Traditionally, plant viruses are viewed as harmful, undesirable pathogens. However, their genomes can provide several useful ‘designer functions’ or ‘sequence modules’ with which to tailor future gene vectors for plant or general biotechnology.The majority (77 %) of known plant viruses have single‐stranded RNA of the messenger (protein coding) sense as their genetic material. Over the past 4 years, improved in vitro transcription systems and the construction of partial of fulllength DNA copies of several plant RNA viruses have enhanced our ability (...) to manipulate and study their genomes, particularly in the context of their pathogenic interactions with host plants.Recently, two forms of genetically engineered protection against plant virus infections have been reported. In both, a virus‐related ‘interfering’ molecule was stably introduced into plants via the DNA‐transfer mechanism of Agro‐bacterium tumefaciens. To date, the choice of ‘interfering’ molecule has been guided by empirical field‐observations and each is effective against only a narrow range of closely‐related viruses. As yet, we do not fully understand the molecular mechanism(s) responsible for the observed protection.The ability to manipulate the plant–pathogen relationship is a powerful tool to increase our knowledge and improve future strategies for uncoventional cropprotection by genetic engineering techniques. (shrink)

This article draws on Jacques Derrida’s and Roberto Esposito’s conceptualisations of the immunitarian paradigm to analyse the Slovenian crime novel _The Virus_. In the first part, we examine the links between neoliberalism and the rise of the Slovenian authoritarian state during the first wave of the Covid-19 pandemic. In the second part, we show that the neoliberal ethos is expressed in the figure of the self-serving and self-disciplined detective, in the nature of desocialised and privatised crime, and in the figure (...) of the self-righteous criminal. Although the actions of the detective and the criminal are autoimmunitarian, both function – paradoxically – as guardians of the common good by pursuing private interests. In the final section, we deconstruct the binary oppositions underlying the dual status of murdered victims, who are simultaneously criminally responsible and possess an unusual (non-heteronormative) or pathological sexual identity. (shrink)

A crucially important part of the biosphere – the virosphere – is too often overlooked. Inclusion of the virosphere into the global picture of protein structure space reveals that 63 protein domain superfamilies in viruses do not have any structural and evolutionary relatives in modern cellular organisms. More than half of these have functions which are not virus‐specific and thus might be a source of new folds and functions for cellular life. The number of viruses on the planet exceeds (...) that of cells by an order of magnitude and viruses evolve up to six orders of magnitude faster. As a result, cellular species are subject to a constitutive ‘flow‐through’ of new viral genetic material. Due to this and the relaxed evolutionary constraints in viruses, the transfer of domains between host‐to‐virus could be a mechanism for accelerated protein evolution. The virosphere could be an engine for the genesis of protein structures, and may even have been so before the last universal common ancestor of cellular life. (shrink)

Los virus nuevos han sido una constante desde el surgimiento de la vida en la Tierra. Estos virus pueden llegar a infectar a los seres humanos y producir pandemias, como la causada por el virus sars-cov-2. Los virus son parte inevitable de la naturaleza; sin embargo, las actividades humanas son las que determinan su contagio, por lo que es posible desarrollar estrategias para detectar y controlar brotes de enfermedades emergentes y prevenir nuevas pandemias.

Herbert, Dilinie The Zika virus has dominated the news media and captured the attention of the international community. Epidemic disease has become the mainstay of public health emergencies in our recent past with Ebola virus in West Africa and now Zika virus in Latin America. An unexpected and troubling feature of this current outbreak is the high incidence of birth defects and neurological health complications. As scientists investigate a possible causal link, health authorities as well as Catholic (...) Church leaders are involved in communicating how women and the wider community should make decisions about their health, reproduction and pregnancy. A morally appropriate, culturally sensitive and socially inclusive approach to managing the immanent risk should be the priority. (shrink)

Though viruses have generally been characterized by their pathogenic and more generally harmful effects, many examples of mutualistic viruses exist. Here I explain how the idea of mutualistic viruses has been defended in recent virology, and I explore four important conceptual and practical consequences of this idea. I ask to what extent this research modifies the way scientists might search for new viruses, our notion of how the host immune system interacts with microbes, the development of new therapeutic approaches, and, (...) finally, the role played by the criterion of autonomy in our understanding of living things. Overall, I suggest that the recognition of mutualistic viruses plays a major role in a wider ongoing revision of our conception of viruses. (shrink)

