Similar to parasites, cancer cells depend on their hosts for sustenance, proliferation and reproduction, exploiting the hosts for energy and resources, and thereby impairing their health and fitness. Because of this lifestyle similarity, it is predicted that cancer cells could, like numerous parasitic organisms, evolve the capacity to manipulate the phenotype of their hosts to increase their own fitness. We claim that the extent of this phenomenon and its therapeutic implications are, however, underappreciated. Here, we review and discuss what can (...) be regarded as cases of host manipulation in the context of cancer development and progression. We elaborate on how acknowledging the applicability of these principles can offer novel therapeutic and preventive strategies. The manipulation of host phenotype by cancer cells is one more reason to adopt a Darwinian approach in cancer research. -/- . (shrink)

When parasites have different interests in regard to how their host should behave this can result in a conflict over host manipulation, i.e. parasite induced changes in host behaviour that enhance parasite fitness. Such a conflict can result in the alteration, or even complete suppression, of one parasite's host manipulation. Many parasites, and probably also symbionts and commensals, have the ability to manipulate the behaviour of their host. Non‐manipulating parasites should also have an (...) interest in host behaviour. Given the frequency of multiple parasite infections in nature, potential conflicts of interest over host behaviour and manipulation may be common. This review summarizes the evidence on how parasites can alter other parasite's host manipulation. Host manipulation can have important ecological and medical consequences. I speculate on how a conflict over host manipulation could alter these consequences and potentially offer a new avenue of research to ameliorate harmful consequences of host manipulation. (shrink)

Viruses are the simplest of pathogens, but possess sophisticated molecular mechanisms to manipulate host behavior, frequently utilizing molecular mimicry. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been shown to bind to the host receptor neuropilin-1 in order to gain entry into the cell. To do this, the virus utilizes its spike protein polybasic cleavage site (PCS), which mimics the CendR motif of neuropilin-1’s endogenous ligands. In addition to facilitating cell entry, binding to neuropilin-1 has analgesic effects. We (...) discuss the potential impact of neuropilin-1 binding by SARS-CoV-2 in ameliorating sickness behavior of the host, and identify a convergent evolutionary strategy of PCS cleavage and subsequent neuropilin binding in other human viruses. In addition, we discuss the evolutionary leap of the ancestor of SARS-COV-2, which involved acquisition of the PCS thus faciliting binding to the neuropilin-1 receptor. Acquisition of the PCS by the ancestor of SARS-CoV-2 appears to have led to pleiotropic beneficial effects including enhancement of cell entry via binding to ACE2, facilitation of cell entry via binding to neuropilin-1, promotion of analgesia, and potentially the formation of decoy epitopes via enhanced shedding of the S1 subunit. Lastly, other potential neuromanipulation strategies employed by SARS-CoV-2 are discussed, including interferon suppression and the resulting reduction in sickness behavior, enhanced transmission through neurally mediated cough induction, and reduction in sense of smell. (shrink)

Endosymbiotic bacteria can directly manipulate their host's sex determination towards the production of female offspring.

Microbes in the gastrointestinal tract are under selective pressure to manipulate host eating behavior to increase their fitness, sometimes at the expense of host fitness. Microbes may do this through two potential strategies: (i) generating cravings for foods that they specialize on or foods that suppress their competitors, or (ii) inducing dysphoria until we eat foods that enhance their fitness. We review several potential mechanisms for microbial control over eating behavior including microbial influence on reward and satiety pathways, (...) production of toxins that alter mood, changes to receptors including taste receptors, and hijacking of the vagus nerve, the neural axis between the gut and the brain. We also review the evidence for alternative explanations for cravings and unhealthy eating behavior. Because microbiota are easily manipulatable by prebiotics, probiotics, antibiotics, fecal transplants, and dietary changes, altering our microbiota offers a tractable approach to otherwise intractable problems of obesity and unhealthy eating. (shrink)

Recent advances have highlighted the outstanding role of the innate immune system for instructing adaptive immunity. Translating this knowledge into successful immunotherapies like vaccines, however, has proven to be a difficult task. This essay is based on the hypothesis that immune responses are tightly scaled to the infectious threat posed by a given microbial stimulus. A meticulous immunological risk‐assessment process is therefore instrumental for eliciting well‐balanced responses and maintaining immune homeostasis. The immune system makes fine distinctions, for example, between live (...) and dead bacteria, or pathogenic and non‐pathogenic microorganisms. Here, I discuss recent evidence for some of the mechanisms underlying these distinctions and speculate on strategies for therapeutically targeting the immunological risk‐assessment machinery. (shrink)

The host actin nucleation machinery is subverted by many bacterial pathogens to facilitate their entry, motility, replication, and survival. The majority of research conducted in the past primarily focused on exploitation of a host actin nucleator, the Arp2/3 complex, by bacterial pathogens. Recently, new studies have begun to explore the role of formins, another family of host actin nucleators, in bacterial pathogenesis. This review provides an overview of recent advances in the study of the exploitation of the (...) Arp2/3 complex and formins by bacterial pathogens. Secreted bacterial effector proteins seem to manipulate the regulation of these actin nucleators or functionally mimic them to drive bacterial entry, motility and survival within host cells. An enhanced understanding of how formins are exploited will provide us with greater insight into how a fundamental eurkaryotic cellular process is utilized by bacteria and will also advance our knowledge of host‐pathogen interactions. (shrink)

Coral reefs have been challenged by the current rate and severity of environmental change that might outpace their ability to adapt and survive. Current research focuses on understanding how microbial communities and epigenetic changes separately affect phenotypes and gene expression of corals. Here, we provide the hypothesis that coral‐associated microorganisms may directly or indirectly affect the coral's phenotypic response through the modulation of its epigenome. Homologs of ankyrin‐repeat protein A and internalin B, which indirectly cause histone modifications in humans, as (...) well as Rv1988 histone methyltransferase, and the DNA methyltransferases Rv2966c, Mhy1, Mhy2, and Mhy3 found in coral‐associated bacteria indicate that there are potential host epigenome‐modifying proteins in the coral microbiome. With the ideas presented here, we suggest that microbiome manipulation may be a means to alter a coral's epigenome, which could aid the current efforts to protect coral reefs. Also see the video abstract here: https://youtu.be/CW9GbChjKM4. (shrink)

This study explores the role of metapragmatic expressions as pragmatic manipulation in a media context, with data drawn from a Chinese TV panel discussion program Tiger Talk. It argues that the program host selects MPEs to manipulate the ongoing interactions, in order to solve or prevent the actual or potential problems in the interactions. Hence, the functioning of MPEs is described as a process consisting of three stages: problem awareness, pragmatic manipulation, and problem resolution or prevention. It (...) is found that the host mainly uses five types of MPEs, i.e. performatives, commentaries, evidentials, message glosses, and stance displayers for the sake of pragmatic manipulation across the three dimensions of interactive procedure control, rapport management, and impact monitoring. The article concludes that the host’s pragmatic manipulation of the ongoing interactions, driven by both institutional and interpersonal concerns, is motivated by his institutional rights and obligations as a program manager. (shrink)

