Subliminal perception (SP) is today considered a well-supported theory stating that perception can occur without conscious awareness and have a significant impact on later behaviour and thought. In this article, we first present and discuss different approaches to the study of SP. In doing this, we claim that most approaches are based on a dichotomic measure of awareness. Drawing upon recent advances and discussions in the study of introspection and phenomenological psychology, we argue for both the possibility and necessity of (...) using an elaborated measure of subjective states. In the second part of the article, we present findings where these considerations are implemented in an empirical study. The results and implications are discussed in detail, both with reference to SP, and in relation to the more general problem of using elaborate introspective reports as data in relation to studies of cognition. (shrink)

Background: With the coming of the Industrial Revolution, the levels of pollution grow significantly. This Technological development contributed to the worsening of shortness breath problems in great shape. especially in infants and children. There are many shortness breath diseases that infants and children face in their lives. Shortness of breath is one of a very serious symptom in children and infants and should never be ignored. Objectives: Along these lines, the main goal of this expert system is to help physician (...) in diagnosing and describe some common causes of shortness of breath in infants and children by diagnosing their cases through our expert system. Moreover, this system which we are presenting will give patient the appropriate diagnosis of disease and the treatment required. Methods: In this paper the strategy of the expert system for diagnosing a number of the existed shortness of breath in infants and children diseases such as (Asthma , Bronchiolitis, Viral Pneumonia, cough, Shortness of breath' dyspnea ', Epiglottitis, Croup, ABSCESS in the tonsil 'peritonsillar abscess', Bronchitis, Viral Bronchitis, Wheezing, sudden infant death syndrome 'SIDS' ) is introduced, an overview about the shortness of breath in children and infants diseases are delineated, the cause of diseases are sketched and the treatment of disease whenever conceivable is given . SL5 Object Expert System language was utilized for designing and implementing the proposed expert system. Results: The proposed shortness of breath in children and infants diseases diagnosis expert system was estimated by Medical students and they were satisfied with its result. Conclusions: The Proposed expert system is very useful for Respiratory physician, pediatrician, recently graduated physician, and for children's parents with shortness of breath problem. (shrink)

Aim: To determine the current state of knowledge on nursing and ethics and to assess the knowledge and experience based on the evidence in this regard. Background: Although ethics is at the center of the nursing profession and the ethical issues affecting nurses are given much importance, few studies have focused on professional ethics in nursing. In this respect, ethics has become a concept that contains controversial and ambiguous situations. Design: The Preferred Reporting Items for Systematic Reviews and Meta-analyses guide, (...) a basic search algorithm, was taken. Data sources: Cochrane, PubMed, CINAHL Complete, PsycINFO, and ULAKBIM from 2012 to 2016. Review methods: Following a systematic search strategy, all papers were assessed in relation to inclusion criteria and type of study. When sufficient information was not available in the title and summary of the works, the necessary data were evaluated in full texts. Results: This review was completed with 27 articles meeting the research criteria. The evaluation identified six themes: (1) ethics and nursing, (2) ethical difficulties/ethical dilemmas and nursing, (3) ethical competence and nursing, (4) professional ethics and nursing, (5) ethics, education, and nursing, and (6) ethics in health research. Conclusion: As a result of the review, a synthesis of high evidence-level research relating to nursing ethics was obtained. The emphasis was on the importance of further research and education so that the ethical aspects of nursing can be better understood throughout the studies. Nursing researchers’ level of evidence on ethics and their orientation to high research design will shed light on uncertain and controversial aspects of the subject. Ethical consideration: Since this was a systematic review, no ethical approval was required. There is no conflict of interest in this literature review. (shrink)

Background: Although ethics consultation has been introduced to clinical practice for many years, the results of empirical studies to evaluate the effectiveness of ethics consultation are still controversial. The design of randomised controlled trials is considered the best research design to evaluate the effect of a clinical practice on the outcomes of interests. In order to understand the effects of ethics consultation, we conducted this search for studies with the design of randomised controlled trials to evaluate ethics consultation.Objective: To provide (...) an integrated review of studies with the design of randomised controlled trials to evaluate the effectiveness of ethics consultation.Methods: PubMed was used to search for studies using the randomised controlled trial design to evaluate the effectiveness of ethics consultation. The search term used was “ethics consultation”. The selection criterion was limited to “randomised controlled trial”.Results: Four articles that met both search criteria were retrieved. One of these articles reported a study that did not actually use the design of a randomised controlled trial and is excluded from the following discussion.Conclusions: To apply randomised controlled trials to evaluate the effectiveness of ethics consultation is extremely difficult as long as two issues are not resolved: the standardisation of ethics consultation and a placebo for ethics consultation to eliminate the placebo effect. Thus, the results generated by the design of randomised controlled trials are always problematic. Furthermore, as long as the two issues exist, the results generated by the design of quantitative research methods always pose problems. (shrink)