This paper argues that Zika virus infection has its ethical implications beyond the reproductive health of women. It claims that Zika virus infection like public health emergency exposes the underlying health determinants and health status of women. Therefore, ethical mitigation of Zika like public health emergencies should consider these underlying health determinants and health status of women. For, undermining and overlooking these underlying determinants and health status of women, during the public health emergencies, enhance the health inequities. The (...) recent Zika virus infection in Brazil has triggered different ethics consultation and has prompted to outline ethical recommendations. However, the recommendations have either focused on the reproductive health of women or on the core strategies of public health emergency. Considering this as a gap in perspective to prepare for Zika like public health emergencies, this paper argues that it is the underlying holistic health of women, precisely, health capability, which should be given due ethical consideration. Finally, the paper concludes highlighting the fact that focusing on the holistic health of the women during Zika like public health emergencies and beyond can bring in long-term benefits for global health equity. (shrink)

"The author tells a history of the study of cancer-causing viruses from the early twentieth century to the development of an HPV vaccine for cervical cancer in 2006. He profiles the "cancer virus hunters" who made breakthroughs in tumor virology"--.

Viruses have been virtually absent from philosophy of biology. In this editorial introduction, we explain why we think viruses are philosophically important. We focus on six issues, and we show how they relate to classic questions of philosophy of biology and even general philosophy.

A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.

Existe una guerra cultural que pretende la destrucción de Occidente utilizando como caballo de Troya el enemigo interno del “virus cultural posmoderno”. Se analiza el origen complejo de dicho virus, con más de una cepa, sin descartar la posibilidad de que fuera diseñado en un laboratorio. Apelando a acabar con las verdades fuertes, el “pensamiento culturalmente correcto”impone su propia verdad fuerte sin buscar acuerdo ni síntesis con quien piensa diferente. Se examinan sus principales variantes que se caracterizan por (...) la ausencia de límites y un exceso de contradicciones que producen el aumento de la polaridad, la confusión y la fragilidad. Para contrarrestar todo ello, el artículo plantea algunas posibles vacunas en torno a la idea de un renacimiento cultural y un nuevo equilibrio entre modernidad y tradición. (shrink)

During the current COVID-19 pandemic, we are experiencing physical viruses infecting our bodies, virtual viruses infecting our computers, and symbolic viruses infecting our thinking. This essay takes up each of these interruptions in a collective attempt to better understand how we are rhetorically and where we might go politically from here.

_A trenchant look at how the coronavirus reveals the dangerous fault lines of contemporary society As seen on CNN's Fareed Zakaria GPS: “A stirring alarm addressed to an unsettled world.” _(Kirkus Reviews_)__ Forget the world that came before. The author of _American Vertigo_ serves up an incisive look at how COVID-19 reveals the dangerous fault lines of contemporary society._ With medical mysteries, rising death tolls, and conspiracy theories beamed minute by minute through the vast web universe, the coronavirus pandemic has (...) irrevocably altered societies around the world. In this sharp essay, world-renowned philosopher Bernard-Henri Lévy interrogates the many meanings and metaphors we have assigned to the pandemic—and what they tell us about ourselves. Drawing on the philosophical tradition from Plato and Aristotle to Lacan and Foucault, Lévy asks uncomfortable questions about reality and mythology: he rejects the idea that the virus is a warning from nature, the inevitable result of global capitalism; he questions the heroic status of doctors, asking us to think critically about the loci of authority and power; he challenges the panicked polarization that dominates online discourse. Lucid, incisive, and always original, Lévy takes a bird’s-eye view of the most consequential historical event of our time and proposes a way to defend human society from threats to our collective future. A portion of the author’s proceeds will be donated to Binc (The Book Industry Charitable Foundation). (shrink)

Graphical AbstractThe finding that viruses with RNA and DNA genomes can recombine to produce chimeric entities provides valuable insights into the origin and evolution of viruses. It also substantiates the hypothesis that certain groups of DNA viruses could have emerged from plasmids via acquisition of capsid protein-coding genes from RNA viruses.

