The National Cancer Institute thesaurus is an important knowledge resource that should ideally be error-free. We investigated the occurrence of errors in the Neoplasm subhierarchy, which is a part...

This paper exposes some examples of continuing murky thinking concerning holism. The exposure is a prelude to noting the importance of proximity in causal explanations of illnesses and wounds. The paper then draws attention to how the proximate should not hold exclusive sway regarding what constitutes best nursing treatment and care. The error of excessive preference for proximity is shown to be an error, using as an example the treatment of leg ulcers. One component of holism that can (...) be clearly expressed amounts therefore simply to the claim: resist the error of excessive proximity preference, resist the error of concentrating solely on nearness. It is left open whether there is any further sense to be gleaned from the holistic babble. (shrink)

Abū Hāmid al-Ghazālī (1058–1111 c.e .) is well known, among other things, for his account, in al-Munqidh min al-ḍalāl (Deliverance from error), of a struggle with philosophical skepticism that bears a striking resemblance to that described by Descartes in the Meditations . This essay aims to give a close comparative analysis of these respective accounts, and will concentrate solely on the processes of invoking or entertaining doubt that al-Ghazālī and Descartes describe, respectively. In the process some subtle differences between (...) them in this regard will be brought to light that are relevant to the comparative issue of the respective solutions at which they arrive. The latter issue will not be touched upon here, although the present discussion is intended as a prelude to a future treatment of that topic. (shrink)

This article scrutinizes in detail much of the extant historiography on the controversy between biometricians and Mendelians, considering in particular how this controversy is related to the evolutionary synthesis. While the historiographic critique concentrates on William Provine’s standard account, it also extends to the proposal by Donald MacKenzie and Barry Barnes. What Provine and these sociologists of scientific knowledge have in common is a set of unquestioned assumptions about the nature of Darwinism, about William Bateson’s anti-Darwinism, and about the very (...) idea of an evolutionary “synthesis.” While these assumptions make for a compelling history of the synthesis, they engender an endemically asymmetrical perspective and bias historiography toward the mere confirmation of antecedent expectations, which renders the years from 1859 to 1929 an age of ignorance and misunderstanding. In contrast, a return to what was probably the original meaning of evolutionary “synthesis” allows for a symmetrical account. It yields an appreciation of the positive contributions made both by Mendelians and biometricians to the gradual development of Darwinism. The article concludes with a synopsis of this alternative account. (shrink)

From the O.J. Simpson verdict to peace-making in the Balkans, the critical role of human judgement--complete with its failures, flaws, and successes--has never been more hotly debated and analyzed than it is today. This landmark work examines the dynamics of judgement and its impact on events that take place in human society, which require the direction and control of social policy. Research on social policy typically focuses on content. This book concentrates instead on the decision-making process itself. Drawing on 50 (...) years of empirical research in decision theory, Hammond examines the possibilities for wisdom and cognitive competence in the formation of social policies, and applies these lessons to specific examples, such as the space shuttle Challenger disaster and the health care debate. Uncertainly, he tells us, can seldom be fully eliminated; thus error is inevitable, and injustice for some unavoidable. But the capacity for make wise judgments increases to the extent that we understand the potential pitfalls and their origin. The judgment process for example involves an ongoing rivalry between intuition and analysis, accuracy and rationality. The source of this tension requires an examination of the evolutionary roots of human judgement and how these fundamental features may be changing as our civilization increasingly becomes an information and knowledge-based society. With numerous examples from law, medicine, engineering, and economics, the author dramatizes the importance of judgment and its role in the formation of social policies which affect us all, and issues the first comprehensive examination of its underlying dynamics. (shrink)

This paper concentrates on the event-triggered H ∞ filter design for the discrete-time Markovian jump neural networks under random missing measurements and cyber attacks. Considering that the controlled system and the filtering can exchange information over a shared communication network which is vulnerable to the cyber attacks and has limited bandwidth, the event-triggered mechanism is proposed to relieve the communication burden of data transmission. A variable conforming to Bernoulli distribution is exploited to describe the stochastic phenomenon since the missing measurements (...) occur with random probability. Furthermore, seeing that the communication networks are vulnerable to external malicious attacks, the transferred information via the shared communication network may be changed by the injected false information from the attackers. Based on the above consideration, sufficient conditions for the filtering error system to maintain asymptotically stable are provided with predefined H ∞ performance. In the end, three numerical examples are given to verify the proposed theoretical results. (shrink)

