The vast majority of experimental studies of music to date have explored music in terms of the processes involved in the perception and cognition of complex sonic patterns that can elicit emotion. This paper argues that this conception of music is at odds both with recent Western musical scholarship and with ethnomusicological models, and that it presents a partial and culture‐specific representation of what may be a generic human capacity. It argues that the cognitive sciences must actively engage with (...) the problems of exploring music as manifested and conceived in the broad spectrum of world cultures, not only to elucidate the diversity of music in mind but also to identify potential commonalities that could illuminate the relationships between music and other domains of thought and behavior. (shrink)

Research with computer systems and musical grammars into improvisation as found in the tabla drumming system of North India has indicated that certain musical sentences comprise (a) variable prefixes, and (b) fixed suffixes (or cadences) identical with those of their original rhythmic themes. It was assumed that the cadence functioned as a kind of target in linear musical space, and yet experiments showed that defining what exactly constituted the cadence was problematic. This paper addresses the problem of the status of (...) cadential patterns, and demonstrates the need for a better understanding and formalization of ambiguity in musico-cognitive processing. It would appear from the discussion that the cadence is not a discrete unit in itself, but just part of an ever-present underlying framework comprising the entire original rhythmic theme. Improvisations (variations), it is suggested, merely break away from and rejoin this framework at important structural points. This endorses the theory of simultaneity. However, the general cognitive implications are still unclear, and further research is required to explore musical ambiguity and the interaction of musical, linguistic, and spatio-motor grammars. (shrink)

This study aims to account for the reception of the philosophy of Carl Stumpf since the turn of the twenty-first century and to emphasize the actuality of some of the aspects of his philosophy. The present text is subdivided into several sections, each corresponding to one of the main topics discussed in the recent literature on the work of Stumpf. In the first section, I try to show, using his classification of sciences, that Stumpf's empirical work is driven by a (...) unitary philosophical program. I then examine the ramifications of this program in several areas of philosophy that have been the subject of recent commentaries and publications. I begin with the commentaries on the recent publication of Stumpf's thesis on mathematical axioms, which stress Stumpf's contribution to the philosophy of mathematics and to theory of knowledge, and more specifically to the debate on logical psychologism that Frege and Husserl will address a few years later. I conclude this section by examining the second of two major themes in the work of Stumpf that have been the subject of several recent studies, namely, on the one hand, logic and the nature of states of affairs and, on the other hand, Stumpf's contribution to the mind-body problem and to the topic of relations. The third section is divided into two parts. In the first one, I try to briefly account for the vast literature on Stumpf's contribution to psychology understood broadly enough as to include his work on the psychology of sound, Gestalt psychology, animal psychology and the psychology of child development. I provide, in the second part of this section, a summary of his studies in the area of aesthetics and musicology in general, i.e. his contribution to the history of music and its origins, to ethnomusicology, and to acoustics. Although this study does not aim at being exhaustive, it provides an overview of the important aspects of Stumpf's contribution to philosophy. (shrink)

Psychological and neuroscientific inquiry pointed out the value of attention for auditory perception. Recent studies have identified that the problem is not one of finding a location for a given task, but of identifying how and what one wants to do with a given stimulus. This radicalises the problem of attention in perception. In this paper I try bring experimental research into dialogue with social role of emotions and attention in sonorous and musical field from the point of view (...) of anthropology and ethnomusicology. (shrink)

Summary During his prolific career, the German Jewish scientist Franz Boas (Minden, 1858 - New York, 1942) recognized as the founding father of American Cultural Anthropology – maintained assiduous contacts with the European scientific community, in a privileged way with that of the German area. The contribution addresses the Boasian correspondence with the two directors of the Berliner Phonogramm-Archiv, the philosopher and psychologist Carl Stumpf, and the ethnomusicolo-gist Erich Moritz von Hornbostel. All three were united by a common scientific (...) class='Hi'>experimental training and a solid musical education, typical of their Bildungsbu ü rgertum. With them, Boas consistently shared his fieldwork findings regarding music, sound, and language among the Indians of British Columbia: indeed, their epistolary exchanges intertwine epistemological reflections centered on the study of «exotische Musik» in context with technical problems, derived from the use of phonographic recordings and the relative shipments of wax cylinders by Boas to the Phonographic Archive. So far, the critical literature has not paid particular attention to their correspondence, that offer instead a privileged look in observing the birth of Ethnomusicology, at the time still defined as comparative Musicology (vergleichende Musikwissenschaft). Starting from a biographical contextualization and following the micro-history of the scientific and personal relationship of these scientists, the contribution aims to explore the hypothesis that the emerging Ethnomusicology significantly contributed to the definition of Cultural Anthropology as a discipline. In his painstaking research devoted to the Native Indian sounds and languages, Boas observed indeed what happens if a mind is exposed to a new sound, musical or linguistic context; he had therefore to rigorously deal with the phenomena of mishearing, sound-blindness and biasing filter related to the perception of «new sounds». Thanks to his fieldwork, Boas would endorse a relativistic and “in context” approach to perception and mental representations of sounds, fostering his eventual lifelong, hectic concern about a broaden antiracist theory of human mental functions. (shrink)

