Regeneration capabilities are found in most or all animals. Whether regeneration is part of the development of an animal or a distinct phenomenon independent of development is a debatable question. If we consider regeneration as a process belonging to development, similarly to embryogenesis or metamorphosis, the existence of regenerative capabilities in adults can be seen as an argument in favor of the theory that development continues throughout the life of animals. Here I perform a comparative analysis of regeneration versus “classical” (...) developmental processes in animals in order to determine to what extent these processes are inclusive or distinct. I identify the existence of regeneration-specific processes, i.e., processes that occur during the regeneration, but not the initial development, of a given structure. In addition, I find that seemingly similar processes acting during development and regeneration may have differential molecular and cellular bases. I thus conclude that there are significant differences between regeneration processes in adult animals and developmental processes occurring during earlier phases of the life cycle. The existence of regenerative capabilities in adult animals can therefore not be used as an argument in favor of the idea that development spans the whole life. (shrink)

It is presumed that the evolution of morphological diversity in animals and plants is driven by changes in the developmental processes that govern morphology, hence basically by changes in the function and/or expression of a defined set of genes that control these processes. A large body of evidence has suggested that changes in developmental gene regulation are the predominant mechanisms that sustain morphological evolution, being much more important than the evolution of the primary sequences and functions of proteins. Recent reports1, (...) 2 challenge this idea by highlighting functional evolution of Hox proteins during the evolutionary history of arthropods. BioEssays 24:775–779, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

This special issue of Biological Theory is focused on development; it raises the problem of the temporal and spatial boundaries of development. From a temporal point of view, when does development start and stop? From a spatial point of view, what is it exactly that "develops", and is it possible to delineate clearly the developing entity? This issue explores the possible answers to these questions, and thus sheds light on the definition of development itself.

Is it possible, and in the first place is it even desirable, to define what "development" means and to determine the scope of the field called "developmental biology"? Though these questions appeared crucial for the founders of "developmental biology" in the 1950s, there seems to be no consensus today about the need to address them. Here, in a combined biological, philosophical, and historical approach, we ask whether it is possible and useful to define biological development, and, if such a definition (...) is indeed possible and useful, which definition can be considered as the most satisfactory. (shrink)

Like most bilaterian animals, the annelid Platynereis dumerilii generates the majority of its body axis in an anterior to posterior temporal progression with new segments added sequentially. This process relies on a posterior subterminal proliferative body region, known as the "segment addition zone" (SAZ). We explored some of the molecular and cellular aspects of posterior elongation in Platynereis, in particular to test the hypothesis that the SAZ contains a specific set of stem cells dedicated to posterior elongation.We cloned and characterized (...) the developmental expression patterns of orthologs of 17 genes known to be involved in the formation, behavior, or maintenance of stem cells in other metazoan models. These genes encode RNA-binding proteins(e.g., tudor, musashi, pumilio) or transcription factors(e.g., myc, id, runx) widely conserved in eumetazoans. Most of these genes are expressed both in the migrating primordial germ cells and in overlapping ring-like patterns in the SAZ, similar to some previously analyzed genes(piwi, vasa). The SAZ patterns are coincident with the expression of proliferation markers cyclin B and PCNA. EdU pulse and chase experiments suggest that new segments are produced through many rounds of divisions from small populations of teloblast-like posterior stem cells. The shared molecular signature between primordial germ cells and posterior stem cells in Platynereis thus corresponds to an ancestral "stemness" program. (shrink)

“ S pace, K no w l edge and P o w e r ” , en tr ev i s t a r ea l i z a d a en 1982 y pub li cada en P aul R ab i no w , The Foucau l t R eade r , N ueva Y o r k, 1984. A quí se pub li ca de acue r do a l a ve r s i ón f r (...) ancesa, t r aduc i da por P ab l o Bli t s t e i n y Tadeo L im a. (shrink)