As a way to address both ominous and ordinary threats of artificial intelligence, researchers have started proposing ways to stop an AI system before it has a chance to escape outside control and cause harm. A so-called “big red button” would enable human operators to interrupt or divert a system while preventing the system from learning that such an intervention is a threat. Though an emergency button for AI seems to make intuitive sense, that approach ultimately concentrates on the point (...) when a system has already “gone rogue” and seeks to obstruct interference. A better approach would be to make ongoing self-evaluation and testing an integral part of a system’s operation, diagnose how the system is in error and to prevent chaos and risk before they start. In this paper, we describe the demands that recent big red button proposals have not addressed, and we offer a preliminary model of an approach that could better meet them. We argue for an ethical core that consists of a scenario-generation mechanism and a simulation environment that are used to test a system’s decisions in simulated worlds, rather than the real world. This EC would be kept opaque to the system itself: through careful design of memory and the character of the scenario, the system’s algorithms would be prevented from learning about its operation and its function, and ultimately its presence. By monitoring and checking for deviant behavior, we conclude, a continual testing approach will be far more effective, responsive, and vigilant toward a system’s learning and action in the world than an emergency button which one might not get to push in time. (shrink)

This study expands the application of deonance theory into organizations’ upper echelons by examining how CEOs imprinted with a sense of duty can influence managerial decision-making. We hypothesize an imprint of bounded autonomy, an ought-force that constrains their decision-making and understanding of behavioral freedom, influences duty-bound CEOs to self-report errors in past financial reporting. We test deonance theory propositions of instrumentality for behavioral expansion, namely loss avoidance and gain attainment, related to institutional ownership concentration and CEO equity ownership. We (...) use CEOs that are graduates of U.S. service academies as a proxy for duty-bound executives and find firms they lead are more likely to issue a financial restatement to correct a previous reporting error. This finding is robust to alternate explanations such as being error-prone, earnings management, auditor oversight, and risk behaviors. We also find evidence that deonance may be subject to behavioral expansion. The likelihood of issuing a restatement decreases as institutional ownership concentration and CEO equity ownership increases. This study shows imprinted deonance within the C-suite influences important organizational outcomes. (shrink)

This article concentrates on two main interpreta- tions of Friedrich Nietzshe's philosophy: hermeneuti- cal , originated in Martin Heidegger's book "Nietzsche" and deconstnlctive -, elaborated in Jacques Derrida's book "Esperon: Le Styles de Nietzsche. Spurs. Nietzshe's Styles".and his article "Interpreting Signatures : Two Questions". The author of the article considers that the idea of in- verted platonism as a main paradigm of Nietzsche's thought is original Heidegger's idea, underlying his interpretation of Nietzsche as a last methaphysisian in Western thought. Derrida, (...) interpreting the same one page fragment "History of an Error" from Nietzche's work "Twilight o f the Idols" opposed Heidegger's intention to unite the diversity o f Nietzsche's thought into one paradigmatic schema. Author of the article considers, that his deconstructive efforts clearly exposed, that Heidegger's interpetation neglecting the pliuralistic diversity of Nietzsche's philosophys is influenced more by his longing for axi- omatic unity common to methaphysical thought than by original Nietzsche's thinking. Raktiniai iodiiai: Platonizmas, ~pvertiina.~, pa- skutinis nzetapzikas, Nietzsclze b stilius. (shrink)

Professor Brenda Baker's recent critique of the Canadian Law Reform Commission's treatment of general standards for criminal liability adds to a growing body of critical theory concerning such standards and their relation to criminal justice. From within the perspective of this same critical movement, I assess the strengths and weaknesses of Professor Baker's efforts and of similar lines of argument in the work of Professor George Fletcher. I find two significant flaws in their shared approach. The first is confusion as (...) to the proper level for analysis of liability standards and, hence, for criticism of the "orthodox" view. This leads Professors Baker and Fletcher to concentrate on issues of culpability rather than responsibility (and to conflate these issues). The second flaw is an error in comprehension of the faults of the orthodox view and, hence, in recognition of the fundamental character of views opposed to that orthodoxy. This leads both theorists to overemphasize a suspect and unilluminating distinction between normative and descriptive approaches to liability problems. The rest of the article is devoted to an overview of my own approach to problems of liability and a general critique of the orthodox view in light of that approach. I argue that the fundamental issue is the relation of liability standards to a conception of agent responsibility. The primary fault of orthodoxy lies, then, in the cognitivist model of responsibility on which it relies. Against this, I propose use of a capacities model of responsibility as the basis for standards of liability. These two models are outlined and compared in final sections. (shrink)

