Over 300 years ago the father of microscopy, Antonie van Leeuwenhoek, observed dried rotifers “coming back to life” upon rehydration. Since then, scientists have been fascinated by the enduring mystery of how certain organisms survive losing essentially drying out completely. Historically sugars, such as the disaccharide trehalose, have been viewed as major functional mediators of desiccation tolerance. However, some desiccation tolerant organisms do not produce this sugar, hinting that additional mediators, and potentially novel mechanisms exist. It has become apparent that (...) a common theme among such organisms is the production and use of intrinsically disordered proteins to mediate survival in this dry state. However, the basic biology of these proteins – which unlike globular proteins lack persistent three-dimensional structure – is poorly understood, as are the functional mechanisms utilized by these enigmatic proteins that allow them to mediate desiccation tolerance. We purpose that probing the biochemical and biophysical nature of stress-related IDPs will provide mechanistic insights into these fascinating proteins. Remarkably, organisms from every kingdom of life can survive losing nearly all their intracellular water. A hallmark of desiccation tolerance is the use of intrinsically disordered proteins, but how IDPs contribute to tolerance is poorly understood. Here, we discuss possible mechanisms and avenues for studying these enigmatic proteins. (shrink)

It has long been shown that medieval builders primarily used geometrical constructions to design medieval architecture. The thought processes involved, however, have been considered to be remote from the natural philosophical speculations of the Scholastics, who, following Aristotle, had taken the basis of physics to be the study of dynamics, or change. However, investigations of the Expertises of Chartres, Florence, Milan, and other documents related to medieval building suggest that medieval architects, in speaking of their work, resort to recognizable dynamic (...) arguments, structured similarly to the speculations of Scholastic philosophers. These dynamic explanations of structural behaviour persist at least into the 17th century, but thereafter lost out to the arguments based on statics made by modern scholars attempting to explain the endurance of these structures. (shrink)

Thomas C. Vinci argues that Kant's Deductions demonstrate Kant's idealist doctrines and have the structure of an inference to the best explanation for correlated domains. With the Deduction of the Categories the correlated domains are intellectual conditions and non-geometrical laws of the empirical world. With the Deduction of the Concepts of Space, the correlated domains are the geometry of pure objects of intuition and the geometry of empirical objects.

'Methinks I am like a man, who having narrowly escap'd shipwreck', David Hume writes in A Treatise of Human Nature, 'has yet the temerity to put out to sea in the same leaky weather-beaten vessel, and even carries his ambition so far as to think of compassing the globe'. With these words, Hume begins a memorable depiction of the crisis of philosophy and his turn to moral and political philosophy as the path forward. In this groundbreaking work, Thomas W. (...) Merrill shows how Hume's turn is the core of his thought, linking Hume's metaphysical and philosophical crisis to the moral-political inquiries of his mature thought. Merrill shows how Hume's comparison of himself to Socrates in the introduction to the Treatise illuminates the dramatic structure and argument of the book as a whole, and he traces Hume's underappreciated argument about the political role of philosophy in the Essays. (shrink)

Each volume in this series of companions to major philosophers contains specially commissioned essays by an international team of scholars, together with a substantial bibliography, and will serve as a reference work for students and non-specialists. One aim of the series is to dispel the intimidation such readers often feel when faced with the work of a difficult and challenging thinker. John Duns Scotus was one of the three principal figures in medieval philosophy and theology, with an influence on modern (...) thought arguably even greater than that of Aquinas. The essays in this volume systematically survey the full range of Scotus' thought. They take care to explain the technical details of his writing in lucid terms and demonstrate the relevance of his work to contemporary philosophical debate. New readers will find this the most convenient and accessible guide to Scotus currently available. (shrink)

In _Georg Wilhelm Friedrich Hegel – A Propaedeutic_, Thomas Sören Hoffmann invites the philosophically interested reader to converse with, to work with, and to think with the “master philosopher of German Idealism,” the last great system builder of European philosophy.

This paper considers Aquinas's accounts of the end of human action and the structure of human action, examines the debate between intellectualist and voluntarist interpretations of Aquinas, and corrects mistaken accounts of Aquinas's views on freedom, necessitation, and causation.

Late in a career of more than sixty years, Thomas Burch, an internationally known social demographer, undertook a wide-ranging methodological critique of demography. This open access volume contains a selection of resulting papers, some previously unpublished, some published but not readily accessible [from past meetings of The International Union for the Scientific Study of Population and its research committees, or from other small conferences and seminars]. Rejecting the idea that demography is simply a branch of applied statistics, his work (...) views it as an autonomous and complete scientific discipline. When viewed from the perspective of modern philosophy of science, specifically the semantic or model-based school, demography is a balanced discipline, with a rich body of techniques and data, but also with more and better theories than generally recognized. As demonstrated in this book, some demographic techniques can also be seen as theoretical models, and some substantive/behavioral models, commonly rejected as theory because of inconsistent observations, are now seen as valuable theoretical models, for example demographic transition theory. This book shows how demography can build a strong theoretical edifice on its broad and deep empirical foundation by adoption of the model-based approach to science. But the full-fruits of this approach will require demographers to make greater use of computer modeling [both macro- and micro-simulation], in the statement and manipulation of theoretical ideas, as well as for numerical computation. This book is open access under a CC BY license. (shrink)