El propósito de este texto es tematizar la precariedad con las herramientas de la filosofía política. Buscaremos equilibrar horizontes conceptuales con prácticas políticas para pensar la acción democrática en nuestro contexto. Nuestro argumento se compone de cuatro premisas. Primero, que elfalso dilema entre teoría y práctica nos permite explorar una relación de tensión creativa entre ambas para conceptualizar la precariedad. Segundo, que la construcción teórica de la precariedad responde tanto a ideas y conceptos como a instituciones y discursos que configuran (...) las vidas de quienes la experimentan. Tercero, que los distintos usos del concepto de precariedad permiten reconocer una fuente común de vulneración de derechos relacionada con la configuración del trabajo en el orden neoliberal. Cuarto, que relacionar la conceptualización de lo plebeyo con la de lo precario nos permite pensar prácticas democráticas renovadas. (shrink)

The first comprehensive reference resource on comparative constitutional law, the Oxford Handbook provides a road map to the field. Leading experts examine the history and development of the discipline, its core concepts, institutions, rights, and emerging trends.

Cet article propose les éléments d’un cadre théorique permettant d’analyser des situations sociales comportant une part d’imprévisibilité. S’intéresser à des ruptures, des changements soudains, c’est en partie revenir sur de vieux tabous de la sociologie et plus généralement des sciences sociales : la contingence, l’événement, l’imprévisible. Une solution possible réside dans la définition précise de ce qui est considéré comme imprévisible et dans la prise en compte de différents niveaux de temporalité, à condition d’accepter l’idée que les temps « courts (...) » peuvent parfois influer sur les temps « longs ».In this article I propose the elements of a theoretical framework that makes it possible to analyse social situations with a part of unpredictability. Being interested in ruptures, unexpected changes, is for a part going back to some old taboos of sociology, and more generally, of social sciences : contingency, events, unpredictability. One possible solution consists in a precise definition of what is considered as unpredictable and in taking into account different levels of temporality, providing to accept the idea that « short » time can sometimes have an influence on « long » time. (shrink)

Three years before his death, Michel Foucault delivered a series of lectures at the Catholic University of Louvain that until recently remained almost unknown. These lectures—which focus on the role of avowal, or confession, in the determination of truth and justice—provide the missing link between Foucault’s early work on madness, delinquency, and sexuality and his later explorations of subjectivity in Greek and Roman antiquity. Ranging broadly from Homer to the twentieth century, Foucault traces the early use of truth-telling in (...) ancient Greece and follows it through to practices of self-examination in monastic times. By the nineteenth century, the avowal of wrongdoing was no longer sufficient to satisfy the call for justice; there remained the question of who the \u201ccriminal\u201d was and what formative factors contributed to his wrong-doing. The call for psychiatric expertise marked the birth of the discipline of psychiatry in the nineteenth and twentieth centuries as well as its widespread recognition as the foundation of criminology and modern criminal justice. Published here for the first time, the 1981 lectures have been superbly translated by Stephen W. Sawyer and expertly edited and extensively annotated by Fabienne Brion and Bernard E. Harcourt. They are accompanied by two contemporaneous interviews with Foucault in which he elaborates on a number of the key themes. An essential companion to Discipline and Punish, Wrong-Doing, Truth-Telling will take its place as one of the most significant works of Foucault to appear in decades, and will be necessary reading for all those interested in his thought.  . (shrink)

Le christianisme bouleverse notre conception de l'homme parce qu'il refuse la manière dont celui-ci se comprend depuis toujours à partir du monde, de sa vérité et de ses lois. Selon le christianisme, l'homme ne procède pas du monde mais de Dieu: il est son " Fils ". Or Dieu est Vie, Vie qui ne se montre en aucun monde, qui s'éprouve elle-même dans son intériorité invisible. L'autorévélation de la Vie est l'essence de Dieu. Cette épreuve de soi de la Vie (...) fonde tout Soi et tout Moi, toute individualité et tout individu - tout " homme " concevable. L'opposition de la Vérité de la Vie et de la vérité du monde permet, d'autre part, de savoir que Jésus est le Christ. Dans le monde, Jésus a l'apparence d'un homme. C'est seulement en se plaçant à l'intérieur du mouvement de la Vie qu'on peut saisir comment celle-ci génère en elle un Premier Vivant et, en lui, tout vivant possible. Ce livre ne demande donc pas si le christianisme est vrai ou faux. Il met à nu le genre de Vérité que le christianisme professe et propose aux hommes. A partir d'une phénoménologie radicale du concept de " Vie ", il donne une idée extrêmement neuve, originale et forte de la Vérité du christianisme. (shrink)