Binding can be described at three different levels: In neuroscience it refers to the integration of single-cell activities to form functional neural assemblies, especially in response to global stimulus properties; in cognitive science it refers to the integration of distributed modular input processing to form unified representations for memory and action, and in consciousness studies it refers to the unity of phenomenal consciousness . To describe and explain the unity of consciousness, detailed phenomenological descriptions of binding at the phenomenal level (...) and clarification of the underlying cognitive and neural mechanisms are required. The disunity of consciousness during dreaming is a fruitful avenue to study phenomenal binding and its mechanisms. The notion of the 'bizarreness' of dreams is closely related to the concept of 'binding': bizarreness can be reconceptualized as referring to different types of unusual combinations of features in the binding of dream images coherently together. The present study concentrates on the representation of human characters and the bizarreness found in these representations. We developed a rating scale that distinguishes different types of bizarreness on the basis of the unusual combinations of elements that are manifested in dream images. The data consisted of 592 dream reports in the home-based dream diaries of 52 students. The results indicate that about half of the human characters appearing in our dreams contain bizarre elements, and that certain types of bizarreness are more frequent than others. Phenomenal features intrinsic to the representation of a person are less frequently bizarre than is the external relation between the person and the context . Thus, binding the local features of a representation coherently together appears to be less prone to errors than binding several different information streams together into a coherent phenomenal model of the world. (shrink)

This book argues that a basic grasp of philosophy and logic can produce written and spoken material that is both grammatically correct and powerful. The author analyses errors in grammar, word choice, phrasing and sentences that even the finest writers can fail to notice; concentrating on subtle missteps and errors that can make the difference between good and excellent prose. Each chapter addresses how common words and long-established grammatical rules are often misused or ignored altogether – including such common words (...) as ‘interesting’, ‘possible’, and ‘apparent’. By tackling language in this way, the author provides an illuminating and practical stylistic guide that will interest students and scholars of grammar and philosophy, as well as readers looking to improve their technical writing skills. (shrink)

When the first publication of Hans-Georg Gadamer's magnum opus Wahrheit und Methode came to life in I960, the work was initially received with a slight sense of puzzlement and yet concurrently acknowledged as monumental. The title, in English, Truth and Method, was regarded by the philosophical community both in Germany and abroad as being somewhat obscure, as Gadamer himself would later admit, but the ingeniousness of the book's content could hardly be debated. Since its initial publication, Truth and Method has, (...) respectively helped to expand and light up the horizon of modern hermeneutics by provoking, at once, a reconsideration of the phenomenon of understanding while, at the same time, enlivening the debate over scientific methodology and its exclusive claim to truth. The central aim of the present thesis has been to focus on Part I of Truth and Method, concentrating primarily on the 'guiding humanistic concepts' and the experience of truth in art, to clarify Gadamer's understanding of truth and to shed new light as to how the experience of tmth is to be grasped in relation to the human sciences, i.e. the humanities. The humanistic concepts, I believe, are vital to understanding the experience of truth. One reason, which leads me to this conclusion, is that in Truth and Method Gadamer begins his philosophical undertaking with the elucidation of the humanistic concepts rather than with a direct exposition of truth. By opening with the humanistic concepts, Gadamer seems to demonstrate subtly the phenomenological and ontological nature of knowledge and understanding. The outcome of this manoeuvre is that one comes to realise that truth does not simply belong to method and that it is not something which can be defined solely as 'absolute certainty'. Moreover, in my interview with Professor Gadamer, the humanistic concepts, he explained to me, are the most 'natural' and 'original' concepts. By natural and original he means that these concepts are intrinsic. They evolve from life as well as being a part of life, i.e. a way of living. Thus these concepts, he affirmed, represent 'a way of life' and a way to truth. Consequently, insofar as comprehending the phenomenon of truth, I believe any and every investigation of the concept of truth must begin with the understanding of the humanistic tradition. The following thesis however does not end simply with the humanistic concepts. It also devotes to examining the truth-claim or the 'truth-experience' of art. This part of the inquiry centres on two important questions: How are we to understand art? What does it mean to experience art? The challenge here has been to show how Gadamer overcomes Kant's subjectivation of the aesthetic experience and to demonstrate how and why Gadamer considers the experience of art as the 'self-presentation' of being. In surveying the various works of criticism I have tried to draw attention to what seem to me to be the most insightful comments and analyses. If 1 have failed in any way to supply proper acknowledgement to ideas, which might seem close to other critical works, I offer my apologies. As I am sure those in the research business know well, in reflection ideas often interfuse with one's own, making it difficult sometimes to discriminate between one's own ideas from another's. However, I have tried my best to keep from that error. (shrink)

