Meaningful participant engagement has been identified as a key contributor to the success of efforts to share data via a “Medical Information Commons”. We present findings from expert stakeholder interviews aimed at understanding barriers to engagement and the appropriate role of MIC participants. Although most interviewees supported engagement, they distinguished between individual versus collective forms. They also noted challenges including representation and perceived inefficiency, prompting reflection on political aspects of engagement and efficiency concerns.

Through examples of embodied and learning-centered pedagogy, we discuss transformative learning of transgressive topics. We begin with a taxonomy of types of learning our students undergo as they resolve inconsistencies among their pre-existing beliefs and the material they confront in our course on feminist ethics and epistemology. We then discuss ways to help students maximize their learning while confronting internal inconsistencies. While we focus on feminist topics, our approach is broad enough to be relevant to anyone teaching a transgressive or (...) controversial topic. (shrink)

Through examples of embodied and learning -centered pedagogy, we discuss transformative learning of transgressive topics. We begin with a taxonomy of types of learning our students undergo as they resolve inconsistencies among their pre-existing beliefs and the material they confront in our course on feminist ethics and epistemology. We then discuss ways to help students maximize their learning while confronting internal inconsistencies. While we focus on feminist topics, our approach is broad enough to be relevant to anyone teaching a transgressive (...) or controversial topic. (shrink)

Drawing on a landscape analysis of existing data-sharing initiatives, in-depth interviews with expert stakeholders, and public deliberations with community advisory panels across the U.S., we describe features of the evolving medical information commons. We identify participant-centricity and trustworthiness as the most important features of an MIC and discuss the implications for those seeking to create a sustainable, useful, and widely available collection of linked resources for research and other purposes.

Pragmatic clinical trials offer important benefits, such as generating evidence that is suited to inform real-world health care decisions and increasing research efficiency. However, PCTs also present ethical challenges. One such challenge involves the management of information that emerges in a PCT that is unrelated to the primary research question, yet may have implications for the individual patients, clinicians, or health care systems from whom or within which research data were collected. We term these findings as?pragmatic clinical trial collateral findings,? (...) or?PCT-CFs?. In this article, we explore the ethical considerations associated with the identification, assessment, and management of PCT-CFs, and how these considerations may vary based upon the attributes of a specific PCT. Our purpose is to map the terrain of PCT-CFs to serve as a foundation for future scholarship as well as policy-making and to facilitate careful deliberation about actual cases as they occur in practice. (shrink)

BackgroundGenetics and genomics research (GGR) is increasingly being conducted around the world; yet, researchers and research oversight entities in many countries have struggled with ethical challenges. A range of ethics and regulatory issues need to be addressed through comprehensive policy frameworks that integrate with local environments. While important efforts have been made to enhance understanding and awareness of ethical dimensions of GGR in Africa, including through the H3Africa initiative, there remains a need for in-depth policy review, at a country-level, to (...) inform and stimulate local policy development and revision on the continent.MethodsTo identify and characterize existing ethics-related guidelines and laws applicable to GGR across much of Africa, we conducted a scoping review of English language policy documents identified through databases, repositories, and web searches. Thirty-six documents were included and coded using a framework that contained a range of themes across five analytical categories: (1) respect, (2) beneficence, (3) justice, (4) independent oversight, and (5) bans and prohibitions. Data analysis software (NVivo 12) was used to organize, code, and tabulate information according to document characteristics and topics. Illustrative examples of policy requirements were selected for inclusion.ResultsDocuments that met inclusion criteria spanned 20 years; published between 1996 and 2018, with the majority (58%) published after 2009. About two-thirds were denoted as “guidelines,” and slightly more than half were non-exclusive to GGR. Very few (six) country-level documents identified were specific to GGR. Requirements related to the principle of “respect” appeared most often across all documents, relative to other principles and processes. The most commonly stated ban was on reproductive cloning. Other prohibitions applied to germline editing, undue inducements in research, sample use for commercial purposes, employee mandatory DNA testing, fetal sex selection, stem cell use, eugenics, and research without public health benefits.ConclusionsEnforceable policies that are indispensable to the ethical conduct and review of GGR are either deficient or missing in many African countries. Existing international, GGR-specific ethics guidelines can be used to inform GGR policy development at a country-level, in conjunction with insight from country specific ethics committees and other local stakeholders. (shrink)