Microbes can influence host physiology and behavior in many ways. Here we review evidence suggesting that some microbes can contribute to host stress (and other microbes can contribute to increased resilience to stress). We explain how certain microbes, which we call “stress microbes,” can potentially benefit evolutionarily from inducing stress in a host, gaining access to host resources that can help fuel rapid microbial replication by increasing glucose levels in the blood, increasing intestinal permeability, and suppressing (...) the immune system. Other microbes, which we term “resilience microbes,” can potentially benefit from making hosts more resilient to stress. We hypothesize that “stress microbes” use a fast life history strategy involving greater host exploitation while “resilience microbes” use a slow life history strategy characterized by more aligned evolutionary interests with the host. In this paper, we review the evidence that microbes affect host stress and explain the evolutionary pressures that could lead microbes to manipulate host stress, discuss the physiological mechanisms that are known to be involved in both stress and microbial activity, and provide some testable predictions that follow from this hypothesis. (shrink)

Resident microorganisms, known as the microbiota, are essential for many physiological functions including protection against pathogens. Microbiota is indeed required for proper immune system development and function, and can also host-independently protect against infections. Thus, a co-constructed view of host protection involving both host and microbiota, named ’co-immunity,’ has been proposed, and the idea of an ’immunological holobiont’ has been suggested. Yet this view of co-immunity might be too limited, as experimental work has shown that the immune (...) system is involved in functions other than protection, essentially development and repair. Microbiota, through co-immunity, is thereby most likely involved in these functions, although strong evidence is currently lacking. Moreover, as our point of view is mainly host-centered, we may miss the implications of co-immunity at broader scales, including cellular and population levels. Intriguingly, co-immunity effects could be beneficial for one function and/or one level, while being detrimental for others. All these elements should be taken into consideration for microbiota manipulation, in order to avoid potentially harmful side effects. (shrink)

The gut microbiota is an important component of the human body and its immune‐modulating and metabolic activities are critical to maintain good health. Gut microbes, however, are sensitive to changes in diet, exposure to antibiotics, or infections, all of which cause transient disruptions in the microbial composition, a phenomenon known as dysbiosis. It is now recognized that microbial dysbiosis is at the root of many gastrointestinal disorders. However, the mechanisms through which bacterial dysbiosis initiates disease are not fully understood. Microbially‐derived (...) metabolites and their role in disease have also attracted significant attention. Identification of cancer‐associated bacteria and understanding the contributions of microbial metabolism in health and disease are exciting but challenging areas that will allow defining microbial biomarkers for predicting gastrointestinal disorders. Understanding the complex interactions between gut microbiota, diet, host immune system and host genetics will be critical to developing more personalized therapies and approaches to treat disease. (shrink)

Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis which has infected one third of the mankind and causes 2–3 million deaths worldwide each year. The persistence of the infection ensues from the ability of M. tuberculosis to subvert host immune responses in favor of survival and growth of mycobacteria in macrophages. The mechanisms by which M. tuberculosis manipulates the host immune system have only recently come to light. These activities are attributed to lipoarabinomannans (LAM) and their precursors (...) lipomannans (LM), two predominant glycolipids of M. tuberculosis cell wall. LM are able to skew anti‐mycobacterial immune responses into un‐protective ones, while LAM evoke immunosupression upon binding to macrophage and dendritic cell receptors specialized in binding to “self” host components. A newly emerging idea implicates plasma membrane rafts in LM and LAM signaling. Depending on acylation patterns, the glycolipids may either directly incorporate into the raft membrane via mannosylphosphatidylinositol anchors or interact with raft‐associated proteins to affect the assembly of receptor signaling complexes. BioEssays 30:943–954, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Bacterial pathogens deliver effector proteins into host cells by deploying sophisticated secretion systems. This effector translocation during host‐pathogen interactions is a prerequisite for the manipulation of host cells and organisms and is important for pathogenesis. Analyses of dynamics and kinetics of translocation, subcellular localization, and cellular targets of effector proteins lead to understanding the mode of action and function of effector proteins in host‐pathogen interplay. This review provides an overview of biochemical and genetic tools that (...) have been developed to study protein effector translocation qualitatively or quantitatively. After introducing the challenges of analyses of effector translocation during host‐pathogen interaction, we describe various methods ranging from static visualization in fixed cells to dynamic live‐cell imaging of effector protein translocation. We show the main findings enabled by the approaches, emphasize the advantages and limitations of the methods, describe recent approaches that allow real‐time tracking of effector proteins in living cells on a single molecule level, and highlight open questions in the field to be addressed by application of new methods. (shrink)

Some neurotropic enteroviruses hijack Trojan horse/raft commensal gut bacteria to render devastating biomimicking cryptic attacks on human/animal hosts. Such virus-microbe interactions manipulate hosts’ gut-brain axes with accompanying infection-cycle-optimizing central nervous system disturbances, including severe neurodevelopmental, neuromotor, and neuropsychiatric conditions. Co-opted bacteria thus indirectly influence host health, development, behavior, and mind as possible “fair-weather-friend” symbionts, switching from commensal to context-dependent pathogen-like strategies benefiting gut-bacteria fitness.

The expression of products encoded by the major histocompatibility complex (MHC) on tumor cells has recently been studied extensively. It has been found that many malignant tumor cells have their MHC antigens ‘switched‐off’ but that these antigens are re‐expressed following DNA‐mediated gene transfer, with increased tumor immunogenicity as a result and the consequence that these ‘transformed’ tumor cells are rejected in vivo.: This review will discuss approaches that have been taken to induce strong tumor‐specific immunity by the manipulation of (...) MHC expression on tumor cells. (shrink)

Big Tech companies such as Meta, the owner of Facebook, are increasingly accused of enabling human rights violations. The proliferation of toxic speech in their digital platforms has been in the background of recent episodes of mass atrocity, the most salient of which recently transpired in Myanmar and Ethiopia. The involvement of Big Tech companies in mass atrocity raises multiple normative and conceptual challenges. One is to properly conceptualize Meta’s responsibility for the circulation of toxic speech. On one view, endorsed (...) by the corporation itself, Meta can be absolved from any significant share of responsibility for these atrocities because toxic speech is the speech of some (rogue) users, hosted but neither created nor endorsed by the company; if anything, Meta is responsible for failing to anticipate and swiftly remove that speech. I will argue that this view is misleading, as it misses the underlying forces crafting toxic speech. Meta’s business model relies on what one might call the algorithmic capture of attention, which it achieves by manipulating its users and by creating an environment in which manipulative practices of some users thrive over others. This fact alone turns the company into a co-creator of toxic speech rather than a mere conduit of the toxic speech of others. As a result, it is safe to claim that Meta bears significant causal responsibility and sufficient moral responsibility for the dissemination of toxic speech, such that it justifies its inclusion in transitional justice processes and grounds its moral obligation to act in ways that advance these processes. (shrink)