Experimental investigations of cross-cultural music perception and cognition reported during the past decade are described. As globalization and Western music homogenize the world musical environment, it is imperative that diverse music and musical contexts are documented. Processes of music perception include grouping and segmentation, statistical learning and sensitivity to tonal and temporal hierarchies, and the development of tonal and temporal expectations. The interplay of auditory, visual, and motor modalities is discussed in light of synchronization and the way music moves (...) via emotional response. Further research is needed to test deep-rooted psychological assumptions about music cognition with diverse materials and groups in dynamic contexts. Although empirical musicology provides keystones to unlock musical structures and organization, the psychological reality of those theorized structures for listeners and performers, and the broader implications for theories of music perception and cognition, awaits investigation. (shrink)

In their theoretical and experimental reflections on the capacities and behaviours of living systems, neuroscientists often formulate generalizations about the behaviour of neural circuits. These generalizations are highly idealized, as they omit reference to the myriads of conditions that could perturb the behaviour of the modelled system in real-world settings. This article analyses an experimental investigation of the behaviour of place cells in the rat hippocampus, in which highly idealized generalizations were tested by comparing predictions flowing from them (...) with real-world experimental results. The aim of the article is to identify under what conditions even single prediction failures regarding the behaviour of single cells sufficed to reject highly idealized generalizations, and under what conditions prima facie counter-examples were deemed to be irrelevant to the testing of highly idealized generalizations. The results of this analysis may contribute to understanding how idealized models are tested experimentally in neuroscience and used to make reliable predictions concerning living systems in real-world settings. (shrink)

Experimental Phenomenology has already been lauded for the ease with which its author explains and demonstrates the kinds of consciousness by which we come to know the structure of objects and the structure of consciousness itself. The format of the book follows the progression of a number of thought experiments which mark out the procedures and directions of phenomenological inquiry. Making use of examples of familiar optical illusions and multi-stable drawings, Professor Ihde illustrates by way of careful and disciplined (...) step-by-step analyses, how some of the main methodological procedures and epistemological concepts of phenomenology assume concrete relevance. Such formidable fare as epoche, noetic and noematic analysis, apodicticity, adequacy, sedimentation, imaginative variation, field, and fringe are rendered into the currency of familiar examples from the everyday world. (shrink)

It has been standard philosophical practice in analytic philosophy to employ intuitions generated in response to thought-experiments as evidence in the evaluation of philosophical claims. In part as a response to this practice, an exciting new movement—experimental philosophy—has recently emerged. This movement is unified behind both a common methodology and a common aim: the application of methods of experimental psychology to the study of the nature of intuitions. In this paper, we will introduce two different views concerning the (...) relationship that holds between experimental philosophy and the future of standard philosophical practice (what we call, the proper foundation view and the restrictionist view), discuss some of the more interesting and important results obtained by proponents of both views, and examine the pressure these results put on analytic philosophers to reform standard philosophical practice. We will also defend experimental philosophy from some recent objections, suggest future directions for work in experimental philosophy, and suggest what future lines of epistemological response might be available to those wishing to defend analytic epistemology from the challenges posed by experimental philosophy. (shrink)

Humans often attribute the things that happen to one or another actual cause. In this chapter, we survey some recent philosophical and psychological research on causal attribution. We pay special attention to the relation between graphical causal modeling and theories of causal attribution. We think that the study of causal attribution is one place where formal and experimental techniques nicely complement one another.

