Antibiotic resistance in bacteria has become a great threat to global public health. Tigecycline is a next‐generation tetracycline that is the final line of defense against severe infections by pan‐drug‐resistant bacterial pathogens. Unfortunately, this last‐resort antibiotic has been challenged by the recent emergence of the mobile Tet(X) orthologs that can confer high‐level tigecycline resistance. As it is reviewed here, these novel tetracycline destructases represent a growing threat to the next‐generation tetracyclines, and a basic framework (...) for understanding the molecular epidemiology and resistance mechanisms of them is presented. However, further large‐scale epidemiological and functional studies are urgently needed to better understand the prevalence and dissemination of these newly discovered Tet(X) orthologs among Gram‐negative bacteria in both human and veterinary medicine. (shrink)

Tim Bayne and Susanna Siegel have recently offered interesting arguments in favor of the view that we can experience high-level properties like being a pine tree or being a stethoscope (Bayne 2009, Siegel 2006, 2011). We argue first that Bayne’s simpler argument fails. However, our main aim in this paper is to show that Siegel’s more sophisticated argument for her version of the high-level view can also be resisted if one adopts a view that distinguishes between (...) perceptual experiences and seemings. (shrink)

Whether we perceive high-level properties is presently a source of controversy. A promising test case for whether we do is aesthetic perception. Aesthetic properties are distinct from low-level properties, like shape and colour. Moreover, some of them, e.g. being serene and being handsome, are properties we appear to perceive. Aesthetic perception also shares a similarity with gestalt effects, e.g. seeing-as, in that aesthetic properties, like gestalt phenomena, appear to ‘emerge’ from low-level properties. Gestalts effects, of course, (...) are widely observed, which raises the question: do gestalt effects make it plausible that we perceive high-level aesthetic properties? Contra Stokes, this paper argues that they don’t. This is interesting in its own right, but it also points to a more general lesson, namely we should resist the temptation to appeal to gestalt effects to argue for high-level perception. (shrink)

While most studies of low-carbon transitions focus on green niche-innovations, this paper shifts attention to the resistance by incumbent regime actors to fundamental change. Drawing on insights from political economy, the paper introduces politics and power into the multi-level perspective. Instrumental, discursive, material and institutional forms of power and resistance are distinguished and illustrated with examples from the UK electricity system. The paper concludes that the resistance and resilience of coal, gas and nuclear production regimes currently (...) negates the benefits from increasing renewables deployment. It further suggests that policymakers and many transition-scholars have too high hopes that ‘green’ innovation will be sufficient to bring about low-carbon transitions. Future agendas in research and policy should therefore pay much more attention to the destabilization and decline of existing fossil fuel regimes. (shrink)

This book offers a truly interdisciplinary exploration of our patterns of engagement with politics, news, and information in current high-choice information environments. Putting forth the notion that high-choice information environments may contribute to increasing misperceptions and knowledge resistance rather than greater public knowledge, the book offers insights into the processes that influence the supply of misinformation and factors influencing how and why people expose themselves to and process information that may support or contradict their beliefs and attitudes. (...) A team of authors from across a range of disciplines address the phenomena of knowledge resistance and its causes and consequences at the macro- as well as the micro-level. The chapters take a philosophical look at the notion of knowledge resistance, before moving on to discuss issues such as misinformation and fake news, psychological mechanisms such as motivated reasoning in processes of selective exposure and attention, how people respond to evidence and fact-checking, the role of political partisanship, political polarization over factual beliefs, and how knowledge resistance might be counteracted. This book will have a broad appeal to scholars and students interested in knowledge resistance, primarily within philosophy, psychology, media and communication, and political science, as well as journalists and policymakers. The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license. (shrink)

Faced with high levels of unemployment and discrimination in Poland, Polish women have made up a very large proportion of those leaving the former Communist states of central Europe, to work in EU member states. They have constituted a large undocumented migrant workforce in Europe, usually working as domestic workers and carers in the informal economy. Poland’s membership of the EU is starting to regulate Polish women’s work abroad and to increase their access to better paid and skilled work (...) in the formal labour market. New market-led immigration policies in Europe are still selective and restricted however. What Polish women really need from the EU is help in securing a new framework of gender equality and equal treatment in Poland that offers hope for an improvement in their rights at home. (shrink)

The issue of regularly feeding low levels of antibiotics to farm animals in order to increase productivity is often portrayed as a dilemma. On the one hand, such antibiotic use is depicted as a necessary condition for producing cheap and plentiful food, such that were such use to stop, food prices would rise significantly and our ability to feed people in developing nations would decrease. On the other hand, such antibiotic use seems to breed antibiotic resistance into pathogens affecting (...) human health. Resolving this dilemma, it is alleged, will require great amounts of research into risk/benefit assessment. Contrary to this claim, we will argue that society has all the data it needs to make a reasonable ethical decision, which would be curtailing such use. Such curtailment will not harm consumers significantly, will not harm developing nations'' evolving agriculture, and could produce hitherto unnoticed benefits, namely restoring the possibility of a more husbandry-based, sustainable agriculture to replace the high-tech agriculture that has hurt animals, the environment, small farms, and sustainability. (shrink)

Scientific socialism as developed by the Social Democratic Party of Germany, the world's largest workers' party, and the Second International, basically a creation of German socialists, viewed utopianism as empirically unverifiable. The publication, wide circulation, and enormous success in Germany of Edward Bellamy's Looking Backward therefore posed a strong challenge to the leaders of the SPD, Karl Kautsky and August Bebel, and it attracted their criticism on several occasions. Such high-level condemnations of Bellamy call for an explanation. The (...) SPD, freshly out of illegality in 1890, scored a decisive victory over Bismarck, and the party's big electoral gains led to utopian hopes among the rank and file. In this expectant milieu, Looking Backward was interpreted as a model for immediate action. However, socialist leaders saw it differently. Kautsky and Bebel reasoned that the immediatism of the American utopia flagrantly violated the ineluctable tendencies of history, recklessly rushed historical destiny, and put the achievements of the socialists at risk. It was not without irony that Kautsky found the absence of utopianism one of the SPD's greatest accomplishments. It was into this utopian vacuum that right-wing futuristic blueprints increasingly moved, portraying Caesaristic leadership, interclass harmony, world power, and racial exclusivity to a rapidly expanding audience. By rejecting future gazing, as exemplified by their rebuff of Looking Backward, socialist leaders failed to wage an extended cultural campaign for hegemonic influence over sectors other than the working class. Their claim that they essentially had no ideals to realize and their adherence to the strategy of fatalistic waiting for the collapse of capitalism came at a high price, as their inaction in face of and even support of colonialism and World War I would reveal. (shrink)

