Autism spectrum disorders (ASD) are heterogeneous neurodevelopmental disorders that are reportedly characterized by aberrant neural networks. Recently developed multiscale entropy analysis (MSE) can characterize the complexity inherent in EEG dynamics over multiple temporal scales in the dynamics of neural networks. We encountered an 18-year-old man with ASD whose refractory catatonic obsessive–compulsive symptoms were improved dramatically after electroconvulsive therapy (ECT). In this clinical case study, we strove to clarify the neurophysiological mechanism of ECT in ASD by assessing EEG complexity using MSE. (...) Along with ECT, the frontocentral region showed decreased EEG complexity at higher temporal scales, whereas the occipital region expressed an increase at lower temporal scales. Furthermore, these changes were associated with clinical improvement associated with the elevation of brain-derived neurotrophic factor, which is a molecular hypothesis of ECT, playing key roles in ASD pathogenesis. Changes in EEG complexity in a region-specific and temporal scale-specific manner we found might reflect atypical EEG dynamics in ASD. Although MSE is not a direct approach to measuring neural connectivity and the results are from only a single case, they might reflect specific aberrant neural network activity and the therapeutic neurophysiological mechanism of ECT in ASD. (shrink)

L’article analyse l'implication des collectifs de personnes handicapées et des organisations connexes dans le processus d’élaboration des politiques du handicap au Japon et envisage de nouvelles formes de collaborations pour résoudre les problèmes politiques à venir, en s’appuyant sur l’étude des mouvements sociaux, des interactions stratégiques et de l’action collective coopérative. Il montre, dans un premier temps, comment la question de la dépendance persistante des personnes handicapées vis-à-vis des institutions résidentielles et des membres de leur famille s’est imposée comme un (...) problème fondamental de la politique japonaise du handicap, à la suite de la tragédie de Tsukui Yamayuri-en en 2016. Il retrace ensuite les grandes lignes de la politique japonaise du handicap depuis les années 1960 afin de bien saisir l’origine du problème en relation avec les mouvements des personnes handicapées et de leur famille. Deux exemples de coopération avec des collectifs de personnes handicapées et des organisations affiliées, qui ont eu lieu dans les années 2010, au moment de la ratification de la CDPH, sont présentés. Enfin, des pistes de collaboration plus étroite entre les collectifs de personnes handicapées et les organisations apparentées, en particulier les organisations de parents/familles, sont proposées en vue de favoriser l’émancipation des personnes handicapées vis-à-vis des institutions et de libérer les familles des responsabilités de leur prise en charge. (shrink)

Since the inception of modern approaches to grammar, Japanese ga has been treated as a marker indicating the grammatical relation `subject.' If this is an accurate characterization of ga, then we would expect ga to occur to mark a grammatical category consisting of `A' and `S'. Our examination of the contexts in which ga is actually used in everyday Japanese conversations shows that this expectation is not borne out. Our findings suggest that it is not appropriate to describe ga in (...) terms of a grammatical relation such as `subject', and that ga may be much less a grammatical marker than a discourse-pragmatic one. (shrink)

In a reenactment, a speaker re-presents or depicts a previously occurring event, often dramatically. In this article we examine the role of gaze in reenactments in conversations from Japanese and American English. Following Goodwin in viewing a reenacted story as ‘a multi-modal, multi-party field of activity’, we show how tellers’ and recipients’ gaze during reenactments is deployed to achieve specific interactional ends. We argue that there are two layers of activities involved in doing reenacting – a) the habitat of the (...) original event; b) the habitat of the reenacting event, including the dynamics of gaining appreciative recipiency – and show how they are interwoven in the joint production of a reenactment. (shrink)

It is generally acknowledged that onomatopoeia poses challenges for translation. However, there is little research into the translation of onomatopoeia in Pragmatics. This study seeks to examine the nature of onomatopoeia and its implications for translation from the perspective of relevance theory, addressing, in particular, the following questions: Can notions from pragmatics help to account for the perceived challenges involved in translating onomatopoeia? Would the showing-meaning nature affect the translation of onomatopoeia? What other factors result in difficulties in translating onomatopoeia (...) and why? To this end, a corpus-based analysis of onomatopoeia was conducted using user-generated data provided by Cookpad Inc. Findings show that the relevance-theoretic notions of the showing-meaning continuum and perceptual resemblance can indeed help account for the perceived challenges in translating onomatopoeia. Findings also show that stylistic aspects, such as types of expressions and text types, also impact on the translation of onomatopoeia. (shrink)