ABSTRACT: In the 18th century, Kant evaluated that his historical period was not a time of enlightenment, but rather minority, because of man’s inability to use his own understanding. Adorno updated this problem, interpreting the minority in our presente in terms of loss of experience. Men are no longer apt to experience, because the technical and economic apparatus prevents the clarification and awareness of reality. From this diagnosis, The aim of this article is to investigate Adorno’s educational thought in its (...) possibilities of emancipation. In our point of view, the role of education, in the thoughts of the Frankfurtian, is to recover the critical autonomy of individuals, through dialectical thinking, to rebuild the damaged experience. (shrink)

This article approaches the city as it is lived in events rather than as it is defined by its material forms or by its standing institutions. In the plays staged in South-African townships, in Brazilian capoeira, or in a carnival parade, the constitution of « instant communities », or « communities of movement », depends upon situations that provide the initiating movement of politics. In all such cases, the city really exists and vibrates when it is attuned to the rhythm (...) of its cultural self-invention. (shrink)

Aesthetics: 50 Puzzles, Paradoxes, and Thought Experiments is a teaching-focused resource, which highlights the contributions that imaginative scenarios—paradoxes, puzzles, and thought experiments alike—have made to the development of contemporary analytic aesthetics. The book is divided into sections pertaining to art-making, ontology, aesthetic judgements, appreciation and interpretation, and ethics and value, and offers an accessible summary of ten debates falling under each section. -/- Each entry also features a detailed annotated bibliography, making it an ideal companion for courses surveying a broad (...) collection of topics and readings in aesthetics. (shrink)

This seminal, multidisciplinary book shows how mathematics can be used to study the first principles of DNA. Most importantly, it enriches the so-called "Chargaff's grammar of biology" by providing the conceptual theoretical framework necessary to generalize Chargaff's rules. Starting with a simple example of DNA mathematical modeling where human nucleotide frequencies are associated to the Fibonacci sequence and the Golden Ratio through an optimization problem, its breakthrough is showing that the reverse, complement and reverse-complement operators defined over oligonucleotides induce a (...) natural set partition of DNA words of fixed-size. These equivalence classes, when organized into a matrix form, reveal hidden patterns within the DNA sequence of every living organism. Intended for undergraduate and graduate students both in mathematics and in life sciences, it is also a valuable resource for researchers interested in studying invariant genomic properties. (shrink)

The aim of this paper is twofold: The general aim is to shed light on the structure of species discoveries new to biology by bringing together a practice-oriented philosophy of science perspective with a philosophy of language perspective. The more specific aim is to argue that and to show how the overall structure of biological species discoveries comprises aspects of both institutional and non-institutional reality. The author proceeds as follows: he shows that placing the focus on the topic of scientific (...) discoveries enables us to circumvent two long-standing problems. He analyzes three fictional cases of discoveries in order to bring about a greater sensitivity for the concept of discovery. He takes a closer look at a real example – the discovery of a deep-sea anglerfish – and identifies the main structural features of species discovery processes in biology. In order to connect these results with Searle’s account of institutional reality, he provides an overview of the conceptual apparatus needed here. In bringing Searle’s account together with the structural features of species discoveries developed before, he shows to what extent declarative speech acts play a central role in species discovery processes in biology. (shrink)

If through rotation of a hollow sphere one produces a Coriolis field inside of it, then a centrifugal field is produced [...] that is not the same as the one that would occur in a rotating rigid system with the same Coriolis field. One can therefore not think of rotational forces as produced by the rotation of the fixed stars ….

