The role of individual factors in behavioral neuroscience is an important, but still neglected, area of research. For example, the Elevated Plus-Maze Test has been one of the most used paradigms to gauge unconditioned aversively motivated behavior in rodents. However, despite a great number of experiments with this test there have been only few efforts to assess systematic individual variations in the elevated plus-maze and related neurobiological functions. The present review aims to give, first, a general overview and introduction about (...) the test, and second, an animal model of anxiety based on natural variance of plus-maze behavior within a given unselected population of rats. Finally, critical aspects of such approaches in animal research are discussed, and suggestions are given as to where to go from here. (shrink)

Advances in psychopharmacology raise the prospects of enhancing neurocognitive functions of humans by improving attention, memory, or mood. While general ethical reflections on psychopharmacological enhancement have been increasingly published in the last years, ethical criteria characterizing physicians’ role in neurocognitive enhancement and guiding their decision-making still remain highly unclear. Here it will be argued that also in the medical domain the use of cognition-enhancing drugs is not intrinsically unethical and that, in fact, physicians should assume an important role in (...) gating their usage. For finding normative orientation, concepts of disease, normality or medicine will not be helpful since—due to their cryptonormative nature—they rather hamper than allow targeted discussion and decision-making. As an alternative, the common and widely accepted bioethical criteria of beneficence, non-maleficence, autonomy and distributive justice allow a clinically applicable, highly differentiated context- and case-sensitive approach. By embedding decision-making in a participative physician–patient relationship extrinsic objections against neurocognitive enhancement (e.g. invalid perceptions about efficacy, benefit or risk; questionable voluntariness; restrained decision-making capacity) can be curtailed. (shrink)

‘Cosmetic psychopharmacology’ is a term coined by Peter Kramer in his 1993 best‐seller, Listening to Prozac. It has come to refer to the use of psychoactive substances to effect changes in function for conditions that are either normal or subclinical variants. In this paper, I ask: What distinguishes an existential ailment from clinical depression, or either of those from normal depressed mood, melancholic temperament, dysthymia or other depressive disorders? Can we reliably distinguish one from the other? Are the boundaries (...) of illness and disorder really so distinct? If not, how can we know that treatment of ‘depression’ with Prozac in any given instance constitutes a cosmetic as opposed to, say, a medical or clinical use of psychopharmacology – a distinction that seems to turn on our ability to clearly differentiate the clinical from the cosmetic. If we cannot reliably distinguish between such conditions, can we even have a cosmetic psychopharmacology that is not a form of malpractice, broadly speaking? What if we unplugged Prozac from all the amplitude and hype that resulted in Listening to Prozac becoming an instant best‐seller and simply asked whether or not we can clearly distinguish an appropriate cosmetic use of Prozac for ‘depression’ from an inappropriate cosmetic use of Prozac, and both of those from Prozac's appropriate clinical, that is, non‐cosmetic uses? If we cannot make these distinctions, perhaps it is too early to say there can be such a thing as a cosmetic psychopharmacology. (shrink)

The extra-therapeutic use of psychotropic drugs to improve cognition and to enhance mood has been the subject of controversial discussion in bioethics, in medicine but also in public for many years. Concerns over a liberal dealing with pharmacological enhancers are raised not only from a biomedical–pharmacological perspective, but particularly from an ethical one. Within these ethical concerns, there is one objection about the normative differentiation between “natural” and “artificial” enhancers, which is theoretically indeed widely discredited in bioethics, which has, however, (...) entrenched itself in such a persistent way in everyday moral consciousness that it keeps a crucial influence on the assessment of pharmacological enhancers made by the public and medical professionals. This paper tries to first show why a normative differentiation between “natural” and “artificial” enhancers is highly problematic. In a second step, the resulting implications for our current dealing with pharmacological enhancers shall be examined. In a specific comparison of synthetic pharmaceuticals (modafinil, SSRIs) with phytopharmaceuticals (ginkgo biloba, St. John’s wort) and other already established enhancers (alcohol, caffeine), argumentative inconsistencies are pointed out which, at least partly, result from a rationally untenable preference for the “natural” over the “artificial”. Therefore, it is conclusively argued the case for an unprejudiced assessment of pharmacological enhancers beyond a “natural”–“artificial” dichotomy, which equally takes into account biomedical and ethical aspects. The goal is to reach a coherent dealing with pharmacological enhancement in the long run. (shrink)