Mitotic spindles constitute the machinery responsible for equidistribution of the genetic material into each daughter cell during cell division. They are transient and hence quite labile structures, changing their morphology even while performing their function. Biochemical, immunological and genetic analyses of mitotic cells have allowed us to identify a variety of molecules that are recruited to form the spindle at the onset of mitosis. Evaluation of the roles of these molecules in both the formation and in the dynamics of spindle (...) microtubules should be important for understanding the molecular basis of mitosis and its regulation. We have recently identified a novel mitosis‐specific microtubule‐associated protein (MAP) using a monoclonal antibody probe raised against the mitotic spindles isolated from cultured mammalian cells. This 95/105 kDa antigen represents a unique component of the spindle distinct from any of the other MAPs reported so far. Antibody microinjection resulted in mitotic inhibition in a stage‐specific and dosedependent manner, indicating that the protein is an essential spindle component. (shrink)

The role of figurative languages such as metaphor and metonymy in creativity has been studied in cognitive linguistics. These methods can also be applied to analyze non-linguistic data such as pictures and gestures. In this paper we analyze fashion design by focusing on visual metaphor and metonymy. The nature of creativity in fashion design is not fully studied from a cognitive perspective compared to other related fields such as art. We especially focus on the aspect of fashion design as a (...) communication tool between the designer and the audience to convey designer’s image of human. Photos from two fashion shows are analyzed. We carried out an experiment to compare how human images in two shows are interpreted by those who are familiar with fashion and those who are not. We got three results: (1) As far as figurative (metaphorical and metonymic) interpretations of human image are concerned, two groups with different familiarity to fashion have significantly different patterns of responses to two shows. (2) For non-figurative interpretations (such as physical or personal attributes), no significant difference in the pattern of response to the show was observed between two groups. The participants as a whole, however, responded to the two shows differently. (3) In addition for non-figurative interpretation, fashion experts found significantly more attributes in human images than the others. The results show that the analysis of figurative interpreations is effective in seeing how the familiarity to fashion affects the mode of seeing fashion shows. (shrink)

自己決定概念は、患者の自律やインフォームド・コンセント、プライバシー概念等の基礎にあり、生命倫理において核となる重要な概念である。しかし、その歴史的由来について、またその概念の意味するところについて、 これまで本巻のように主題的に扱われることはほとんどなかった。ここでの諸論考は、「自己決定権」や「自律」概念の理解にも大いに役立つはずである。.

Purpose This study aims to map Swedish students’ attitudes towards Snowden’s revelations and their effects in the political and socio-cultural environment of Sweden. Design/methodology/approach A questionnaire was answered by 190 Swedish university students. The quantitative responses to the survey and qualitative considerations of free text answers were statistically analysed. Findings Swedish students had a high level of knowledge about the Snowden revelations; they actively searched for information, gave a positive judgement of Snowden’s actions and were willing to follow his example (...) in Sweden, although not in the USA. They trusted their country and most of its institutions and authorities except for secret service agencies and the internet and computer software companies. Practical implications This study could be used as a design of education for university students, especially in information technology programmes. Social implications The study can be used for developing and applying policies on privacy, surveillance and whistle-blowing. Originality/value This study is part of a bigger international study to map students’ attitudes towards Snowden’s revelations and their opinions about privacy, surveillance and whistle-blowing opening up for cross-cultural analyses. (shrink)

In this thesis, we study the least fixed point principle in a constructive setting. A constructive theory of functions and sets has been developed by Feferman. This theory deals both with sets and with functions over sets as independent notions. In the language of Feferman's theory, we are able to formulate the least fixed point principle for monotone inductive definitions as: every operation on classes to classes which satisfies the monotonicity condition has a least fixed point. This is called the (...) principle of monotone inductive definition. Furthermore, we may formulate this principle in a uniform way as: there is an operation which maps a monotone operation to its least fixed point. This is called the principle of uniform monotone inductive definition. Feferman raised the question of the strength of the principle of monotone inductive definition when adjoined to his theory . This question is our primary concern in this thesis. ;Our main results are the consistency of both the principle of monotone inductive definition and the principle of uniform monotone inductive definition adjoined to his theory, and the proof theoretical equivalence between the principle of monotone inductive definition with Feferman's system without the inductive generation axiom and the system of the Pi-one-one Comprehension Axiom. Determination of the proof-theoretical strength of the principle of monotone inductive definition adjoined to Feferman's theory still remains open. ;The consistency of both the principle of monotone inductive definition and the principle of uniform monotone inductive definition with Feferman's theory will be achieved by constructing their models in set theoretical sense. The proof theoretical equivalence between the principle of monotone inductive definition with Feferman's system without the inductive generation axiom and the system of the Pi-one-one Comprehension Axiom can be obtained by a careful examination of the model construction for the principle of monotone inductive definition with Feferman's system without the inductive generation axiom, which is parallel to the model construction for the principle of monotone inductive definition with his theory. (shrink)

