Insulators play a central role in subdividing the chromosome into a series of discrete topologically independent domains and in ensuring that enhancers and silencers contact their appropriate target genes. In this review we first discuss the general characteristics of insulator elements and their associated protein factors. A growing collection of insulator proteins have been identified including a family of proteins whose expression is developmentally regulated. We next consider several unexpected discoveries that require us to completely rethink how insulators (...) function (and how they can best be assayed). These discoveries also require a reevaluation of how insulators might restrict or orchestrate (by preventing or promoting) interactions between regulatory elements and their target genes. We conclude by connecting these new insights into the mechanisms of insulator action to dynamic changes in the three‐dimensional topology of the chromatin fiber and the generation of specific patterns of gene activity during development and differentiation. (shrink)

What is indoctrination? This paper clarifies and defends a structural epistemic account of indoctrination according to which indoctrination is the inculcation of closed-minded belief caused by “epistemically insulating content.” This is content which contains a proviso that serious critical consideration of the relevant alternatives to one's belief is reprehensible whether morally or epistemically. As such, it does not demand that indoctrination be a type of unethical instruction, ideological instruction, unveridical instruction, or instruction which bypasses the agent's rational evaluation. In this (...) way, we can account for why indoctrination can occur for liberal democratic beliefs as much as it occurs for fascist, fundamentalist, or fanatical belief: for indoctrination is fundamentally a structural epistemic phenomenon. (shrink)

Bypassing occurs on sharing platforms when users decide to finalize the exchange directly with each other and engage in tactics to circumvent the payment stage. While previous studies have focused on the antecedents associated with bypass practices, more research is needed to better understand the prevalence of bypassing, which bypass practices are enacted, which types of users bypass, and which do not. Using a mixed-methods design, we first conduct semi-structured interviews (_N_ = 19) to identify several motivations (...) behind bypass tactics that complement the existing literature. We also establish four different bypassing behaviors: (1) paying the other peer directly, (2) transacting via another platform, (3) a combination of on- and off-platform booking, and (4) repeat transactions. Next, by carrying out cluster analysis on a sample of Airbnb users (_N_ = 416), we uncover three groups of bypassers: serial maximizers, rookies, and safe players. Further analysis of Airbnb users who have never bypassed shows that they can be categorized into three additional segments: risk-conscious users, hassle-avoiders, and borderline bypassers. Each of these six groups corresponds to a specific profile, which we describe and characterize based on motivational, relational, and psychographic factors. This research provides an actionable segmentation framework that will help sharing platform managers develop tailored bypass mitigation strategies. (shrink)

Bypassing Lewis’ Triviality Results. A Kripke-Style Partial Semantics for Compounds of Adams’ Conditionals Alberto Mura University of Sassari Abstract According to Lewis’ Triviality Results (LTR), conditionals cannot satisfy the equa­tion (E) P(C if A) = P(C | A), except in trivial cases. Ernst Adams (1975), however, provided a probabilistic semantics for the so-called simple conditionals that also sat­isfies equation (E) and provides a probabilistic counterpart of logical consequence (called p-entailment). Adams’ probabilistic semantics is coextensive to Stalnaker­Thomason’s (1970) and Lewis’ (1973) (...) semantics as far as simple conditionals are concerned. A theorem, proved in McGee 1981, shows that no truth-functional many-valued logic allows a relation of logical consequence coextensive with Adams’ p-entailment. This paper presents a modified modal (Kripke-style) version of de Finetti’s se­mantics that escapes McGee’s result and provides a general truth-conditional se­mantics for indicative conditionals. It agrees with Adams’ logic and is not affected by LTR. The new framework encompasses and extends Adams’ probabilistic se­mantics (APS) to compounds of conditionals. A generalised set of axioms for prob­ability over the set of tri-events is provided, which coincide with the standard axioms over the set of the two-valued ordinary sentences. -/- Keywords: Conditionals, Probability logic, de Finetti, Tri-events, Adams’ logic, Stal­naker’s thesis, Partial logic, Lewis’ triviality results, Ramsey test. (shrink)