Contemporary mental health professionals exhibit interest in integrating spirituality into the services they provide to clients. This clinical integration raises questions about both the goals of mental health services and the professional relevance of mental health providers’ spiritual competency. Drawing on the Christian anthropology of St. Thomas Aquinas, Benedict Ashley’s approach to psychotherapy differentiates psychopharmacological, psychotherapeutic, and spiritual approaches on the basis of the different domains of a client’s personality. These domains are the focus of different professions, and Ashley’s account (...) suggests that mental health providers who lack additional spiritual-moral training should adopt a clinical model that recognizes their work is spiritually oriented but not spiritually directive. (shrink)

The increasing use of pharmacotherapy raises specific ethical concerns for psychologists working with vulnerable populations. Due to a shortage of trained specialists, professionals without training in mental health, such as primary care providers, are increasingly prescribing and monitoring psychotropic medications. Vulnerable populations face additional barriers to mental health treatment and are at heightened risk when these factors intersect. Hence, these patients experience unique barriers to receiving optimal psychopharmacological care and are differentially vulnerable to deleterious outcomes associated with misdiagnosis and overmedication. (...) Taken together, these factors fuel inequities in the access, quality, and utilization of mental health care. Psychologists working with these patients are ethically mandated to protect patients from harm and ensure equitable care across patient populations. Specifically, psychologists must respond to the dilemma of how to effectively treat patients within these vulnerable populations who have been misdiagnosed or poorly medicated while remaining within the bounds of their competence. This article recommends pathways to address these dilemmas through education, training, research, and advocacy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Diagnostic Criteria, Psychological Tests, and Ratings Scales: Extending the HistoryPeter Zachar, PhD (bio)Le moigne narrates a history of the development of psychiatric ratings scales as hybrids between psychological tests and diagnostic categories. In his telling, psychological tests seek to quantify population-based traits on which every person has a position and which tend to be conceptualized as being stable. Personality traits are often conceptualized as dispositions. Diagnostic categories represent not (...) trait-like properties of populations but episodic states consisting of clusters of symptoms experienced by individuals with disorders. Ratings, scales, he notes, are hybrids between the two. They are used to quantify psychiatric symptom clusters so that change over time can be measured. Le Moigne argues that these distinctions were initially suggested during the development of measures that could assess outcomes in psychopharmacological treatment studies.With respect to depression, Le Moigne writes that in the 1970s and 1980s something akin to depressive personality was reconceptualized as a temperament. A key move, somewhat reflective of Kraepelin’s notion of a depressive temperament, was to view a dysthymic temperament as both a predisposing factor and an attenuated form of depression. Thus, an episodic state commandeered the predisposing–dispositional role that was assigned to stable personality traits.This conceptual shift allowed test-like ratings scales to be seen as useful for quantifying not just stable traits, but salient features of episodic states that are potentially subject to change in response to interventions. To put it another way, in the development of a psychological test, one goal is to have high test-retest reliability (i.e., stability of measurement). With rating scales used to measure change, one wants the scores to not be as stable; ideally the scores on the later assessments will be lower. According to Le Moigne, when dysthymia was subsequently placed on axis I of the Diagnostic and Statistical Manual of Mental Disorders (DSM)-III (as a syndrome) and segregated from personality disorders which were placed on axis II, personality traits were evicted from the conceptualization of depressive disorders.One perennial feature of psychiatry and psychology is that even if an older idea is superseded [End Page 253] in the view of some thinkers, it can still attract adherents. Indeed, interest in understanding a relationship between personality and attenuated states did not fully disappear. For example, based on research in genetics, the schizophrenia spectrum concept included not only schizophrenia, but also milder conditions such that were conceptualized as personality disorders; that is, schizotypal personality disorder and paranoid personality disorder (Kety, Rosenthal, Wender, & Schulsinger, 1971).During the development of the DSM-IV, some people wanted to add depressive personality disorder to the manual (Phillips, Hirschfeld, Shea, & Gunderson, 1995). It seems to have become a territorial dispute between mood disorder specialists and personality disorder specialists The mood disorders specialists challenged the personality disorder specialists to differentiate depressive personality disorder from early onset, chronic dysthymia. They were able to do so by using criteria such as critical, blaming, and derogatory toward self. After the mood disorders work group proposed incorporating some of those criteria into a revised criteria set for dysthymia, the two sets overlapped. The result was the old criteria for dysthymia were printed in DSM-IV and criteria for depressive personality disorder and the revised criteria for dysthymia were both placed in the appendix.In the DSM-5, Axis II was eliminated and personality disorders were placed alongside all the syndromic symptom clusters at the same level. Even so, interest in attenuated presentations as personality-related lingered still. During the development of the DSM-5 there was some thought to using diagnostic spectra as a meta-structure for organizing the manual (Andrews et al., 2009). One idea was to move some personality disorders into a best fitting spectrum, akin to attenuated forms. This did occur with schizotypal personality disorder which is both in the DSM-5 chapter on schizophrenia and in the chapter on personality disorder. In the schizophrenia chapter it is positioned as the earliest emerging disorder on the spectrum. There was also some interest in grouping avoidant personality disorder with the anxiety disorders, but the evidence supporting such a change was not available.These issues may... (shrink)