Comparative quantifiers, such as more than three books, cannot take scope over any quantifier in subject position if they occupy object position. This is clearly different from the behavior of other quantifiers (e.g., universal quantifiers). This paper argues that this scope puzzle is due to a more complex internal structure of comparative quantifiers than other quantifiers. In the decompositional approach that I pursue, comparative quantifiers are decomposed into two generalized quantifiers (i.e., in the case above, the comparative operator er than (...) three and the DP many books). In this approach, obligatory narrow scope of comparative quantifiers in object position is a consequence of the interplay of the independently motivated principles of grammar that also constrain other quantifiers. On the basis of the scope puzzle, I specifically argue for two constraints on Scope Shifting Operations (SSOs) a locality condition on SSOs and Scope Economy, proposed by Fox (2000), which prohibits SSOs that have no effect on semantic interpretation. Thus, I argue that the apparently peculiar facts of comparative quantifiers are, in fact, additional evidence for the core properties of SSOs. (shrink)

The Dominican theologian Albert the Great was one of the first to investigate into the system of the world on the basis of an acquaintance with the entire Aristotelian corpus, which he read under the influence of Islamic philosophers. The present study aims to understand the core of Albert's natural philosophy. Albert's emblematic phrase, “every work of nature is the work of intelligence” , expresses the conviction that natural things are produced by the intellects that move the celestial bodies, just (...) as houses are made by architects moving their instruments. Albert tried to fathom the secret of generation of natural things with his novel notion of “formative power” , which flows from the celestial intellects into the sublunary elements. His conception of the natural world represents an alternative to the dominant medieval view on the relationship between the artificial and the natural. (shrink)

This book is an excellent book on business ethics and will be an invaluable resource for all readers who are keen to learn about the business ethics and key characteristics of a successful company. It focuses on the case study of a global company, Johnson & Johnson (J&J), which oversees more than 250 operating units throughout the world. Through extensive interviews with top executives at J&J's headquarters, including Masami Atarashi and Mitsuo Hirose and attending workshops, Prof Hiroo Takahashi acquired (...) an in-depth understanding of the management style of J&J, grasped the company's ethics and the code of business conduct which is shared by J&J's members throughout the world. (shrink)

In the monograph [1] of Chang and Keisler, a considerable extent of model theory of the first order continuous logic is ingeniously developed without using any notion of provability.In this paper we shall define the notion of provability in continuous logic as well as the notion of matrix, which is a natural extension of one in finite-valued logic in [2], and develop the syntax and semantics of it mostly along the line in the preceding paper [2]. Fundamental theorems of model (...) theory in continuous logic, which have been proved with purely model-theoretic proofs in [1], will be proved with proofs which are natural extensions of those in two-valued logic. (shrink)

This essay aims to deepen our comprehension of the economic ethics of different peoples in Asia, as well as realizing a degree of cultural relativism, in order to enhance amicable economic associations. It counterbalances the conventionally strong West-oriented views which regard exotic features of non-Western economies as backward and illogical elements that disturb smooth and orthodox development and, hence, should be eradicated. The author, first, recalls a number of facts which depict the eruptive economic transformation in Asia. He, then, criticizes (...) the imposition of Western-style development and exploitation without excluding Japan’s colonialism in Taiwan and Korea, and pleads for multiple forms of development and modernity. Economic transactions should be analysed in relation to sociocultural aspects, and, therefore, communities and ethics groups play a substantive role between the public and private sectors, the market, and individuals. For instance, small farmers in Southeast Asia, struggling with the weakness of tenant farmers and pressures of the market mechanism, developed ingenious and participatory forms of survival, increasingly supported by non-governmental organizations. Case studies from Thailand, Malaysia, and the Philippines give a vivid picture of these activities. Because the developing economies are composed of market and non-market sectors, reasonable attention should be given to theethics beyond market principles, with particular emphasis on community as foundation. (shrink)

This paper examines the semantics and pragmatics of the Japanese causal connective mono. We show that the meaning of mono has three components: a causal relation, an emotive attitude toward the causing proposition, and an indication that the causal relation is of high quality. Further, we show that the latter two components are not at-issue content but expressive content. A formalization is provided in terms of the analysis of mixed content in McCready (2010). Finally, the proposal is briefly compared with (...) previous, informal, accounts of the meaning of mono. (shrink)