This article seeks to render Sigmund Freud's unfamiliar conception of consciousness more evident and accessible; because Freud was the greatest theorist psychology has so far known, and because present-day psychologists stand in special need of a variety of conceptual frameworks in whose terms they can give coherent and cogent expression to their different hypotheses pertaining to consciousness. The three main sections respectively address Freud's complex property of intrinsic consciousness, which characterizes each instance of every conscious psychical process and includes qualitative (...) content, direct awareness, and tertiary consciousness; the cognitive contents of purportedly pure, or contentless, emotions and feelings; and certain limits and variations of Freud's intrinsic consciousness. A special effort is made to be faithful to Freud's own conception of consciousness; though the discussion includes clarification, explication, and extension of parts of his conception that are undeveloped, summarily stated, or implicit. In fact, Freud's conception of consciousness is treated here as something very much alive today. Implications are drawn and developed that Freud probably never thought of. However, note that the conception presented does not belong to the author of this article. Rather, I present here Sigmund Freud's own conception of consciousness as he might have developed it judging from the part of it that he did express. (shrink)

This paper examines two ways in which the ‘privileged coordinates’ of a geometric space might have significance. First, the structure of the space might be ‘determined by its privileged coordinates’. Second, the space might be presentable using ‘Kleinian methods’. We examine the geometric spaces for which these two conditions hold. Along the way, we investigate the relationship between these two conditions.

The temporal orientations of any sociocultural grouping are major factors comprising its central identity. The manner in which the past (memories), the present (perception), and the future (anticipation/expectation) are commonly articulated also concern cultural identity. The identity of a cultural group is altered by developmental changes in time keeping and related objective, scientific temporalities.Three modes of temporality, objective, narrative, and transcendental, congruent with different kinds of brain processes, are common throughout our planet. Objective temporality tends to alter and replace traditional (...) narrative and transcendental (spiritual) time, timing, and tempos. Objective temporality is concerned with what is transitory, modern and “progressive”. Objective time is not a traditional form of cultural time; it is a derived Westernized scientific imposition, rather than any cultural formation. This essay develops a new conception of how semiosis occurs. All information is essentially rhythmic, transduced through sensory systems as signals in a space-time domain, but deposited for use into a spectral thermodynamic domain in the human cortex.A “chronemic” perspective, (temporality as it is based in semiotic processes related to human communication) is assumed throughout. Such a perspective appears to be somewhat novel in both communication and semiotic studies. (shrink)

This chapter contains sections titled: Early life Breaking with idealism The principles of mathematics The theory of descriptions Avoiding the contradiction Logical atomism Later philosophy.

Humanity’s creative capacity has never been more unsettling than it is at our current moment, when it has ushered us into new technological worlds that challenge the very definition of “the human.” Those anxious to safeguard the human against techno-scientific threats often appeal to religious traditions to protect the place and dignity of the human. But how well do we understand both theological tradition and today’s technological culture? In _The Indiscrete Image, _Thomas A. Carlson challenges our common ideas about both, (...) arguing instead that it may be humanity’s final lack of definition that first enables, and calls for, human creativity and its correlates—including technology, tradition, and their inextricable interplay within religious existence. Framed in response to Martin Heidegger’s influential account of the relation between technological modernity and theological tradition, _The Indiscrete Image_ builds an understanding of creativity as conditioned by insurmountable unknowing and incalculable possibility through alternative readings of Christian theological tradition and technological culture—and the surprising resonance between these two. Carlson concludes that the always ongoing work of world creation, tied essentially to human self-creation, implies neither an idol’s closure nor an icon’s transcendence, but the “indiscrete image” whose love makes possible—by keeping open—both the human and its world. (shrink)

The present work is a study of the method of contemporary Soviet philosophy. By "Soviet philosophy" we mean philosophy as published in the Soviet Union. For practical purposes we have limited our attention to Soviet sources in Russian in spite of the fact that Soviet philosophical works are also published in other languages (see B 2029(21)(38». The term "method" is taken in the sense usual in Western books on methodology .1 In view of the content of the first chapter it (...) will be useful to explain the last term a little more fully. By method we mean a procedure and it is obvious that the principles according to which a procedure is carried out are rules, i.e. imperatives, which tell us not what is but what should be done. Such imperatives mayor may not be connected with and founded on certain descriptive statements (the fact that every rule of formal logic is based on a corresponding law has been well-known since Husserl's "Logische Unter suchungen" and is generally accepted in contemporary logic), but such a foundation is irrelevant to a methodological study. The object of such a study is to find out what these rules are, why they are accepted and how they are inter-connected and applied. This is how methodology - the science of method - is conceived in Western treatises on the subject and this is also the standpoint assumed here. (shrink)

