This paper discusses the evidence for the role of CREB in neural stem/progenitor cell (NSPC) function and oncogenesis and how these functions may be important for the development and growth of brain tumours. The cyclic‐AMP response element binding (CREB) protein has many roles in neurons, ranging from neuronal survival to higher order brain functions such as memory and drug addiction behaviours. Recent studies have revealed that CREB also has a role in NSPC survival, differentiation and proliferation. Recent work has shown (...) that over‐expression of CREB in transgenic animals can impart oncogenic properties on cells in various tissues and that aberrant CREB expression is associated with tumours in patients. It is the central position of CREB, downstream of key developmental and growth signalling pathways, which give CREB the ability to influence a spectrum of cell activities, such as cell survival, growth and differentiation in both normal and cancer cells. (shrink)

Fueled by ever-growing amounts of (digital) data and advances in artificial intelligence, decision-making in contemporary societies is increasingly delegated to automated processes. Drawing from social science theories and from the emerging body of research about algorithmic appreciation and algorithmic perceptions, the current study explores the extent to which personal characteristics can be linked to perceptions of automated decision-making by AI, and the boundary conditions of these perceptions, namely the extent to which such perceptions differ across media, (public) health, and judicial (...) contexts. Data from a scenario-based survey experiment with a national sample (N = 958) show that people are by and large concerned about risks and have mixed opinions about fairness and usefulness of automated decision-making at a societal level, with general attitudes influenced by individual characteristics. Interestingly, decisions taken automatically by AI were often evaluated on par or even better than human experts for specific decisions. Theoretical and societal implications about these findings are discussed. (shrink)

The brain adapts to changes that take place in the body. Deprivation of input results in size reduction of cortical representations, whereas an increase in input results in an increase of representational space. Amputation forms one of the most dramatic disturbances of the integrity of the body. The brain adapts in many ways to this breakdown of the afferent–efferent equilibrium. However, almost all studies focus on the sensorimotor consequences. It is not known whether adaptation takes place also at other “levels” (...) in the system. The present study addresses the question whether amputees dream about their intact body, as before the amputation, or about the body after the amputation and whether the dream content was a function of time since the amputation and type of amputation. The results show that the majority of the dreamers reported dreams about their intact body although the mean time that elapsed since the amputation was twelve years. There is no clear relation with the type of amputation. The results give modest evidence for the existence of a basic neural representation of the body that is, at least, partly genetically determined and by this relatively insensitive for changes in the sensory input. (shrink)

Peptidylprolyl‐isomerases (PPIases) comprise of the protein families of FK506 binding proteins (FKBPs), cyclophilins, and parvulins. Their common feature is their ability to expedite the transition of peptidylprolyl bonds between the cis and the trans conformation. Thus, it seemed highly plausible that PPIase enzymatic activity is crucial for protein folding. However, this has been difficult to prove over the decades since their discovery. In parallel, more and more studies have discovered scaffolding functions of PPIases. This essay discusses the hypothesis that PPIase (...) enzymatic activity might be the consequence of binding to peptidylprolyl protein motifs. The main focus of this paper is the large immunophilins FKBP51 and FKBP52, but other PPIases such as cyclophilin A and Pin1 are also described. From the hypothesis, it follows that the PPIase activity of these proteins might be less relevant, if at all, than the organization of protein complexes through versatile protein binding. Also see the video abstract here https://youtu.be/A33la0dx5LE. (shrink)