In his target paper, John Welwood tells us that we have to beware of 'spiritual bypassing -- using spiritual ideas and practices to sidestep personal, emotional -- unfinished business--, to shore up a shaky sense of self, or to belittle basic needs, feelings, and develop-mental tasks, all in the name of enlightenment'. It's arguable that there is an equal danger of 'narrative bypassing' -- using the idea of one's life as a narrative to 'sidestep personal, emotional --unfinished business--, to shore (...) up a shaky sense of self -- all in the name of' a good life. (shrink)

Periurban bypasses are enclaves that appear to be left behind of conventional spatial and technological processes. With the focus on cities and their development, the hinterland serves as a resource that barely makes its appearance in mainstream policy debates. Hidden even further in the periurban are areas whose inhabitants are marginalised in many ways. Developing an ethical framework for assessing periurban bypasses is rendered difficult by the complexity of attribution of harm to particular agents. Nevertheless, by using multiple modes of (...) interpretation and assessment of periurban bypasses, it is possible to create ethical profiles that identify social agents and elite networks for generating these harms. (shrink)

The learning account of the puzzle of ideography cannot be dismissed as readily as Morin maintains, and is compatible with the standardization account. The reading difficulties of deaf and dyslexic individuals, who cannot easily form connections between written letter strings and spoken words, suggest limits to our ability to bypass speech and reliably access meaning directly from graphic symbols.

The early discovery of cis‐regulatory elements able to promote transcription of genes over large distances led to the postulate that elements, termed insulators, should also exist that would limit the action of enhancers, LCRs and silencers to defined domains. Such insulators were indeed found during the past fifteen years in a wide range of organisms, from yeast to humans. Recent advances point to an important role of transcription factors in insulator activity and demonstrate that the operational observation of an (...) insulator effect relies on a delicate balance between the “efficiency” of the insulator and that of the element to be counteracted. In addition, genuine insulator elements now appear less common than initially envisaged, and they are only found at loci displaying a high density of coding or regulatory information. Where this is not the case, chromatin domains of opposing properties are thought to confront each other at “fuzzy” boundaries. In this article, we propose models for both fixed and fuzzy boundaries that incorporate probabilistic and dynamic parameters. BioEssays 26:523–532, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Eddy Nahmias and Dylan Murray have recently argued that when people take agents to lack responsibility in deterministic scenarios, they do so because they take agents’ beliefs, desires and decisions to be bypassed, having no effect on their actions. This might seem like an improbable mistake, but the Bypass Hypothesis is bolstered by intriguing experimental data. Moreover, if the hypothesis is correct, it provides a straightforward error theory for incompatibilist intuitions. This chapter argues that the Bypass Hypothesis, although (...) promising and potentially highly significant, does not provide the best explanation of the data. Results from two new studies strongly suggest that subjects with incompatibilist intuitions do not take determinism to imply that belief, desires, and decisions are bypassed. Together with an independently motivated account of judgments of moral responsibility, the Explanation Hypothesis, they instead suggest, first, that subjects have incompatibilist intuitions because they see agents in deterministic scenarios from an explanatory perspective in which mental states and decisions provide no independent input into what happens, and, second, that this explains why subjects seem to think that these states and decisions are causally bypassed. The results also undermine the suggestion, by David Rose and Shaun Nichols, that subjects make what seems like bypass judgments because they take determinism to exclude he existence of decisions. (shrink)

Insulation is a noticeable phenomenon in the case of most non-Pyrrhonian sceptics about human knowledge. A sceptic is experiencing insulation when his scepticism does not have any effect on his common sense beliefs, and his common sense beliefs do not have any effect on his scepticism. I try to show why this is a puzzling phenomenon, and how it can be explained. It is puzzling because insulation seems to require blindness to one's own epistemic irresponsibility and irrationality, while the sceptic (...) presumably cares a lot about being epistemically responsible and rational. Insulation can be explained by means of a notion of philosophical detachment: to be detached from one's own beliefs about the world is to take an other-personal position towards those beliefs, treating them as if they are another person's beliefs. It is because of this that the sceptic's scepticism is insulated from his scepticism because he cannot be detached from his beliefs about the world when he is engaging in everyday, practical activities. I conclude the paper with a brief discussion of the generality of the problem of insulation. (shrink)