In this review, we describe some of the central philosophical issues facing origins-of-life research and provide a targeted history of the developments that have led to the multidisciplinary field of origins-of-life studies. We outline these issues and developments to guide researchers and students from all fields. With respect to philosophy, we provide brief summaries of debates with respect to (1) definitions (or theories) of life, what life is and how research should be conducted in the absence of an accepted theory (...) of life, (2) the distinctions between synthetic, historical, and universal projects in origins-of-life studies, issues with strategies for inferring the origins of life, such as (3) the nature of the first living entities (the “bottom up” approach) and (4) how to infer the nature of the last universal common ancestor (the “top down” approach), and (5) the status of origins of life as a science. Each of these debates influences the others. Although there are clusters of researchers that agree on some answers to these issues, each of these debates is still open. With respect to history, we outline several independent paths that have led to some of the approaches now prevalent in origins-of-life studies. These include one path from early views of life through the scientific revolutions brought about by Linnaeus (von Linn.), Wöhler, Miller, and others. In this approach, new theories, tools, and evidence guide new thoughts about the nature of life and its origin.We also describe another family of paths motivated by a” circularity” approach to life, which is guided by such thinkers as Maturana & Varela, Gánti, Rosen, and others. These views echo ideas developed by Kant and Aristotle, though they do so using modern science in ways that produce exciting avenues of investigation. By exploring the history of these ideas, we can see how many of the issues that currently interest us have been guided by the contexts in which the ideas were developed. The disciplinary backgrounds of each of these scholars has influenced the questions they sought to answer, the experiments they envisioned, and the kinds of data they collected. We conclude by encouraging scientists and scholars in the humanities and social sciences to explore ways in which they can interact to provide a deeper understanding of the conceptual assumptions, structure, and history of origins-of-life research. This may be useful to help frame future research agendas and bring awareness to the multifaceted issues facing this challenging scientific question. (shrink)

Understanding the clinical significance of variants associated with hereditary cancer risk requires access to a pooled data resource or network of resources—a “cancer gene variant commons”—incorporating representative, well-characterized genetic data, metadata, and, for some purposes, pathways to case-level data. Several initiatives have invested significant resources into collecting and sharing cancer gene variant data, but further progress hinges on identifying and addressing unresolved policy issues. This commentary provides insights from a modified policy Delphi process involving experts from a range of stakeholder (...) groups involved in the data-sharing ecosystem. In particular, we describe policy issues and options generated by Delphi participants in five domains critical to the development of an effective cancer gene variant commons: incentives, financial sustainability, privacy and security, equity, and data quality. Our intention is to stimulate wider discussion and lay a foundation for further work evaluating policy options more in-depth and mapping them to those who have the power to bring about change. Addressing issues in these five domains will contribute to a cancer gene variant commons that supports better care for at-risk and affected patients, empowers patient communities, and advances research on hereditary cancers. (shrink)

The research aimed to produce an appropriate product, namely a cooperative learning model in the rituals of Hajj, to realize an independent Hajj congregation in terms of knowledge, understanding, attitudes, and skills, to specify the level of validity, realism, effectiveness, and attractiveness and so that the problems above can be resolved immediately resolved. This research uses the Research and Development (R&D) approach to achieve the aforementioned objectives. In general, the research and development model is the Four D model. This model (...) consists of four stages of development, i.e., define, design, develop, and develop. The results of the preliminary study / pre-field survey show that in terms of teaching performance of Hajj rituals, it appears that the learning services provided by the instructor/instructor have not been able to accommodate and appreciate the differences in ability (attitude) of Hajj pilgrims. The results of the model development trial show that "(1) it is necessary to improve the teaching performance of the Hajj ritual guide / instructor, (2) the development of the model requires specific teaching performance of Hajj rituals from the supervisor / instructor, and does not want excessive facilities and facilities. (3) there is an increase in the learning activities of Hajj pilgrims in all small groups (high, medium and low), (4) the realization of the optimization of the achievement of learning outcomes for Hajj rituals for Hajj pilgrims, both in the high, medium, and low groups. (shrink)