We investigate the provability or nonprovability of certain ordinary mathematical theorems within certain weak subsystems of second order arithmetic. Specifically, we consider the Cauchy/Peano existence theorem for solutions of ordinary differential equations, in the context of the formal system RCA 0 whose principal axioms are ▵ 0 1 comprehension and Σ 0 1 induction. Our main result is that, over RCA 0 , the Cauchy/Peano Theorem is provably equivalent to weak Konig's lemma, i.e. the statement that every infinite {0, (...) 1}-tree has a path. We also show that, over RCA 0 , the Ascoli lemma is provably equivalent to arithmetical comprehension, as is Osgood's theorem on the existence of maximum solutions. At the end of the paper we digress to relate our results to degrees of unsolvability and to computable analysis. (shrink)

Ecological fitness has been suggested to provide a unifying definition of fitness. However, a metric for this notion of fitness was in most cases unavailable except by proxy with differential reproductive success. In this article, I show how differential persistence of lineages can be used as a way to assess ecological fitness. This view is inspired by a better understanding of the evolution of some clonal plants, colonial organisms, and ecosystems. Differential persistence shows the limitation of an (...) ensemblist noncausal understanding of evolution. Causal explanations are necessary to understand the evolution by natural selection of these biological systems. †To contact the author write to: Department of Philosophy, University of Montreal, P.O. Box 6128, Station Centre‐Ville, Montreal, Quebec, H3C 3J7 Canada; e‐mail: [email protected]. (shrink)

Anger and disgust may have distinct roles in sexual morality; here, we tested hypotheses regarding the distinct foci, appraisals, and motivations of anger and disgust within the context of sexual offenses. We conducted four experiments in which we manipulated whether mutual consent (Studies 1–3) or desire (Study 4) was present or absent within a counter-normative sexual act. We found that anger is focused on the injustice of non-consensual sexual acts, and the transgressor of the injustice (Studies 1 and 3). Furthermore, (...) the sexual nature of the act was not critical for the elicitation of anger—as anger also responded to unjust acts of violence (Study 3). By contrast, we hypothesised and found that disgust is focused on whether or not a person voluntarily engaged in, desired or consented to a counter-normative sexual act (Studies 2–4). Appraisals of abnormality and degradation were the primary appraisals of disgust, and the sexual nature of the act was a critical elicitor of disgust (Study 3). A final study ruled out victimisation as the mechanism of the effect of consent on disgust and indicated that the consenter's sexual desire was the mechanism (Study 4). Our results reveal that anger and disgust have differential roles in consent-related sexual offenses due to the distinct appraisals and foci of these emotions. (shrink)