The second of Lorca's great trilogy of rural dramas, "Yerma" is a concentrated blend of contrasting moods through which Lorca charts the increasingly destructive obsession of a childless young country wife, and probes the darker zones of human fears and desires. The play's rich mode of expression--a powerful combination of verbal, visual and auditory images and rhythms--is also geared to celebrating sexual attraction and fertility, creation and procreation.

Chapman and colleagues make a compelling case for reforming the Common Rule to better protect group interests in genomics and data-centric research (Chapman et al. 2025). Drawing on insights from p...

Uterus transplantation (UTx) is an experimental surgery likely to face the issue of organ shortage. In my article, I explore how this issue might be addressed by changing the prevailing practices around live uterus donor recruitment. Currently, women with children – often the mothers of recipients – tend to be overrepresented as donors. Yet, other potentially eligible groups who may have an interest in providing their uterus – such as transgender men, or cisgender women who do not wish to gestate (...) or to have children – tend to be excluded as potential donors. Moving forward, I recommend that donor inclusion criteria for UTx be broadened to be more inclusive of these latter groups. (shrink)

This paper aims at explicating a theory of hope that is also suitable for gravely ill people and based on virtue ethics, research in the psychology of “well-being,” and the philosophy of palliative care. The working hypotheses of the theory are that hope is conditioned neither by past events nor by present needs, but is not necessarily oriented toward the future, especially the distant future; that hope is related to personal agency and to freedom; and that hope is deliberative, hence (...) evaluative, motivatory, and rationally critical. Following Higgins’ distinction between “prevention-focus” and “promotion-focus” strategies of coping, and Rawls’ notion of the “Aristotelian principle,” it is argued that hope is the valuation of and personal identification with “promotion-focus” goals with an attitude of nonattachment to any one goal. (shrink)

In his paper ‘On what there’s not’, Joseph Melia disavows commitment to the existence of objects like average mothers, possibilities, numbers, etc. Since quantification over such objects is at times unavoidable, Melia tries to argue that we can deny the existence of such objects despite the fact that our (true) theories of the world quantify over them. Melia calls this ‘weaseling’. In this paper, I argue that these assumptions of Melia’s render his position incoherent.

The author argues that to explore what is distinctly Christian about Christian bioethics requires clarity about what is Christian. He distinguishes between the Christian (that which can be identified as authentically Christian), Christianity (the sum of that which is authentically Christian), and ecclesiastical traditions (the historic communities of faith and practice that are predicated upon both Christian and extra-Christian tradition) to critically assess what is to be declared Christian. In addition to exploring the role of New Testament scripture in identifying (...) the Christian, the author emphasizes the need to recognize the extent to which the content of Christianity is Hebraic and Jewish. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2018 Heft: 225 Seiten: 457-487.

Two thought experiments are discussed which suggest, first, a geometric interpretation of the concept of a (say, vector) potential (i.e., as a kinematic quantity associated with a transformation between moving frames of reference suitably related to the problem) and, second, that, in a quantum treatment one should extend the notion of the equivalence principle to include not only the equivalence of inertial forces with suitable “real” forces, but also the equivalence of potentials of such inertial forces and the potentials of (...) suitable real forces. The two types of cancellation are physically independent of each other, because of the Aharonov-Bohm effect. Finally, we show that the latter effect itself can be understood “geometrically” as a kinematic effect arising upon the transformation between the two reference frames. (shrink)