Since the beginning of the Covid-19 pandemic, we have been wondering about the "how" of this health crisis. How did the virus pass from animals to humans? How did it arrive in Europe? How can it spread so quickly? But the question that is the subject of this article is "why"? Not about certain aspects, such as its spread in a specific country, but about the fundamental question: why the virus, as we would say "why do birds sing", (...) "why are there thunderstorms" or "why are there drones". While there is no guarantee of an answer to the question posed, the fact remains that it allows us to question our relationship to a disease caused by an elusive agent. (shrink)

This paper follows the circuitous path of theories concerning the origins of viruses from the early years of the twentieth century until the present, considering RNA viruses in particular. I focus on three periods during which new understandings of the nature of viruses guided the construction and reconstruction of origin hypotheses. During the first part of the twentieth century, viruses were mostly viewed from within the framework of bacteriology and the discussion of origin centered on the “degenerative” or the “retrograde (...) evolution theory.” However, concomitantly, in the context of origin-of-life theorizing, the notion that viruses are vestiges of a prebiotic world was also being contemplated. In the 1960s the idea that viruses were genetic elements that “escaped” from cells became prevalent. These traditional hypotheses are being revisited nowadays by evolutionary virologists, who have placed them within a new conceptual framework that is supported by cutting-edge genomic and proteomic data. Two current, opposing scenarios of virus origin are presented. The philosophical dimensions of “revisiting” the original hypotheses are briefly discussed. (shrink)

Los principales patógenos víricos que podemos ad­quirir ingiriendo alimentos contaminados son los norovirus, el virus de la hepatitis A y el virus de la hepatitis E que se propagan principalmente a través de la vía fecal oral. En los últimos años, la incidencia de brotes de transmisión alimentaria causados por estos patógenos ha experimentado un aumento considerable, en parte debido al comercio globalizado y a los cambios en los hábitos de consumo. Las matrices alimentarias que mayor riesgo representan (...) para el consumidor son los moluscos bivalvos, ve­getales de IV gama, frutas tipo baya y platos listos para comer. Actualmente las técnicas moleculares son las más habituales para la detección de estos patógenos en alimentos, aunque toda­vía existen dudas acerca del significado de la presencia de estos genomas víricos en términos de seguridad alimentaria. La infec­tividad de estos patógenos en alimentos viene también determi­nada por su elevada persistencia ambiental y por su resistencia a los tratamientos aplicados para la conservación de los alimentos. (shrink)

Viruses have generally been thought of as infectious agents. New data on mimivirus, however, suggests a reinterpretation of this thought. Earth’s biosphere seems to contain many more viruses than previously thought and they are relevant in the maintenance of ecosystems and biodiversity. Viruses are not considered to be alive because they are not free-living entities and do not have cellular units. Current hypotheses indicate that some viruses may have been the result of genomic reduction of cellular life forms. However, new (...) studies relating to the origins of biological systems suggest that viruses could also have originated during the transition from First to the Last Universal Common Ancestor. Within this setting, life has been established as chemical informational system and could be interpreted as a macrocode of multiple layers. The first entity to acquire these features was the First Universal Common Ancestor that evolved to an intermediate ancestral that could be named T-LUCA and be equated to Woese’s concept of progenotes. T-LUCA may have remained as undifferentiated subsystems with viruses-like structures. The net result is that both cellular life forms and viruses shared protein synthesis apparatuses. In short, virus is a strategy of life reached by two paths: T-LUCAs like entities and the reduction of cellular life forms. (shrink)

Recent progress in the study of short‐distance (cell‐to‐cell) movement of plant virus, facilitated by ‘movement proteins’, has led to a resurgence of interest in long‐distance virus transport in the phloem. Relatively little is known about phloem‐specific barriers to virus movement or about the form in which virus enters, travels within and exits this tissue. Progress in understanding virus and photoassimilate transport is limited by a paucity of information on the substructure and properties of plasmodesmata at (...) specific interfaces. The direction of virus movement, once it has entered the phloem, can be understood by following photoassimilate translocation, a complex and dynamic process influenced by plant growth, development and vascular topology. (shrink)