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

In the recent methodological individualism-holism debate on explanation, there has been considerable focus on what reasons methodological holists may advance in support of their position. We believe it is useful to approach the other direction and ask what considerations methodological individualists may in fact offer in favor of their view about explanation. This is the background for the question we pursue in this paper: Why be a methodological individualist? We start out by introducing the methodological individualism-holism debate while distinguishing two (...) forms of methodological individualism: a form that says that individualist explanations are always better than holist accounts and a form that says that providing intervening individualist mechanisms always makes for better explanations than purely holist ones. Next, we consider four lines of reasoning in support of methodological individualism: arguments from causation, from explanatory depth, from agency, and from normativity. We argue that none of them offer convincing reasons in support of the two explanatory versions of individualism we consider. While there may well be occasions in which individualists’ favorite explanations are superior, we find no reason to think this always must be the case. (shrink)

Reactivity in qualitative data collection occurs when a researcher generates data about a situation with reactivity, that is, a situation in which the ongoing research affects the research participants such that they, say, diverge from their routines when the researcher is present, or tell the researcher what they think she wants to hear. In qualitative research, there are two basic approaches to reactivity. The traditional position maintains that data should ideally be collected in situations without any reactivity. In other words, (...) good data are reactivity free. By contrast, the more recent view holds that data from situations with reactivity are fine as long as the researcher is aware of the occurring reactivity so that she can take it into account when interpreting her data. In this fashion, good data are reactivity transparent. In this paper, I first spell out and defend the more recent approach to reactivity. I argue that qualitative data are reactivity transparent when conjoined with true reactivity assumptions and that, thus supplemented, data are informative about social life independently of its being studied. Next, I examine various issues raised by the requirement to put forth true reactivity assumptions. Lastly, I use my discussion of reactivity transparency as a basis for providing a framework for thinking about good qualitative data. (shrink)

Today, a major challenge for climate science is to overcome what is called the “usability gap” between the projections derived from climate models and the needs of the end-users. Regional Climate Models (RCMs) are expected to provide usable information concerning a variety of impacts and for a wide range of end-users. It is often assumed that the development of more accurate, more complex RCMs with higher spatial resolution should bring process understanding and better local projections, thus overcoming the usability gap. (...) In this paper, I rather assume that the credibility of climate information should be pursued together with two other criteria of usability, which are salience and legitimacy. Based on the Swiss climate change scenarios, I study the attempts at meeting the needs of end-users and outline the trade-off modellers and users have to face with respect to the cascade of uncertainty. A conclusion of this paper is that the trade-off between salience and credibility sets the conditions under which RCMs can be deemed adequate for the purposes of addressing the needs of end-users and gearing the communication of the projections toward direct use and action. (shrink)

The article makes four interrelated claims: (1) The mechanism approach to social explanation does not presuppose a commitment to the individual-level microfoundationalism. (2) The microfoundationalist requirement that explanatory social mechanisms should always consists of interacting individuals has given rise to problematic methodological biases in social research. (3) It is possible to specify a number of plausible candidates for social macro-mechanisms where interacting collective agents (e.g. formal organizations) form the core actors. (4) The distributed cognition perspective combined with organization studies could (...) provide us with explanatory understanding of the emergent cognitive capacities of collective agents. (shrink)