Theo C. Meyering, in “Mind Matters: Physicalism and the Autonomy of the Person,” takes yet a third approach to the issue of reduction. He states that “if (true, downward) mental causation implies nonreducibility [as Stoeger and Murphy argue] and physicalism implies the converse, it is hard to see how these two views could be compatible.” Meyering distinguishes three versions of reductionism: radical (industrial strength) physicalism; ideal (regular strength) physicalism, and mild or token physicalism. Radical physicalism asserts that all special (...) sciences are reducible to physics in the sense that their laws can be deduced via bridge laws from those of physics. Ideal physicalism asserts that while it is practically impossible to reduce the special sciences, such reduction would be possible were there an ideally complete physics" (Note: This distinction parallels Stoeger’s recognition that epistemological reducibility is relative to the meaning of “laws of nature). Token physicalism is ontologically reductionist: there are no events that are not “token-identical” with some physical event or other (Note: See above, sec. 3.3). However, there are no identities between higher-level and lower- level types of events; consequently some events described by the special sciences have no physical explanation at all. -/- All of these reductionist positions are to be contrasted with compositional (milder than mild) physicalism, which asserts that some higher-level events are not even token-identical with physical events because the higher-level event (say, a crash in the stock market) is constituted by innumerable physical particulars in all sorts of states and interactions. -/- Meyering then surveys some of the existing arguments for the nonreducibility of the special sciences. One of the most important is the argument from multiple realizability. The claim is that economics, for example, is not reducible to physics because economic concepts (for example, monetary exchange) are “wildly multiply realizable” (for example, using coins, strings of wampum, signing a check). Thus, there can be no bridge laws and no reduction. Such an argument, however, only cuts against radical physicalism, not the weaker (and a priori more plausible) ideal physicalism. -/- A stronger argument for the indispensability of special-science explanations is based on the role of functional explanations. For example, the functional description of aspirin as an analgesic is in some instances a more useful explanation of its causal role (relieving a headache) than is its description as the chemical level. -/- Meyering’s own contribution focuses neither on multiple realizability of supervenient properties nor on multiple “fillers” of functional roles, but on “multiple supervenience.” In particular, a single subvenient state of affairs (for example, a cloud of free electrons permeating the metal of which a ladder is constructed) may realize a variety of supervenient dispositional properties (in this case, electrical conductivity, thermal conductivity, opacity). An explanation (say, of the cause of a deadly accident) requires reference to the dispositional property (electrical conductivity), not merely to the subvenient property. Meyering argues that it is this possibility of multiple supervenience, not multiple realizability, that gives arguments against reduction based on functional properties their real force. Downward causation, then, can be understood in terms of selective activation of one of several dispositional properties of a lower-level state, and thus can be assigned a stable place in our picture of how the world is organized without upsetting our conception of physics as constituting a closed and complete system of physical events. (shrink)

We examine an article of Paul Ricoeur on autonomy and vulnerability. Ricoeur presents the two notions in the field of justice as intricately woven into each other. He analyzes their interdependence on three levels of human agency. Ricoeur’s exposition has a focus on judicial judgment. After presenting Ricoeur’s argument and an analysis of his main points, the author argues that Ricoeur’s reflection lines up with some essential intentions of care ethics. Ricoeur’s contribution to care ethics is given in a delicate (...) balance of autonomy and its vulnerability. (shrink)

"When a country legalizes active euthanasia, it puts itself on a slippery slope from where it may well go further downward." If true, this is a forceful argument in the battle of those who try to prevent euthanasia from becoming legal. The force of any slippery slope argument, however, is by definition limited by its reference to future developments which cannot empirically be sustained. Experience in the Netherlands—where a law regulating active euthanasia was accepted in April 2001—may shed light on (...) the strengths as well as the weaknesses of the slippery slope argument in the context of the euthanasia debate. This paper consists of three parts. First, it clarifies the Dutch legislation on euthanasia and explains the cultural context in which it originated. Second, it looks at the argument of the slippery slope. A logical and an empirical version are distinguished, and the latter, though philosophically less interesting, proves to be most relevant in the discussion on euthanasia. Thirdly, it addresses the question whether Dutch experiences in the process of legalizing euthanasia justify the fear of a slippery slope. The conclusion is that Dutch experiences justify some caution. (shrink)

Theo Verbeek provides the first book-length examination of the initial reception of Descartes’s written works. Drawing on his research of primary materials written in Dutch and Latin and found in libraries all over Europe, even including the Soviet Union, Theo Verbeek opens a period of Descartes’s life and of the development of Cartesian philosophy that has been virtually closed since Descartes’s death. Verbeek’s aim is to provide as complete a picture as possible of the discussions that accompanied the (...) introduction of Descartes’s philosophy into Dutch universities, especially those in Utrecht and Leiden, and to analyze some of the major problems that philosophy raised in the eyes of Aristotelian philosophers and orthodox theologians. The period covered extends from 1637, the year in which Descartes published his _Discours de la Méthode, _until his death in 1650. Verbeek demonstrates how Cartesian philosophy moved successfully into the schools and universities of Holland and how this resulted in a real evolution of Descartes’s thought beyond the somewhat dogmatic position of Descartes himself. Verbeek further argues that this progression was an essential step in the universal propagation of Cartesian philosophy throughout Europe during the second half of the seventeenth century. As he details the disputes between Cartesians and anti-Cartesians in Holland, Verbeek shows how the questions raised were related on the one hand to religious conflicts between the Remonstrants and the Orthodox Calvinists and on the other hand to political conflicts between more liberal factions fighting for the union of church and state to enhance religious control of society in general. Contending that Descartes and Cartesian philosophy were central to the development of the modern Dutch state, Verbeek illuminates the role they played in Dutch political, religious, and intellectual life. (shrink)