ABSTRACTThe Theory of Event Coding predicts that exposure to affective cues can automatically trigger affectively congruent behaviour due to shared representational codes. An intriguing hypothesis from this theory is that exposure to aversive cues can automatically trigger actions that have previously been learned to result in aversive outcomes. Previous work has indeed found such a compatibility effect on reaction times in forced-choice tasks, but not for action selection in free-choice tasks. Failure to observe this compatibility effect for aversive cues in (...) free choice tasks suggests that control processes aimed at directing behaviour toward positive outcomes may overrule the automatic activation of affectively congruent responses in case of aversive cues. The present study tested whether minimising such control could cause selection of actions that have been learned to result in aversive outcomes. Results showed incidental exposure to aversive cues biased selection of behaviours with learned aver... (shrink)

The idea that incompatibilism is intuitive is one of the key motivators for incompatibilism. Not surprisingly, then philosophers who defend incompatibilism often claim that incompatibilism is the natural, commonsense view about free will and moral responsibility (e.g., Pereboom 2001, Kane Journal of Philosophy 96:217–240 1999, Strawson 1986). And a number of recent studies find that people give apparently incompatibilist responses in vignette studies. When participants are presented with a description of a causal deterministic universe, they tend to deny that people (...) are morally responsible in that universe. Although this suggests that people are intuitive incompatibilists, Eddy Nahmias and Dylan Murray, in a recent series of important papers, have developed an important challenge to this interpretation. They argue that people confuse determinism with bypassing, the idea that one’s mental states lack causal efficacy. Murray and Nahmias present new experiments that seem to confirm the bypassing hypothesis. In this paper, we use structural equation modeling to re-examine the issue. We find support instead for an incompatibilist explanation of the bypassing results, i.e., incompatibilist judgments seem to cause bypassing judgments. We hypothesize that this phenomenon occurs because people think of decisions as essentially indeterministic; thus, when confronted with a description of determinism they tend to think that decisions do not even occur. We provide evidence for this in three subsequent studies which show that many participants deny that people make decisions in a deterministic universe; by contrast, most participants tend to allow that people add numbers in a deterministic universe. Together, these studies suggest that bypassing results don’t reflect a confusion, but rather the depth of the incompatibilist intuition. (shrink)

It has been claimed that a key difference between ancient and contemporary skepticism is that, unlike the ancient skeptics, contemporary skeptics consider ordinary beliefs to be insulated from skeptical doubt. In the case of metaethics, this issue is related to the following question: what attitude towards ordinary moral thought and discourse should one adopt if one is a moral skeptic? Whereas moral abolitionists claim that one should do away with ordinary moral thought and discourse altogether, moral fictionalists maintain that, given (...) that morality produces practical benefits, one should continue to make moral utterances and have moral thoughts, while at the same time refraining from asserting such utterances and believing such thoughts. Focusing particularly on Mackie’s skeptical stance, the present essay considers whether the view that first-order moral beliefs are unaffected by moral skepticism is defensible, whether moral fictionalism is compatible with moral insulation, and whether contemporary moral skeptics are in general committed to there being insulation between first- and second-order levels. (shrink)

Topologically associating domain (TAD) boundaries are the flanking edges of TADs, also known as insulated neighborhoods, within the 3D structure of genomes. A prominent feature of TAD boundaries in mammalian genomes is the enrichment of clustered CTCF sites often with mixed orientations, which can either block or facilitate enhancer–promoter (E‐P) interactions within or across distinct TADs, respectively. We will discuss recent progress in the understanding of fundamental organizing principles of the clustered CTCF insulator codes at TAD boundaries. Specifically, both (...) inward‐ and outward‐oriented CTCF sites function as topological chromatin insulators by asymmetrically blocking improper TAD‐boundary‐crossing cohesin loop extrusion. In addition, boundary stacking and enhancer clustering facilitate long‐distance E‐P interactions across multiple TADs. Finally, we provide a unified mechanism for RNA‐mediated TAD boundary function via R‐loop formation for both insulation and facilitation. This mechanism of TAD boundary formation and insulation has interesting implications not only on how the 3D genome folds in the Euclidean nuclear space but also on how the specificity of E‐P interactions is developmentally regulated. (shrink)

