms) post “infection”, which isolate false from trustworthy scientific information in the context of the Corona pandemic. This is followed by a demonstration of the threat to biological fitness posed by the effects of an infection with fake news, which leads to a reduced willingness to vaccinate and follow health measures. We identify fake news on Covid as pseudoscience, trying to immunize itself from external influences. We then address the question of how to combat the infodemic. Since debunking strategies, such as warnings by fact-checking, have proven relatively ineffective in combating fake news, the inoculation theory from psychology might offer an alternative solution. Through its underlying ‘prebunking strategy’, which educates individuals about the risks and tactics of fake news prior to a potential infection, they could be ‘immunized’ in advance, similar to a virological vaccination. Although we recognize that the pandemic/infodemic analogy is in fact far from perfect, we believe that CET could provide a theoretical underpinning in order to give much more semantic depth to the concept ‘infodemic’. (shrink)

Objectives: This study aimed to provide a comprehensive understanding of all intervention for learning burnout by meta-analyzing their effects.Methods: Relevant studies that had been published up to September 18, 2020, were identified through a systematic search of the PubMed, Web of Science, the China National Knowledge Infrastructure, and Wan Fang databases. Eligible studies included randomized control trials of any learning burnout intervention conducted among students. The Jadad scale was used to evaluate the quality of the study. Random-effect meta-analyses, subgroup analyses, (...) meta-regression analysis, and sensitivity analysis were conducted. Funnel plots and Egger's tests were used to evaluate publication bias. Duval and Tweedie's non-parametric trim-and-fill method was used to adjust the effect of publication bias.Results: Of the 5,245 articles found, 39 met the inclusion criteria for the systematic review. There were 3,400 students, including 1,847 students in the intervention group and 1,553 in the control group. A meta-analysis of 44 studies showed that the interventions were effective. Subgroup analyses were conducted according to education, scales, intervention measures, and intervention time. The results showed that, compared with the control group, the learning burnout scores of undergraduates, secondary vocational students, and middle school students were significantly lower. Based on different scales, all interventions were also effective. The funnel plot was asymmetric and consistent with the results of Egger's test. The trim-and-fill method was used, and seven missing studies were merged to obtain a symmetric funnel plot.Conclusions: This meta-analysis indicated that learning burnout interventions are effective. The subgroup analyses showed that group counseling is the most widely used, exercise intervention is probably the most effective, and 8 weeks or more is the appropriate intervention time. An integrated intervention study based on the factors of learning burnout adds value. More studies are needed to supplement the results in the future. (shrink)

RNA processing in Escherichia coli and some of its phages is reviewed here, with primary emphasis on rRNA and tRNA processing. Three enzymes, RNase III, RNase E and RNase P are responsible for most of the primary endonucleolytic RNA processing events. The first two are proteins, while RNase P is a ribozyme. These three enzymes have unique functions and in their absence, the cleavage events they catalyze are not performed. On the other hand a relatively large number of exonucleases participate (...) in the trimming of the 3′ ends of tRNA precursor molecules and they can substitute for each other. Primary processing is the first event that happens to the nascent RNA molecule, while in secondary RNA processing, the substrate is a product of a primary processing event. Although most RNA processing occurs in RNP particles, it seems that only in secondary RNA processing is the RNP particle required for the reaction. Bacteria and especially bacteriophages contain self‐splicing introns which in cases were probably acquired from other species. (shrink)

Beards are a sort of dwelling. Much like Heidegger's linguistic play with related etymologies of building and dwelling, beards are in a constant state of becoming, forever changing length, shape, and color. To the person—usually, but not always, a man—who grows a beard, the end product is always projected out into the future, like Heidegger’s concept of being. The beard is trimmed and groomed constantly; it is cultivated in a way that feels authentic to its wearer. But the same ontological (...) problems that Heidegger applies to dwelling in a home also apply to beards. Long facial hair symbolizes wisdom in many cultures, but anyone who has grown a beard can attest to the existential dilemma of long facial hair. I didn’t recognize you with the beard, someone will say. Beards can serve as symbols of erudition, yes, but they are also masks for our social selves. The beard is, after all, is a curious appendage, as it is an extension of the self, but not the self per se. Herman Melville called beards “suburbs of the chin.” If, like Heidegger, we are to see being as not a fixed entity divorced from other beings, but a being-in-the-world, a set of relations among other beings, then beards are not simply static accessories or styles, but an example of the slippery nature of being itself. (shrink)

The received wisdom among welfare state scholars is that policy feedbacks render social insurance programs durable. Yet, in the case of Detroit’s municipal bankruptcy, a voting majority of retired city workers accepted a settlement that asked them to waive key legal protections, formally accept gutted medical benefits, trimmed pension benefits, and a new public-private pension financing mechanism. This article synthesizes interactionist theories of loss to introduce the concept of “collective cooling.” I argue that collective cooling helps to establish the limits (...) of policy feedbacks by explaining how a group of retirees’ collective self-understandings were adjusted from that of contractual rights holders to charitable dependents. Key components of this process included: First, seeking to adjust understandings of how pensioners were perceived by powerful outsiders; And, second, seeking to adjust the loss from one that reflected poorly on pensioners to one that did not. Implications are discussed for how people accept unexpected economic losses, especially those imposed by a trusted institution such as an employer or government organization. (shrink)

Can our present-day anxieties be stated in terms of the ancient world? Can this be done without risking the accusation of self-deception or pedantry? That is the question.Hellenism in en vogue; there is satisfaction in defining in ever more exact terms a new aspect, long underestimated, of Greek grandeur. A certain ‘modernism’ cannot be denied to Greek thought: a tendency that existed then as it does now. Two millennia and more have trimmed down what was pretensions: tricks and scandals of (...) innovation become less important ; the essence of contributions becomes apparent, distilled by the labour of preceding centuries. It remains sure that the Greeks faced new human circumstances with the vigour of youth and with intelligence, and launched themselves freely upon the path of world discovery. This is truly modem: modern for us as it was for the Greeks of the third century B.C. A comparison between such experiences may be worth while. (shrink)