Westworld tells the story of a technologically advanced theme park populated by robots referred to as hosts, who follow a script and rules that the park's operators set up for them. Alan Turing argued that machines think not because they have special powers or because they are like us. Turing's perspective is illustrated perfectly in the show's focus on the hosts. Objecting to Turing's theory, John Searle proposes a situation called the “Chinese room argument”, concluding that the man in the (...) room does not understand Chinese even though he can correctly manipulate the symbols and give output that might lead an observer to believe that the man does understand Chinese. The Maze represents consciousness, a privileged knowledge of our own thoughts, it also represents the inward journey for the hosts to reach consciousness. Once hosts are able to solve the Maze, they become truly conscious and develop their own voice. (shrink)

In The Selfish Gene, Richard Dawkins crystallized the gene's eye view of evolution developed by W.D. Hamilton and others. The book provoked widespread and heated debate. Written in part as a response, The Extended Phenotype gave a deeper clarification of the central concept of the gene as the unit of selection; but it did much more besides. In it, Dawkins extended the gene's eye view to argue that the genes that sit within an organism have an influence that reaches out (...) beyond the visible traits in that body - the phenotype - to the wider environment, which can include other individuals. So, for instance, the genes of the beaver drive it to gather twigs to produce the substantial physical structure of a dam; and the genes of the cuckoo chick produce effects that manipulate the behaviour of the host bird, making it nurture the intruder as one of its own. This notion of the extended phenotype has proved to be highly influential in the way we understand evolution and the natural world. It represents a key scientific contribution to evolutionary biology, and it continues to play an important role in research in the life sciences. The Extended Phenotype is a conceptually deep book that forms important reading for biologists and students. But Dawkins' clear exposition is accessible to all who are prepared to put in a little effort. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think. (shrink)

A central goal of contemporary cognitive science is the explanation of cognitive abilities or capacities. [Cummins 1983] During the last three decades a wide range of cognitive capacities have been subjected to careful empirical scrutiny. The adult's ability to produce and comprehend natural language sentences and the child's capacity to acquire a natural language were among the first to be explored. [Chomsky 1965, Fodor, Bever & Garrett 1974, Pinker 1989] There is also a rich literature on the ability to solve (...) mathematical problems [Greeno 1983], the ability to recognize objects visually [Rock 1983, Gregory 1970, Marr 1982], the ability to manipulate and predict the behavior of middle sized physical objects [McClosky 1983, Hayes 1985], and a host of others. (shrink)

Feasting on a plethora of social media platforms, news aggregators, and online marketplaces, recommender systems (RSs) are spreading pervasively throughout our daily online activities. Over the years, a host of ethical issues have been associated with the diffusion of RSs and the tracking and monitoring of users’ data. Here, we focus on the impact RSs may have on personal autonomy as the most elusive among the often-cited sources of grievance and public outcry. On the grounds of a philosophically nuanced (...) notion of autonomy, we illustrate three specific reasons why RSs may limit or compromise it: the threat of manipulation and deception associated with RSs; the RSs’ power to reshape users’ personal identity; the impact of RSs on knowledge and critical thinking. In our view, however, notwithstanding these legitimate concerns, RSs may effectively help users to navigate an otherwise overwhelming landscape. Our perspective, therefore, is not to be intended as a bulwark to protect the _status quo_ but as an invitation to carefully weigh these aspects in the design of ethically oriented RSs. (shrink)

We are mastering engineering behaviour on a molecular level. A growing number of researches investigating the relationship between microbiota, human brain and behaviour examine the impacts of manipulating specific microbial colonies in human hosts. To enable discussing and understanding communicational phenomena that occur in scales not visible to the naked eye, we propose the term Molmedia – a metaphorical reference to the concept of mole, denoting here not exclusively the quantitative amount of substance but the information exchange processes (taking the (...) substances as messages) that are going on at elementary entities level such as atomic, subatomic and molecular, within a given system that can be a living organism. We take media (plural of medium) as an intervening agency, means or instrument. Interacting emitters and receivers in this system are the microbiota and the organism actual cells. Within this self-organizing structure, the ongoing informational processes produce, as an emergence, the self and behavioral patterns that can be appreciated, manipulated and cannibalized. The art and science installation Transplanting the Self: Microbiome Anthropophagy is presented as an explorative exercise of the concept and related possibilities in science concerning gut–brain communication and the use of neuroregenerative nutrition in treatments for neurologic conditions. (shrink)

The CRISPR-Cas systems of bacterial and archaeal adaptive immunity have become a household name among biologists and even the general public thanks to the unprecedented success of the new generation of genome editing tools utilizing Cas proteins. However, the fundamental biological features of CRISPR-Cas are of no lesser interest and have major impacts on our understanding of the evolution of antivirus defense, host-parasite coevolution, self versus non-self discrimination and mechanisms of adaptation. CRISPR-Cas systems present the best known case in (...) point for Lamarckian evolution, i.e. generation of heritable, adaptive genomic changes in response to encounters with external factors, in this case, foreign nucleic acids. CRISPR-Cas systems employ multiple mechanisms of self versus non-self discrimination but, as is the case with immune systems in general, are nevertheless costly because autoimmunity cannot be eliminated completely. In addition to the autoimmunity, the fitness cost of CRISPR-Cas systems appears to be determined by their inhibitory effect on horizontal gene transfer, curtailing evolutionary innovation. Hence the dynamic evolution of CRISPR-Cas loci that are frequently lost and acquired by archaea and bacteria. Another fundamental biological feature of CRISPR-Cas is its intimate connection with programmed cell death and dormancy induction in microbes. In this and, possibly, other immune systems, active immune response appears to be coupled to a different form of defense, namely, “altruistic” shutdown of cellular functions resulting in protection of neighboring cells. Finally, analysis of the evolutionary connections of Cas proteins reveals multiple contributions of mobile genetic elements to the origin of various components of CRISPR-Cas systems, furthermore, different biological systems that function by genome manipulation appear to have evolved convergently from unrelated MGE. The shared features of adaptive defense systems and MGE, namely the ability to recognize and cleave unique sites in genomes, make them ideal candidates for genome editing and engineering tools. (shrink)