This chapter discusses the relation between Christian Wolff's philosophy and the methodological views of early modern experimental philosophers. The chapter argues for three claims. First, Wolff's system relies on experience at every step and his views on experiments, observations, hypotheses, and the a priori are in line with those of experimental philosophers. Second, the study of Wolff's views demonstrates the influence of experimental philosophy in early eighteenth-century Germany. Third, references to Wolff's empiricism and rationalism are best identified (...) or replaced with references to his endorsement of the tenets of experimental philosophers and of a mathematical demonstrative method. (shrink)

It used to be a commonplace that the discipline of philosophy was deeply concerned with questions about the human condition. Philosophers thought about human beings and how their minds worked. They took an interest in reason and passion, culture and innate ideas, the origins of people’s moral and religious beliefs. On this traditional conception, it wasn’t particularly important to keep philosophy clearly distinct from psychology, history, or political science. Philosophers were concerned, in a very general way, with questions about how..

Alternative theories to quantum mechanics motivate important fundamental tests of our understanding and descriptions of the smallest physical systems. Here, using spontaneous parametric downconversion as a heralded single-photon source, we place experimental limits on a class of alternative theories, consisting of classical field theories which result in power-dependent normalized correlation functions. In addition, we compare our results with standard quantum mechanical interpretations of our spontaneous parametric downconversion source over an order of magnitude in intensity. Our data match the quantum (...) mechanical expectations, and do not show a statistically significant dependence on power, limiting quantum mechanics alternatives which require power-dependent autocorrelation functions. (shrink)

Scolnicov highlights Harold Pinter as an experimental playwright who attempted to free the theatre from the legacy of realism, causality, and motivation.

In recent years, experimental philosophers have questioned the reliance of philosophical arguments on intuitions elicited by thought experiments. These challenges seek to undermine the use of this methodology for a particular domain of theorizing, and in some cases to raise doubts about the viability of philosophical work in the domain in question. The topic of semantic reference has been an important area for discussion of these issues, one in which critics of the reliance on intuitions have made particularly strong (...) claims about the prospects for philosophical theories of reference and arguments based on claims about reference. In this article, I review the main lines of argument in this area of experimental philosophy, with particular emphasis on the relevance of empirical data about intuitions to philosophical views. I argue that although traditional philosophical theorizing about reference faces little threat from experimental data about intuitions, there is nevertheless much to be gained from collecting and analyzing such data, which holds the promise of greatly enriching our conception of the mechanisms governing judgments about semantic reference in ways that are highly relevant to philosophers. (shrink)

Once symbolized by a burning armchair, experimental philosophy has in recent years shifted away from its original hostility to traditional methods. Starting with a brief historical review of the experimentalist challenge to traditional philosophical practice, this chapter looks at research undercutting that challenge, and at ways in which experimental work has evolved to complement and strengthen traditional approaches to philosophical questions.

Experimental psychology in the early 20th century was targeted by several authors who described a crisis— often expressed as a lack of theoretical and experimental progress. In the 21st century, the crisis of competing theories has been largely overcome but several current emphases hinder the development of a mature experimental science. Central among these are an ethnocentrism that focuses on Western standards and populations, neuroscientism which often treats neurological evidence independently of mental and behavioral events, and the (...) tendency for demonstration experiments to replace coordinated theoretical approaches. (shrink)

Practitioners of the new ‘experimental philosophy’ have collected data that appear to show that some philosophical intuitions are culturally variable. Many experimental philosophers take this to pose a problem for a more traditional, ‘armchair’ style of philosophizing. It is argued that this is a mistake that derives from a false assumption about the character of philosophical methods; neither philosophy nor its methods have anything to fear from cultural variability in philosophical intuitions.

This special issue aims to explore and investigate a new subfield, namely experimental philosophy of medicine. Whereas experimental philosophy is relatively new on the philosophical block, some of its takes and findings have already shaped central debates in ethics, philosophy of action, philosophy of language, and epistemology. Interestingly, the approach of this program was for a long time almost wholly ignored within bioethics and philosophy of medicine—although this seems to have changed somewhat recently. In this introduction, we briefly (...) sketch the program of experimental philosophy and how it can be used to shed philosophical light on issues in the philosophy of medicine. (shrink)

