The potential power of predictive genetic testing as a risk regulator is impressive. By identifying asymptomatic individuals who are at risk of becoming ill, predictive genetic testing may enable those individuals to take prophylactic measures. As new therapies become available, the usefulness of genetic testing undoubtedly will increase. Further, when a person's family medical history indicates a propensity towards a particular genetic disease, a negative test result may open up otherwise denied opportunities by showing that this person has not inherited (...) suspect genes. In the latter type of case, a negative test result may reassure the individual that pursuing a particular course of action is worthwhile, or may convince prospective employers that the individual will be a serviceable employee. (shrink)

The posterior parietal cortex (PPC) is the most likely site where egocentric spatial relationships are represented in the brain. PPC cells receive visual, auditory, somaesthetic, and vestibular sensory inputs; oculomotor, head, limb, and body motor signals; and strong motivational projections from the limbic system. Their discharge increases not only when an animal moves towards a sensory target, but also when it directs its attention to it. PPC lesions have the opposite effect: sensory inattention and neglect. The PPC does not seem (...) to contain a “map” of the location of objects in space but a distributed neural network for transforming one set of sensory vectors into other sensory reference frames or into various motor coordinate systems. Which set of transformation rules is used probably depends on attention, which selectively enhances the synapses needed for making a particular sensory comparison or aiming a particular movement. (shrink)

This paper considers a central objection to evolutionary epistemology. The objection is that biological and epistemic development are not analogous, since while biological variation is blind, epistemic variation is not. The generation of hypotheses, unlike the generation of genotypes, is not random. We argue that this objection is misguided and show how the central analogy of evolutionary epistemology can be preserved. The core of our reply is that much epistemic variation is indeed directed by heuristics, but these heuristics are analogous (...) to biological preadaptations which account for the evolution of complex organs. We also argue that many of these heuristics or epistemic preadaptations are not innate but were themselves generatedby a process of blind variation and selective retention. (shrink)

The availability of a range of new psychotropic agents raises the possibility that these will be used for enhancement purposes (smart pills, happy pills, and pep pills). The enhancement debate soon raises questions in philosophy of medicine and psychiatry (eg, what is a disorder?), and this debate in turn raises fundament questions in philosophy of language, science, and ethics. In this paper, a naturalistic conceptual framework is proposed for addressing these issues. This framework begins by contrasting classical and critical concepts (...) of categories, and then puts forward an integrative position that is based on cognitive-affective research. This position can in turn be used to consider the debate between pharmacological Calvinism (which may adopt a moral metaphor of disorder) and psychotropic utopianism (which may emphasize a medical metaphor of disorder). I argue that psychiatric treatment of serious psychiatric disorders is justified, and that psychotropics are an acceptable kind of intervention. The use of psychotropics for sub-threshold phenomena requires a judicious weighing of the relevant facts (which are often sparse) and values. (shrink)

In his paper 'The Voluntariness of Judgment' Mark Thomas Walker claims that judgments are voluntary acts. According to Walker, theoretical reasoning can be seen as an instance of practical reasoning, and the outcomes of practical reasoning are actions. There are two reasons why Walker's argument does not establish this conclusion: (i) There are non-reflective judgments which cannot reasonably be described as instances of practical reasoning; Walker's argument does not apply to these judgments, (ii) If one judges that p as a (...) result of deliberation, one has had no choice sincerely to judge as well that non-p instead of p , that is, one cannot judge contrary to one's evidence. Therefore, reflective judgments are not voluntary actions. Walker cannot show that reflective judgments are voluntary, because he fails to give a clear notion of a voluntary action and the role of choice. (shrink)

Scholars have grown concerned around the increasing carceral logics embedded in social media practices. In this essay, we explore the process of getting “zucked” as a trend within digital platforms that disproportionately punishes minoritized digital users. Specifically, Black women report that with the advent of increased safety measures and policies to secure users on digital platforms, they become subject to harms of the institutional practices. By extending the conversation on carcerality beyond the confines of prisons, jails, and other forms of (...) criminal justice supervision, we argue that structures and institutions expand the lines of surveillance and that those traditionally subject to such harm continue to be affected. Although the concept of getting “zucked” might seem like an innocent response to individuals who violate terms of service, Black women suggest that this practice disparately targets them for speaking about racist and sexist incidents on- and offline. Such surveillance is misogynoir in public spaces, as Black women are punished for organizing on social media. (shrink)