We evaluated the reliability, validity, and differential item functioning (DIF) of a shorter version of the Defining Issues Test-1 (DIT-1), the behavioral DIT (bDIT), measuring the development of moral reasoning. 353 college students (81 males, 271 females, 1 not reported; age M = 18.64 years, SD = 1.20 years) who were taking introductory psychology classes at a public University in a suburb area in the Southern United States participated in the present study. First, we examined the reliability of the (...) bDIT using Cronbach’s α and its concurrent validity with the original DIT-1 using disattenuated correlation. Second, we compared the test duration between the two measures. Third, we tested the DIF of each question between males and females. Findings reported that first, the bDIT showed acceptable reliability and good concurrent validity. Second, the test duration could be significantly shortened by employing the bDIT. Third, DIF results indicated that the bDIT items did not favour any gender. Practical implications of the present study based on the reported findings are discussed. (shrink)

It is now generally accepted that the motor system is not purely dedicated to the control of behavior, but also has cognitive functions. Mirror neurons have provided a new perspective on how sensory information regarding others’ actions and gestures is coupled with the internal cortical motor representation of them. This coupling allows an individual to enrich his interpretation of the social world through the activation of his own motor representations. Such mechanisms have been highly preserved in evolution as they are (...) present in humans, apes and monkeys. Recent neuroanatomical data showed that there are two different connectivity patterns in mirror neuron networks in the macaque: one is concerned with sensorimotor transformation in relation to reaching and hand grasping within the traditional parietal-premotor circuits; the second one is linked to the mouth/face motor control and the new data show that it is connected with limbic structures. The mouth mirror sector seems to be wired not only for ingestive behaviors but also for orofacial communicative gestures and vocalizations. Notably, the hand and mouth mirror networks partially overlap, suggesting the importance of hand-mouth synergies not only for sensorimotor transformation, but also for communicative purposes in order to better convey and control social signals. (shrink)

In this study, we implemented a new numerical method known as the Chebyshev Pseudospectral method for solving nonlinear delay differential equations having fractional order. The fractional derivative is defined in Caputo manner. The proposed method is simple, effective, and straightforward as compared to other numerical techniques. To check the validity and accuracy of the proposed method, some illustrative examples are solved by using the present scenario. The obtained results have confirmed the greater accuracy than the modified Laguerre wavelet method, (...) the Chebyshev wavelet method, and the modified wavelet-based algorithm. Moreover, based on the novelty and scientific importance, the present method can be extended to solve other nonlinear fractional-order delay differential equations. (shrink)

Topologists Nabutovsky and Weinberger discovered how to embed computably enumerable (c.e.) sets into the geometry of Riemannian metrics modulo diffeomorphisms. They used the complexity of the settling times of the c.e. sets to exhibit a much greater complexity of the depth and density of local minima for the diameter function than previously imagined. Their results depended on the existence of certain sequences of c.e. sets, constructed at their request by Csima and Soare, whose settling times had the necessary dominating properties. (...) Although these computability results had been announced earlier, their proofs have been deferred until this paper. Computably enumerable sets have long been used to prove undecidability of mathematical problems such as the word problem for groups and Hilbert's Tenth Problem. However, this example by Nabutovsky and Weinberger is perhaps the first example of the use of c.e. sets to demonstrate specific mathematical or geometric complexity of a mathematical structure such as the depth and distribution of local minima. (shrink)

Skepticism toward the existence of neonatal differential imitation is fostered by views that assign it an excessive significance, making it foundational for social cognition. Moreover, a misleading theoretical framework may generate unwarranted expectations about the kinds of findings experimentalists are supposed to look for. Hence we propose a theoretical analysis that may help experimentalists address the empirical question of whether early differential imitation really exists. We distinguish three models of early imitation. The first posits automatic visuo-motor links evolved (...) for sociocognitive functions and we call it Genetically Programmed Direct Matching. The second is Meltzoff and Moore’s Active Intermodal Matching, which postulates a comparison between the acts of self and other. The third is the alternative we propose and we call it “Association by Similarity Theory”, as it relies on the tacit functioning of this domain-general process. AST describes early imitation merely as the differential induction or elicitation of behaviors that already tend to occur spontaneously. We focus on the contrast between AIM and AST, and argue that AST is preferable to AIM for two reasons. First, AST is more parsimonious and more plausible, especially because it does not require infants to be able to recognize self-other similarities. Second, whereas the extant findings tend to disqualify AIM, AST can account for them adequately. Furthermore, we suggest that AST has the potential to give new impulse to empirical research because it discriminates promising lines of inquiry from unproductive ones. (shrink)