In this article, I offer a partial analysis of the role of values in qualitative data collection in social research. The partial analysis shows that nonepistemic values have both required and permissible roles to play during this phase of research. By appeal to the analysis, I reject the ideal of value-free science as applied to qualitative data collection, and I demonstrate why two alternative ideals should likewise be dismissed as standards for values in qualitative data collection. Also, I briefly discuss (...) the extent to which the partial analysis carries over to quantitative data collection in social research. (shrink)

This paper discusses the so-called non-interference assumption (NIA) grounding causal inference in trials in both medicine and the social sciences. It states that for each participant in the experiment, the value of the potential outcome depends only upon whether she or he gets the treatment. Drawing on methodological discussion in clinical trials and laboratory experiments in economics, I defend the necessity of partial forms of blinding as a warrant of the NIA, to control the participants’ expectations and their strategic interactions (...) with the experimenter. (shrink)

Historically the terms “final,” “unconditional,” and “intrinsic” have played a foundational role in ethical theory. I argue that final/instrumental distinction is best understood in terms of the for-sake-of relation and involves a tri-part division of goods. I show that this first way of categorizing goods is more closely aligned with a second way of categorizing goods in terms of intrinsic/extrinsic goods than has thus far been acknowledged. Lastly, I distinguish yet a third way of categorizing goods: unconditional/conditional goods. While the (...) final/instrumental and intrinsic/extrinsic distinctions have received the lion’s share of philosophical attention, the unconditional/conditional distinction is no less important. (shrink)

One issue of dispute between methodological individualists and methodological holists is whether holist explanations are dispensable in the sense that individualist explanations are able to do their explanatory job. Methodological individualists say they are, whereas methodological holists deny this. In the first part of the paper, I discuss Elder-Vass’ version of an influential argument in support of methodological holism, the argument from emergence. I argue that methodological individualists should reject it: The argument relies on a distinction between individualist and holist (...) explanations that they find unacceptable and Elder-Vass’ reasons in support of his way of drawing this distinction are not good ones. In the second part, I examine what, if anything, would be good reasons in support of a particular way of differentiating between individualist and holist explanations. I propose that a good reason is one which shows, in an acceptable manner, that the distinction, drawn in the same way in all contexts, is useful from the perspective of offering explanations of the social world. I show that if this criterion is adopted, it will result in a fruitful reorientation of the whole debate between methodological individualists and methodological holists. (shrink)

What are the aims of legal philosophy? Which questions should it seek to address? How should legal philosophers approach and engage with their subject-matter, and what constraints are incumbent on them as they do so? What are the criteria of success of theories of law, and how do we know if they have been met? Can there be progress in legal philosophy? In Elucidating Law, Julie Dickson addresses these and other questions concerning the methodology, or the philosophy, of legal philosophy (...) and offers her own distinctive response to them. The book advocates that legal philosophers should espouse an approach that Dickson terms 'Indirectly Evaluative Legal Philosophy.' This distinctive approach can facilitate legal philosophers' understanding of aspects of the nature of law, whilst avoiding prematurely or inappropriately regarding law as inherently morally valuable. Law is a powerful, systemic, and institutionalized social tool. It should be understood in a manner appropriate to its character. (shrink)

Although performance pressure has desirable consequences, there is evidence that it can produce unintended outcomes as employees tend to engage in dysfunctional and unethical behaviors to meet performance goals. Thus, the process through which employees think and behave unethically under performance pressure deserves more research attention. This study goes beyond the stress-appraisal perspective and investigates whether and when performance pressure influences individual work mindsets and behaviors from a moral reasoning perspective. Specifically, we contend that performance pressure is related to employee (...) expediency through moral decoupling. We further hypothesize dialectical thinking and moral identity to be the boundary conditions of the proposed relationships. Analyses of data from a field study in three waves provide support for most of the hypotheses. In particular, we find that moral decoupling accounts for additional variance after we control for the stress-appraisal effect of performance pressure on employee expediency. The study offers several contributions to the literature on performance pressure and unethical behavior. (shrink)