En la primera parte de este artículo, respondemos a los comentarios críticos de Michel Paty sobre nuestro trabajo "Einstein y el efecto Compton". Si bien nuestra intención no fue evaluar la respuesta de Einstein a la evidencia experimental de la hipótesis cuántica de la luz más allá del año 1923, en la segunda parte del artículo evaluamos dos importantes experimentos completados en 1924: los realizados por Bothe y Geiger en Alemania y los de Compton y Simon en los Estados (...) Unidos. Discutimos por qué ambos experimentos proporcionaron pruebas adicionales que respaldaron los puntos de vista de Einstein sobre la teoría cuántica de la radiación. Sin embargo, afirmamos que aun después de conocer estos resultados, Einstein nunca expresó un juicio categórico sobre la realidad de los cuantos de luz tal como el que formuló De Broglie a principios de 1923, con el que comparamos el punto de vista de Einstein. In the first part of this paper we reply to Michel Paty's critical remarks on our paper "Einstein and the Compton effect". We state that we did not evaluate Einstein's response to the experimental evidence about the light quantum hypothesis beyond 1923. Nevertheless, in the second part we analyze two important experiments completed in 1924: those performed by Bothe and Geiger in Germany and by Compton and Simon in the United States. We point out that both experiments provided additional evidence that supported Einstein's views about the quantum theory of radiation. Nonetheless, we contend that even after becoming aware of these results, Einstein never expressed a categorical judgment about the reality of light quanta, such as the one stated by De Broglie as early as 1923, with which we compared Einstein's position. (shrink)

This article aims at reducing the gap between mathematics and physics from a Wittgensteinian point of view. This gap is usually characterized by two discriminating features. The propositions of physics assert something which might be false; they have a hypothetical character. On the contrary, since mathematical propositions are rules that condition the form of assertions, they remain immune from falsification. The propositions of physics refer to facts that may confirm or refute them. On the contrary, since mathematical propositions have no (...) meaning independently of the demonstration procedures, it cannot be said that they refer to “facts” that pre-exist demonstrations. If we take a closer look, however, these two differences fade away. On the one hand, the propositions of physics are more resistant to experimental tests than has been said in the wake of logical positivism. On the other hand, the “factual” empirical material is defined and co-constituted by instruments whose arrangement is determined by the theory to be tested. I conclude by discussing the possibility of a Wittgensteinian philosophy of contemporary physics. (shrink)

Many scientists believe that there is a uniform, interdisciplinary method for the prac- tice of good science. The paradigmatic examples, however, are drawn from classical ex- perimental science. Insofar as historical hypotheses cannot be tested in controlled labo- ratory settings, historical research is sometimes said to be inferior to experimental research. Using examples from diverse historical disciplines, this paper demonstrates that such claims are misguided. First, the reputed superiority of experimental research is based upon accounts of scientific methodology (...) (Baconian inductivism or falsificationism) that are deeply flawed, both logically and as accounts of the actual practices of scientists. Second, although there are fundamental differences in methodology between experimental scien- tists and historical scientists, they are keyed to a pervasive feature of nature, a time asymmetry of causation. As a consequence, the claim that historical science is methodo- logically inferior to experimental science cannot be sustained. (shrink)

In this article, we analyse the evidential value of the corpus of experimental philosophy. While experimental philosophers claim that their studies provide insight into philosophical problems, some philosophers and psychologists have expressed concerns that the findings from these studies lack evidential value. Barriers to evidential value include selection bias and p-hacking. To find out whether the significant findings in x-phi papers result from selection bias or p-hacking, we applied a p-curve analysis to a corpus of 365 x-phi chapters (...) and articles. Our results suggest that this corpus has evidential value, although there are hints of p-hacking in a few parts of the x-phi corpus. (shrink)

What are the folk-conceptual connections between free will and consciousness? In this paper I present results which indicate that consciousness plays central roles in folk conceptions of free will. When conscious states cause behavior, people tend to judge that the agent acted freely. And when unconscious states cause behavior, people tend to judge that the agent did not act freely. Further, these studies contribute to recent experimental work on folk philosophical affiliation, which analyzes folk responses to determine whether folk (...) views are consistent with the view that free will and determinism are incompatible (incompatibilism) or with the opposite view (compatibilism). Conscious causation of behavior tends to elicit pro-free will judgments, even when the causation takes place deterministically. Thus, when controlling for consciousness, many folk seem to be compatibilists. However, participants who disagree with the deterministic or cognitive scientific descriptions given of human behavior tend to give incompatibilist responses. (shrink)