The existing literature on the development of recombinant DNA technology and genetic engineering tends to focus on Stanley Cohen and Herbert Boyer's recombinant DNA cloning technology and its commercialization starting in the mid-1970s. Historians of science, however, have pointedly noted that experimental procedures for making recombinant DNA molecules were initially developed by Stanford biochemist Paul Berg and his colleagues, Peter Lobban and A. Dale Kaiser in the early 1970s. This paper, recognizing the uneasy disjuncture between scientific authorship and legal invention (...) in the history of recombinant DNA technology, investigates the development of recombinant DNA technology in its full scientific context. I do so by focusing on Stanford biochemist Berg's research on the genetic regulation of higher organisms. As I hope to demonstrate, Berg's new venture reflected a mass migration of biomedical researchers as they shifted from studying prokaryotic organisms like bacteria to studying eukaryotic organisms like mammalian and human cells. It was out of this boundary crossing from prokaryotic to eukaryotic systems through virus model systems that recombinant DNA technology and other significant new research techniques and agendas emerged. Indeed, in their attempt to reconstitute 'life' as a research technology, Stanford biochemists' recombinant DNA research recast genes as a sequence that could be rewritten thorough biochemical operations. The last part of this paper shifts focus from recombinant DNA technology's academic origins to its transformation into a genetic engineering technology by examining the wide range of experimental hybridizations which occurred as techniques and knowledge circulated between Stanford biochemists and the Bay Area's experimentalists. Situating their interchange in a dense research network based at Stanford's biochemistry department, this paper helps to revise the canonized history of genetic engineering's origins that emerged during the patenting of Cohen-Boyer's recombinant DNA cloning procedures. (shrink)

The evolving Ebola epidemic in West Africa is unprecedented in its size and scope, requiring the rapid mobilization of resources. It is too early to determine all of the ethical challenges associated with the outbreak, but these should be monitored closely. Two issues that can be discussed are the decision to implement and evaluate unregistered agents to determine therapeutic or prophylactic safety and efficacy and the justification behind this decision. In this paper, I argue that it is not compassionate use (...) that justifies this decision and suggest three lines of reasoning to support the decision. (shrink)

The COVID-19 pandemic prompted immense work on the investigation of the SARS-CoV-2 virus. Rapid, accurate, and consistent interpretation of generated data is thereby of fundamental concern. Ontologies––structured, controlled, vocabularies––are designed to support consistency of interpretation, and thereby to prevent the development of data silos. This paper describes how ontologies are serving this purpose in the COVID-19 research domain, by following principles of the Open Biological and Biomedical Ontology (OBO) Foundry and by reusing existing ontologies such as the Infectious Disease (...) Ontology (IDO) Core, which provides terminological content common to investigations of all infectious diseases. We report here on the development of an IDO extension, the Virus Infectious Disease Ontology (VIDO), a reference ontology covering viral infectious diseases. We motivate term and definition choices, showcase reuse of terms from existing OBO ontologies, illustrate how ontological decisions were motivated by relevant life science research, and connect VIDO to the Coronavirus Infectious Disease Ontology (CIDO). We next use terms from these ontologies to annotate selections from life science research on SARS-CoV-2, highlighting how ontologies employing a common upper-level vocabulary may be seamlessly interwoven. Finally, we outline future work, including bacteria and fungus infectious disease reference ontologies currently under development, then cite uses of VIDO and CIDO in host-pathogen data analytics, electronic health record annotation, and ontology conflict-resolution projects. (shrink)

El presente ensayo toma como punto de partida varios artículos de opinión con el propósito de reflexionar sobre varias cuestiones que han surgido a raíz de la crisis sanitaria, económica y social del COVID-19. La pandemia ha puesto de relieve distintos asuntos trascendentales de nuestra sociedad: la desigualdad, el uso de la tecnología, la percepción de la realidad, el lenguaje, la solidaridad o los servicios públicos.

As the Zika virus pandemic continues to bring worry and fear to health officials and medical scientists, Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) have recommended that residents of the Zika-infected countries, e.g., Brazil, and those who have traveled to the area should delay having babies which may involve artificial contraceptive, particularly condom. This preventive policy, however, is seemingly at odds with the Roman Catholic Church’s position on the contraceptive. As least since the promulgation (...) of Paul VI’s 1968 encyclical, Humanae Vitae, the Church has explicitly condemned artificial birth control as intrinsic evil. However, the current pontiff, Pope Francis, during his recent visit to Latin America, remarked that the use of artificial contraception may not be in contradiction to the teaching of Humanae Vitae while drawing a parallel between the current Zika Crisis and the 1960’s Belgian Congo Nun Controversy. The pope mentioned that the traditional ethical principle of the lesser of two evils may be the doctrine that justified the exceptions. The authors of this paper attempt to expand the theological rationale of the pope’s suggestion. In so doing, the authors rely on casuistical reasoning as an analytic tool that compares the Belgian Congo Nun case and the given Zika case, and suggest that the former is highly similar to, if not the same as, the latter in terms of normative moral feature. That is, in both cases the use of artificial contraception is theologically justified in reference to the criteria that the doctrine of the lesser of two evils requires. The authors wish that the paper would provide a solid theological-ethical ground based on which condom-use as the most immediate and effective preventive measure can be recommended in numerous Catholic hospitals as well as among Catholic communities in the world, particularly the most Zika-affected and largest Catholic community in the world, Brazil – 123 million present Brazilian citizens are reported to be Roman Catholic. (shrink)