Hegel, in his work _Philosophy of Right_, defines ownership through three elements: acquisition by occupation, use, and transfer. To own something involves mere acquisition and encompasses its appropriate use and potential transfer to others. Subsequently, the final aspect mentioned was the concept of infinite judgement. The acts of owning and transferring to others are diametrically opposed, and Hegel’s unique logic forcibly connects these opposing concepts. This form of infinite judgement was advocated by the young Hegel during the era of _Phenomenology (...) of Spirit_. There, he stated, “Spirit is a bone”. However, when he later wrote _Science of Logic_ or _Encyclopedia_, the formulation of infinite judgement changed to “Spirit is not something that is bone”. This shift was influenced by Kant. In _Logic_, the discourse advances into syllogism, inferential theory, leading to “Spirit is a bone for such-and-such reasons”. In essence, Hegel binarily connected spirit and bone in his youth and introduced a mediating term in this connection later in his life, establishing inferential links. However, the notion of forcibly connecting opposing concepts remains. Therefore, the statement “Ownership is transfer” represents an infinite judgement while simultaneously signifying syllogism that “I truly own this object if I can transfer it to others”. This contributes to the reasoning that “I and objects can be connected through the intermediary of others”, progressing to the inference that “I and others can be connected through objects”, thereby laying the foundation for society. (shrink)

This article provides an experimental analysis of attitude toward imprecise and variable information. Imprecise information is provided in the form of a set of possible probability values, such that it is virtually impossible for the subjects to guess or estimate, which one in the set is true or more likely to be true. We investigate how geometric features of such information pieces affect choices. We find that the subjects care about more features than the pairs of best-case and worst-case, which (...) is a counter-evidence to the well-known models, maximin and α-maximin. We find that presence of nonextreme points in the set affects choice, which suggests that attitude toward imprecision is ‘nonlinear.’ We also obtain an observation, though not significant, that information pieces have a complementarity that may not be explained by the Bayesian view. (shrink)

Organisms must adapt to environmental stresses to ensure their survival and prosperity. Different types of stresses, including thermal, mechanical, and hypoxic stresses, can alter the cellular state that accompanies changes in gene expression but not the cellular identity determined by a chromatin state that remains stable throughout life. Some tissues, such as adipose tissue, demonstrate remarkable plasticity and adaptability in response to environmental cues, enabling reversible cellular identity changes; however, the mechanisms underlying these changes are not well understood. We hypothesized (...) that positive and/or negative “Integrators” sense environmental cues and coordinate the epigenetic and transcriptional pathways required for changes in cellular identity. Adverse environmental factors such as pollution disrupt the coordinated control contributing to disease development. Further research based on this hypothesis will reveal how organisms adapt to fluctuating environmental conditions, such as temperature, extracellular matrix stiffness, oxygen, cytokines, and hormonal cues by changing their cellular identities. (shrink)

Gentzen's three consistency proofs for elementary number theory have a common aim that originates from Hilbert's Program, namely, the aim to justify the application of classical reasoning to quantified propositions in elementary number theory. In addition to this common aim, Gentzen gave a “finitist” interpretation to every number-theoretic proposition with his 1935 and 1936 consistency proofs. In the present paper, we investigate the relationship of this interpretation with intuitionism in terms of the debate between the Hilbert School and the Brouwer (...) School over the significance of consistency proofs. First, we argue that the interpretation had the role of responding to a Brouwer-style objection against the significance of consistency proofs. Second, we propose a way of understanding Gentzen's response to this objection from an intuitionist perspective. (shrink)

Recently, agent technologies have attracted a lot of interest as an emerging programming paradigm. With such agent technologies, services are provided through collaboration among agents. At the same time, the spread of mobile technologies and communication infrastructures has made it possible to access the network anytime and from anywhere. Using agents and mobile technologies to realize ubiquitous computing systems, we propose a new framework based on KODAMA and VPC. KODAMA provides distributed management mechanisms by using the concept of community and (...) communication infrastructure to deliver messages among agents without agents being aware of the physical network. VPC provides a method of defining peer-to-peer services based on agent communication with policy packages. By merging the characteristics of both KODAMA and VPC functions, we propose a new framework for ubiquitous computing environments. It provides distributed management functions according to the concept of agent communities, agent communications which are abstracted from the physical environment, and agent collaboration with policy packages. Using our new framework, we conducted a large-scale experiment in shopping malls in Nagoya, which sent advertisement e-mails to users' cellular phones according to user location and attributes. The empirical results showed that our new framework worked effectively for sales in shopping malls. (shrink)

Barhebraeus' major philosophical work draws on earlier Greco-Syriac and Arabic sources. This partial edition of the work casts important light on the manner in which Greek science and philosophy were transmitted in the Orient.

In the context of the controversies surrounding »globalisation« and In the context of the controversies surrounding »globalisation« and »multiculturality« the comparative study of cultures has the task of aiding intercultural communication and of contributing to the success of intercultural understanding. The model of contrastive cultural comparison discussed here is claimed to have applacibility to every possible study of other countries (»Auslandswissenschaft«) and to be able to provide the Geisteswissenschaften with an intercultural orientation.

A psycho-historical framework for the science of art appreciation will be an experimental discipline that may shed new light on the highest capacities of the human brain, yielding new scientific ways to talk about the art appreciation. The recent findings of the contextual information processing in the human brain make the concept of the art-historical context clear for empirical experimentation.