Moti Mizrahi provides experimental evidence according to which subjects judge that a person ought to ? even when she cannot ?. He takes his results to constitute a falsification of the alleged intuitiveness of the ‘Ought Implies Can’ principle. We point out that in the light of the fact that (a) ‘ought’ is multiply ambiguous, that (b) only a restricted set of readings of ‘ought’ will be relevant to the principle, and that (c) he did not instruct his subjects (...) appropriately – or otherwise ensure that in their ‘ought’ judgements they applied the relevant concept(s) – Mizrahi’s conclusions appear premature. We suggest two ways in which the experimental design could be adjusted or supplemented. First, Mizrahi could instruct (or prime) subjects to read the ‘ought’ question in a particular way. Second, he could complement his experiment by asking follow-up questions aimed at uncovering the implications for blame of subjects’ judgements. Once these adjustments are applied, an experiment with a similar outcome would be more significant. (shrink)

The graphical presentation of experimental data in the physical sciences has several advantages which today are too familiar to require very detailed enumeration. Its greatest strength lies in the clarity and succinctness with which it displays the information contained in tabulated results: for the experimenter a graph provides a rough and immediate check on the accuracy and suitability of the methods he is using, and for the reader of a scientific report it may convey in a few seconds information (...) that could only be gleaned from a table of measurements by hours of close study. There are occasions whereonlythe analysis of experimental graphs will provide the information we require, but usually the actual analysis of results is carried out nowadays by computational methods. The use of graphs is therefore not so much a necessary part of scientific procedure as an extremely useful one, and one that is often taken very much for granted. (shrink)

The present paper consists of two parts. In the first, some issues related to the character of biological experiments conducted under in vitro cultures are portrayed. The relevant aspects of these procedures are explicated from the viewpoint of the experimental botanist. It is a case study for the considerations in the second part, which presents selected philosophical and legal issues involved in biological experiments from the general perspective of philosophical investigations concerning the problem of plants’ axiology. Obviously, the nature (...) of the considerations is limited; not all important questions from the perspective of biology and philosophy have been raised. Nevertheless, the authors hope that the analyzed issues may be interesting for both biologists and philosophers. (shrink)

After years of relative neglect, experimental science has once again become an object of scrutiny. Philosophers such as Hacking and Cartwright have examined contemporary science in an attempt to display the epistemic status of experimental results, while sociologists such as Shapin and Schaffer have focussed on historical cases in an attempt to display the conventional basis of experimentation. In this study I am concerned with the epistemological question: How can one justify the claim that it is rational to (...) believe that the methods of experimental science yield knowledge about the unobserved causal structures of our world? My answer to this question is produced by way of an historical analysis and philosophical retrieval of Robert Boyle's epistemological defense of experimental science. ;The first two chapters examine contemporary issues surrounding experimental science, particularly those challenges posed to its knowledge-producing ability by philosophical instrumentalists and sociological constructionists. I then turn to an examination of Boyle's version of experimental philosophy, which includes a detailed discussion of the background traditions from which he drew in its formulation, and his response to critics of experimentation, such as Hobbes and Spinoza. ;Boyle's work is not only historically important, but is philosophically significant in light of the fact that he developed epistemological strategies in defense of experimental techniques at a time when it was not clear that experimentation would become the standard of modern science. His philosophy is characterized as a sophisticated and complex method that employs the elements of inductive, retroductive, and hypothetico-deductive reasoning. This combination, he argues, yields a system of checks and balances on sense, reason, and ideology that, while fallible, offers us the best assurance that we have of coming closer to the truth about the processes operative in our world. ;In a concluding chapter it is argued that Boyle's philosophy of science, by virtue of its richness and complexity, is sufficient to respond to the general challenges to scientific objectivity posed by sociologists of knowledge, and the more specific challenges to the realist import of the theoretical claims of experimental science posed by philosophers such as Laudan and van Fraassen. (shrink)

Recent years have seen an explosion of new work at the intersection of philosophy and experimental psychology. This work takes the concerns with moral and conceptual issues that have so long been associated with philosophy and connects them with the use of systematic and well-controlled empirical investigations that one more typically finds in psychology. Work in this new field often goes under the name "experimental philosophy".