'This study is extremely authoritative and up-to-date... This book has much to offer linguists motivated by any one of several primary interests, particularly universals and the connection between language and cognition' -Journal of Linguistics 'Aikhenvald displays the rare gift of being able to inspire interest in new research through the success of her own results, without stifling those future possibilities through undue certitude in having discovered all of the answers already. The best thing about this very excellent book is precisely (...) the author's keen awareness that it is not the last word on the subject' -Journal of Linguistics 'Data presented in a clear, straightforward manner... also cutting edge research presented in the spirit of a work in progress' -Journal of LinguisticsAlmost all languages have some ways of categorizing nouns. Languages of South-East Asia have classifiers used with numerals, while most Indo-European languages have two or three genders. They can have a similar meaning and one can develop from the other. This book provides a comprehensive and original analysis of noun categorization devices all over the world. It will interest typologists, those working in the fields of morphosyntactic variation and lexical semantics, as well as anthropologists and all other scholars interested in the mechanisms of human cognition. (shrink)

The article surveys and analyzes the roles in Judaism of the value of imago Dei/human dignity, especially in bioethical contexts. Two main topics are discussed. The first is a comparative analysis of imago Dei as an anthropological and ethical concept in Jewish and Western thought (Christianity and secular European values). The Jewish tradition highlights the human body and especially its procreative function and external appearance as central to imago Dei. The second is the role of imago Dei as a moral (...) value relative to others. In rabbinic Judaism, respect for human dignity is not the primary moral maxim; it is secondary to the value of neighborly love and sometimes to other moral laws and values. (shrink)

In heterogeneous markets, one of the many consumer groups is that of green product buyers. With rising ethical values, the green market is assuming its place in a general growth trend. Given this, it is important to determine the profile of green product buyers. This study aims to find out whether there are sub-markets for green product buyers, based on their personal values and consumption values, and to determine a detailed profile for these buyers. Both personal values and consumption values (...) are basic factors guiding consumer behaviour and affecting consumption preferences. The data was collected, through surveys in Turkey, from green consumers who were members of the TEMA (the Turkish Foundation for Combating Soil Erosion, for Reforestation and the Protection of Natural Habitats) council. The result of our clustering analysis indicates that green product buyers could be segmented into subgroups according to their personal values and consumption values. (shrink)

This study aimed to identify the learning and business incubation processes and their impact on developing the performance of business incubators in Gaza Strip, and the study relied on the descriptive analytical approach, and the study population consisted of all employees working in business incubators in Gaza Strip in addition to experts and consultants in incubators where their total number reached (62) individuals, and the researchers used the questionnaire as a main tool to collect data through the comprehensive survey method, (...) where (55) questionnaires were retrieved with a recovery rate of (88.7%). The results of the study showed that there is a high approval of the variables of the study, where the dimension of incubation operations came with a relative weight (84.89%), followed by the learning dimension which got a relative weight (82.50%), while the performance level of the incubators got a relative weight (80.12%) and as the study results showed There is a positive relationship statistically between the two dimensions of learning and business incubation processes and performance development in business incubators, and the linear regression analysis model showed that the main effect in improving the performance of business incubators is "after business incubation operations" while it showed weak effect after learning. The study came out with several recommendations, the most important of which is that business incubators seek to reinforce the learning process and incubation processes for business, and the need to periodically evaluate their performance, and that a more effective mechanism be designed to follow up with companies after the end of the incubation period and monitor the progress of these companies. (shrink)

I think the important discussions on artificial intelligence tools in the last few issues of your journal have made important contributions to the literature. We have seen that many authors, especially in the field of medicine and health sciences, have followed and contributed to the topic with interest. In an article that I had previously tried to contribute to, I had argued that we should ask ethical and philosophical questions about the issue depending on the sensitivity of the issue [1]. (...) At this point, it is possible to say that various applications of AI have a significant impact on our lives. In this article, I would like to briefly mention the concept of “the extended mind”, which has had a significant impact on fields such as the philosophy of technology and the philosophy of mind with the articles published in 1998 by the important philosophers of technology Andy Clark and David Chalmers, and then I would like to mention that this concept can form a strong basis for academic (and other) uses of artificial intelligence. However, I argue that the uses we can justify with this concept should also be balanced with ethical sensitivity, awareness, and constant questioning. (shrink)