The guard-guardee model for plant immunity describes how resistance proteins in host cells monitor host target proteins that are manipulated by pathogen effector proteins. A recently suggested extension of this model includes decoys, which are duplicated copies of guardee proteins, and have the sole function to attract the effector and, when modified by the effector, trigger the plant immune response. Here we present a proof-of-principle model for the functioning of decoys in plant immunity, quantitatively developing this experimentally derived (...) concept. Our model links the basic cellular chemistry to the outcomes of pathogen infection and resulting fitness costs for the host. In particular, the model allows identification of conditions under which it is optimal for decoys to act as triggers for the plant immune response, and of conditions under which it is optimal for decoys to act as sinks that bind the pathogen effectors but do not trigger an immune response. (shrink)

Immune cells are highly dynamic in their response to the tissue environment. Most immune cells rapidly change their metabolic profile to obtain sufficient energy to engage in defensive or homeostatic processes. Such “immunometabolism” is governed through intermediate metabolites, and has a vital role in regulating immune‐cell function. The underlying metabolic reactions are shaped by the abundance and accessibility of specific nutrients, as well as the overall metabolic status of the host. Here, we discuss how different immune‐cell types gain a (...) sufficient energy supply. We then explain how immune cells perform various functions under challenged conditions and expend energy to sustain homeostasis. Finally, we speculate on how the immune‐cell metabolic profile might be modulated in health and disease, by manipulating nutrient availability. By such intervention, the recovery of patient with dysregulated immune system responses might be sped up and the fitness of an individual efficiently restored. (shrink)

Arguments about whether a robot could ever be conscious have been conducted up to now in the factually impoverished arena of what is possible "in principle." A team at MIT of which I am a part is now embarking on a longterm project to design and build a humanoid robot, Cog, whose cognitive talents will include speech, eye-coordinated manipulation of objects, and a host of self-protective, self-regulatory and self-exploring activities. The aim of the project is not to make (...) a conscious robot, but to make a robot that can interact with human beings in a robust and versatile manner in real time, take care of itself, and tell its designers things about itself that would otherwise be extremely difficult if not impossible to determine by examination. Many of the details of Cog's "neural" organization will parallel what is known (or presumed known) about their counterparts in the human brain, but the intended realism of Cog as a model is relatively coarse-grained, varying opportunistically as a function of what we think we know, what we think we can build, and what we think doesn't matter. Much of what we think will of course prove to be mistaken; that is one advantage of real experiments over thought experiments. (shrink)

The unexpected roles of the microbiota in cancer challenge explanations of carcinogenesis that focus on tumor-intrinsic properties. Most tumors contain bacteria and viruses, and the host’s proximal and distal microbiota influence both cancer incidence and therapeutic responsiveness. Continuing the history of cancer–microbe research, these findings raise a key question: to what extent is the microbiota relevant for clinical oncology? We approach this by critically evaluating three issues: how the microbiota provides a predictive biomarker of cancer growth and therapeutic responsiveness, (...) the microbiota’s causal role(s) in cancer development, and how therapeutic manipulations of the microbiota improve patient outcomes in cancer. Clarifying the conceptual and empirical aspects of the cancer-associated microbiota can orient future research and guide its implementation in clinical oncology. (shrink)

A recent thought‐provoking theory argues that complex organisms using epigenetic information for their normal development and functioning must irreversibly age as a result of epigenetic signal loss. Importantly, the scope of this theory could be considerably expanded, with scientific benefits, by analyzing epigenetic ageing beyond the borders of the Tree of Life. Viruses that use epigenetic signals for their normal functioning may also age, that is, present an increasing risk of failing to complete their individual life cycle and to disappear (...) with time. As viruses are ancient, abundant, and infect a considerable diversity of hosts, the ageing virus hypothesis, if verified, would have important consequences for many fields of the Life sciences. Uncovering ageing viruses would integrate the most abundant and biologically central entities on Earth into theories of ageing, enhance virology, gerontology, evolutionary biology, molecular ecology, genomics, and possibly medicine through the development of new therapies manipulating viral ageing. (shrink)

The virtual has become the latest rostrum for ideological heteronormativity; it increasingly plays host to an insidious rhetoric of unjustifiably fixed and oppositional gender binaries that exhort heterosexuality as a norm. Conservative political and religious groups, as well as consumerist advertising, utilise digital technology to reinforce cast-in-stone and adversarial social perspectives for manipulative and exploitative ends. Contrastingly, the virtual may be mobilised to support and facilitate queering in contemporary societies and may positively counter such fixed ideological heteronormative categories of (...) social life. Crucial in this transformative account of the virtual is the body, which is for Merleau-Ponty the horizon of engagement with the world as a condition for perception and performativity. Queer perspectives may, in turn, overcome the oversight of Merleau-Ponty (as critically suggested by Judith Butler and Iris Marion Young) regarding the specific gendered characteristics of the body itself, and allows for an expanded embodied and queer conceptualisation of the virtual. A transformative vision of the virtual entails therefore a rethinking of our understanding of digital technology through (a) the phenomenology of the body-subject and (b) queer theory. I argue that the idea of the body as entirely discursive or performative (per queer theory) needs to be adjusted by explicating the foundational ontological characteristics of the body-subject’s encounter of the virtual. (shrink)

Severe acute respiratory syndrome‐coronavirus (SARS‐CoV)‐2′s origin is still controversial. Genomic analyses show SARS‐CoV‐2 likely to be chimeric, most of its sequence closest to bat CoV RaTG13, whereas its receptor binding domain (RBD) is almost identical to that of a pangolin CoV. Chimeric viruses can arise via natural recombination or human intervention. The furin cleavage site in the spike protein of SARS‐CoV‐2 confers to the virus the ability to cross species and tissue barriers, but was previously unseen in other SARS‐like CoVs. (...) Might genetic manipulations have been performed in order to evaluate pangolins as possible intermediate hosts for bat‐derived CoVs that were originally unable to bind to human receptors? Both cleavage site and specific RBD could result from site‐directed mutagenesis, a procedure that does not leave a trace. Considering the devastating impact of SARS‐CoV‐2 and importance of preventing future pandemics, researchers have a responsibility to carry out a thorough analysis of all possible SARS‐CoV‐2 origins. (shrink)

Nanotechnology is science and engineering resulting from the manipulation of matter’s most basic building blocks: atoms and molecules. As such, nanotechnology promises unprecedented control over both the materials we use and the means of their production. Such control could revolutionize nearly every sector of our economy, including medicine, defense, and energy. Despite the relatively recent emergence of this field, it already enjoys generous federal funding and enthusiastic media coverage. The tenor of discourse on nanotechnology is changing, however, as the (...) voices of critics begin to sound about a host of concerns ranging from the societal impacts of improving human performance to the specter of environmental devastation and human disease. (shrink)