Foucault's previously unpublished doctoral dissertation on Kant offers the definitive statement of his relationship to Kant and to the critical tradition of philosophy. This introduction and commentary to Kant's least discussed work, Anthropology from a Pragmatic Point of View, is the dissertation that Michel Foucault presented in 1961 as his doctoral thesis. It has remained unpublished, in any language, until now. In his exegesis and critical interpretation of Kant's Anthropology, Foucault raises the question of the relation between psychology and (...) anthropology, and how they are affected by time. Though a Kantian “critique of the anthropological slumber,” Foucault warns against the dangers of treating psychology as a new metaphysics, explores the possibilities of studying man empirically, and reflects on the nature of time, art and technique, self-perception, and language. Extending Kant's suggestion that any empirical knowledge of man is inextricably tied up with language, Foucault asserts that man is a world citizen insofar as he speaks. For both Kant and Foucault, anthropology concerns not the human animal or self-consciousness but, rather, involves the questioning of the limits of human knowledge and concrete existence. This long-unknown text is a valuable contribution not only to a scholarly appreciation of Kant's work but as the first outline of what would later become Foucault's own frame of reference within the history of philosophy. It is thus a definitive statement of Foucault's relation to Kant as well as Foucault's relation to the critical tradition of philosophy. By going to the heart of the debate on structuralist anthropology and the status of the human sciences in relation to finitude, Foucault also creates something of a prologue to his foundational The Order of Things. Michel Foucault is widely considered to be one of the most important academic voices of the twentieth century and has proven influential across disciplines. (shrink)

L'originalité de la philosophie de Platon et de Plotin est de situer l'origine de toutes choses dans un principe supérieur au monde physique et matériel. Cette décision philosophique, qui ne va pas de soi, visant à placer la cause de toutes choses dans un principe transcendant et immatériel, est concomitante d'un autre choix philosophique consistant à "séparer" la cause de son effet, le haut du bas, l'intelligible du sensible, l'invisible du visible, l'incorporel du corporel. De telles "séparations" poseront à Platon (...) et à Plotin le problème de l'unité du monde et des "relations" que ces deux niveaux différents peuvent ou doivent malgré tout entretenir afin d'éviter toute forme de dérive dualiste et de vision pessimiste du monde. Cet ouvrage propose d'affronter cette question épineuse et d'apprécier la pertinence de la solution qu'y apportent Platon et Plotin, en développant chacun une "philosophie de la relation" tout à fait originale et stimulante. (shrink)

In 1942-1943, when he was completing his doctoral thesis in medicine, Georges Canguilhem gave at the Faculté des Lettres of Strasbourg relocated to Clermont-Ferrand a lecture on Les normes et le normal. In 1962-1963, he again gave a lecture at the Sorbonne, this time entitled La norme et le normal. The first of these lectures identified the “philosophical demon” that also inspired the medical thesis: the aim was to make philosophy a philosophy of values. The second does not abandon this (...) commitment. Canguilhem draws the conclusion that philosophy, whose task is the critical resolution of conflicts of values, cannot itself have one of these values as its norm. Hence the apparent paradox that “there is no such thing as philosophical truth”. (shrink)

In this accessible and fascinating book, Michel Morange draws on recent advances in molecular genetics, evolutionary biology, astrobiology, and other disciplines to find today’s answers to the question of life.

Julian Dodd has characterized the default position in metaphysics as meta-ontologically realist: the answers to first-order ontological questions are thought to be entirely independent of the things we say and think about the entities at issue. Consequently, folk ontologies are liable to substantial error. But while this epistemic humility is commendable where the ontology of natural kinds is concerned, it seems misplaced with respect to social kinds since their ontology is dependent upon the human social world. Using art and art-kinds (...) as paradigmatic examples of social kinds, I argue that meta-ontological realism sets conditions that are too strict to apply to social kinds. Nevertheless, I argue that we should not be too quick to embrace the conclusion that our folk theories of social kinds cannot err substantially. By modelling the reference of social kind-terms on that of natural kind-terms, it becomes clear that in both cases, our sole epistemic privilege lies in our ability to pinpoint the subject of our inquiries. (shrink)