Punishment and democracy appear to exacerbate each other’s worst features. The institutions and moral intuitions used to punish those that break the law can hollow out civic participation, distort the electorate, and undermine core democratic values. Likewise, many have argued the decentralized character of democracy is a key, albeit indirect, cause of increasingly punitive public policies that are divorced from any reasonable penological purpose. Given the effects of electoral politics, many have called for the separation, or general insulation, of state (...) punishment from public influence. However, recent empirical work on punitive attitudes and institutional design has begun to chip away at this common sense. This article contextualizes and qualifies the various mechanisms of policy feedback and public opinion formation thought by political theorists to undermine democratic participation in penal institutions and makes a normative case that insulating the public from penal law actively sustains injustice. (shrink)

This article examines the Buddhist idea of anātman, ‘no- self ’ and pudgala, ‘the person’ in relation to the notion of ‘self ’ emerging from contemporary cognitive science. The Buddhist no-self doctrine is enriched by the cognitive scientist’s understanding of the multiple facets of selfhood, or structures of experience, and the causative action of a functional self in the world. A proper understanding of the Buddhist concepts of anātman and pudgala proves critical to mindfulness-based therapeutic interventions: this is as the (...) ‘person’, as constituted by various structures of selfhood, including—the ecological, interpersonal, extended, private, narrative, relational and conceptual selves—which may be disrupted by traumatic events which disorder one’s experience of time, defence, relationality, memory, resource and agency. In the absence of this understanding, the no-self doctrine might encourage a sort of bypass, in which traumatic facets of selfhood are overlooked in the quest for spiritual liberation. With a proper understanding of the function served by the Buddhist concepts of no-self and ‘person’, psychotherapeutic work may be situated as a necessary ‘preliminary practice’ for meditative exploration of deeper transpersonal domains and soteriological goals. (shrink)

The subject of this study, the step forward—which the author felt to be ‘of evolutionary value’—was occasioned by a Delphi discussion. The debate was opened by Varga's (2003, 2006a) contrastive exposition of diagnoses of present history with respect to Hungary's accession to the European Union, offered by some leading Hungarian sociologists (Henrik Kreutz, Kálmán Kulcsár, Iván Szelényi, Iván Vitányi), in which he tried to place the views of these authors in a value sociological system by Charles Morris (1956, 1964) and (...) Geert Hofstede (1991). In Morris’ case, this involved recourse to his combination of two systems: one semiotic, the other axiological; in Hofstede's, to his system of ‘software of the mind’ embracing axiology and organizational psychology. This synthesis was opposed by Kreutz (2006a) who offered a new ordering principle which he advanced as truer to life. The present confrontation between the value sociological synthesis advanced by Kreutz, on the one hand, and the trends hallmarked by the names of Morris and Hofstede, on the other hand, provided the author with an opportunity to find a resolution of the tension between desired and desirable, for which he has gained some side light from Robert K. Merton's (1957) theory of the different degrees of insulation of role–activities from observability by members of the role–set (and which has derived further refinement from Jean–Paul Sartre's conception of ‘glance and shame’). (shrink)

In the early 1800s galvanometers could be constructed with the fine gauges of silk-covered copper or silver wires produced for decorative purposes, but when Faraday was making his classic electrical experiments in 1831 he needed a sturdier gauge of copper wire. Bare copper wire was available in many diameters for mechanical applications, but coils for electromagnetic investigations had to be insulated with string and calico. It was soon realized that the cotton-covered springy iron wire then used to hold out the (...) brims of ladies' bonnets showed how copper wire might be similarly wrapped to provide a flexible insulation. The simple manual machines used by the bonnet-wire makers were readily adapted and improved, and a six-head version was built by William Henley. This craftsman's vision of the growing importance of insulated copper wire was abundantly justified, and he built up a large—but poorly organised—empire in the wire and cable trade. Henley's original multiple-head wrapping machine has been located in the Science Museum, London, and the associated silk-covered copper wire subjected to physical, chemical, and electrical testing. For comparison, the electrical conductivity of the ‘mechanical grade’ copper wire used by Faraday has also been determined. (shrink)

Why does it matter whether and how individuals consciously control their behavior? It matters for many reasons. Here I focus on concerns about social influences of which agents are typically unaware on aggressive behavior.