The Knowledge-Based Bio-Economy has gained prominence as an agricultural R&D agenda of the European Union. Specific research policies are justified as necessary to create a KBBE for societal progress. Playing the role of a master narrative, the KBBE attracts rival visions; each favours a different diagnosis of unsustainable agriculture and its remedies in agro-food innovation. Each vision links a technoscientific paradigm with a quality paradigm: the dominant life sciences vision combines converging technologies with decomposability, while a marginal one combines agro-ecology (...) with integral product integrity. From these divergent visions, rival stakeholder networks contend for influence over research policies and priorities, especially within the Framework Programme 7 on Food, Agriculture, Fisheries and Biotechnology, which has aimed to promote a Knowledge-Based Bio-Economy. Although the FAFB programme has favoured a life sciences vision, agro-ecological approaches have gained a presence, thus overcoming their general lock-out from agricultural research agendas. In their own way, each rival paradigm emphasises the need for collective systems to gather information for linking producers with users, as a rationale for the public sector to fund distinctive research priorities. (shrink)

Physicalism ? or roughly the view that the stuff that physics talks about is all the stuff there is ? has had a popular press in philosophical circles during the twentieth century. And yet, at the same time, it has become quite fashionable lately to believe that the mind matters in this world after all and that psychology is an autonomous science irreducible to physics. However, if (true, downward) mental causation implies non-reducibility and Physicalism implies the converse, it is hard (...) to see how these two views could be compatible. This paper reviews some classical arguments purportedly showing how the autonomy of the special sciences can be upheld without violating the laws of physics or the principle that physics constitutes a complete and closed system. These arguments are presented in order of increasing strength, indicating how the more popular arguments in fact fall short of establishing anti-reductionism of the intended kind. New arguments are added which claim to demonstrate quite effectively how downward causation is possible compatibly with the reign of physics. The paper begins with a section which distinguishes various kinds of reductionism. (shrink)

"Philosophical Foundations of India" is a 1945 work by Theos Bernard. Within it, he attempts to outline the fundamental principles of the six classic systems of Hindu philosophy, namely: Nyaya, Vaisesika, Samkhya, Yoga, and Vedanta. Presented in a clear, easy-to-understand form, this volume is highly recommended for those looking for an introduction to Indian philosophy and related subjects. Contents: "Preface," "Introduction," "Nyaya," "Vaisesika," "Semkhya," "Yoga," "Mimamsa," "Vedanta," "Kasmir Saivism," "Bibliography," "Glossary." Theos Casimir Bernard (1908-194) was an author and explorer most (...) famous for his work on yoga and religious studies, especially Tibetan Buddhism. Other notable works by this author include: "Heaven Lies Within Us" (1939), and "Penthouse of the Gods" (1939). Many vintage books such as this are increasingly scarce and expensive. It is with this in mind that we are republishing this volume now in an affordable, high-quality, modern edition complete with a specially-commissioned new biography of the author. (shrink)

This collection of 21 essays explores the creative interaction among the cognitive neurosciences, philosophy, and theology. It is the result of an international research conference co-sponsored by the Vatican Observatory, Rome, and the Center for Theology and the Natural Sciences, Berkeley.

Dividido entre a filosofia e a poesia, Hölderlin e seu drama incompleto A morte de Empédocles são hoje peças essenciais para se pensar o trágico na Modernidade. Ponte entre a nostalgia da Antiguidade e uma filosofia que nega o projeto metafísico do Idealismo Alemão – projeto que Hölderlin, ironicamente, ajudou a erigir – esta empreitada hölderliniana é uma singular investigação não somente da relação entre arte e pensamento, mas também coloca em questão a constituição da própria Modernidade.

The biological body: The body as thing in a postphenomenological perspective In phenomenology the lived body (le corps vécu) is considered as the subject of reflection while the biological body (le corps objective) is destined for medical sciences. As an alternative I give a view on the basis of the philosophical anthropology of Helmuth Plessner who thinks a person as a subject to have a lived body (Leib) and a biological body (Körper) from an eccentric or third perspective (excentric positionality). (...) A person experiences herself from that eccentric point of view as a lived body and at the same time as a biological and instrumental body. These two perceptions can only be characterized as a dual aspect (Doppelaspekt), and cannot be separated from each other. Plessner moreover considers the biological body as a thing among other things. I place this bodily thing in a postphenomenological perspective as worked out by Don Ihde and discuss the idea to consider it as a mediating thing between the person who has it and at the same time is it as a lived body in the world she lives in. I work out the effects on the person in case of organ transplantation or implantation of artefacts in the postphenomenological perspective of the embodiment and the hermeneutic relation. I conclude that from that perspective both relations appear to be too simple to elucidate what really takes place in a patient and suggest that in case of incorporation of organs or artefacts the postphenomenological mediating relations should be expanded to a triadic (semiotic) variant of mediating technologies that considers the biological body itself as mediating thing in order to encompass the whole of the human experiences including meaning. (shrink)