Recent studies revealed how the reference to Zhuangzi played a determining role in the evolution of Heidegger’s thinking. Among the sources is a work written in 1945 under the title _Country Path Conversations_. The last of these conversations presents strong similarities with another between Confucius and Yan Hui, imagined by Zhuangzi at the beginning of the fourth chapter. Analogies between these two conversations are so numerous that it is surprising that it has not been noticed until now. However, the establishment (...) of this rapprochement is crucial. It might show how deep is the echo that Heidegger acknowledged between his work and the Lao-Zhuang perspective. Moreover, it reveals that this resonance is not limited to the themes of the “path” and the “letting be,” but also concerns the essential problem of evil and the way to face it. (shrink)

In psychiatry, pharmacological research has played a crucial role in the formulation, revision, and refinement of neurobiological theories of psychopathology. Besides being utilized as potential treatments for various mental disorders, pharmacological drugs play an important epistemic role as experimental instruments that help scientists uncover the neurobiological underpinnings of mental disorders (Tsou, 2012). Interventions with psychiatric patients using pharmacological drugs provide researchers with information about the neurobiological causes of mental disorders that cannot be obtained in other ways. This important source of (...) evidence for the biological causes of mental disorder is often overlooked in philosophical analyses of psychiatry, especially in skeptical analyses that debase the biological aspects of psychopathology (e.g., Szasz, 1960; Scheff, 1963; Laing, 1967). In discussing pharmacological interventions as a form of evidence for the physical basis of mental disorders, this paper aims to clarify the nature, reliability, and limitations of this evidence. In addition, it illustrates the central role that pharmacological findings in applied clinical contexts play in the acquisition of neurobiological knowledge in research contexts. (shrink)

Nowadays, the increasingly increasing focus on material things and the decreasing importance given to spirituality have started to have negative effects on people. As these observed negativities began to increase, the importance of spirituality was recognized by positive sciences such as psychology, medicine and pedagogy and began to be addressed scientifically again. Studies on this subject are increasing. In this study, the book titled "Spirituality Education", written about spirituality, will be evaluated in terms of its content, scope, contributions to the (...) field and suggestions it offers. Assoc. Dr. This work, written by Yasin Yiğit, is 253 pages and consists of 4 chapters. It is noteworthy that an original spiritual education model is presented, especially in the last chapter of the book. It can be said that the book makes a significant contribution to the systematization of spirituality education. Reading the book by all stakeholders in the field of theology will contribute to their professional development, and the study can be read by everyone in terms of personal development. (shrink)

(2000). ADORNO AND HORKHEIMER'S CONCEPT OF ‘ENLIGHTENMENT’. British Journal for the History of Philosophy: Vol. 8, No. 3, pp. 521-544. doi: 10.1080/096087800442165.

In this article I argue that textual evidence from David Hume's A Treatise of Human Nature does not support J. Baird Callicott's professedly Humean yet holistic environmental ethic, which understands the community (e.g., the biotic community) as a ‘metaorganismic’ entity ‘over and above’ its individual members. Based on Hume's reductionist account of the mind and his assimilation of the metaphysical nature of the mind to that of the community, I also argue that a Humean account of the community should be (...) likewise reductionist. My conclusion is that Callicott's anti-reductionist holism is at least foreign to, and at worst incompatible with, Hume's philosophy. (shrink)

It is important to determine the attitudes of employees towards occupational accidents and diseases and whether these events are perceived as inevitable or out of control. Inaccurate interpretation of the perception of fatalism towards occupational accidents and diseases may lead to more occupational accidents and diseases. The use of scales to determine the perception of fatalism in the context of occupational accidents and diseases allows for a quantitative assessment of these issues. This approach makes it possible to objectively measure and (...) analyze the perception of fatalism, thus paving the way for a more in-depth examination of related phenomena. This study is a scale development study to determine the level of fatalism towards occupational accidents and diseases. This methodological study was conducted between October 2021 and June 2023. The scale was shaped by taking expert opinions for the scale items prepared by making use of the literature, pre-applied and pilot applied with 75 people; Exploratory Factor Analysis and Confirmatory Factor Analysis were conducted with 242 people; and all evaluated with validity and reliability analyzes. In the exploratory factor analysis for the developed scale of fatalism towards occupational accidents and diseases, it was seen that the scale items were gathered under 4 factors and the explanatory coefficient was 53.68%. In order to measure the applicability of exploratory factor analysis for the scale, KMO value was 0.854 and Bartlett's Test of Sphericity value was χ2=1996.527; df=153, p. (shrink)