Geometry was a main source of inspiration for Carnap’s conventionalism. Taking Poincaré as his witness Carnap asserted in his dissertation Der Raum (Carnap 1922) that the metrical structure of space is conventional while the underlying topological structure describes "objective" facts. With only minor modifications he stuck to this account throughout his life. The aim of this paper is to disprove Carnap's contention by invoking some classical theorems of differential topology. By this means his metrical conventionalism turns out to be (...) indefensible for mathematical reasons. This implies that the relation between to-pology and geometry cannot be conceptualized as analogous to the relation between the meaning of a proposition and its expression in some language as logical empiricists used to say. (shrink)

As a continuation of the work of the third author in [5], we make further observations on the features of Galois cohomology in the general model theoretic context. We make explicit the connection between forms of definable groups and first cohomology sets with coefficients in a suitable automorphism group. We then use a method of twisting cohomology (inspired by Serre’s algebraic twisting) to describe arbitrary fibres in cohomology sequences—yielding a useful “finiteness” result on cohomology sets.Applied to the special case of (...) differential fields and Kolchin’s constrained cohomology, we complete results from [3] by proving that the first constrained cohomology set of a differential algebraic group over a bounded, differentially large, field is countable. (shrink)

The aim of this study is to develop an integrative model linking the effect of authoritarian leadership and differential leadership on employee turnover intention, and further explore the moderating role of the in-group/out-group on the above-mentioned relationships. We collected a sample of 624 supervisor–subordinate dyads from 87 teams in Mainland China and Taiwan. We find that, at the individual level, authoritarian leadership is positively related with employee turnover intention, and the relationship will be enhanced especially when the subordinate is (...) an in-group member. Through hierarchical linear modeling analysis, we find a negative relationship between differential leadership and employee turnover intention, significantly moderated by the within-team mean degree and the within-team variance degree of in-group/out-group. Contributions, limitations, and future research directions are discussed. (shrink)

In [T. Brihaye, C. Michaux, C. Rivière, Cell decomposition and dimension function in the theory of closed ordered differential fields, Ann. Pure Appl. Logic .] the authors proved a cell decomposition theorem for the theory of closed ordered differential fields which generalizes the usual Cell Decomposition Theorem for o-minimal structures. As a consequence of this result, a well-behaving dimension function on definable sets in CODF was introduced. Here we continue the study of this cell decomposition in CODF by (...) proving three additional results. We first discuss the relation between the δ-cells introduced in the above-mentioned reference and the notion of Kolchin polynomial in differential algebra. We then prove two generalizations of classical decomposition theorems in o-minimal structures. More exactly we give a theorem of decomposition into definably d-connected components and a differential cell decomposition theorem for a particular class of definable functions in CODF. (shrink)

The category \(\mathbb {DRDL}{'}\), whose objects are c-differential residuated distributive lattices satisfying the condition \(\textbf{CK}\), is the image of the category \(\mathbb {RDL}\), whose objects are residuated distributive lattices, under the categorical equivalence \(\textbf{K}\) that is constructed in Castiglioni et al. (Stud Log 90:93–124, 2008). In this paper, we introduce weak monadic residuated lattices and study some of their subvarieties. In particular, we use the functor \(\textbf{K}\) to relate the category \(\mathbb {WMRDL}\), whose objects are weak monadic residuated distributive (...) lattices, and the category \(\mathbb {WMDRDL}{'}\), whose objects are pairs formed by an object of \(\mathbb {DRDL}{'}\) and a center weak universal quantifier. (shrink)

This target article examines the clinical and experimental evidence for a role of peripheral and central hyperexcitability in persistent pain in four key areas: cutaneous hyperalgesia, referred pain, neuropathic pain, and postoperative pain. Each suggests that persistent pain depends not only on central sensitization, but also on inputs from damaged peripheral tissue. It is instructive to think of central sensitization as comprised of both an initial central sensitization and an ongoing central sensitization driven by inputs from peripheral sources. Each of (...) these factors, initial sensitization, ongoing central sensitization, and inputs from peripheral sources, contributes to the net activity in dorsal horn neurons and thus influences the expression of persistent pain or hyperalgesia. Since each factor, peripheral inputs and central sensitization (initial or ongoing), can contribute to both the initiation and maintenance of persistent pain, therapies should target both peripheral and central sources of pathology. (shrink)