Negative attitudes toward robots are considered as one of the psychological factors preventing humans from interacting with robots in the daily life. To verify their influence on humans‘ behaviors toward robots, we designed and executed experiments where subjects interacted with Robovie, which is being developed as a platform for research on the possibility of communication robots. This paper reports and discusses the results of these experiments on correlation between subjects’ negative attitudes and their behaviors toward robots. Moreover, it discusses influences (...) of gender and experience of real robots on their negative attitudes and behaviors toward robots. (shrink)

Francis Bacon's experimental philosophy is discussed, and the way in which it not only shapes scientific methodology but also deeply pervades all philosophical and social learning. Bacon draws us in to participate in an experiment with experience. The central driving force is the idea that learning how to learn is necessary in order to know. To meet this requirement, he considers the relation of form and content of pivotal importance, and therefore the selection of the literary form and the (...) form of data inscription is decisive in the construction of a heuristic tool. His inductive method serves a dual purpose: first, the so-called indicative form aims at securing knowledge by a comprehensible procedure that controls and guides hypothetical thinking. Second, the literary forms "fragment" and "aphorism" embody the subjunctive, and invite intellectual openness and even speculation. In this article, special emphasis is put on Bacon's use and justification of the aphorism. Bacon's pervasive experimentalism meets in some sense today's broad adoption of the experimental mode. His philosophy calls for an ontology that is also at work in recent notions of co-action and co-working, or of affordance. (shrink)

The primary aim of this paper is to highlight, at least in short, how the resources of experimental philosophy could be fruitfully applied to the evidential problem of evil. To do this, we will consider two of the most influential and archetypal formulations of the problem: William L. Rowe’s article, “The Problem of Evil and Some Varieties of Atheism” (1979). and Paul Draper’s article, “Pain and Pleasure: An Evidential Problem for Theists” (1989). We will consider the relevance of (...) class='Hi'>experimental philosophy to Rowe’s 1979 argument in §1 and to Draper’s 1989 argument in §2. But in addition to exploring how the resources of experimental philosophy might apply to the problem of evil, it is also worth exploring what broader empirical factors might contribute to people having the intuitions that have—from someone’s affective state to someone’s need for closure. In §3, we want to very briefly elucidate a few areas where the psychology of philosophy might be productively explored in future empirical research. (shrink)

Exploring issues ranging from the metaphysical to the moral and legal, a team of esteemed contributors bring together some of the most important and cutting-edge findings in experimental philosophy of the self to address longstanding philosophical questions about personal identity, such as: What makes us today the same person as our childhood and future selves? Can certain changes transform us into a different person? Do our everyday moral practices presuppose a false account of who we are? Chapters offer a (...) survey of recent empirical work and foster dialogue between experimental and traditional philosophical approaches to identity, covering the moral self, dual character concepts, true self, transformative experience and the identity conditions collective entities. With novel experiments and thought-provoking applications to practical concerns including law, immigration, bioethics and politics, this collection highlights the value and implications of empirical work on personal identity. (shrink)

Must philosophers incorporate tools of experimental science into their methodological toolbox? I argue here that they must. Tallying up all the resources that are now part of standard practice in analytic philosophy, we see the problem that they do not include adequate resources for detecting and correcting for their own biases and proclivities towards error. Methodologically sufficient resources for error- detection and error-correction can only come, in part, from the deployment of specific methods from the sciences. However, we need (...) not imagine that the resulting methodological norms will be so empirically demanding as to require that all appeals to intuition must first be precertified by a thorough vetting by teams of scientists. Rather, I sketch a set of more moderate methodological norms for how we might best include these necessary tools of experimental philosophy. (shrink)

Philosophers of science diverge on the question what drives the growth of scientific knowledge. Most of the twentieth century was dominated by the notion that theories propel that growth whereas experiments play secondary roles of operating within the theoretical framework or testing theoretical predictions. New experimentalism, a school of thought pioneered by Ian Hacking in the early 1980s, challenged this view by arguing that theory-free exploratory experimentation may in many cases effectively probe nature and potentially spawn higher evidence-based theories. Because (...) theories are often powerless to envisage workings of complex biological systems, theory-independent experimentation is common in the life sciences. Some such experiments are triggered by compelling observation, others are prompted by innovative techniques or instruments, whereas different investigations query big data to identify regularities and underlying organizing principles. A distinct fourth type of experiments is motivated by a major question. Here I describe two question-guided experimental discoveries in biochemistry: the cyclic adenosine monophosphate mediator of hormone action and the ubiquitin-mediated system of protein degradation. Lacking underlying theories, antecedent data bases, or new techniques, the sole guides of the two discoveries were respective substantial questions. Both research projects were similarly instigated by theory-free exploratory experimentation and continued in alternating phases of results-based interim working hypotheses, their examination by experiment, provisional hypotheses again, and so on. These two cases designate theory-free, question-guided, stepwise biochemical investigations as a distinct subtype of the new experimentalism mode of scientific enquiry. (shrink)