Cells utilize diverse organelles to maintain homeostasis and to respond to extracellular stimuli. Recently, multifaceted aspects of organelle stress caused by various factors have been emerging. The endosome is an essential organelle, functioning as the central hub for membrane trafficking in cooperation with the ubiquitin system. However, knowledge regarding endosomal stress, which refers to organelle stress of the endosome, is currently limited. We recently revealed ubiquitin‐mediated endosomal stress of early endosomes (EEs) and its responsive signaling pathways. These findings shed light (...) on the relevance of ubiquitin‐mediated endosomal stress to physiological and pathological processes. Here, we present a hypothesis that ubiquitin‐mediated endosomal stress may have significant roles in biological contexts and that ubiquitin‐specific protease 8 is a key regulator of ubiquitin clearance from EEs. (shrink)

Standard notions of democracy assume people’s equality. This poses a dilemma for conceptualising democracy in the context of caregiving and receiving among asymmetrically positioned people. One way to overcome this dilemma is to generalise dependency as a universal human condition. However, addressing how democracy is possible among unequally situated people is necessary for developing a distinctive theory of democracy that takes the fact of human dependency seriously. To this end, I develop an expanded conception of democracy that goes beyond the (...) individual exercise of voice to that of interacting with others according to an ethic of care that supports the autonomy of others. Drawing on Hannah Arendt’s notion of a ‘common world’ as a web of narratives arising from the complex interaction of plural perspectives, I argue that democracy conceived as ‘being part of the story’ can foster such an ethic. This has practical relevance for societies where the sites of social cooperation are shifting from employment to care. (shrink)

This article discusses three policy ideas that address the limitations of the traditional welfare state: universal basic income (UBI), universal basic services (UBS), and the social economy. As a lens from which to evaluate these policy alternatives, we develop a concept of active citizenship as an interactive and recursive process between people’s equal political influence and the institutional conditions in which they are placed. While the social policy discourse on active citizenship has centred on the debate between increasing individual responsibilities (...) or enhancing people’s capabilities, our conception recentres the political dimension of active citizenship as people’s capacity, not only to exercise individual self-determination, but also collective self-determination over shared conditions. We conclude that, in addition to the conditions for security and autonomy, opportunities for organised social cooperation are necessary to achieve a virtuous cycle between people’s political influence and the institutions that support it. (shrink)

江戸後期に活躍した平田篤胤の思想を宗教性に注目して内在的に把握し、さらにその展開を門人組織=気吹舎の実践が幕末社会ではたした役割から捉えかえし、思想史研究・社会史研究・宗教史研究の三つの視点と方法を有 機的に結びつけた注目の成果。.

「カワイイ」価値をめぐる冒険の旅へ。「カワイイ」に代表されるポピュラーな感性的価値に、一流の研究者たちが学問領域の枠を超えて真摯に向き合う。社会のダイナミズムとメカニズムの実態に迫る、シリーズ第二弾。 .

Reading is a peculiar kind of experience. Although its practice and theory have a very long tradition, the question of aesthetic pleasure is as perplexing as ever. Why do we read? What exactly thrills us in the text? Taking the work of Roland Barthes as a central reference, the aim of this collection of essays is to investigate a variety of themes and issues associated with the question of readerly pleasure. Pleasure 'in' the text is related to the content of (...) the text and associated with various methods of representing the pleasures of 'real life', whereas pleasure 'of' the text is discovered in the literary form. The imperfect, if not erroneous, distinction between form and content, constitutes one of the main methodological techniques for identifying the two major sources of pleasure, and serves as a starting point for the inquiry. This bookdoes not merely offer a personal view of the problem in question, nor an exposition of this problem locked within the limits of a given theory, but a broader perspective consisting of the reflections of academics who critically evaluate both its theoretical and practical aspects, across disciplines such as literary theory and criticism, semiology, philosophy and psychoanalysis. (shrink)