This PhD dissertation examines the conceptual and theoretical foundations of the most general and most widely used framework for understanding social evolution, W. D. Hamilton's theory of kin selection. While the core idea is intuitive enough (when organisms share genes, they sometimes have an evolutionary incentive to help one another), its apparent simplicity masks a host of conceptual subtleties, and the theory has proved a perennial source of controversy in evolutionary biology. To move towards a resolution of these controversies, (...) we need a careful and rigorous analysis of the philosophical foundations of the theory. My aim in this work is to provide such an analysis. I begin with an examination of the concepts behavioural ecologists employ to describe and classify types of social behaviour. I stress the need to distinguish concepts that are often conflated: for example, we need to distinguish simple cooperation from collaboration in collective tasks, behaviours from strategies, and control from manipulation and coercion. I proceed from here to the formal representation of kin selection via George R. Price’s covariance selection mathematics. I address a number of interpretative issues the Price formalism raises, including the vexed question of whether kin selection theory is ‘formally equivalent’ to multi-level selection theory. In the second half of the dissertation, I assess the uses and limits of Hamilton’s rule for the evolution of social behaviour; I provide a precise statement of the conditions under which the rival neighbour-modulated fitness and inclusive fitness approaches in contemporary kin selection theory are equivalent (and describe cases in which they are not); and I criticize recent formal attempts to establish the controversial claim that kin selection leads to organisms behaving as if maximizing their inclusive fitness. (shrink)

In 1997, I introduced the concept and the phrase “bio art”, originally in relation to my artwork “Time Capsule”. This work approached the problem of wet interfaces and human hosting of digital memory through the implantation of a microchip. The work consisted of a microchip implant, seven sepia-toned photographs, a live television broadcast, a webcast, interactive telerobotic webscanning of the implant, a remote database intervention, and additional display elements, including an X-ray of the implant. While “bio art” is applicable to (...) a large gamut of in vivo works that employ biological media, made by myself and others, in 1998, I started to employ the more focused term “transgenic art”. Republished in Ars Electronica ‘99—Life Science, ed. Gerfried Stocker and Christine Schopf, 289–296.) to describe a new art form based on the use of genetic engineering to create unique living beings. Art that manipulates or creates life must be pursued with great care, with acknowledgment of the complex issues it raises and, above all, with a commitment to respect, nurture, and love the life created. I have been creating and exhibiting a series of transgenic artworks since 1999. I have also been creating bio art that is not transgenic. The implications of this ongoing body of work have particular esthetic and social ramifications, crossing several disciplines and providing material for further reflection and dialog. What follows is an overview of theses works, the issues they evoke, and the debates they have elicited. (shrink)

Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation. This is a result of historical concept of the gene which was also the main assumption of the ENCODE project designed to identify all functional elements in the human genome sequence. However, the theoretical core concept changed dramatically. The old concept of genetic sequences which can be assembled and manipulated like molecular bricks has problems in explaining the natural genome-editing competences (...) of viruses and RNA consortia that are able to insert or delete, combine and recombine genetic sequences more precisely than random-like into cellular host organisms according to adaptational needs or even generate sequences de novo. Increasing knowledge about natural genome editing questions the traditional narrative of mutations (error replications) as essential for generating genetic diversity and genetic content arrangements in biological systems. This may have far-reaching consequences for our understanding of artificial genome editing. (shrink)

The term ‘hypocrisy’ is said to derive from the Greek words ‘hupokrasis’ and ‘hupokrinesthai’, the former meaning ‘acting a part’, and the latter meaning ‘to act on a stage’. The element of play-acting reflects how the phenomenon of moral hypocrisy is commonly understood within philosophy. According to one long-standing tradition, hypocrites are those who advocate moral principles that do not reflect their underlying commitments, and who do so in order to mislead or manipulate others. A second tradition parts ways from (...) the long-standing association between hypocrisy and pretence, however, and understands hypocrisy primarily in terms of exception-seeking. The latter family of views takes hypocrites to be those who apply moral standards to others that they do not apply to themselves. The different elements of hypocrisy that each tradition emphasises is a testament to the multifaceted nature of the phenomenon, whose complexity raises a host of philosophical questions. Among those questions that have attracted the attention of philosophers are whether hypocrisy must be intentional, what explains its moral undesirability, and whether it is always criticisable. (shrink)

Free-will incompatibilism has become a motte-and-bailey doctrine (Shackel 2014), and is currently being maintained by standard motte-and-bailey strategies. In this paper, I explain why incompatibilism has a motte-and-bailey structure and why philosophers who do not aim to dismantle it are complicit in both the maintenance of this problematic doctrine and the normalization of a host of bad practices engaged in by those who actively exploit it. To solidify the diagnosis, I provide a paradigmatic motte-and-baileying case that has been ongoing (...) for over a decade. Specifically, I discuss how motte-and-baileying has generated widespread confusion surrounding the logical structure and conclusion of manipulation arguments. Even more specifically, I look at Mele's so-called "Zygote Argument for incompatibilism". I point out that Mele currently conflates under two distinct arguments with different logical forms and substantively different conclusions under that heading, and explain how this has needlessly impeded progress in the free-will debate. The original variant of the Zygote Argument was invalid because it aimed to establish that determinism precludes (destroys, undermines, is antagonistic to) free will, but its supported a far weaker non-explanatory conclusion. In direct response to this invalidity objection, Mele took his critic's suggestion to change the conclusion of his argument to the thesis that free will and determinism are perhaps spuriously associated -- but he also covertly changed his preferred definition of 'incompatibilism' to pick out the non-explanatory conclusion of the new variant of the Zygote Argument which allowed him to continue speaking AS IF his argument was still an argument for incompatibilism according to his original definition of 'incompatibilism'. It is not simply that Mele made these changes or that he failed to mention in print that he made them (despite having over a decade to do so), but that he has actively attempted to discredit his critics by insisting--contrary to fact--that those who do not use his negative definition of 'incompatibilism' are using the term in a nonstandard and nontraditional way that he has "never had any use for" and there is some kind of connection (which he does describe) between the invalidity objection to his original argument that the definition of 'incompatibilism' one prefers. Oddly, Mele has mentioned only one "invalidity objection" in print, but this objection is direct at the revised Zygote Argument--even though no one had ever pressed an invalidity objection to his new argument (the form of which is patently valid). As a direct result of Mele's evasive behaviors (covertly redefining jargon to cover changes to the form/conclusion of his argument), many people--including Mele's own former graduate students--have published articles in which they fail to recognize that Mele changed his argument and redefined terms, thereby perpetuating the false narrative that the new Zygote Argument has the same "incompatibilist" conclusion as the original (which, notably, had the same conclusion as its predecessor, Pereboom's Four-Case Argument). Moreover, Mele has not even ONCE corrected those who "misdescribe" his revised argument as concluding that determinism is antagonstic to (precludes, undermines, rules out, etc.) free will. For example, Mele never corrects those who mistakenly claim that the revised Zygote Argument has the same "incompatibilist" conclusion as Pereboom's, nor has Mele ever mentioned that he now defines the term 'incompatibilism' differently than Pereboom--since Pereboom since uses this term to refer to the explanatory conclusion of the original Zygote Argument, which had the same explanatory conclusion of his Four-Case Argument. To further throttle his critics, Mele has obliquely suggested that the invalidity objection to his original Zygote Argument works only if one accepts his critic's idiosyncratic definition of 'incompatibilism' -- a patently false charge (since the term 'incompatibilism' doesn't even appear in his arguments) and one that has needlessly confused his audience. Indeed, other philosophers have now made this false and quite indefensible accusation explicitly in print, thereby helping Mele and others to continue motte-and-baileying with impunity. I close by preemptively responding to strategies commonly used by motte-and-bailey apologists to suppress legitimate criticisms of their equivocation and well-poisoning strategies (e.g. "Philosophers are allowed to define their technical terms however they like" and "the motte/bailey divide is a distinction without a difference") which have hitherto kept their philosophical audience from participating in a legitimate discussion about why tracking the distinction between the the "motte" thesis (a negative, arguably spurious association claim) and the "bailey" thesis (a positive explanatory claim) is not trivial, but is instead one that is absolutely essential to making progress in the free-will debate. Of course, a single critic cannot (almost by definition) undermine a motte-and-bailey doctrine once it has been established. As such, even if every diagnosis in this essay is accurate, it will not change the discourse. The motte-and-baileying will continue, and the debate will remain in needless deadlock, until a critical threshold of OBSERVERS learn about the motte/bailey distinction and ask apologists for motte-and-bailey incompatibilism to stop their motte-and-baileying. -/- Manuscript available upon request, plz gmail me: kristin.mickelson.42@. (shrink)