Où en sont aujourd'hui les études au sujet de Maître Eckhart (1260-1327), frère prêcheur et maître en théologie de l'université de Paris, dont plusieurs propositions ont été condamnées par le pape Jean XXII dans la bulle In agro dominico? De la variété et de la richesse des directions de recherche actuelles, ce volume en propose, conformément à l'esprit de la collection, une sélection. Quatre perspectives principales se dégagent. La première concerne les questions métaphysiques et théologiques majeures - Dieu, l'Un, la (...) Trinité, les transcendantaux - ainsi que la théorie de l'intellect. La deuxième regroupe les questions spirituelles, morales et anthropologiques soulevées par la réflexion eckhartienne. Une troisième s'intéresse aux auteurs aux-quels les textes d'Eckhart ouvrent, que ces auteurs précèdent ou suivent chronologiquement le maître thuringien : Plotin, Maïmonide, le Liber de causis et l'idéalisme allemand, Heidegger, Derrida ou encore les études comparatistes de Shizuteru Ueda avec le bouddhisme zen. Une quatrième manière de lire ce recueil consiste à suivre la distinction et la complémentarité de oeuvre latine et de oeuvre allemande de Maître Eckhart avec les différents problèmes herméneutiques et doctrinaux qu'elles posent. Que chaque lecteur puisse trouver à son gré, à travers les différences d'approches et de voix, ses propres chemins pour entrer dans oeuvre de Maître Eckhart. (shrink)

In this paper, I examine a heretofore ignored critic of Descartes on the heterogeneity problem: Anton Wilhelm Amo. Looking at Amo’s critique of Descartes reveals a very clear case of a thinker who attempts to offer a causal system that is not a solution to the mind-body problem, but rather that transcends it. The focus of my discussion is Amo’s 1734 dissertation: The Apathy [ἀπάθεια] of the Human Mind or The Absence of Sensation and the Faculty of Sense in the (...) Human Mind and their Presence in our Organic and Living Body. Amo’s discussion of the interaction, or lack thereof, of the mind and body hinges on the essential feature he identifies for the human mind—apathy, that is, impassivity. In this work, Amo engages explicitly with Descartes’s writing, which allows us to more precisely see the nature of his agreement and disagreement with the Cartesian metaphysics of mind. I proceed by treating Amo’s five stated criteria for spirit-hood which, in turn, reveal the kinds of causal connections that are possible for embodied spirits on his view. My aim is threefold: To lay out what I take to be Amo’s view of and arguments for the five criteria he takes to be required for a substance to be spirit. To locate Amo’s agreement and disagreement with Descartes. To suggest that Amo’s view on mind-body interaction involves a kind of occasional causation. (shrink)

Social scientists associate agent-based simulation (ABS) models with three ideas about explanation: they provide generative explanations, they are models of mechanisms, and they implement methodological individualism. In light of a philosophical account of explanation, we show that these ideas are not necessarily related and offer an account of the explanatory import of ABS models. We also argue that their bottom-up research strategy should be distinguished from methodological individualism.

Broadly speaking, an entity has moral status if and only if it or its interest matters morally for its own sake. Some philosophers, who think of moral status in terms of duties and rights owed to an entity, allow that moral status can come in degrees, with only some beings having status of the highest degree – that is, full moral status (FMS). We critically review the competing accounts of what qualifies one for FMS. Some accounts demand cognitive sophistication, which (...) excludes many children, while others are inclusive of children but fail by (a) putting children morally on a par with most animals (experiencing subject of a life), (b) invoking criteria of dubious moral relevance (potentiality, membership in a biological species), or (c) not securing impartial moral status (special relationships). We end with our own account, which attempts to rectify such problems, addressing specifically the moral status of children. (shrink)

Nous remercions Julie Perrin de nous avoir autorisé à reproduire cet article. Il a déjà paru dans le n° 3 d'Ambiances. Revue internationale sur l'environnement sensible, l'architecture et l'espace urbain – Animer l'espace public? Entre programmation urbaine et activation citoyenne, en 2017. Résumé : Dans Walk, Hands, Eyes, l'artiste chorégraphique Myriam Lefkowitz propose à un spectateur à la fois une balade urbaine silencieuse, les yeux fermés. Cet article examine la dimension spatiale, - Urbanisme.