There are indications that the interpersonal affective factor and the social deviation factor, both of which are underlying dimensions of psychopathy, have a positive and a negative relationship, respectively, with executive functioning. However, this is seldom taken into consideration in the research on the relationship between executive functioning and psychopathy, which may be an explanation for the many inconsistent results in this area as reported in the literature (e.g., Rogers, 2006). In the present study, executive functioning was studied using the (...) Wisconsin Card Sorting Test (WCST) in 53 inpatients of a Dutch forensic psychiatric clinic who were classified by means of the Psychopathy Checklist-Revised (PCL-R). Special attention was given to the relationship between the two separate factors and executive functioning. Age, educational level, and substance abuse were controlled for in the analysis. No difference was found between psychopathic (N = 17) and nonpsychopathic (N = 36) patients in the WCST scoring categories, nor was there a significant difference in the four diagnostic subgroups defined by the two factors. However, the trends observed do justify further study in this direction. (shrink)

Micro-expressions, as fleeting facial expressions, are very important for judging people’s true emotions, thus can provide an essential behavioral clue for lie and dangerous demeanor detection. From embodied accounts of cognition, we derived a novel hypothesis that facial feedback from upper and lower facial regions has differential effects on micro-expression recognition. This hypothesis was tested and supported across three studies. Specifically, the results of Study 1 showed that people became better judges of intense micro-expressions with a duration of 450 (...) ms when the facial feedback from upper face was enhanced via a restricting gel. Additional results of Study 2 showed that the recognition accuracy of subtle micro-expressions was significantly impaired under all duration conditions (50 ms, 150 ms, 333 ms, and 450 ms) when facial feedback from lower face was enhanced. In addition, the results of Study 3 also revealed that blocking the facial feedback of lower face, significantly boosted the recognition accuracy of subtle and intense micro-expressions under all duration conditions (150 ms and 450 ms). Together, these results highlight the role of facial feedback in judging the subtle movements of micro-expressions. (shrink)

According to the No Alternate Possibilities argument, if time passes then the rate at which it passes could be different but time cannot pass at different rates, and hence time cannot pass. Typically, defenders of the NAP argument have focussed on defending premise, and have taken the truth of for granted: they accept the orthodox view of rate necessitarianism. In this paper we argue that the defender of the NAP argument needs to turn her attention to. We describe a series (...) of worlds that appear to contain differential passage: worlds where time passes at different rates in different subregions. If the NAP argument is to succeed, rate necessitarians must show that each of these worlds is either metaphysically impossible, or does not contain differential passage. (shrink)

Alexis Fontaine des Bertins was the first French mathematician to make use of the calculus of several variables in the integration of ordinary differential equations . In this paper I argue that this usage evolved from Fontaine's ‘fluxio-differential method’ of the early 1730s. In this way I extend the thesis enunciated in an earlier paper in this journal.

A new class of polynomials investigates the numerical solution of the fractional pantograph delay ordinary differential equations. These polynomials are equipped with an auxiliary unknown parameter a, which is obtained using the collocation and least-squares methods. In this study, the numerical solution of the fractional pantograph delay differential equation is displayed in the truncated series form. The upper bound of the solution as well as the error analysis and the rate of convergence theorem are also investigated in this (...) study. In five examples, the numerical results of the present method have been compared with other methods. For the first time, a -polynomials are used in this study to numerically solve delay equations, and accurate approximations have been displayed. (shrink)

This article explores the foundational place of disharmony in Deleuze's metaphysics and examines the consequences of this for the ethics that can be drawn from his work. For Deleuze, the space in which difference manifests itself is one of discord, monstrosity and violence. This becomes evident in his revision of Leibniz's notion of harmony in which he offers a “new harmony” based on the violent discords of differential relations, his evocation of the monstrosity of difference, and his theorization of (...) the violence of thought. This paper addresses the critically neglected juncture between Deleuze's violent metaphysics and the kinds of speculative ethics that this metaphysics calls forth. (shrink)