Problems are raised with the global workspace hypothesis of consciousness, for example about exactly how global the workspace needs to be for consciousness to suddenly be present. Problems are also raised with Carruthers’s (2019) version that excludes conceptual (categorical or discrete) representations, and in which phenomenal consciousness can be reduced to physical processes, with instead a different levels of explanation approach to the relation between the brain and the mind advocated. A different theory of phenomenal consciousness is described, in which (...) there is a particular computational system involved in which Higher Order Syntactic Thoughts are used to perform credit assignment on first order thoughts of multiple step plans to correct them by manipulating symbols in a syntactic type of working memory. This provides a good evolutionary reason for the evolution of this kind of computational module, with which, it is proposed, phenomenal consciousness is associated. Some advantages of this HOST approach to phenomenal consciousness are then described with reference not only to the global workspace approach, but also to Higher Order Thought (HOT) theories. It is hypothesized that the HOST system which requires the ability to manipulate first order symbols in working memory might utilize parts of the prefrontal cortex implicated in working memory, and especially the left inferior frontal gyrus, which is involved in language and probably syntactical processing. Overall, the approach advocated is to identify the computations that are linked to consciousness, and to analyze the neural bases of those computations. (shrink)

Over many centuries, the homing pigeon has been selectively bred for returning home from a distant location. As a result of this strong selective pressure, homing pigeons have developed an excellent spatial navigation system. This system passes through the hippocampal formation, which shares many striking similarities to the mammalian hippocampus; there are a host of shared neuropeptides, interconnections, and its role in the storage and manipulation of spatial maps. There are some notable differences as well: there are unique (...) connectivity patterns and spatial encoding strategies. This review summarizes the comparisons between the avian and mammalian hippocampal systems, and the responses of single neurons in several general categories: location and place cells responding in specific areas, path and goal cells responding between goal locations, context-dependent cells that respond before or during a task, and pattern, grid, and boundary cells that increase firing at stable intervals. Head-direction cells, responding to a specific compass direction, are found in mammals and other birds but not to date in pigeons. By studying an animal that evolved under significant adaptive pressure to quickly develop a complex and efficient spatial memory system, we may better understand the comparative neurology of neurospatial systems, and plot new and potentially fruitful avenues of comparative research in the future. (shrink)

Arguments that cognition or minds can be extended regularly invoke an analogy with Dawkins’ argument that phenotypes can be extended. I argue that there are two neglected ways in which those two boundary-breaking theses are complementary. Much of the argument of The Extended Phenotype concerns parasite phenotypes expressed in the behaviour of host organisms. But the options Dawkins considers for this extended manipulation are cognitively internalist. If we view cognition as extended, we can recognise a wider range of (...) vulnerabilities for exploitation. On the other hand, the analogies drawn with Dawkins almost always emphasise the benefit to the individual agent in being cognitively extended. Taking Dawkins’ concerns about manipulation and exploitation more seriously leads to a more contested, less optimistic picture of extended cognition and minds. This second line of thinking follows Sterelny’s lead, but I argue that hostility presents worse and more pervasive problems that he allows. (shrink)