Kur’ân-ı Kerîm lafızlarının eda keyfiyetlerini ihtiva eden kıraatler İslâmî ilimlerin birçoğunun önemli mevzuları arasında yer almaktadır. Özellikle tefsir ilminin temel konularından olan kıraatler söz konusu ilmin sembol şahsiyetlerinden olan Zemahşerî’nin (öl. 538/1144) tefsirinde de kayda değer bir yer işgal etmektedir. el-Keşşâf tefsirinde kıraat ihtilaflarına sıkça müracaat eden Zemahşerî’nin kıraatler konusundaki yaklaşımı kendisinden sonraki müfessirleri de etkilemesi yönüyle önem arz etmektedir. O, ele aldığı kıraatlerin bazen hüccet bazen de nispet yönüne temas etmektedir. Kıraatlere daha çok lügavî açıdan yaklaşan Zemahşerî, ilgili kıraatlerin (...) özellikle dilde hüccetliği üzerinde durmaktadır. Bununla birlikte çoğu zaman bahse konu ettiği telaffuzla okuyan isimleri zikretmeyi de ihmal etmemektedir. Onun zikrettikleri arasında sahih kıraat sahibi imamlar (kıraat-i aşere imamları), şâz kıraat imamları ve seleften kıraati ile meşhur şahıslar yer almaktadır. Müfessirin bu tavrı onun meseleye vukûfiyetini de ortaya koymaktadır. el-Keşşâf’ta sahih kıraatlerin yanında birçok şâz kıraate de yer verilmektedir. Müfessir zaman zaman -sahih olsun şâz olsun- bazı telaffuzların naklî temeline de inmekte, ilgili telaffuzu tâbiîne, sahabeye hatta Hz. Peygamber’e nispet etmektedir. Ancak bu nispet esnasında bir sorun göze çarpmaktadır. O da söz konusu telaffuz şekillerinin sıhhati meselesidir. Zira bir kıraatin sahih olabilmesi için onun kıraatçiler nezdinde makbul bir senetle gelmesi, Arapça’ya ve Hz. Osman tarafından yazdırılan mushaflardan birinin imlasına uygun olması gerekmektedir. Müfessir birçok yerde sadece “Hz. Peygamber’in kıraati bu şekildedir.” gibi kesin ve net ifadeler kullanmakta, ele aldığı telaffuz şekli hakkında bir değerlendirme ya da bir kaynağa atıfta bulunma ihtiyacı hissetmemektedir. Mevzubahis tefsirde Hz. Peygamber’in okuduğu söylenen şâz kıraatler Yazma Eserler Kurumu (YEK) tarafından neşredilen Keşşâf Tefsiri mütercimlerinin de dikkatini çekmiş, konuyu değerlendirdikleri “el-Keşşâf’ta Kıraatler” başlığı altında şu cümleye yer vermişlerdir: “Bunların en ilginci herhalde Hz. Peygamber’e nispet edilen -fakat mütevâtir kıraatlerde yer almayan- kıraatlerdir.” Bu tespit, el-Keşşâf’ta yer alan bu kıraatlerin derinlemesine incelenmesini gerekli kılmaktadır. Ancak önemine rağmen ilgili konuda yapılmış bir çalışmaya rastlanılmamıştır. Bu çalışmada el-Keşşâf tefsirinde Hz. Peygamber’e nispet edilen kıraatlerin tespit, teyit ve tenkidi hedeflenmektedir. Öncelikle eserde bahsedilen bu kıraatlerin sayısı, kaynak ve isnatları tespit edilmiş, daha sonra bunların kıraat imamları arasında ne şekilde karşılık bulduğu ortaya konulmuştur. Tespitlerimize göre Zemahşerî bir kıraatin Hz. Peygamber’e nispetine özel bir önem vermemekte, rivayet ve kıraatin sıhhat ve şöhretine bakmamaktadır. Onun bu yaklaşımı hadisçiler nezdinde de kıraatçiler nezdinde de kabul görmemiştir. (shrink)