Introduction and Overview Content Type Journal Article Category Introduction Pages 151-163 DOI 10.1007/s10670-011-9288-9 Authors Theo Kuipers, Faculty of Philosophy, University of Groningen, Groningen, The Netherlands Gerhard Schurz, Department of Philosophy, University of Duesseldorf, Universitaetsstrasse 1, Geb. 23.21, 40225 Duesseldorf, Germany Journal Erkenntnis Online ISSN 1572-8420 Print ISSN 0165-0106 Journal Volume Volume 75 Journal Issue Volume 75, Number 2.

This monograph presents new ideas in nomic truth approximation. It features original and revised papers from a philosopher of science who has studied the concept for more than 35 years. Over the course of time, the author's initial ideas evolved. He discovered a way to generalize his first theory of nomic truth approximation, viz. by dropping an unnecessarily strong assumption. In particular, he first believed to have to assume that theories were maximally specific in the sense that they did not (...) only exclude certain conceptual possibilities, but also that all non-excluded possibilities were in fact claimed to be nomically possible. Now, he argues that the exclusion claim alone, or for that matter the inclusion claim alone, is sufficient to motivate the formal definition of being closer to the nomic truth. The papers collected here detail this generalized view of nomic truthlikeness or verisimilitude. Besides this, the book presents, in adapted form, the relation with several other topics, such as, domain revision, aesthetic progress, abduction, inference to the best explanation, pragmatic aspects, probabilistic methods, belief revision and epistemological positions, notably constructive realism. Overall, the volume presents profound insight into nomic truth approximation. This idea seeks to determine how one theory can be closer to, or more similar to, the truth about what is nomically, e.g. physically, chemically, biologically, possible than another theory. As a result, it represents the ultimate goal of theory oriented empirical science. Theo Kuipers is the author of Studies in Inductive Probability and Rational Expectation, From Instrumentalism to Constructive Realism and Structures in Science. He is the volume-editor of the Handbook on General Philosophy of Science. In 2005 there appeared two volumes of Essays in Debate with Theo Kuipers, entitled Confirmation, Empirical Progress, and Truth Approximation and Cognitive Structures in Scientific Inquiry. (shrink)

What meaning does the theological notion of discernment have in a postsecular cultural condition? Three levels of the meaning of postsecular are distinguished: first, the ‘postsecular’, as a notion that characterises a cultural condition, mainly in Western society, full of diverse religious expressions; second, ‘postsecularity’, as a reflective model for interpreting religious expressions and behaviour; and third, ‘postsecularism’, as a cultural-philosophical or theological programme. After elucidating the concept of the postsecular, we consider some key elements in discernment, investigating the subject, (...) the nature and the object of discernment. We then turn to Richard Kearney’s Anatheism as a fine example of how the notion of discernment receives a new usage in postsecular reflection. We ponder upon his idea of discernment as ‘prereflective carnal response to the advent of the Other’ and reflect upon its meaning for postsecular thinking. The concluding section offers a consideration of the meaning of Kearney’s interpretation of discernment for judgement in postsecular culture. (shrink)

All but 4 of the 31 papers in this collection deal with late Neoplatonism. Descriptions of each paper are offered in Peter Lautner's review at Bryn Mawr Classical Review BMCR 2004.04.34.