Obsessive–compulsive disorder is a debilitating mental health disorder that can easily become a treatment-resistant condition. Although effective therapies exist, only about half of the patients seem to benefit from them when we consider treatment refusal, dropout rates, and residual symptoms. Thus, providing effective augmentation to standard therapies could improve existing treatments. Group compassion-focused interventions have shown promise for reducing depression, anxiety, and avoidance related to various clinical problems, but this approach has never been evaluated for OCD individuals. However, cultivating compassion (...) for self and others seems crucial for OCD patients, given the accumulating research suggesting that fear of guilt, along with isolation and self-criticism, can strongly contribute to the development and maintenance of OCD. The primary aim of this pilot study was to evaluate the acceptability, tolerability, and effectiveness of an 8-week group compassion-focused intervention for reducing OCD symptoms, depression, fear of guilt and self-criticism, and increasing common humanity and compassionate self-reassuring skills in treatment-resistant OCD patients. Using a multiple baseline experimental design, the intervention was evaluated in a sample of OCD patients who had completed at least 6 months of CBT treatment for OCD, but who continued to suffer from significant symptoms. Participants were randomized to different baseline assessment lengths; they then received 8 weekly, 120-min group sessions of compassion-focused therapy for OCD, and then were tested again at post-treatment and at 1 month follow up. Despite the adverse external circumstances, by the end of treatment, all participants demonstrated reliable decreases in OCD symptoms, and these improvements were maintained at 4-week follow-up for seven of eight participants. The intervention was also associated with improvements in fear of guilt, self-criticism, and self-reassurance, but less consistent improvements in depression and common humanity. Participants reported high levels of acceptability of and satisfaction with the intervention. Results suggest that the intervention may be beneficial as either a stand-alone treatment or as an augmentation to other treatments. (shrink)

Effectiveness is a key criterion in assessing the justification of antibiotic resistance interventions. Depending on an intervention’s effectiveness, burdens and costs will be more or less justified, which is especially important for large scale population-level interventions with high running costs and pronounced risks to individuals in terms of wellbeing, integrity and autonomy. In this paper, we assess the case of routine hospital screening for multi-drug-resistant Gram-negative bacteria (MDRGN) from this perspective. Utilizing a comparison to screening programs for (...) Methicillin-Resistant Staphylococcus aureus (MRSA) we argue that current screening programmes for MDRGN in low endemic settings should be reconsidered, as its effectiveness is in doubt, while general downsides to screening programs remain. To accomplish justifiable antibiotic stewardship, MDRGN screening should not be viewed as a separate measure, but rather as part of a comprehensive approach. The program should be redesigned to focus on those at risk of developing symptomatic infections with MDRGN rather than merely detecting those colonised. (shrink)

Several studies have examined victim blaming in rape scenarios. However, there is limited research on the analysis of the perception of blame when two or more perpetrators are involved. The present article explores the perception of blame in cases involving rape based on the level of resistance shown by the victim and the presence of one or more perpetrators. A study was carried out involving 351 university students who responded to a survey after reading a hypothetical assault scenario. (...) Six situations were established where the victim showed either low or high resistance, depending on whether the resistance was verbal or physical and verbal, and in the presence of one or two male perpetrators. It is expected that perpetrators are more culpable when acting in groups and that less resistance from the victim leads to greater attribution of blame. The results confirm that more blame is attributed to the perpetrators when they act in groups than when they act alone. Likewise, women consider the victim generally exerts greater resistance and this variable influences the attribution of greater blame. (shrink)

In addition to ordinary conversations among relatively small numbers of individuals, human societies have public conversations. These are diffuse, ongoing discussions about various topics, which are largely sustained by journalistic activities. They are conversations about news – what is happening now – that members of various groups (such as the residents of a certain country, a certain town, or practitioners of a certain profession) need to know about in their capacity as members of those groups, and about how to react (...) to the news. Our topic in this chapter is a type of resistance to evidence that can arise at the level of these public conversations, rather than at the level of individual agents. We call it “relevance-based resistance to evidence”. A public conversation exhibits this kind of evidence resistance when it becomes overly focused on topics that members of the group that the conversation concerns do not in fact need to know about qua members of the group – topics which are, in a word, irrelevant. We argue that the risks of such relevance-based knowledge resistance are significantly amplified by certain structural features of online discourse. (shrink)

Sylvia Burrow explores self-confidence as integral to autonomy development within everyday contexts threatening gender violence, arguing that self-defense training is significant to resistance and resilience. -/- Choice Reviews, December 2022 Issue: “Gender Violence explores the myths and realities of the threat of gender-based violence and active forms of resistance to it…. She advocates specifically for martial arts and self-defense programs rooted in feminist frameworks. These are the most successful because they resist rape culture while increasing the capacities of (...) women and other people with marginalized identities who face high risk for sexual violence. This book is a must-read for anyone working at the intersections of gender-based violence prevention and somatic practice. Essential. All levels.”. (shrink)

Previous research indicates that the depletion of self-regulatory resources can promote unethical behavior that benefits the self. Extending this literature, we focus on norm-transgressing behavior that is intended to primarily benefit others. In particular, we predicted a differing effect of self-regulatory resource depletion on dishonesty that benefits one’s group, depending on the degree of identification with the group. Following a dual process approach, we argue that if identification with the group is strong, then people may have an automatic inclination to (...) benefit their group even perhaps by lying. In contrast, if identification with the group is weak, then the default, uncontrolled impulse may be to tell the truth. Accordingly, identification with the social group should interact with self-regulatory resource depletion in predicting group-benefiting dishonesty. Focusing on pro-organizational dishonesty, we tested our hypotheses in one field study with 1269 employees and in one experimental study with 71 university students. As predicted, the results revealed a highly significant interaction of organizational identification and self-control strength: Depletion of self-regulatory resources increased the level of pro-organizational dishonesty among those who identify highly with the organization, but decreased the level of such behavior among those who identify less. (shrink)

Control measures directed at carriers of multidrug-resistant organisms are traditionally approached as a trade-off between public interests on the one hand and individual autonomy on the other. We propose to reframe the ethical issue and consider control measures directed at carriers an issue of solidarity. Rather than asking “whether it is justified to impose strict measures”, we propose asking “how to best care for a person’s carriership and well-being in ways that do not imply an unacceptable risk for others?”. A (...) solidarity approach could include elevating baseline levels of precaution measures and accepting certain risks in cases where there is exceptionally much at stake. A generous national compensation policy that also covers for costs related to dedicated care is essential in a solidarity approach. An additional benefit of reframing the questions is that it helps to better acknowledge that being subjected to control measures is a highly personal matter. (shrink)

To combat the OneHealth threat of antimicrobial resistance (AMR), the use of antibiotics in agriculture is subject to significant governance-led initiatives to change food system behaviours, including promoting more responsible use of antibiotics on farms through market-level interventions. To combat knowledge gaps about how consumers perceive risks associated with antibiotic use and AMR in farming, the current study carried out an in-depth qualitative focus group study incorporating a risk information exposure exercise with food consumers on the island of (...) Ireland (_n_ = 36). Using a theoretical lens of social representation theory, a thematic analysis of the collected data identified how participants made sense of, often new, information on agricultural antibiotic use and AMR. Participants displayed high awareness and concern for AMR but low understanding and misconceptions around AMR transmission from the agri-food sector. Social representations about antibiotics and food and farming systems shaped preferences for a movement away from antibiotics in farming, and in particular, prophylactic use. However, participants acknowledged the role of antibiotics to protect animal health and the integrity of the food supply chain. They debated the lack of a simple fix to antibiotics in the agri-food system and revealed preferences for preventive actions at farm level and supporting actions at market level. The study highlights the need to first tackle low levels of public understanding through effective risk communication including strategies such as targeted message framing and proactive, cross-sector OneHealth awareness campaigns, followed by the introduction of a trusted antibiotic use food labelling system. (shrink)