Mustafa Sabri Efendi, Osmanlı Devleti’nin siyasi kayıplar yaşadığı dönemin sonlarında Şeyhülislamlık yapmış, Cumhuriyet’in ilanı sürecinde yaşamıştır. Batı’daki bilimsel gelişmelerle birlikte İslam düşüncesinde duraklamanın tecrübe edildiği dönemde, geleneksel ilmî mirası ve bu ilimlerin metotlarını savunmuş bir isimdir. Bu hassasiyetle modern bilimsel yöntemleri savunan çoğu İslam düşünürüne eleştiriler yöneltmiştir. O, bu dönemde düşünce akımlarının etkisiyle gelişen inanç problemleri karşısında geleneksel yöntem ve bilgi birikiminin etkinliğini gündeme getirmiştir. Mustafa Sabri, İslam’ın temel kaynaklarından biri olan sünnet ve bunun kayıt altına alındığı rivayetleri içeren muteber (...) hadis kaynaklarının metot ve sıhhat açısından son derece güvenilir olduğunu ve itikadî konularda belirleyici olduğunu vurgulamıştır. Mustafa Sabri’nin sünnet tasavvurunu göstermesi açısından onun nüzûl-i Îsâ konusundaki görüşleri önemli bir örnektir. O, nüzûl-i Îsâ hadisesi hakkındaki yaklaşımını, Mahmut Şeltut’a yönelik itirazlarıyla ortaya koymaktadır. O, bu hadisenin Hz. Peygamber’in gayba ilişkin verdiği haberlerden biri olması ve kıyamet alametlerinden sayılması noktasında, sünnetin kaynaklığını öne çıkarmaktadır. Nüzûl-i Îsâ’nın gerçekleşme imkânını günümüzde sıhhati açısından problemli kabul edilen rivayetler, sahabe, tabiûn ve sonraki İslam âlimlerinin ortaya koyduğu yaklaşım ve hadis kaynaklarına duyduğu itimat üzerinden inşa etmektedir. Mustafa Sabri bu anlamda geleneksel birikimi öne çıkaran bir sünnet tasavvuru ortaya koymaktadır. Bu kapsamda çalışmamız Mustafa Sabri’nin nüzûl-i Îsâ çerçevesinde sünnetin kaynaklığına ilişkin yaklaşımını ele almayı amaçlamaktadır. (shrink)

While the problem of nihilism is derived from a particular historical and intellectual context in Western philosophy, i.e., the pantheism controversy in modern German philosophy and the ideas of Nietzsche, non-Western thinkers also engaged with it and developed responses to it. In this article, I am interested in analyzing Muhammad Iqbal’s (1877–1938), a leading Muslim thinker (a Sufi) from India, engagement with the problem of nihilism and his response to it from a Sufi perspective. Arguing that the existing literature on (...) Iqbal fails to understand the deeper impact of Nietzsche’s ideas on Iqbal’s philosophy and the dramatic role “the problem of nihilism” played in causing changes in Iqbal’s philosophy, or on Iqbal’s intellectual development, in this article, I analyze how Iqbal’s encounter with the ideas of Nietzsche during his study period in Europe between 1905 and 1908 has introduced him to the problem of nihilism in its Nietzschean form, how this led Iqbal to a nihilistic mood/crisis from 1909 to 1913, and then how he later developed a response to nihilism by reconstructing the Sufi cosmology and by revaluating the Sufi values of the pantheistic/Persian type of Sufism – the outcome of which is found in his philosophical poemAsrar-i-Khudî(1915). (shrink)

The objective in this article is to apply a Daoist model of an ethic derived from the _Laozi_ on writings of the Huang Lao tradition to offer a unique Daoist cosmically derived ethic _in its own terms_. Having our point of departure in the _Laozi_ we refer to its paradoxical language as a _living riddle_ that is inherent in the tradition, and as such it suggests a "model of modeling." We find this model in _Laozi_ 25, according to which self-so (...) (_ziran_ 自然) serves as foundation for an ethic that is neither dichotomizing nor resting on human moral conventions, but serves rather as a guiding philosophy of living. On this basis we explore the question of an ethic in the Huang Lao tradition. (shrink)

In the first part of this article we survey the concept of human rights from a philosophical perspective and especially in relation to the “right to healthcare”. It is argued that regardless of meta-ethical debates on the nature of rights, the ethos and language of moral deliberation associated with human rights is indispensable to any ethics that places the victim and the sufferer in its centre. In the second part we discuss the rise of the “right to privacy”, particularly in (...) the USA, as an attempt to make the element of personal free will dominate over the element of basic human interest within the structure of rights and when different rights seem to conflict. We conclude by discussing the relationship of human rights with moral values beyond the realm of rights, mainly human dignity, free will, human rationality and response to basic human needs. (shrink)

Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

Antik Yunan düşüncesinde özgürlük meselesini irdelemek doğa kavrayışını ele almakla mümkün olabilir. Özgürlük her halükarda sınırları belirsiz bir kavramdır ve onu tanımlama çabaları bu yüzden çoğunlukla tek taraflı bir yaklaşımın örnekleridir. Söz konusu dönem dilinde özgürlük sözcüğünün muadili olarak kabul edilebilecek bir sözcük bulunmamaktadır ama bu, orada özgürlüğün sorun edilmediği anlamına gelmemektedir. Çünkü insanlar arası etkileşimin bulunduğu her bağlamda özgürlük bir sorunsal olarak zaten orada olan bir şeydir. Bu çalışmada öncelikle Antik Yunan mitoslarında doğumlarla şekillenen evren anlatısının bir özeti verildi. (...) İnsanın bu evrene dahil oluşuna değinildikten sonra Prometheus’un ateşi çalıp ulaştırmasıyla insanda meydana gelen değişimler özgürlük bağlamında değerlendirildi. Böylece doğa kavrayışı bağlamında Antik Yunan mitoslarında özgürlük sorunsalının tespiti yapıldı. İster tanrısal ister beşeri olsun, özgürlüğün doğa kavrayışıyla kayıtlı olduğu vurgulandı ve özgürlük sorunsalının ancak dönemin ‘doğa’ kavrayışının değerlendirilmesiyle ele alınabileceği ileri sürüldü. (shrink)

İsrā’iliyyat which is the narration material passed on to Islam from other religions and cultures, primarily Judaism and Christianity has been one of the topics discussed especially within the frame of tafsir discipline throughout the fourteen centuries of Islamic history. While these narrations were used as one of the sources of information without being subjected to a normative evaluation in the early day tafsirs, they have been started to be criticized emphasizing mainly on the weakness of their imputation in the (...) classical tafsirs. When it was reached to the modern era, with the effect of movements of thoughts such as Western originated positivism, rationalism, and historical criticism, and orientalist allegations. İsrā’iliyyat has been criticized rather content-wise, reviewed as unreal, imaginary, mythological story-type narrations mixed with superstitions. As a result of these criticisms, both a distance has been kept from İsrā’iliyyat and also alternatives to it have been pursued. Although in the modern-day tafsirs, it has been consulted to the Bible as the strongest alternative to İsrā’iliyyat, this situation has made way for many debates, and it has dwelled on other alternatives than that. These points mentioned are valid for Tunisian scholar Tāhir İbn ʿĀshūr’s (1879-1973) tafsir named al-Tahrīr wa’t-Tanwīr, too. An important feature of this tafsir is that although it has been looked kindly upon İsrā’ili narrations within the frame of certain criteria, it has been criticized in general. The writer has developed alternatives to İsrā’ili narrations without complimenting them as much as possible. Among these alternatives, while he prioritized the Bible narrations, he didn’t settle for this and he headed for other alternatives, too. In this study, it has been emphasized on methods of text-centered commentary, socio-psychologic commentary, and foresight-based commentary, which İbn ʿĀshūr used as an alternative to İsrā’iliyyat from time to time. It has been seen that the writer developed stronger and farther-from-a-debate-ground methods compared to İsrā’iliyyat and used these methods successfully in this way. It has come to the conclusion that in the case of these methods being used in Qura’ân parables accurately, they can be an important alternative to İsrā’iliyyat. (shrink)

Should involuntarily childless people have the same opportunities to access parenthood as those who are not involuntarily childless? In the context of assisted reproductive technologies, affirmative answers to this question are often cashed out in terms of positive rights, including rights to third-party reproduction. In this paper, we critically explore the scope and extent to which any such right would hold up morally. Ultimately, we argue for a departure away from positive parental rights. Instead, we argue that the state has (...) an imperfect duty to benefit involuntarily childless people in relation to their parental aspirations. (shrink)

The ‘prohibitionist’ idea that slurs have the same linguistic properties as their neutral counterparts hasn’t received much support in the literature. Here I offer a modified version of prohibitionism, according to which the taboo on using slurs is part of their conventional meaning. I conclude with explanations of the behaviour of slurs in embedded constructions.