In this essay, I offer a utilitarian perspective on humanitarian intervention. There is no generally accepted precise definition of the term ‘humanitarian intervention’. I will provisionally, and roughly, define humanitarian intervention as the use of force by a state, beyond its own borders, that has as a purpose or an effect the protection of the human rights of noncitizens or the reduction of the suffering of noncitizens.

Cohen (1981) and others have made an interesting argument for the thesis that humans are rational: normative principles of reasoning and actual human reasoning ability cannot diverge because both are determined by the same process involving our intuitions about what constitutes good reasoning as a starting point. Perhaps the most sophisticated version of this argument sees reflective equilibrium as the process that determines both what the norms of reasoning are and what actual cognitive competence is. In this essay, I will (...) evaluate both the general argument that humans are rational and the reflective equilibrium argument for the same thesis. While I find both accounts initially appealing, I will argue that neither successfully establishes that humans are rational. (shrink)

Many contemporary accounts of moral status consider an individual's status to be grounded in some cognitive capacity, e.g. the capacity to experience certain states, to reason morally, etc. One proposed cognitive capacity significant particularly to killing, i.e. having a status that precludes being killed absent cause, is the capacity to value one's own life. I argue that considering this a condition for moral status is a mistake, as it would lead to the exclusion of some individuals with mental health problems (...) who are generally considered clear cases. -/- While a cognitive capacities approach may turn out to be generally feasible, that particular cognitive capacity is not. In the course of this discussion I address two conceptual issues, the first regarding what it means to 'value ones life' and the second regarding what conditions must obtain for something to count as a capacity. These conceptual issues, when resolved pursuant to this account of moral status, lead the account to exclude individuals with major depressive disorder, i.e. deny that it is morally wrong to kill such individuals based on their moral status. I then argue that this is a decisive reason to reject this particular cognitive capacity as implicated in moral status. (shrink)

Utilitarianism is more convincing than resource egalitarianism or welfare egalitarianism as a theory of how resources should be distributed between disabled people and nondisabled people. Unlike resource egalitarianism, utilitarianism can redistribute resources to the disabled when they would benefit more from those resources than nondisabled people. Unlike welfare egalitarianism, utilitarianism can halt redistribution when the disabled would no longer benefit more than the nondisabled from additional resources. -/- The author considers one objection to this view: it has been argued, by (...) Sen and others, that there are circumstances under which utilitarianism would unfairly distribute fewer resources to the physically disabled than to nondisabled people, on the ground that the disabled would derive less benefit from those resources. In response, the author claims that critics of utilitarianism have fallaciously exaggerated the circumstances under which the disabled would benefit less than the nondisabled from additional resources. In those limited circumstances in which the disabled really would benefit less from resources, the author argues, it does not seem unfair to distribute fewer resources to them. (shrink)

Excerpt“From the river to the sea, Palestine will be free” and “We don’t want no two states, we want 1948” are two of the slogans that have been heard on American campuses during the protests in recent weeks. These reflect the idea that Israel should be replaced by a Palestinian-Arab state and violence should be used to achieve this goal if necessary. While much of the discourse since October 7 has focused on the nature of Hamas’s attack—the rapes, the burnings, (...) the shootings—not enough has been written on what it actually sought to achieve. (shrink)

A puzzle about false judgement is raised in the Theaetetus (187d-200c), but not successfully answered there. On the proposed account, the confusion that explicitly vitiates Theaetetus’ final attempt to define knowledge is already at work implicitly in this puzzle. Theaetetus shares popular assumptions about knowledge (epistēmē), but also accepts that there are cognitive constraints on judgement (doxa): the puzzle arises because he fails to distinguish the one cognitive condition from the other.