Based on the conflict-of-values theory, this study examines the influences of Machiavellianism and ethical values on anxiety in college students when they face moral dilemmas. Questionnaires on the Chinese equivalent of Machiavellianism, moral identity, and anxiety were completed by 115 Chinese college students. The results suggest that Machiavellianism and ethical values influence anxiety, and the interaction between ethical values and Machiavellianism is significant—among individuals with high ethical values, those with high levels of Machiavellianism exhibit markedly higher levels of (...) anxiety than those with low levels of Machiavellianism. However, among individuals with low ethical values, there is no difference in anxiety between those with low or high levels of Machiavellianism. This research, depicting complex relationships among anxiety, Machiavellianism, and ethical values, suggests that leading people to do good deeds not only requires high ethical values but also necessitates the resistance to negative values such as Machiavellianism. (shrink)

Ultra-high-performance concrete (UHPC) is gaining popularity due to its superior mechanical properties, including high strength, toughness, durability, and excellent seismic performance. However, the risk of explosive spalling in UHPC structures exposed to fire poses a significant challenge, fundamentally hindering comprehensive studies on fire safety and limiting the broader engineering applications of UHPC. In this study, the mixture proportion of UHPC was developed and optimized by comparing the usage of yellow river and standard sands, different types of chemical admixtures, (...) and different curing regimes. Furthermore, a sensitive case study was also conducted to optimize the calcined bauxite content to improve UHPC's fire resistance. For these purposes, 189 UHPC cubes, incorporating variations in particle types, superplasticizer types, and curing regimes, were tested under three thermal levels, such as 200℃,400℃, and 600℃. The microstructural evolution of heated cube specimens was then observed using a scanning electron microscope (SEM) examination. Calcined bauxite was then considered to replace the standard sand to improve the fire resistance of UHPC and enhance the residual compressive strength of cube specimens under thermal conditions. For this purpose, 0%, 20%, 40%, 60%, 80%, and 100% calcined bauxite content was designed as six case studies. Furthermore, the degradation of UHPC strength was also investigated for the corresponding six case studies by conducting the uniaxial compressive experiments. Finally, the microstructural evolution under both thermal conditions and calcined bauxite content was observed and discussed. (shrink)

Trust is one of the big buzzwords in debates about the shaping of society, democracy, and emerging technologies. For example, one prominent idea put forward by the High‐Level Expert Group on Artificial Intelligence appointed by the European Commission is that artificial intelligence should be trustworthy. In this essay, we explore the notion of trust and argue that both proponents and critics of trustworthy AI have flawed pictures of the nature of trust. We develop an approach to understanding trust (...) in AI that does not conceive of trust merely as an accelerator for societal acceptance of AI technologies. Instead, we argue, trust is granted through leaps of faith. For this reason, trust remains precarious, fragile, and resistant to promotion through formulaic approaches. We also highlight the significance of distrust in societal deliberation, as it is relevant to trust in various and intricate ways. Among the fruitful aspects of distrust is that it enables individuals to forgo technology if desired, to constrain its power, and to exercise meaningful human control. (shrink)

The aim of this paper is to elaborate on the phenomenological approach to expertise as proposed by Dreyfus and Dreyfus and to give an account of the extent to which their approach may contribute to a better understanding of how athletes may use their cognitive capacities during high-level skill execution. Dreyfus and Dreyfus's non-representational view of experience-based expertise implies that, given enough relevant experience, the skill learner, when expert, will respond intuitively to immediate situations with no recourse to (...) deliberate actions or mental representations. The paper will subsequently outline some implications and consequences of such an approach and will also examine to what extent Dreyfus and Dreyfus's skill model is capable to resist different attacks that have been made against their view, and in particular regarding the practical application of their approach to the skill domain of competitive sport. (shrink)

This discussion of Sally Haslanger’s recent book, Resisting Reality: Social Construction and Social Critique (Oxford 2012), investigates how her theory of race and gender handles the problem of intersectionality; that is, the problem of how to understand the ways in which one’s location in multiple socially constructed categories affects one’s lived experiences, social roles, and relative privilege or disadvantage. Haslanger defines race and gender as locations within hierarchical social structures. This high-level structural analysis allows her to find commonality (...) without claiming that, for example, all women share social roles or psychological characteristics. However, race-based oppression seems sometimes to cancel out gender-based privilege; thus raising the question of how, on Haslanger’s model, we are to understand race and gender working together. (shrink)

Change is inevitable, and increasingly rapid and continuous in healthcare as organizations strive to adapt, improve and innovate. Organizational change challenges healthcare providers because it restructures how and when patient care delivery is provided, changing ways in which nurses must carry out their work. The aim of this doctoral study was to explore frontline nurses’ experiences of living with rapid and continuous organizational change. A critical hermeneutic approach was utilized. Participants described feeling voiceless, powerless and apolitical amidst rapid and continuous (...) organizational changes which fuelled apathy, cynicism and disengagement from the organization. However, critical analysis of the data showed that nurses actively engaged with power, voice and politics through resistant and transgressive behaviours in micro‐ethical moments of practice. There is a need to reconceptualize the concepts of voice, power and politics in nursing as there is dissonance between nurses’ beliefs about these concepts and what they are enacting in practice. Recognizing their enactment of power, voice and political agency at the micro‐level may empower nurses. Empowerment would mitigate the high levels of reports of powerlessness experienced in practice during organizational changes. (shrink)