This book examnines the developments, themes, and social frameworks that determined the development of American linguistics since the founding of the American Philosophical Society in 1769 to the founding of the Linguistic Society of America in 1924. Julie Andersen proposes that three developments capture a significant portion of American linguistics activity. These are the study of American Indian languages, the emergence of a distinctive Anglo-American `thought' which has been accompanied by the defence of American English and the influence of European (...) linguistic theories on American scholarship. Throughout the book the idea is developed that theories of language do not transcend the language in which they are written, and metaphors and images are uncovered that are particular to the American-language linguisitc tradition. Undergraduate and graduate students of linguistics will find this book ideal background reading. It will be particularly useful to all students of historical linguisitcs. (shrink)

This paper highlights the need to apply an equity lens when assessing the impact of preemption and related legal doctrines on community health. Community autonomy to set and pursue public health priorities is an essential part of achieving health equity. Unfortunately, the priorities of organized industry interest groups often conflict with health equity goals. These groups have a history of successfully using law to limit community autonomy to pursue public health measures, most notably through preemption and related legal doctrines. We (...) examine this phenomenon using two examples. First, we look at dental association efforts to block the spread of dental therapists in Indian Country. Native dental therapists have been improving the oral health of native people in Alaska for over a decade; yet the national and state dental associations have sought with mixed success to leverage state and federal laws to hinder other tribal governments from utilizing these providers. We compare these efforts with a restaurant association-led movement to limit what municipal governments can do to address food-based health inequities, focusing on a “model” ALEC bill that started in Ohio. Finally, we discuss how municipalities and Tribes are fighting back and continuing to pursue health equity for their communities. (shrink)

Julie Piering - The Philosophy of Simone de Beauvoir: Critical Essays - Journal of the History of Philosophy 45:4 Journal of the History of Philosophy 45.4 675-676 Muse Search Journals This Journal Contents Reviewed by Julie Piering Northern Arizona University Margaret A. Simons, editor. The Philosophy of Simone de Beauvoir: Critical Essays. Bloomington, IN: Indiana University Press, 2006. Pp. xi + 316. Paper, $24.95. At the risk of overstating the case, this collection of essays provides further evidence that Beauvoir scholarship (...) is in its richest and most vital period yet. As Margaret Simons, its editor, points out and its authors demonstrate, Beauvoir is less and less considered a writer who applies Sartrean existentialism to concrete situations.. (shrink)

The argument from multiple realization is currently considered the argument against intertheoretic reduction. Both Little and Kincaid have applied the argument to the individualism-holism debate in support of the antireductionist holist position. The author shows that the tenability of the argument, as applied to the individualism-holism debate, hinges on the descriptive constraints imposed on the individualist position. On a plausible formulation of the individualist position, the argument does not establish that the intertheoretic reduction of social theories is highly unlikely. Nonetheless, (...) the reductive project may run into other potential obstacles. For this reason, it is concluded that the prospect of intertheoretic reduction is uncertain rather than unlikely. Key Words: argument from multiple realization • intertheoretic reduction • reductionism • individualism • holism. (shrink)

Here Julie Landsman chronicles one year as a teacher in a program for students in such serious trouble they are asked to leave their middle schools and attend a special program for disruptive students. She allows her readers to get to know the students, their home and street situations, and how their stories develop over the year, and in doing so, shows the complexity of young people, their beauty, and their individuality.

Acknowledgments THROUGHOUT this book I cite the many people who have provided information on individual programs and activities. ...