In recent years, the impact of party leaders on voting behavior has attracted increasing attention, leading some scholars to identify a phenomenon of ‘presidentialization’. Many extant studies of this topic in Japan are limited to one or two electoral cycles. In order to trace long-term trends, this paper analyses longitudinal survey data to investigate the existence and magnitude of the effect party leader evaluations exert on vote choice in Japan. Empirical results show that while only dominant and forceful personalities substantially (...) influenced voters' likelihood of supporting their parties in the 1980s and 1990s, by the 2000s assessments of most major party leaders had a significant impact on their parties' electoral performance. In short, party leaders affect vote choice due not to their personalities, but instead to the position they hold. We also test the hypotheses that the association between leader appraisal and voting behavior would be particularly conspicuous among voters who lack party identification and those who are most heavily exposed to media reportage. Analysis reveals that independent voters are not more likely to vote on the basis of leader evaluations than partisans; a leader effect is found more frequently among voters with greater exposure to election coverage on television. (shrink)

人間であること、これを問う政治哲学の徹底。その先に見えるのは、果たして平和的共存の根源性か、戦いのそのとき、自分以外ではありえない人間の生々しさか。.

The genomics community has long acknowledged the lack of diversity in datasets used for research, prompting various stakeholders to confront this issue. In response, the Global Alliance for Genomics and Health (GA4GH) formulated a policy framework that recognizes the multiplicity of perspectives on diversity and proposed a systemic approach for more optimal data diversity. Given the importance of the research context, assessing this policy’s applicability within countries where diversity is less discussed is important. This study investigated the feasibility of implementing (...) the GA4GH policy in Japan, a nation with a smaller genetic diversity than many Western countries. As the proportion of East Asian genomic research is limited internationally, focusing on the Japanese genome contributes to enhancing diversity. Meanwhile, labelling findings as “Japanese” can inadvertently reinforce perceptions of homogeneity and overlook ethnic minorities. Regions and socioeconomic status are also recognized as substantial factors of diversity within academia, yet concerns persist among the public regarding the heritability of stigmatized conditions. Social inclusion of sexual minorities has begun in Japan, but research surveys generally still use binary sex and gender categories, which underscores the need for additional variables. This study found that both academia and the public need to confront the overemphasis on homogeneity within Japanese society and hesitancy in addressing genetic factors. By doing so, more inclusive and diverse datasets can advance the field both ethically and scientifically. Perhaps the most important impact of the GA4GH policy will be to draw greater attention to the complex diversity challenges ahead in Japan. (shrink)

Background: An external locus of control is associated with poorer psychopathology in individualist cultures, but associations are reported to be weaker in collectivist cultures where an external style is less maladaptive. We investigated the prospective association between externality and psychotic-like experiences and depressive symptoms and compared the strength of associations between a UK and a Japanese cohort.Method: Cross-cultural cohort study of a UK and a Japanese cohort. Externality was assessed using the Children's Nowicki and Strickland Internal, External Scale and DS (...) using the Short Moods and Feelings Questionnaire in both cohorts, PLE were assessed with the Psychosis-Like Experiences Questionnaire, and the Adolescent Psychotic-Like Symptom Screener. Associations were investigated using multivariable regression models and bivariate regression models to compare the strength of associations.Results: Mean externality in both childhood and adolescence was higher in ALSPAC than in the TTC. Childhood externality was associated with PLE in late childhood and adolescence in both cohorts and adolescent externality was associated with PLE in young adulthood in the ALSPAC cohort. There was a more mixed pattern of association between externality and DS scores. There was little evidence of any differences in the strength of associations between externality and different psychopathologies, or between cohorts. In ALSPAC adolescent externality and early adult psychopathology were more strongly associated than childhood externality and adolescent and early adult psychopathology. There was no evidence that change in externality between childhood and adolescence was associated with new onset PLE or DS in early adulthood.Conclusion: An external locus of control is associated with poor mental health regardless of cultural context. (shrink)