No two individuals with the autism diagnosis are ever the same—yet many practitioners and parents can recognize signs of ASD very rapidly with the naked eye. What, then, is this phenotype of autism that shows itself across such distinct clinical presentations and heterogeneous developments? The “signs” seem notoriously slippery and resistant to the behavioral threshold categories that make up current assessment tools. Part of the problem is that cognitive and behavioral “abilities” typically are theorized as high-level disembodied and (...) modular functions—that are assessed discretely (impaired, normal, enhanced) to define a spectral syndrome. Even as biology reminds us that organic developing bodies are not made up of independent switches, we remain often seduced by the simplicity of mechanistic and cognitive models. Developmental disorders such as autism have accordingly been theorized as due to different modular dysfunctions—typically of cortical origin, i.e., failures of “theory of mind” (Baron-Cohen et al., 1985), of the “mirror neuron system” (Ramachandran and Oberman, 2006), of “weak central coherence” (Happe and Frith, 2006) or of the balance of “empathizing” and “systemizing” (Baron-Cohen, 2009), just to list a few. -/- The broad array of autonomic (Ming et al., 2005; Cheshire, 2012) and sensorimotor (Damasio and Maurer, 1978; Maurer and Damasio, 1982; Donnellan and Leary, 1995; Leary and Hill, 1996; Donnellan and Leary, 2012; Donnellan et al., 2012) differences experienced and reported by people with autism have by such theories typically been sidelined as “co-morbidities,” possibly sharing genetic causes, but rendered as incidental and decisively behaviorally irrelevant symptoms—surely disconnected from cognition. But what if the development of cortically based mental processes and autonomous control relies on the complexities and proper function of the peripheral nervous systems? Through such an “embodied” lens the heterogeneous symptoms of autism invites new interpretations. We propose here that many behavioral-level findings can be re-defined as downstream effects of how developing nervous systems attempt to cope and adapt to the challenges of having various noisy, unpredictable, and unreliable peripheral inputs. (shrink)

Many philosophers working on virtue theory have resisted the idea that the virtues are practical skills, apparently following Aristotle’s resistance to that idea. Bucking the trend, Matt Stichter defends a strong version of this idea in The Skillfulness of Virtue by marshaling a wide range of conceptual and empirical arguments to argue that the moral virtues are robust skills involving the cognitive-conative unification of Aristotelian phronêsis (‘practical intelligence’). Here I argue that Aristotle overlooks a more delimited kind of practical (...) intelligence, strongly analogous to his own account of phronêsis, that unifies complex forms of expertise such as medicine or even high-level sports. Insofar as the skill model of virtue is compelling, it must draw on a robust conception of practical expertise (technê) like the one developed here rather than the ordinary, anemic conception of practical skills. (shrink)

I sketch my general model of the roles of intentions in the planning of agents like us-agents with substantial resource limitations and with important needs for coordination. I then focus on the stability of prior intentions: their rational resistance to reconsideration. I emphasize the importance of cases in which one's nonreconsideration of a prior intention is nondeliberative and is grounded in relevant habits of reconsideration. Concerning such cases I argue for a limited form of two-tier consequentialism, one that is (...) restricted in ways that aim at blocking an analogue of Smart's concerns about rule-worship. I contrast this with the unrestricted two-tier consequentialism suggested by McClennen. I argue that my restricted approach is superior for a theory of the practical rationality of reflective, planning agents like us. But I also conjecture that an unrestricted two-tier consequentialism may be more appropriate for the AI project of specifying a high level architecture for a resource-bounded planner. (shrink)

Since its inception, Stakeholder Management Capability (SMC) has constituted a powerful hermeneutic through which business organizations have understood and leveraged stakeholder relationships. On this model, achieving a high level of capability largely depends on managerial ability to effectively bargain with stakeholders and establish solidarity vis-à-vis the successful negotiation, implementation, and execution of "win–win" transactional exchanges. Against this account, it is rightly pointed out that a transactional explanation of stakeholder relationships, regarded by many as the bottom line for stakeholder (...) management, fails to provide managerial direction regarding how to resolve a variety of normative stakeholder claims that resist commoditization. In response to this issue, this paper has two overlapping goals. It seeks to elaborate a discourse theoretical approach to the problem by first drawing out Jurgen Habermas’ theory of communicative action and delineating the various types of rational discourse. Second, the paper attempts to present concrete implications for SMC relative to reshaping the contours of rational, process, and transactional analysis in light of central discourse theoretical conclusions. (shrink)

The reason which is generally given in the usage-based literature to account for the retention of irregularity in high frequency items during analogical change is entrenchment: a frequently occurring irregular linguistic unit resists analogical levelling because it is highly entrenched in speakers’ mental lexicons through its repeated use. Although previous research similarly suggests that the entrenchment of irregular and regularised forms competing during analogical levelling should be proportional to their frequency of use, evidence for this relation between frequency and (...) entrenchment comes exclusively from corpus-based studies; what is missing, therefore, are behavioural tests contrasting the competing innovative and conservative forms. The present paper aims to provide converging evidence for an entrenchment-based explanation of frequency patterns in analogical change on the basis of data obtained from an experiment in which participants are presented with traditional and analogical variants of a variable currently undergoing analogical levelling. Differences in processing latencies obtained during the experiment are interpreted as differences in entrenchment. The results provide i) evidence in favour of the prevalent entrenchment-based explanation of the conserving effect of frequency in analogical change, and ii) evidence of the current state and spread of the change under investigation. (shrink)

IntroductionDuring the COVID-19 outbreak, many citizens were asked to stay at home in self-quarantine, which can pose a significant challenge with respect to remaining physically active and maintaining mental health. This study aimed to evaluate the prevalence of inadequate physical activity, anxiety, and depression and to explore the relationship of physical activity with anxiety and depression symptoms among Chinese college students during quarantine.MethodUsing a web-based cross-sectional survey, we collected data from 1,396 Chinese college students. Anxiety and depression were assessed with (...) the Self-Rating Anxiety Scale and the Self-Rating Depression Scale, respectively. The data on physical activity were collected by types of physical activity and the International Physical Activity Questionnaire.ResultsDuring the COVID-19 outbreak, about 52.3% of Chinese college students had inadequate physical activity. The rates of anxiety and depression symptoms were 31.0 and 41.8%, respectively. A high level of physical activity was significantly closely associated with low anxiety, while a moderate, or high level of physical activity was significantly closely associated with reduced depression after adjusting confounding demographic factors. Moreover, specific types of physical activity, such as stretching and resistance training, were negatively correlated with both anxiety and depression; doing household chores was negatively correlated with depression.ConclusionOur findings highlight specific levels and types of home-based physical activities that need to be taken into consideration to protect the mental health of college students during the COVID-19 epidemic. (shrink)

MacDonald develops an evolutionary perspective on Judaism. Judaism is conceptualized as a group evolutionary strategy characterized by a high degree of endogamy and resistance to genetic and cultural assimilation. Data are provided to support the author's theory that Judaism is characterized by a high level of within-group altruism and competition with outgroups. Finally, MacDonald argues that Judaism has been characterized by eugenic practices aimed at high intelligence and high investment parenting. After outlining a theory (...) of evolutionary group strategies, MacDonald discusses the evidence from modern studies showing population genetic differences between Jews and Gentiles. He then shows that Jewish religious writing points to a pronounced tendency toward idealizing endogamy and condemning exogamy, and he points to the ways religious ideology and practice have facilitated the genetic and cultural separation of Jews and Gentiles. He then reviews evidence for resource and reproductive competition and the importance of kin-based cooperation and altruism as well as assortative mating for intelligence and resource aquisition ability among Jews. This study is a highly original attempt to develop an evolutionary understanding of one of the world's great religions. As such, it will be of concern to scholars and researchers in the fields of sociobiology and religion as well as the general reading public. (shrink)