From the outset the Belgian press has been a political press. The catholic and liberal newspapers, however, have never been tightly linked to the corresponding political parties, whereas the socialist and communistnewspapers depend officially from their respective political party so that they can be considered as real party-papers.Of the 39 Belgian newspapers 20 can be defined as catholic, 7 as liberal, 7 as socialist and 1 as communist ; 4 newspapers call themselves «neutral», but on several political occasions they heve (...) nevertheless taken up position. Among these 39 newspapers only 19 can be considered as «independent» : of the 20 catholic newspapers 16 belang to 5 different newspaper chains ; 7 of the liberal dailies are owned by only 3 newspaper groups; 3 of the 7 socialist papers belang to the same chain and 3 of the so-called «neutral» dailies are published by only one group.From the circulation figures of the Flemish press it emerges that the catholic and liberal newspapers make some progress, while the socialist dailies are constantly regressing. The total circulation of the Frenchspeaking newspapers is slightly receding, but here again the socialist newspapers are the big losers. It should be noticed that only the circulation figures of the Flemish newspapers are officially ascertained, whereas the major part of the French-speaking newspapers do not allow such an official control.From this it is clear that in Belgium there exists a real disproportion between the number of readers of political opinionnewspapers and the voters for the corresponding political parties. For the moment the number of readers of catholic newspapers surpasses the amount of voters for the CVP-PSC-party in an considerable way. This also applies to the liberal press, where the amount of readers outnumbers the voters for the PW-PLP-party. On the other hand, the number of readers of socialist newspapers even does not amount to half of the numbers of voters for the BSP-PSB-party. (shrink)

An interesting consequence of the structuralist theory of truth approximation, as developed in my From Instrumentalism to Constructive Realism, henceforth ICR, concerns so-called ‘inference to the best explanation’. It will be argued that this popular rule among scientific realists can better be replaced by, various kinds of, ‘inference to the best theory’.

This paper critically examines the argument structure of Fodor's theory of modularity. Fodor claims computational autonomy as the essential properly of modular processing. This property has profound consequences, burdening modularity theory with corollaries of rigidity, non-plasticity, nativism, and the old Cartesian dualism of sensing and thinking. However, it is argued that Fodor's argument for computational autonomy is crucially dependent on yet another postulate of Fodor's theory, viz. his thesis of strong modularity, ie. the view that functionally distinct modules must also (...) have physical counterparts in the neural architecture of the brain. Yet, Fodor offers little or no independent support for this neurological speculation. Moreover, due to the cognitivist underpinnings of Fodor's theory his view of modules as 'mental organs'faces an untenable dilemma that is to be traced back to the earliest history of modem cognitive science, viz. to the rationalist-computationalist research program initiated by Descartes and Male-branche. The tension characteristic for the Cartesian program was one that arose between information correlation and information processing accounts of the transactions between body and mind. Similarly, the tension characteristic for Fodor's theory of modularity is one between a causal account of modules on the model of simple detection mechanisms, and an information processing account of modules on the model of vast and elaborate cognitive systems. It is argued that the resulting concept of a cognitive module Fodorian style constitutes an amalgam of incompatible desiderata that fails to stake out a natural kind for cognitive science. As an alternative account, the final section shows connectionism to be capable of encompassing both Gibsonian and 'new look' accounts of cognitive achievements within one theoretical perspective, thus providing a fruitful interfield theory capable of combining the theoretical resources of the ecological approach with the indispensable theoretical complement provided by psychological processing accounts. This change of perspective would ultimately involve recasting the symbo-functionalist notion of cognitive function along bio-psychological lines. (shrink)

This paper primarily deals with theconceptual prospects for generalizing the aim ofabduction from the standard one of explainingsurprising or anomalous observations to that ofempirical progress or even truth approximation. Itturns out that the main abduction task then becomesthe instrumentalist task of theory revision aiming atan empirically more successful theory, relative to theavailable data, but not necessarily compatible withthem. The rest, that is, genuine empirical progress aswell as observational, referential and theoreticaltruth approximation, is a matter of evaluation andselection, and possibly new (...) generation tasks forfurther improvement. The paper concludes with a surveyof possible points of departure, in AI and logic, forcomputational treatment of the instrumentalist taskguided by the `comparative evaluation matrix''. (shrink)

The naive structuralist definition of truthlikeness is an idealization in the sense that it assumes that all mistaken models of a theory are equally bad. The natural concretization is a refined definition based on an underlying notion of structurelikeness.In Section 1 the naive definition of truthlikeness of theories is presented, using a new conceptual justification, in terms of instantial and explanatory mistakes.

David Theo Goldberg engages Achille Mbembe in a wide-ranging conversation on the key lines of analysis of Mbembe’s book, The Critique of Black Reason. The discussion ranges across a broad swath of key themes: the constitutive feature of racisms in the making of modernity and modern capitalism as conceived through the global black experience; the African and French archives in constituting, resisting, and refashioning ‘black reason’ and its multiple registers; the centrality of slavery to this constitution and resistance; thinghood (...) and humanity; liberalism as the basis for racial pessimism. The discussion closes with Mbembe’s plea for a shared being and an exchange about repair and reparation. (shrink)