Currently, the concept of the cell as a society or an ecosystem of molecular elements is gaining increasing acceptance. The basic idea arose in the 19th century, from the surmise that there is not just a single unit underlying an individual’s appearance, but a plurality of entities with both collaborative and conflicting relationships. The following hypothesis is based around this model. The incompatible activities taking place between different original elements, which were subsumed into the first cell and could not be (...) eliminated, had to be controlled very closely. Similarly, a strong level of control had to be developed over many cellular elements after the cell changed its genome to DNA. We assume that at least some of those original RNA agents and other biomolecules which carry incompatibilities and risks, are retained within current cells, although they are now under strict control. A virus functions as a signal informing these repressed cellular RNAs and other elements of ancient origin how to restore suppressed degrees of molecular freedom, favoring pre-existing molecular affinities and activities, re-establishing ancient molecular webs of interactions, and giving fragments of ancient coded information the opportunity to be re-expressed. Collectively, these newly activated mechanisms lead to different possibilities for pathological cell states. All these processes are opposed by cell-control mechanisms. Thus, in this new scenario, the battle is considered intracellular rather than between the virus and the cell. And so the virus is treated as the signal that precipitates the cell’s change from a latent to an active pathological state. (shrink)

Membrane damage induced by haemolytic agents does not necessarily lead to lysis: the pores that are formed at low concentration of agent are formed at low concentration of agent are not large enough to allow leakage of cytoplasmic proteins, and in many instances the lesions become repaired with time. Quite different agents induce a similar type of lesion: in each case leakage is reduced at low ionic strenth, and is prevented by divalent cations such as Ca2+ or Zn2+, suggesting a (...) possible therapeutic approach to the containment of several membrane‐damaging diseases. (shrink)

ABSTRACT Unless a democratic citizenry, when it gets shaped at school, is asked to formulate complex answers to simple questions, there is no other avenue for their destiny than ressentiment against “the world,” which expresses itself in either a parading of culture or an inordinate sense of revolt.

Virus and information spreading dynamics widely exist in complex systems. However, systematic study still lacks for the interacting spreading dynamics between the two types of dynamics. This paper proposes a mathematical model on multiplex networks, which considers the heterogeneous susceptibility and infectivity in two subnetworks. By using a heterogeneous mean-field theory, we studied the dynamic process and outbreak threshold of the system. Through extensive numerical simulations on artificial networks, we find that the virus’s spreading dynamics can be suppressed (...) by increasing the information spreading probability, decreasing the protection power, or decreasing the susceptibility and infectivity. (shrink)

Gender and public markets have long been intertwined in Peru. The vast majority of market-sellers are women, and significantly this kind of work has been intimately related to women’s empowerment and agency within a deeply patriarchal society. However, with the arrival of COVID-19 the woman-centred space of the marketplace became compromised. While once a place of female empowerment, during the pandemic the market became seen as a dangerous ‘viral vector’, with 79% of Lima market sellers testing positive for Coronavirus during (...) the first lockdown of 2020. Further still, a gender-segregated quarantine policy drove women to the markets en-masse; a policy that was withdrawn early due to its spectacular, although unsurprising, failure, causing a total inability to social distance on ‘women’s days’. As such, this paper investigates the extent to which the pandemic increased the ‘feminised burden of care’ to include deadly viral infection during the gender segregated quarantine. Applying an intersectional, post-colonial framework, the ‘feminised burden of care’ is approached as stratified along racial and class lines since markets are not spaces for all women. Furthermore, this paper will show how these intersecting structures of power that have persisted through time may become more visible and observable in times of crisis, such as through Peru’s short-lived gender segregated quarantine. With this in mind, it will be possible to suggest that the events of 2020 were more than just policymaker missteps, but a persistence and exacerbation of long-existing entangled structures of colonial and patriarchal powers. As such, it can be inferred that in an emergency, it is these power structures that were automatically adopted as the first port of call, and thereby perpetuate and strengthen them into the future. (shrink)

Exploro os conceitos de campo e de estado de exceção e tento mostrar como Giorgio Agamben, por um lado, é coerente com sua obra, além de estar certo no diagnóstico do presente, mas, por outro, exagera na desconfiança da real mortalidade do Coronavírus e, também, como este posicionamento do filósofo italiano não serve à experiência brasileira, especialmente quanto à problemática de uma aparente concordância do ministro Araújo do Governo Bolsonaro com seu alerta para o estado de exceção permanente.