Dalit studies are making a come back. This is also reflected in the field of Indian Christian theology where Dalit theology has emerged as a separate discipline and not simply as a branch of theology. Dominant forms of discourse have the disconcerting habit of raising questions like ‘relevance’ and ‘viability’ which forces people to enter into the ‘bypass mode’. Questions raising issues like ‘reality’ and ‘representation’, often lead to internecine conflicts that help no one but the dominant discourses. Although (...) much has been achieved, including major interventions in the field of Biblical studies and hermeneutics and the rediscovery of Dalit literature, there is much that still needs to be done in the field of Dalit theology. (shrink)

Why does it matter whether and how individuals consciously control their behavior? It matters for many reasons. Here I focus on concerns about social influences of which agents are typically unaware on aggressive behavior.

As neuroscience progresses, we will not only gain a better understanding of how our brains work, but also a better understanding of how to modify them, and as a result, our mental states. An important question we are faced with is whether the state could be justified in implementing such methods on criminal offenders, without their consent, for the purposes of rehabilitation and reduction of recidivism; a practice that is already legal in some jurisdictions. By focusing on a prominent type (...) of view of free action, which I call bypassing views, this paper evaluates how such interventions may negatively impact the freedom of their subjects. The paper concludes that there will be a tension between the goals of rehabilitation and reduction of recidivism, on the one hand, and the negative impact such interventions may have on free action, on the other. Other things equal, the better that a particular intervention is at achieving the former, the more likely it is to result in the latter. (shrink)

Religion is often singled out for special legal treatment in Western societies - which raises an important question: what, if anything, is special about religious conscience beliefs that warrants such special legal treatment? In this paper, I will offer an answer to this specialness question by investigating the relationship between religious conscientious objections and their insulation from relevant evidence. I will begin my analysis by looking at Brian Leiter’s arguments that religious beliefs are insulated from evidence and not worthy of (...) special legal treatment as a result. I will argue that he fails to show that religious conscience beliefs are both in principle responsive to empirical evidence and in practice typically more insulated from this evidence than secular conscience beliefs. If I am right about this, then Leiter fails to answer the “central puzzle” of his recent book and fails to sufficiently distinguish the religious conscience from the secular conscience. Second, I will look at whether or not it is plausible to understand the religious conscience as insulated from other forms of evidence. Following the research of social-psychologist Jonathan Haidt, I will argue that, typically, both forms of conscience seem to be similarly insulated from moral argumentation. I will also show that, while it seems as though the religious conscience usually draws from a larger set of moral values when compared to the secular conscience, this should make no legal difference overall. To conclude, I will explain that the arguments in this paper can be understood as evidence in support of an egalitarian response to religion’s specialness. (shrink)

This paper interrogates the idea of a virtue-first approach to the question of what has fundamental epistemic value. It has been suggested that a virtue-first approach is needed to strengthen the view known as veritism, according to which only truth has fundamental epistemic value. I distinguish between an ontological and a methodological virtue-first approach, and suggest that only the latter is an attractive option for a veritist. I then argue that the methodological virtue-first approach is incompatible with the idea that (...) the epistemic domain is insulated, in the sense that being of epistemic value does not entail being of value. But insulationism is arguably an important tool for veritists in meeting various objections to their view, aside from being considered generally attractive by many. Veritists thus face a dilemma that requires them to give up one of two arguably attractive tools in their kit: either the virtue-first motivation of their view, or the insulationist conception of epistemic value. (shrink)

What are conspiracy theories? And what, if anything, is epistemically wrong with them? I offer an account on which conspiracy theories are a unique way of holding a belief in a conspiracy. Specifically, I take conspiracy theories to be self-insulating beliefs in conspiracies. On this view, conspiracy theorists have their conspiratorial beliefs in a way that is immune to revision by counter-evidence. I argue that conspiracy theories are always irrational. Although conspiracy theories involve an expectation to encounter some seemingly disconfirming (...) evidence (allegedly planted by the conspirators), resistance to all counter- evidence cannot be justified on these grounds. (shrink)

Modern readings of the Dionysian corpus often subordinate its hierarchical treatises to its theological treatises. Two unfortunate consequences follow: one, the thetic positions and aphairetic removals of the Divine Names and Mystical Theology bypass or transcend the hierarchical ranks and hierurgical rituals of the Celestial Hierarchy and Ecclesiastical Hierarchy. Second, the return to God occurs through apophatic abstraction rather than sacramental performance. This article interprets the Dionysian corpus differently, offering four arguments why Dionysian negative theology is not the means (...) by which ranks and rituals are negated or abandoned but rather a means by which they are affirmed and accomplished. (shrink)