Trade-Unions, Social Movements, and the Dynamic of Emancipation : theChallenge of the New Radicalism The article analyses the relations between trade-unions, associations and partisan movements inFrance today. These relations would appear to be characterised by a degree of mistrust which the crisisaffecting political projects of emancipation has accentuated. The growing autonomy of the French labour movement in relation to the existing political movements represents a major shift. Trade-unionsnow cling to their independence, regarding it as an essential element of their legitimacy. (...) The principleaccording to which there is no prior hierarchy governing the relation between the agenda of social issues and the agenda of the political is the precondition for any form of cooperation. If trade-unionistsand activists in associations call for a « normalisation » of their relations with political parties, theyrefuse any invitation to engage in any “co-elaboration” of projects, which would cause them to assumeresponsibility for decisions which are not their prerogative. What they urge is a strategy of resonancerather than a strategy of alliance : confrontation rather than subordination. (shrink)

Cette étude dégage la critique de James de l’ontologie et de la psychologie de la substance en suivant une double piste : après avoir spécifié le contexte dans lequel se déploie l’argumentation jamesienne, on montre les difficultés qu’affronte la pensée substantialiste et la réponse qu’apporte, parfois implicitement, James. On montre particulièrement la corrélation qui existe entre la pensée du processus et une nouvelle conception de la conscience.

Hoje eu gostaria de completar o que iniciei anteriormente a respeito da parrhesia e a crise das instituições democráticas no século 4 a.C. E, a seguir, gostaria de deslocarme para outra forma de parrhesia: a parrhesia no campo das relações pessoais, ou parrhesia e o cuidado de si.

Diogène n'aimait pas Platon, et l'auteur de La République qui commença sa carrière par la lutte et le théâtre sans jamais vraiment y renoncer, le lui rendait bien. Entre ces deux-là, ce fut la haine leur vie durant. Normal, ils campent chacun aux deux extrémités idéologiques, métaphysiques, philosophiques. L'homme au Chien aime la vie, la joie, le réel, le rire, la liberté, l'indépendance, l'individu ; l'homme aux Idées chérit exactement l'inverse : la mort - voir la thanatophilie du Phédon! -, (...) l'ascétisme, les arrière-mondes, la servitude, la dilution des subjectivités dans la communauté. Au-delà des siècles, Diogène et Platon incarnent deux façons d'appréhender le pouvoir, de le considérer et d'en user. Deux anecdotes ramassent leurs conceptions. L'une, célèbre, participe de l'iconographie philosophique classique et met en présence un Diogène qui bronze au Cranéion, une colline de Corinthe couverte de cyprès, et Alexandre, le Prince aux pouvoirs absolus. Alexandre s'adresse à Diogène et lui demande un souhait afin de jouir de l'exaucer. Réponse célèbre de Diogène : " ôtes toi de mon soleil " - ce qui, dans une traduction moins faite pour le marbre de la postérité donne : " tires-toi, tu me fais de l'ombre "... (shrink)

How might we fathom out what is maturity? Is it by opposing it to immaturity? Is it a polysemous word? Who or what is to be said mature? And what are the domains where maturity reveals itself? In this paper, I probe how Merleau-Ponty innovatively fields those questions. He establishes that maturity is conquered in the actual work of an artist. Maturity consists in an awareness that makes our reading of the world and of others reach a higher degree and (...) pass a critical point. Such a movement in maturity is conceptually refined as a too lengthy maturation that inhabits a process of learning, historical, and perceptual, also as a maturing of thought that is slow and shows intrinsic limitations. In such a facticity that is also an anticipation, maturity essentially becomes a prematuration, which is by no means premature for psychoanalysis, politics, and philosophy. (shrink)

The author discusses in detail the basic issues related to the practice of philosophical discussions with children. He identifies and problematizes the different methods or modalities for doing philosophy with children currently practised throughout the world. He presents a series of pedagogic and didactic issues and puts forward some proposals and directions for the future that might allow us to facilitate philosophy-oriented discussions with children.