Mindfulness, derived from Buddhist psychology and philosophy, has gained broad popularity in the last decades, due importantly to scientific interest and findings. Yet Buddhist mindfulness developed in Asian pre-scientific culture and religion, and is predicated upon long-term cultivation of introspective awareness of lived experience, not highly accessible to empirical study. Further complicating the ‘science' of mindfulness, mindfulness's very definition is multifaceted, resistant to dismantling and requires substantial amounts of personal practice to gain expertise. Most scientists investigating mindfulness have not achieved (...) a high level of this expertise. Here I address how mindfulness is currently being invented as a scientific fact or object of inquiry. The intrinsic porosity of subjective and objective factors influencing the investigation of mindfulness is highlighted: the evolving body of ‘scientific' experts, instruments used to measure mindfulness, the alliances of funders and other supporters of mindfulness research, and the public representation of the related findings. (shrink)

The problem of free will has persistently resisted a solution throughout centuries. There is reason to believe that new elements need to be introduced into the analysis in order to make progress. In the present physicalist approach, these elements are emergence and information theory in relation to universal limits set by quantum physics. Furthermore the common, but vague, characterization of free will as "being able to act differently" is, in the spirit of Carnap, rephrased into an explicatum more suitable for (...) formal analysis. It is argued that the mind is an ontologically open system; a causal high-level system, the future of which cannot be reduced to the states of its associated low-level neural systems, not even if it is rendered physically closed. A positive answer to the question of free will is subsequently outlined. (shrink)

This study investigates the impact of bank digitalization on capital reallocation using the adoption of digital lending platforms and a difference-in-differences design. We find that digital transformation in banking facilitates the reallocation of capital from higher-risk to lower-risk sectors. This effect is particularly pronounced in regions with high levels of government influence and in city and rural commercial banks, which are more susceptible to government intervention. Our findings suggest that banks that implement digital platforms are better positioned to resist (...) political pressures, as the data-driven, automated decision-making processes make it difficult to justify risky, politically motivated loans, while increased transparency limits local government influence over credit allocation. The effects of digitalization on capital reallocation are further amplified in banks with opaque information environments, weak internal control, and high credit risks. Additional analyses show that the adoption of digital lending platforms improves the timeliness of loan loss recognition, reduces bank risk, and enhances operating performance. This study contributes to the literature on digitalization by highlighting its role in improving capital allocation in the banking sector and offers insights into how technological advancements can mitigate the risks posed by political intervention and high-risk lending. (shrink)

Recent advances in paleoarchaeology show why nothing in the Tate Modern, where a conference on "Agency & Automatism" took place, challenges the roots of 'the idea of the fine arts' (Kristeller) as high levels of craft, aesthetics, mimesis and mental expression, as exemplifying cultures: it is by them that we define our species. This paper identifies and deals with resistances, early and late, to photographic fine art as based on concerns about automatism reducing human agency--that is, mental expression--then offers (...) the fuller account of agency lacking in such discussions. But fine art is not the only value classification we use. (shrink)

Extremists who have been well educated in science are quite common, but nevertheless puzzling. How can individuals with high levels of scientific education fall prey to irrationalist ideologies? Implicit assumptions about rationality may lead to tremendous and conspicuous developments. When correction of social deficits is seen as a pressing problem, it is quite common that individuals conclude that some religious or political system contains the all-encompassing answer, if only it is applied with sufficiently high standards. Implicit assumptions about (...) rationally high standards often demand consistency, system and justification. The strict application of these standards to political and/or religious systems leads quite readily to extremism. J. L. Talmon has shown how the rationality of the Enlightenment led to intolerance, dictatorship and torture. The Enlightenment view of rationality can also encourage irrationalist ideologies and extremism: it leads individuals to conclude that various religions and/or political systems contain all encompassing answers, if only they are systematic, coherant and justified. Alternative theories of science and rationality, which view rationality as critical, partial, and progressive, and which seek to improve imperfect standards, can help avoid the unintended support of extremism rendered by established views of rationality. Unfortunately such theories meet enormous resistance: they call into question well-established canonical doctrines. (shrink)

Plea bargains are the stock-in-trade of the modern American prosecutor’s office. The basic scenario, wherein a defendant agrees to plea guilty in exchange for a reduced sentence, is familiar to viewers of police procedurals. In an equally famous variation on the theme, the prosecutor requests something more than an admission of guilt: leniency will only be forthcoming if the defendant is willing to cooperate with the prosecutor in securing the conviction of another suspect. In some of these cases, the defendant (...) is a low-level criminal who has information on a high-level malefactor who is of more interest to the police. In others, the defendant and the person she is asked to testify against are of the same criminal rank, but evidentiary weaknesses induce the prosecutor to seek the aid of one suspect in order to convict the other. In this latter version, the classic tactic of film detectives is to offer the bargain to both defendants in the hopes that one will crack and agree to reveal what he knows about the other. The defendants could either be in custody for different crimes or be accomplices in the same offense. -/- The last variation (involving accomplices) is the subject of this Article. I take issue with the prosecutorial tactics in these cases because of the risk they create of punishing the comparatively virtuous person more than the comparatively vicious one for the same acts. As I will argue, it is the less honest person who is more likely to accept the prosecutor’s deal, leading the more honest person, who resisted temptation, to suffer greater penalties. -/- I contend that this scenario offends distributive justice, runs counter to the idea (accepted by some) that a proper goal of the state is the cultivation of good character in the citizenry, and is perverse insofar as a person will suffer more from the prosecutor's dilemma insofar as she is more or less a person of conscience. These negative considerations notwithstanding, I do not call for the abolition of accomplice plea bargaining but argue that the problems I raise should be considered when weighing its pros and cons. -/- This article was published in the company of a strong critical response by Guha Krishnamurthi, whose contribution I greatly appreciate. (shrink)

School administrators are mandated to take the instructional leadership roles. On this premise, a study assessed the extent of instructional leadership practices of public elementary school administrators in El Salvador City Division, Philippines. Also, it explored their actual practices, challenges encountered, and the ways they overcome the challenges in practicing instructional leadership. It employed a mixed-method research design. It administered the adopted assessment tool on instructional leadership to 15 school administrators and 12 of them were involved in the individual interviews. (...) This was conducted between the last quarter of 2019 and the first quarter of 2020. Descriptive statistics were used to describe the extent of instructional leadership practices. Also, it analyzed the actual practices, the challenges encountered, and the ways of overcoming these challenges using thematic narrative analysis. Results revealed that public school administrators have always practiced the four domains or strands of instructional leadership to a very high extent. Providing the technical assistance, conducting clinical supervision, and innovating teaching and learning emerged as themes of their actual practices. These administrators had encountered challenges in dealing with teachers’ attitudes, conflicting schedules and activities, and teachers’ resistance to changes. They overcome the challenges by trying to meet the competency standards, adapting and modifying the existing programs, contextualizing teaching and learning, and inculcating the value and benefits of class observation. Looking at the findings from the lens of deliberate practice theory, it was concluded that school administrators have indicated they have acquired knowledge and a high level of understanding of their instructional leadership roles. But despite of this, they still met challenges and have tried their best to manage them. This study presented some doable and practical recommendations to the Department of Education (DepEd) and concerned offices which may benefit both the internal and external stakeholders of the schools. (shrink)