Recent advances in reprogramming technology do not bypass the ethical challenge of embryo sacrifice. Induced pluripotent stem cell (iPS) research has been and almost certainly will continue to be conducted within the context of embryo sacrifice. If human embryos have moral status as human beings, then participation in iPS research renders one morally complicit in their destruction; if human embryos have moral status as mere precursors of human beings, then advocacy of iPS research policy that is inhibited by embryo (...) sacrifice concerns renders one morally complicit in avoidable harms to persons. Steps may be taken to address these complicity concerns, but in the final analysis there is no alternative to achieving clarity with respect to the moral status of the human embryo. (shrink)

A common style of argument in the literature on free will and moral responsibility is the Manipulation Argument. These tend to begin with a case of an agent in a deterministic universe who is manipulated, say, via brain surgery, into performing some action. Intuitively, this agent is not responsible for that action. Yet, since there is no relevant difference, with respect to whether an agent is responsible, between the manipulated agent and a typical agent in a deterministic universe, responsibility is (...) not compatible with the truth of determinism. In response, some theorists have argued that there is a relevant difference, and have developed two sorts of accounts of that difference: bypassing views, and manipulator-focused views. Manipulator-focused views suggest that the difference concerns the presence of a manipulator, whereas bypassing views suggest that the relevant difference concerns the fact that the action issues from attitudes that the manipulated agent acquired in a way that bypassed her capacities for control over her mental life. One sort of case used to decide between these sorts of accounts is a case of machine induction, which is just like a manipulation case, yet the change in the agent is the result of some natural force. Against the received view, Xiaofei Liu argues that such cases pose problems for bypassing views, and favor manipulator-focused views instead. This paper addresses Liu’s arguments, as well as a variety of cases, concluding that cases of machine induction do not provide motivation for a bypassing theorist to adopt a manipulator-focused view. (shrink)

Ethical controversy over transplantation of human fetal tissue has arisen because the source of tissue is induced abortions. Opposition to such transplants has been based on various arguments, including the following: rightful informed consent cannot be obtained for use of fetal tissue from induced abortions, and fetal tissue transplantation might result in an increase in the number of abortions. These arguments were not accepted by the National Institutes of Health (NIH) Human Fetal Tissue Transplantation Research Panel. The majority opinion of (...) the panel stated that abortion and fetal tissue use are entirely separate issues, and that tissue use is ethically acceptable because it can be morally insulated from the issue of abortion. In support of this view, panel members and others have replied to the arguments put forward by opponents of fetal tissue use. However, replies to the two arguments mentioned above have been unsatisfactory, and the shortcomings of those replies are identified herein. Examination of the arguments pro and con suggests that fetal tissue use cannot be completely insulated from the issue of abortion. Thus, in seeking an ethical justification for fetal tissue transplantation we must consider reasons other than those put forward by the NIH panel. In this paper it is argued that whatever wrong is involved in using fetal tissue from induced abortions must be balanced against the benefits for patients, and it is on this basis that fetal tissue transplantation can be ethically justified. (shrink)

Johnson et al. suggest that we rely on narratives to make choices under radical uncertainty. We argue that in its current version Conviction Narrative Theory (CNT) does not account for embodied, direct sensorimotor influences on choices under radical uncertainty that may bypass narratives, particularly in highly time-constrained situations. We therefore suggest to extend CNT by an embodied choice perspective.

In this research work, we have explored the physical and topological properties of the crystal structure of metal-insulator transition superlattice. In recent times, two-dimensional substantial have enamored comprehensive considerations owing to their novel ophthalmic and mechanical properties for anticipated employment. Recently, some researchers put their interest in modifying this material into useful forms in human life. Also, Metal-Insulator Transition Superlattice is useful in form of a thin film to utilize as two-dimensional transition metal dichalcogenides. Moreover, we have defined (...) the computed-based bond properties such as the degree constructed topological indices and their heat of formation for single crystal and monolayered structure of Ge-Sb-Te. Also, this structure is one of the most interesting composites in modern resources of science. (shrink)