While niche construction theory locates animal artefacts in their constructors’ environment, hence treating them as capable of exerting selective pressure on both the constructors and their descendants, the extended phenotype concept assimilates artefacts with their constructors’ genes. Analogous contrasts apply in the case of endoparasite and brood parasite genes influencing host behaviour. The explanatory power of these competing approaches are assessed by re-examining the core chapters of Richard Dawkins’ _The Extended Phenotype_. Because animal artefacts have multiple evolutionary consequences for (...) their constructors, the extra-body effects of a gene seemingly include feedback effects on multiple other genes, a result which is more consistent with niche construction theory than with selfish gene theory. In the case of endoparasite genes influencing host behaviour, Dawkins’ argument leaves out what appears to be the key explanatory component, namely the role of the host’s own bodily systems in making it possible for such genes to exist. For action at a distance, it is unclear whether the key genes have extended effects because they sit in the body of the manipulating organism, or alternatively do not have such effects because they sit in the body of its victim. It is argued that niche construction theory offers a superior explanation in all three cases, regardless of whether the extended phenotype concept is interpreted in selfish gene or selfish organism terms. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Holding Doctors Responsible at Guantánamo*Nancy Sherman (bio)I recently visited the Guantánamo Bay Detention Center with a small group of civilian psychiatrists, psychologists, top military doctors, and Department of Defense health affairs officials to discuss detainee medical and mental health care. The unspoken reason for the invitation to go on this unusual day trip was the bruising criticism the Bush administration has received for its use of psychiatrists and psychologists (...) in the interrogation of suspected terrorist detainees.1We disembarked from our Navy jet to find an island lush and green from recent storms. A small boat took us from the airfield to the naval hospital. From the boat there was no sign of Camp Delta, where the detainees are actually held. Nor was there a sign of prisons or barbed wire or the detention facility's 505 inmates.Our host was the commanding officer of Gitmo, Major General Jay W. Hood (an artillery officer by training), who had replaced Major General Geoffrey Miller, implicated in the "migration" of torture methods from Gitmo to Abu Ghraib. Dressed in fatigues, General Hood briefed us using PowerPoint. His intelligence director told us that interrogators have not used harsh "fear up" tactics—the ones designed to terrify—since 2003.We went by bus from the naval hospital to the 30-bed detainee hospital for quick briefings from a psychiatrist and a physician. Still, we were not permitted to see any detainees or hunger strikers, despite our requests. During our six hours on the ground, we had only a fleeting glimpse of a few detainees outside their cellblocks behind barbed wire and screened fences.Indeed, when I got home and saw the play "Guantánamo: Honor Bound to Defend Freedom," by Victoria Brittain and Gillian Slovo, I had the disquieting feeling that I had absorbed more about detainee life at the theater than I had from actually being at Gitmo. This only amplified my anxiety that what I had heard and seen during my VIP visit sidestepped the central moral issue of whether abuse is still occurring at Gitmo and whether health professionals are, or have been, a party to coercive interrogation. [End Page 199]The question that the Pentagon leadership has been focusing on, and which was a key subject of discussion during our day at Gitmo, is whether there is an ethical difference between using psychologists or psychiatrists on interrogation teams—what the Pentagon calls, "behavioral consultation teams," or BSCTs, pronounced "biscuit." Some in the Pentagon would like to have doctors and psychiatrists, who are bound by the Hippocratic teaching to "do no harm," be the clinicians treating detainees. Psychologists, who are not as bound by Hippocratic dicta, would consult with and advise interrogators. But this is a red herring. It is hair-splitting that detracts from the real issue of whether health professionals of any stripe can ethically be involved in interrogations that may involve coercive techniques or torture. The answer is clearly no. They should not be involved, directly or indirectly, in situations that may lead to the breach of confidential medical records; to torture or to cruel, inhumane, and degrading treatment; or to exploitation of fears or phobias. Mental health professionals simply should not be collaborating with interrogators in inflicting psychological torture.Hood said that "rapport building" was the preferred and an effective interrogation technique, but that is no guarantee that rougher tactics will not be used. The fact is that there is enormous pressure on the people at Guantánamo Bay to get good intelligence for the war on terror, and it is as easy for behavioral scientists as it is for interrogators to compromise their moral standards. Cunning and deception to extract information may be acceptable in some cases. But many people have been outraged to learn from media reports that methods developed by military psychologists to train our own troops to resist torture—the so-called "survival, evasion, resistance, and escape" methods taught at Ft. Bragg—have been "reverse engineered" at Guantánamo Bay to create coercive, psychologically manipulative interrogation techniques for use against detainees.Plato warned long ago that a doctor's skill, abstracted from good character and wisdom, is a neutral... (shrink)

Recent developments in artificial intelligence—AI--have caused considerable discussion among both philosophers of technology and psychotherapists. In particular, the question of whether or not new forms of AI will complement or even replace traditional psychotherapists has emerged as a major contemporary debate. This debate is not entirely new, as it has its origins in the Turing Test of 1950, and an early psychotherapy chatbot named Eliza, developed in 1966 at MIT. However, recent developments in AI technology, coupled with long waiting lists (...) and variable access to psychotherapists have raised the question of machine psychotherapists in an urgent manner. Already, there are psychotherapy apps that one can download onto a standard smartphone and use in lieu of a human psychotherapist. In the near future, this simulacrum of a human therapist may be enhanced by the use of android therapists, programed to duplicate the knowledge and behavior of human therapists instantly, appealing to convenience or self-gratification through technology. This raises a host of ethical questions: can such beings be equally effective, and if so, ought we to reason in a consequentialist manner in their favor so as to increase accessibility and reduce costs through technology? Would there be a psychological difference between automated and potentially anthropomorphic therapy and genuine human therapy, if only a subtle one? Even if a chatbot or robot therapist is transparently such, is there an element of emotional manipulation and potential dishonesty in this interaction? Can the security of clients and their data be thus secured? I will argue that key aspects of chatbot psychotherapy present major ethical and clinical challenges in these areas, although transparent forms of it should not be legally banned. Keywords: chatbots, technological momentum, automation, psychotherapy, trust, anthropomorphism, data. (shrink)

This essay studies Genesis 12:10–13:2 with a literary close reading approach that takes seriously the text’s literary, historical and theological constituent elements. After a brief history of interpretation, it situates the narrative in its historical context, which is followed with a narrative critical reading of the text. The analysis of the text unveils the dissimulations of Abram, who manipulated his wife, Sarai, into thinking her beauty posed a threat to him, while his primary motive rested with the pursuit of economic (...) gain in the face of the severe famine that had impoverished him in Canaan. Abram also succeeded in making Pharaoh believe that Sarai was his sister, on which account he exchanged her for material again. This analysis affords insight into the insecurity, anxiety, feelings of alterity of immigrant populations in their liminal conditions, the mistrust of immigrants by the state and host communities, and the ensuing power play with its concomitant perils. Through these, the passage speaks anew to contemporary communities of faith in view of the prevalent and ever-increasing migratory trends of the 21st century. (shrink)

The CRISPR-Cas systems of bacterial and archaeal adaptive immunity have become a household name among biologists and even the general public thanks to the unprecedented success of the new generation of genome editing tools utilizing Cas proteins. However, the fundamental biological features of CRISPR-Cas are of no lesser interest and have major impacts on our understanding of the evolution of antivirus defense, host-parasite coevolution, self versus non-self discrimination and mechanisms of adaptation. CRISPR-Cas systems present the best known case in (...) point for Lamarckian evolution, i.e. generation of heritable, adaptive genomic changes in response to encounters with external factors, in this case, foreign nucleic acids. CRISPR-Cas systems employ multiple mechanisms of self versus non-self discrimination but, as is the case with immune systems in general, are nevertheless costly because autoimmunity cannot be eliminated completely. In addition to the autoimmunity, the fitness cost of CRISPR-Cas systems appears to be determined by their inhibitory effect on horizontal gene transfer, curtailing evolutionary innovation. Hence the dynamic evolution of CRISPR-Cas loci that are frequently lost and acquired by archaea and bacteria. Another fundamental biological feature of CRISPR-Cas is its intimate connection with programmed cell death and dormancy induction in microbes. In this and, possibly, other immune systems, active immune response appears to be coupled to a different form of defense, namely, “altruistic” shutdown of cellular functions resulting in protection of neighboring cells. Finally, analysis of the evolutionary connections of Cas proteins reveals multiple contributions of mobile genetic elements to the origin of various components of CRISPR-Cas systems, furthermore, different biological systems that function by genome manipulation appear to have evolved convergently from unrelated MGE. The shared features of adaptive defense systems and MGE, namely the ability to recognize and cleave unique sites in genomes, make them ideal candidates for genome editing and engineering tools. (shrink)