Abstract:Austin’s (in)famous characterization of poetry as parasitical has been subject to many interpretations, from Derrida’s considering it a limit of and a central problem in Austin’s theory to Cavell’s attempt to reintegrate poetic uses of language within the framework of Ordinary Language Philosophy. In this essay, I argue that poetry, rather than being excluded from the realm of the performative, can be considered as a performative dispositif that acts upon ordinary language and, through it, upon our forms of life. To (...) reevaluate poetry, I suggest moving from the ‘parasite’ metaphor (poetry is passively feeding on ordinary uses of language) to a ‘virus’ metaphor (poetry is actively disrupting ordinary uses of language). By building on works of French theorists and poets Christophe Hanna, Franck Leibovici, and Manuel Joseph among others, I explore how poetry reveals the virality of language. (shrink)

Este artigo, de caráter ensaístico, não se furta a pensar o fenômeno de maior proeminência no momento em que fora escrito, a pandemia desencadeada pelo Covid-19. Partindo literalmente da premissa foucaultiana, segundo a qual a filosofia deve ter como alvo o tempo presente, e abalizado por reflexões recentes de filósofos contemporâneos influenciados por Foucault, como Paul B. Preciado e Roberto Esposito, defendo a hipótese de que o vírus carrega em si, como um espelho, tudo o que ainda não conseguimos deixar (...) de ser. Com efeito, a abordagem aqui adotada lança mão da estratégia, já recorrente na filosofia contemporânea, de ampliar a noção de “vírus” como metáfora pertinente para os mais diversos fenômenos societários. Após introduzir o que está em jogo neste contingente virótico e global, decomponho a reflexão em quatro partes: enquadramento – de uma atmosfera previamente carregada de certos hábitos de exceção e anticorpos fronteiriços; estranhamento – como princípio da imunização e da redistribuição da vulnerabilidade; confinamento – como disciplina assimétrica de sobrevivência e autossacrifício; desaparecimento – como horizonte ontológico de uma existência inerte que nos espelha. O que me interessa aqui é, mais do que delinear uma interpretação filosófica da pandemia, indiciar a lógica insuspeita e virulenta que há décadas nos cerceia enquanto corpos e anticorpos descartáveis. Concluo, à guisa do diagnóstico de Paul B. Preciado, segundo o qual o vírus atua “à nossa imagem e semelhança”, que o fenômeno pandêmico implica o recrudescimento do paradoxo neoliberal segundo o qual, para “sobrevivermos”, devemos sacrificar a nós mesmos. (shrink)

A recent thought‐provoking theory argues that complex organisms using epigenetic information for their normal development and functioning must irreversibly age as a result of epigenetic signal loss. Importantly, the scope of this theory could be considerably expanded, with scientific benefits, by analyzing epigenetic ageing beyond the borders of the Tree of Life. Viruses that use epigenetic signals for their normal functioning may also age, that is, present an increasing risk of failing to complete their individual life cycle and to disappear (...) with time. As viruses are ancient, abundant, and infect a considerable diversity of hosts, the ageing virus hypothesis, if verified, would have important consequences for many fields of the Life sciences. Uncovering ageing viruses would integrate the most abundant and biologically central entities on Earth into theories of ageing, enhance virology, gerontology, evolutionary biology, molecular ecology, genomics, and possibly medicine through the development of new therapies manipulating viral ageing. (shrink)

Graphical AbstractTesting for respiratory viruses and SARS-CoV-2 in clinical and epidemiological settings has contrasting purposes and utility. Symptomatic patients are best tested with respiratory virus panels to establish the pathogen and guide personalized treatment. Asymptomatic patients are tested for a single infectious pathogen to establish carrier status and guide containment.

The pathogenesis of dengue haemorrhagic fever has been the subject of intense research and considerable controversy. One hypothesis proposes that the immune response in a sensitized host is the primary mechanism. In contrast, others have suggested that the disease is caused by a more virulent, variant strain of dengue virus. Recent advances in molecular biology and hybridoma technology are providing valuable clues toward a solution and illustrating the fact that the course of a human viral disease is often a (...) net result of unseparated interactions between host and virus. (shrink)