Article seeks to explain the resistance to China's agricultural collectivization movement in the relative lack of experience with the Soviet Union, by contrast, the collectivization of agriculture far encountered great social resistance. This analysis of five factors: the impact of land reform; innovative class system; social control system; the party's primary structure; legalization of words. Analysis of these factors in rural China, "climax" is an organization's success: the organizers are dense, united and effective, is scattered by the organizers, (...) subordination and standstill in space, by pointing to the success of the history of mass mobilization experience and symbolic words, both of which link up well. This paper tries to explain the relative lack of resistance during China's agricultural collectivization campaign, in contrast to the Soviet Union experience in which agricultural collectivization encountered much heavier social resistance. Five factors are analysed: the effects of the Land Reform; the innovative class system; the social control system; th basic-level Party apparatus; the legitimizing discourse. Analyses of these factors reveal that the High Tide in rural China was an organizational success: the organizers were dense, cohesive and efficient, the organized were divided, dependent and spatially paralysed, and the two were well connected through historical experiences and symbolic discourse, all of which point to the success of mass mobilization. (shrink)

Gender, sexuality and embodiment in digital spheres have been increasingly studied from various critical perspectives: From research highlighting the articulation of intimacies, desires, and sexualities in and through digital spaces to theoretical explorations of materiality in the digital realm. With such a high level of (inter)disciplinarity, theories, methods, and analyses of gender, sexuality, and embodiment in relation to digital spheres have become highly diversified. Aiming to reflect this diversity, this special issue brings together innovative and newly developed theoretical, (...) empirical, analytical, and critical approaches in the study of gender, sexuality, and embodiment in digital spheres. By connecting intersectionality and digitality to one another, it adopts an integrated approach that reflects the intricacy and interconnectedness of social categories and markers of difference, privilege, performance, and discrimination. The contributions explore a range of differently situated digital cultural practices, including intimate and sexual experiences with(in) digital media, online self-presentation, expressions of digital resistance, and forms of backlash and online attacks. What connects all these articles, is their critical approach to intersectional inequalities and privileges in relation to digitality, plus their nuanced perspective on gender, sexuality, and embodiment interferentially. The final article is based on a roundtable discussion and aims to encourage interdisciplinary connections and suggests ways of doing research that builds bridges between academia and activism. (shrink)

Staphylococcus aureus is an opportunistic pathogen capable of causing a variety of diseases including osteomyelitis, endocarditis, infections of indwelling devices and wound infections. These infections are often chronic and highly recalcitrant to antibiotic treatment. Persister cells appear to be central to this recalcitrance. A multitude of factors contribute to S. aureus virulence and high levels of treatment failure. These include its ability to colonize the skin and nares of the host, its ability to evade the host immune system and (...) its development of resistance to a variety of antibiotics. Less understood is the phenomenon of persister cells and their role in S. aureus infections and treatment outcome. Persister cells occur as a sub‐population of phenotypic variants that are tolerant to antibiotic treatment. This review examines the importance of persisters in chronic and relapsing S. aureus infections and proposes methods for their eradication. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Evangelical Peacemakers: Gospel Engagement in a War-Torn World ed. by David P. GusheeLisa Sowle CahillEvangelical Peacemakers: Gospel Engagement in a War-Torn World Edited by David P. Gushee EUGENE, OR: WIPF AND STOCK, 2013. 135 PP. $21.00This short volume collects papers from a 2012 Evangelicals for Peace conference at Georgetown University. This should not mislead potential readers as to the book's timeliness, coherence, significance, or ecumenical and interreligious appeal. (...) Much of its incisive analysis owes to the editor's preface, introductory chapter, and concluding critical discussion of the positions represented, including his own.Four chapters lay out the Christian arguments for just war, biblical pacifism, and the late Glen Stassen's "just peacemaking theory," presenting ten practices to deter or transform violent conflict. Although Gushee's chapter would have to be placed among just war theorists, he stresses that war must be a last resort to defend innocent life, carried out with the least violence possible. Gushee appreciates the paradox of expressing love through acts of violence. Lisa Sharon Harper insists this goes beyond paradox to outright denial of the redemption Jesus brings, failing to honor the image of God in all persons. Following Anglican theologian Oliver O'Donovan, Erik Patterson sees publicly authorized force to protect society as a positive Christian duty. Striving to unite these two sides in practice, Stassen derives alternative, nonviolent strategies from the Sermon on the Mount to transform conflict at the local, national, regional, and international levels.But are such efforts successful? Can and do Christian peacemakers actually bring about significant societal and political change? Twelve further chapters offer experience-based evidence from Evangelical organizations and ministries that the answer is yes. Authors describe initiatives at home and abroad, giving special attention to Christian–Muslim outreach and understanding. Examples range from Evangelical pastors and churches welcoming Muslims and mosques; to educational ventures in Pakistani madrassas; to organizing Afghan youth as "peace volunteers"; to conflict mediation in Egypt and Indonesia; and the memoir of a Lockerbie bombing victim's sister, who went personally to reconcile with Muammar Gaddafi. Sojourners editor Jim Wallis gives plenty of illustrations of the power in the United States of massive civil disobedience and efforts to pressure Congress or the president through letter and phone campaigns, protests, media attention, and high-level advocacy. Christian political resistance and mobilization can no longer be dismissed as utopian, naïve, or marginal. In many cases, it works.Gushee honestly and acutely articulates why pacifism and just war have had longstanding places in Christian political ethics, and why their adherents are [End Page 206] not easily reconciled. First, Jesus was nonviolent, and even those who construe rare and restrained violence as a form of neighbor love cannot deny that Jesus himself never expressed love in this way (121). Second, although Jesus calls disciples to participate in God's reign, that reign is but "eschatologically" present in a fallen world (119). Violence-transforming practices do not always work (125). Reconciling love may define kingdom discipleship, but when do we gauge love-in-action by the "present" reality of the kingdom, and when by the "not yet"? Third, according to Gushee, there is a difference (not separation) between church and government. This yields the conundrum that although their roles are different, Christians participate in both spheres, responsible not only for the peacemaking activities of the church but also for their social effects and for building just structures (5–6).Gushee does not claim to resolve these paradoxes. The collection underscores a more urgent challenge: to embody and expand Evangelical peacemaking as an integral dimension of discipleship and a powerful form of real-world politics. This book furthers theological-ethical analysis while leading scholars, students, and congregations to become active agents of change.Lisa Sowle CahillBoston CollegeCopyright © 2017 Society of Christian Ethics... (shrink)