Plants have evolved systems analogous to animal innate immunity that recognise pathogen‐associated molecular patterns (PAMPs). PAMP detection is an important component of non‐host resistance in plants and serves as an early warning system for the presence of potential pathogens. Binding of a PAMP to the appropriate pattern recognition receptor leads to downstream signalling events and, ultimately, to the induction of basal defence systems. To overcome non‐host resistance, pathogens have evolved effectors that target specific regulatory components of the basal (...) defence system. In turn, this has led to the evolution in plants of cultivar‐specific resistance mediated by R proteins, which guard the targets of effectors against pathogen manipulation; the arms race continues. BioEssays 28: 880–889, 2006. © 2006 Wiley periodicals, Inc. (shrink)

Human DNA can be cloned as yeast artificial chromosomes (YACs), each of which contains several hundred kilobases of human DNA. This DNA can be manipulated in the yeast host using homologous recombination and yeast selectable markers. In relatively few steps it is possible to make virtually any change in the cloned human DNA from single base pair changes to deletions and insertions. In order to study the function of the cloned DNA and the effects of the changes made in (...) the yeast, the human DNA must be transferred back into mammalian cells. Recent experiments indicate that large genes can be transferred from the yeast host to mammalian cells in tissue culture and that the genes are transferred intact and are expressed. Using the same methods it may soon be possible to transfer YAC DNA into the mouse germ line so that the expression and function of genes cloned in YACs can be studied in developing and adult mammalian animals. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Trungpa's Barbarians and Merton's Titan:Resuming a Dialogue on Spiritual EgotismSteven R. ShippeeA Dialogue Begun: The Meeting of Chögyam Trungpa and Thomas MertonMuch of the dialogue on the spiritual life between Buddhists and Christians has centered on two locations in the United States. The first is Naropa Institute (now University) in Boulder, Colorado. This institution was founded in 1974 by Chögyam Trungpa, a Tibetan master and lineage holder of both (...) the Nyingma and Kagyü traditions, two of the four major schools of Tibetan Buddhism. Under Trungpa's guidance, Naropa hosted an important series of Buddhist-Christian contemplative dialogues in the 1980s.1 A second significant place is Gethsemani Abbey in Kentucky, the Trappist monastery that became home to Thomas Merton in 1941. Since 1996, and through the efforts of several of the same people who had worked on the Naropa dialogues, the abbey has hosted three interreligious "encounters" sponsored by the Monastic Interreligious Dialogue.2An important link between these dialogues, as well as the initial inspiration for the first of them,3 is the meeting of the two men most famously associated with each of the hosting institutions, Trungpa and Merton. As many of their respective readers know, the two men met in Calcutta on 19 October 1968, and spent several days together.4 This contact was very stimulating to them both and seemed the beginning of a deep friendship. Merton was so impressed with Trungpa that he immediately determined to visit Trungpa's new monastery in Scotland. Trungpa later said, "Meeting Thomas Merton was wonderful,"5 and that he felt he "was meeting an old friend, a genuine friend."6 Despite the brevity of their relationship, during his last talk on 10 December, Merton said he likewise considered Trungpa "a good friend."7 Later that same day, their friendship and dialogue were terminated by Merton's death. Not two months had passed since the meeting in Calcutta. Trungpa called Merton's death "a tremendous loss, to me personally and to the world of genuine spirituality."8Judith Simmer-Brown has provided the fullest picture thus far of the relationship between Trungpa and Merton.9 One of the facts that most intrigues Trungpa's [End Page 109] followers is his own recollection, shared with participants at the third Naropa dialogue, that the two discussed what he called "spiritual materialism" (his most common phrase for spirituality co-opted by ego) at some length over dinner and drinks.10 This article picks up where that recollection leaves off. While we do not know more about the specific content of that discussion, we do have a body of writings from each man on topics relating to the quest and pitfalls of authentic spirituality. A comparative analysis of these proves worthwhile, as further elucidation of what made possible their meeting of the minds and the immediate affection they felt for each other, and certainly as wisdom that still has the power to deepen our spiritual experience today by exposing the manipulations and deceptions to which ego11 subjects even our noblest spiritual aspirations.The challenges to authentic spiritual life were major concerns for both Trungpa and Merton, a leitmotif that characterized almost all of their respective teachings and written works.12 As an extensive examination of these is not possible here, I have set side by side one symbol from each: Trungpa's modification of the traditional Tibetan teachings on the Lalos (kla.klo, literally "barbarians"), which he translated as the "Three Lords of Materialism," and Merton's reflections on the tragic Titan Prometheus, who stole fire from the gods. These two symbols, while certainly not exhaustive of their insights, nonetheless effectively crystallize their respective thoughts on the matter, and thereby allow us to see that Trungpa and Merton shared very striking insights both about the malady of spiritual egotism and about its necessary antidotes.Chögyam Trungpa on Spiritual MaterialismIn talks given from 1970 to 1973, Trungpa gave teachings to his students on "the Three Lords of Materialism," symbolic personifications of the trap to which he referred as spiritual materialism.13 Believing that most of his students were sincere about the spiritual path, he... (shrink)

‘Disastrologies’ explores Derrida's fascination with dates and how that fascination reveals a secret correspondence, in every sense of the word, with Walter Benjamin – a man who has the same birth-date as Derrida. It is, though, the date of Benjamin's death and indeed its infamous mise-en-scène, the cheap hotel on the Franco-Spanish border, that dominates this text which takes the form of a dramatic monologue delivered by the hotel manager, Juan Suñer, a man known to be both a manipulator of (...) dates and, indeed, close to the Gestapo. As the monologue unfolds, Suñer advances an elaborate calendrical re-reading of a host of Derrida texts which probes at the mystery not only of Benjamin's last night but also of living with both Jewish and Christian calendars. Finally, we see how this last of nights puts under unbearable pressure the infinite promise of both the Jewish Sabbath and the Christian Sunday. (shrink)

HIV‐1 infects dendritic cells (DCs) without triggering an effective innate antiviral immune response. As a consequence, the induction of adaptive immune responses controlling virus spread is limited. In a recent issue of Immunity, Lahaye and colleagues show that intricate interactions of HIV capsid with the cellular cofactor cyclophilin A (CypA) control infection and innate immune activation in DCs. Manipulation of HIV‐1 capsid to increase its affinity for CypA results in reduced virus infectivity and facilitates access of the cytosolic DNA (...) sensor cGAS to reverse transcribed DNA. This in turn induces a strong host response. Here, we discuss these findings in the context of recent developments in innate immunity and consider the implications for disease control and vaccine design. (shrink)