This book is about Enlightenment ideas of "character." It argues for their central importance in eighteenth-century thought and culture. The scope of this volume extends well beyond the confines of literary history. It examines discussions of race, nation, the self, virtue, sociability, and historical progress. The specially commissioned essays in this volume are the first, collectively, to address the broader significance of Enlightenment "character," and to do so from an interdisciplinary perspective. The focus is on the Scottish Enlightenment, but contributors (...) consider these debates in their international contexts and in relation to parallel developments in Britain, Europe, and America. (shrink)

Through a critical analysis of the work of Henry Davis, S.J. and Francis, C.SS.R., this study examines the Catholic tradition in respect to the moral responsibilities of physicians. It first reviews the historical formation of the manuals of moral theology in order to historically situate Davis and Connell in the twentieth century. The study then examines the work of Davis and Connell in light of David Kelly's The Emergence of Roman Catholic Medical Ethics in North America, wherein he posits a (...) shift in moral methodology in 1940 from physicalism to ecclesiastical positivism. Contrary to Kelly's thesis, this study finds essentially no methodological difference between Davis' commandment-centered methodology and Connell's virtue-centered method. In actuality, both theologians throughout their careers focused upon the physical nature of the action and employed the traditional principles of double effect and cooperation when determining the morality of an intrinsically evil act. ;Through a comparison of the work of Davis and Connell, the study concludes with a description of the moral responsibilities of physicians for a contemporary practice of medicine. These duties include basic responsibilities, social responsibilities and the responsibilities to the dying patient. (shrink)

An intriguing question in the field of stress is what makes an individual more likely to be susceptible or resilient to stress‐induced depression. Predisposition to stress susceptibility is believed to be influenced by genetic factors and early adversity. However, beyond genetics and life experiences, recent evidence has highlighted social rank as a key determinant of susceptibility to stress, underscoring dominant individuals as the vulnerable ones. This evidence is in conflict with epidemiological, clinical, and animal work pointing at a link between (...) social subordination and depression. Here, we review and analyze rodent protocols addressing the relevance of social rank to predict vulnerability to chronic social stress. We also discuss whether a specific social status (i.e., dominance or subordination) is the appropriate predictor of vulnerability to develop stress‐induced depression or rather, the loss of social rank and resources. (shrink)

Hans Maes has collected a number of conversations he has had with major figures in philosophical aesthetics over the last ten years in Conversations on Art and Aesthetics. These include, in order of appearance, Jerrold Levin-son, Arthur Danto, Cynthia Freeland, Carolyn Korsmeyer, Jenefer Robinson, Roger Scruton, Gregory Currie, Paul Guyer, Noël Carroll, and Kendall Walton. This book will be of interest to anyone who wishes to see some important living figures in this essential subdiscipline of philosophy in action. As with (...) all efforts of this sort, however, certain choices had to be made. The book is explicitly limited to philosophers in the Anglo-American tradition, largely American (including eight past... (shrink)

The small article “Statutory Injustice and Suprastatutory Law” published in 1946 by Gustav Radbruch is one of the most important texts in 20th century legal philosophy. Until recently, its importance was said to stem from its renewal of ‘natural law’ and from its ‘formula’, according to which the value of justice should override that of legal certainty in extreme cases. In this contribution, a close examination will show that Radbruch's text is less univocal than often suggested. I argue that Radbruch (...) deals here with the acute problems of apparent criminal legality during the Nazi-era rather than with problems of validity. In order to make this clear, I first briefly sketch Radbruch's personal history and the context into which the article fits. Secondly, I analyze the text itself and focus on how to understand the well-known grudge informer case. Finally, I pay some attention to the renewed topical interest of Radbruch's formula, owing to the fact that it was used in the trials against former-GDR soldiers who shot fugitives at the Berlin Wall,and their superiors. (shrink)

After two sections of background discussion regarding some views of inner some recent deployments of James J. Gibson's ecological approach to visual perception relevant to our understanding of reflective seeing, I present my own view of reflective seeing for the remainder of the present article. Although I include detailed references to Edmund Husserl's conception of straightforward perceptual consciousness and reflective perceptual consciousness, the present article is not about Husserl. Rather, I use quotations from and about Husserl to add resonance and (...) depth to my own conception of the complex psychological process that is reflective seeing - particularly, the stream of perceptual consciousness that is a product and a part of it, that flows at the heart of reflective seeing. It will be evident that I very largely agree with the Husserl material which I use. And I do not take the space to bring out any disagreements that I might have with him. Thus, this article has as its main purpose making known, in an introductory way, just one, my own, view of reflective seeing. (shrink)

Biographical note: Thomas Alkemeyer (Dr. phil.) ist Professor für Soziologie und Sportsoziologie an der Carl von Ossietzky Universität Oldenburg. Ulrich Bröckling (Dr. phil.) ist Professor für Kultursoziologie an der Albert-Ludwigs-Universität Freiburg. Tobias Peter (Dr. rer. pol.) ist wissenschaftlicher Mitarbeiter am Institut für Soziologie der Albert-Ludwigs-Universität Freiburg.