This paper details the experience of planning, orchestrating, teaching, and participating in a writing-intensive, team-taught, introductory philosophy class designed to expand the diversity of voices included in philosophical study. Accordingly, this article includes the various perspectives of faculty, TAs, and students in the class. Faculty authors discuss the administrative side of the course, including its planning and goals, its texts and structure, its working definition of “philosophy,” its balance of canonical and non-canonical texts, the significant resistance met in getting (...) the course approved, the complex pedagogical difficulties that attend teaching non-canonical texts, the motivation and execution of the course’s writing-intensive dimension, and a summary of student evaluations of the course. The TA authors reflect on the high level of student engagement and interest compared to other introductory philosophy courses, the perception that students found the material highly relevant to their own lives, and the capacity of the material to bring about philosophical insight for the instructors in the class. The student author offers a favorable account of the class and remarks on how the structure of the course aided the accessibility and relevance of the texts. (shrink)

My title refers to a very modern problem, for what else is modernization than a process of rational differentiation of society in autonomous, mutually isolated sub-spheres, to the point where no one any longer knows what the unity of it all is? We differentiate, we specialize, we hyperspecialize, and then we get puzzled over the fragmentation we have produced around us, between ourselves and even within ourselves. Look at our own area. You cannot even specialize in practical ethics any more. (...) You have to limit your attention to medical ethics, for example, the ethics of engineering, or business ethics. And within business ethics, my own field of research, the homo universalis is also threatened with extinction. You can do marketing ethics, ethics of finance or computer ethics, until you finally become the typical ‘expert’: someone who knows almost everything about almost nothing.From the despair over hyper-differentiation, the call for integration arises: the call for meaning, for reconfiguration, for making sense of our world and our lives again, the call for reconnection with the great traditions of our culture, the call for community.If we read the great theorists of modernization — Weber, Durkheim, Parsons, Habermas, Münch — we learn that the quest for integration is in fact an equally important aspect of modernization as is differentiation. They are two sides of the same coin. In this sense, I think, the integrative endeavour of the EEN can still be considered a modern one.We are presently facing an escalation, or a climax, of modernity. We live in a state of hypermodernity, in which technological, economic and cultural forces dynamize our society on an unprecedented scale. We are really living high up on the dazzling slopes of the exponential growth curves that the Club of Rome predicted over 25 years ago. Everyone speaks of change. Everything is changing, and with institutionalized change, everything has become uncertain. Within uncertainty, however, social disintegration is lurking. Does not the structural uncertainty that we are introducing in our society bring us back to a state of nature, to a state outside the hypothetical social contract on which modern social communities are based? Is not the life of the individualized, flexible wanderers on the labour market again resembling the pledge of man which Hobbes described as ‘solitary, nasty and brutish’ . Has not the life of many in our society again become ‘very unsafe and very insecure, full of fears and continual dangers’, in the way that Locke depicted the state of nature .I understand business ethics as an integrative undertaking in our society, integrative in particular with respect to the economy and the realm of formal organization, integrative also at the interface between life-world and system, to use the terminology of Habermas.Integrative endeavours in our society have an ambiguous relation to change. Change is a key challenge to business ethics. Should we accept disruptive forms of change as inevitable, in order to remain on speaking terms with the economy and its spokesmen? Or should we fiercely resist certain changes? Is change on our side, perhaps? Business ethics is sometimes presented as a way to help managers cope with the many paradoxes of our time. One-dimensional technological rationality, we say, is no longer adequate to grasp the complexities, ambiguities and paradoxes of our world. Successful management requires more flexible, more creative forms of thinking. Philosophy and ethics are then presented as alternatives. But then aren’t we, the philosophers, simply promoting ourselves as the new masters of change for our time? Isn’t the so-called postmodern consciousness in fact an ideological underpinning of hyper differentiation, and in this sense the ultimate self-realization of the spirit of modernity? What sense of direction do we offer, as business ethicists?I would like to speak about the integration of micro, meso and macro-levels in business ethics, from the perspective of social change. My basic thesis is that only an adequate ethics of responsibility can integrate a highly differentiated and ultra-complex society like ours. This integration through responsibility opens up new directions of social change, that proceed simultaneously at the micro, meso and macro-level.In order not to complicate matters too much, I will limit myself to two dimensions of change which are important for business ethics at the moment: economic change ; organizational change . In relation to these changes, I will conclude with some reflections on changes in business ethics itself, the ones that I think are needed. (shrink)

The correlational study is aimed at validating theAuthenticity Scalein Russian culture. Authenticity is considered a trait responsible for a person’s ability to be oneself. It helps people resist environment pressure and prevent self-alienation, which contributes to maintaining psychological wellbeing. The original Authenticity Scale includes three subscales:Authentic Living, Accepting External Influence, andSelf-Alienation. In total, 2,188 respondents (Mage= 26.30,SDage= 13.81; 78.1% female) participated in the survey. The dimensionality of theAuthenticity Scaleand its measurement invariance across sex, age, and depression rate subgroups was examined (...) with exploratory and confirmatory factor analyses; the original tripartite structure was kept. Convergent validity was tested through correlation analyses with theWarwick-Edinburgh Mental Well-being Scale, theInternational Positive and Negative Affect Schedule Short-Form, theCentre of Epidemiological Studies-Depression Scale, theRosenberg Self-Esteem Scale, and theSatisfaction with Life Scale. According to the CFA results, the structure of the Russian version differs from the original one slightly (item 1 was moved from the subscaleAuthentic Livingto the subscaleAccepting External Influenceand item 4 was excluded); however, the modified factor model showed the best absolute and comparative fit statistics [CFI = 0.961, TLI = 0.949, RMSEA = 0.050 (90% CI [0.40; 0.60]) and SRMR = 0.037]. The reliability (McDonald’s Omega) of theAuthenticity Scalesubscales was satisfactory and ranged from 0.78 to 0.84. It was revealed that youth are more likely to have high scores onAccepting External InfluenceandSelf-Alienationthan adults. Men and women did not significantly differ on the sub-scores ofAuthenticity Scale. Multigroup CFA also showed thatAuthenticity Scalescores may be biased in people with high levels of clinical depression, in terms of the item intercepts.Authentic Livingis positively connected with mental wellbeing, self-esteem, positive affect, satisfaction with life, and negatively with depressive symptoms and negative affect; reverse trends were found forAccepting External InfluenceandSelf-Alienationsubscales. The Russian version of theAuthenticity Scaleis a valid, reliable tool that may be recommended for use in various areas of non-clinical practice. (shrink)

Effective public health responses to many infectious diseases require sustained collective action. Communicable disease control in populations can only be achieved by high levels of public compliance with health directives. However, governing authorities have limited options if public compliance is insufficient and collective action is failing. Mechanisms to promote public compliance occur on a spectrum from providing public health advice, offering incentives so people cooperate more, to enacting coercive public health orders and mandates. Because the burdens and benefits of (...) these interventions have patterned distributions across society and raise questions of fairness and legitimacy, they have ethical dimensions. Against the background of government responses to COVID-19, we draw on Amatai Etzioni’s compliance mechanisms to analyse the ethics and politics of using state power to drive collective action during public health emergencies. We show how different compliance mechanisms have been applied simultaneously and strategically and that the political and ethical impacts of their interaction warrant particular attention. When considering the adoption of compliance strategies, at the level of individuals and groups, it is important to recognise that intervention uptake will vary based on the threat faced, the characteristics of the population and communities, and local capacity to implement strategies. The use of compliance mechanisms during COVID-19 is also instructive. Significant preparatory work to enculture more restrictive social norms and high levels of public compliance must be undertaken immediately if efforts to sustain collective action against pressing global health problems such as global heating and antimicrobial resistance are to be successful. (shrink)