Leslie Tharp proves three theorems concerning epistemic and metaphysical modality for conventional modal predicate logic: every truth is a priori equivalent to a necessary truth, every truth is necessarily equivalent to an a priori truth, and every truth is a priori equivalent to a contingent truth. Lloyd Humberstone has shown that these theorems also hold in the modal system Actuality Modal Logic, the logic that results from the addition of the actuality operator to conventional modal logic. We show that Tharp’s (...) theorems fail for the expressively equivalent Subjunctive Modal Logic, the logic that was developed by Kai Wehmeier as an alternative to AML. We then argue that the existence of Tharp’s theorems for AML is due to a faulty interpretation of the notion of necessary truth, a feature that is not shared by SML. The paper concludes with an argument for the thesis that the existence of the distinction between truth at all worlds w and truth at all worlds w from the point of view of w as the actual world is an artifact owing to the interaction of the necessity and actuality operator. (shrink)

No primeiro esforço de aproximaçãoentre analítica existencial e antropologia filosófica,este ensaio procura estabelecer, em lugarde destaque, a idéia de compreensão do sercomo elemento determinante do modo de serno-mundo do ser humano. Dessa primeira idéiadecorrem então os dois teoremas de finitude: ocirculo hermenêutico e a diferença ontológica.Temos, nestes dois pilares da filosofia hermenêutica,um novo modo de fundação e um novomodo de dar-se de todo ente. A diferençaontológica constitui o como tudo é acessível,vem ao encontro, mas ela mesma éinacessível ao pensamento objetificador. (...) Todonosso modo de pensar e conhecer o ente passapor aquilo que é sua condição de possibilidade.Mas todo, a dar-se nesse como é articuladono enquanto, no algo enquanto algoda estrutura da compreensão que é o modo deser do Dasein, a dimensão hermenêutica docirculo do hermenêutico. A articulação dessesdois teoremas da finitude, que são os elementosdeterminantes presentes em todo conhecimentohumano, constitui o modo de ser e omodo primeiro de conhecer do ser do Dasein. Aantropologia filosófica, a partir da analíticaexistencial, encontra nos dois teoremas dafinitude seu estatuto filosófico. (shrink)

Mealey's article on the sociobiology of sociopathy raises questions about the relationship between adaptiveness and abnormality. Although sociopathy may be adaptive, simply defining medical and psychiatric disorders in terms of evolutionary function is problematic. Rather, sociopathy may be characterized as a relatively atypical disorder, an entity to which it may be useful to extend the metaphors of the medical model.

Dans un premier temps, cette contribution fournit une présentation rapide des corpus médiévaux, principalement pour l’anglais et le français, en relation avec des projets d’annotation centrés sur l’annotation syntaxique. La seconde partie traite des aspects spécifiques de l’annotation syntaxique pour les textes d’ancien français et s’intéresse particulièrement aux interactions entre la préannotation automatique et les outils d’annotation manuelle.

Understanding the origins of evil behaviour is one of our most important intellectual tasks. A distinction can perhaps be drawn between overt sadistic cruelty and the lack of empathy to suffering that is a hallmark of evil. There is increasing data available on the prevalence, proximal psychobiological underpinnings, and distal evolutionary basis for these contrasting phenomena.

Perhaps the central focus of American bioethics has been to push against medical paternalism on the grounds that it impedes the autonomy of patients—that is, their ability to make choices of their...

There is now a wealth of information that histone proteins play a primary role in the structural and transcriptional properties of chromatin, the protein‐DNA complex which constitutes the eukaryotic genome1, 2. In light of the crucial role of histones in cellular function, it is not surprising that their structural genes are found to be controlled in conjunction with the cell cycle, with the synthesis of most histones tightly coupled to nuclear DNA replication. The evidence suggests that this linkage between DNA (...) replication and histone synthesis involves the regulated adjustment of histone mRNA levels through both transcriptional and posttranscriptional control process. The possible mechanisms underlying these diverse control processes are described here. (shrink)