Following on the arguments adumbrated in his previous works, Piotr Hoffman here argues that the notion of and concern with violence are not limited to political philosophy but in fact form the essential component of philosophy in general. The acute awareness of the ever-present possibility of violence, Hoffman claims, filters into and informs ontology and epistemology in ways that require careful analysis. In his previous book, Doubt, Time, Violence , Hoffman explored the theme of violence in relation to Descartes' problematic (...) of doubt and Heidegger's work on temporality. The pivotal notion deriving from that investigation is the notion of the other as the ultimate limit of one's powers. In effect, Hoffman argues, our practical mastery of the natural environment still leaves intact the limitation of human agents by each other. In a violent environment, the other emerges as an insurmountable obstacle to one's aims and purposes or as an inescapable danger which one is powerless to hold at bay. The other is thus the focus of an ultimate resistance to one's powers. The special status of the other, as Hoffman articulates it, is at the root of several key notions around which modern philosophy has built its problematic. Arguing here that when the theme of violence is taken into account many conceptual tensions and puzzles receive satisfying solutions, Hoffman traces the theme through the issue of things versus properties; through Kant's treatment of causality, necessity, and freedom in the Critique of Pure Reason; and through the early parts of Hegel's Logic. The result is a complete reorientation and reinterpretation of these important texts. Violence in Modern Philosophy offers patient and careful textual clarification in light of Hoffman's central thesis regarding the other as ultimate limit. With a high level of originality, he shows that the theme of violence is the hidden impulse behind much of modern philosophy. Hoffman's unique stress on the constitutive importance of violence also offers a challenge to the dominant "compatibilist" tradition in moral and political theory. Of great interest to all philosophers, this work will also provide fresh insights to anthropologists and all those in the social sciences and humanities who occupy themselves with the general theory of culture. (shrink)

Akt, a protein kinase hyperactivated in many tumors, plays a major role in both cell survival and resistance to tumor therapy. A recent study,1 along with other evidences, shows interestingly, that Akt is not a single‐function kinase, but may facilitate rather than inhibit cell death under certain conditions. This hitherto undetected function of Akt is accomplished by its ability to increase reactive oxygen species and to suppress antioxidant enzymes. The ability of Akt to down‐regulate antioxidant defenses uncovers a novel (...) Achilles' heel, which could be exploited by oxidant therapies in order to selectively eradicate tumor cells that express high levels of Akt activity. (shrink)

The Democratic Republic of the Congo is facing two crises: a potentially explosive Ebola epidemic and a major insurgency. But they are not wholly distinct from each other: the first is intertwined with the second, and public mistrust and political violence add a dangerous dimension to the Ebola epidemic. The World Health Organization and other health emergency responders will increasingly find themselves fighting outbreaks in insecure, misgoverned or ungoverned zones, possibly experiencing active conflict. Yet the WHO has neither the mission (...) nor the capabilities to navigate these security threats. We cannot expect that the usual public health strategy will succeed when health workers’ lives are directly imperiled and community resistance runs deep. Tackling health emergencies amidst complex humanitarian crises requires fresh thinking. Here, we offer a blueprint for fighting diseases in complex humanitarian emergencies. The building blocks of security and trust include high‐level political support, street‐level diplomacy, community engagement, enhanced funding, and protection of health professionals working in conflict or disaster zones. (shrink)

The authors ground their reflections on gender and the complex realities of the second Palestinian intifada against Israeli occupation in the political processes unleashed by the signing of the Israeli–Palestinian rule, noting that the profound inequalities between Israel and Palestine during the interim period produced inequalities among Palestinians. The apartheid logic of the Oslo period – made explicit in Israel's policies of separation, seige and confinement of the Palestinian population during the intifada and before it – is shown to shape (...) the forms, sites and levels of resistance which are highly restricted by gender and age. In addition, the authors argue that the Palestinian Authority and leadership have solved the contradictions and crisis of Palestinian nationalism in this period through a form of rule that the authors term ‘authoritarian populism’, that tends to disallow democractic politics and participation. The seeming absence of women and civil society from the highly unequal and violent confrontations is contrasted with the first Palestinian intifada (1987–91), that occurred in a context of more than a decade of democratic activism and the growth of mass-based organizations, including the Palestinian women's movement. The authors explore three linked crises in gender roles emerging from the conditions of the second intifada: a crisis in masculinity, a crisis in paternity and a crisis in maternity. (shrink)

The nature and factors of the existence of the nation-state in the doctrine of H. Ortega y Gasset are revealed. Ortehovoyi in interpreting the nation-state is a metaphysical strength and unity of past and future, tradition and consolidating new purpose-idea alloy democratic institutions and subconscious zovu blood, land, language, mature nation. As an instrument of the nation, the nation state is a political entity that legitimizes the idea of social order and public self is an initiative of the people and (...) personality. The democratic nature of the nation-state is its indispensable advantage - it gives real grounds separate individual and values harmonious collective resist oppression. Simultaneously, the nation state is the result of integration of peoples to new historical stage of development, volitional act elite, which determine the call-idea and transform it into a state-based form of "call" world capabilities of the people. This creative process is not possible without a high level of social elasticity without close consolidate elites with public miles, without the democratic principles of cooperation, which together store representations, symbolic and real-institutional unity of the body politic of the nation, and is the key to the dichotomy of nation-state - its dynamics and statics. Thus, the concept of nation-state process of reconciliation Madrid provides citizens with the idea of a sovereign political body which defends freedom and respects their interests and concluded lifestyle. Thus, the concept of the nation state H. Ortega y Gasset is the liberal-conservative trait. It is presented as a result of historical passages mature nation and a compromise individual rights of the person will and ability of elites. (shrink)

Three thoughts of culture: (1) the logogram: high-level software, the ROM BIOS of civilisation, the ‘best that has ever been thought and written’ (Matthew Arnold), secular theology, social phylum, explicitly ideal rampart against philistine disaggregation and the entropy of commodification, desperate and universal cognitive erection in the face of the massive loss of integrity brought about by capital; (2) the decay of the logogram: low-level shoring-up routine, localised resistance mediated through patchy and fragmented attempts at reconstitution, (...) quotidian custom and regional habit nostalgically valorised at the point of their historical evaporation, instantly fit only for museums, tourists and markets; (3) the death of the logogram: evacuation of the hard-wired constraint of organic programming, reinterfacing of cognition and culture with the machine, technological reprogramming of consciousness driven by intensive economic shifts. (shrink)