It is an interesting paradox that on the one hand intemperate enthusiasm greets new medical discoveries. On the other hand, the lack of science in medicine is paraded from time to time, usually as a matter of apologetics, as, when a physician wishes to excuse an error, a lawyer to discredit a physician, or a jury to render a verdict contrary to medical evidence. Philosophers who insist on the mathematical or quantitative aspects in any definition of science ascribe very (...) little that is truly scientific to biology in general or to its daughter medicine in particular. Jerome Frank comments approvingly that “many scientific-minded physicians today deny that medicine is, or is likely ever to be, a science.” Articulate physicians themselves may be highly critical. Dr. Ian Stevenson, for example, declares, “Medicine will not achieve the status of a science until the basic laws of health and disease have been disclosed. But the search for these laws has hardly begun.” Stevenson goes on to point out that instead of seeking basic laws, medicine is concentrating on facts, from which no laws emerge. (shrink)

As interpersonal, racial, social, and international conflicts intensify in the world, it is important to safeguard the mental health of individuals affected by them. According to a Buddhist notion “if you want others to be happy, practice compassion; if you want to be happy, practice compassion,” compassion practice is an intervention to cultivate conflict-proof well-being. Here, compassion practice refers to a form of concentrated meditation wherein a practitioner attunes to friend, enemy, and someone in between, thinking, “I’m going to help (...) them.” The compassion meditation is based on Buddhist philosophy that mental suffering is rooted in conceptual thoughts that give rise to generic mental images of self and others and subsequent biases to preserve one’s egoism, blocking the ultimate nature of mind. To contextualize compassion meditation scientifically, we adopted a Bayesian active inference framework to incorporate relevant Buddhist concepts, including mind, compassion, aggregates, suffering, reification, conceptual thoughts, and superimposition. In this framework, a person is considered a Bayesian Engine that actively constructs phenomena based on the aggregates of forms, sensations, discriminations, actions, and consciousness. When the person embodies rigid beliefs about self and others’ identities and the resulting ego-preserving bias, the person’s Bayesian Engine malfunctions, failing to use prediction errors to update prior beliefs. To counter this problem, after recognizing the causes of sufferings, a practitioner of the compassion meditation aims to attune to all others equally, friends and enemies alike, suspend identity-based conceptual thoughts, and eventually let go of any identity-grasping belief and ego-preserving bias that obscure reality. We present a brain model for the Bayesian Engine of three components: Relation-Modeling, Reality-Checking, and Conflict-Alarming, which are subserved by the Default-Mode Network, Frontoparietal Network and Ventral Attention Network, and Salience Network, respectively. Upon perceiving conflicts, the strengthening or weakening of ego-preserving bias will critically depend on whether the SN up-regulates the DMN or FPN/VAN, respectively. We propose that compassion meditation can strengthen brain regions that are conducive for suspending prior beliefs and enhancing the attunements to the counterparts in conflicts. (shrink)

Milton Friedman's article, The Social Responsibility of Business Is To Increase Its Profits, owes its appeal to the rhetorical devices of simplicity, authority, and finality. More careful consideration reveals oversimplification and ambiguity that conceals empirical errors and logical fallacies. It is false that business does, or would, operate exclusively in economic terms, that managers concentrate obsessively on profitability, and that ethics can be marginalized. These errors reflect basic contradictions: an apolitical political base, altruistic agents of selfishness, and good deriving from (...) greed. (shrink)

ABSTRACTDiffraction gratings are famously associated with Henry Rowland of Johns Hopkins University but there were precursors. Although gratings were first made and used in Europe, reliable machines for ruling gratings were developed in the USA, and two men, Lewis Rutherfurd and William Rogers, tackled the problem before Rowland. Rutherfurd, a wealthy independent astronomer, designed and built the first screw-operated engine for ruling diffraction gratings, the fore-runner of almost all subsequent ruling engines. With it he and his assistant D. C. Chapman (...) ruled many gratings which he generously distributed to practising scientists, thereby materially advancing the science of spectroscopy. Rogers was a Harvard astronomer who developed an interest in the ruling of fine lines on glass that led him to construct a ruling engine with which he investigated the causes of the errors in the rulings he had examined. He continued to seek improvements with a second engine designed for ruling diffraction gratings. He ceased developing this engine when Rowland’s excellent gratings began to be available, concentrating instead on related problems to which he could apply the knowledge and skills he had gained, but his investigations assisted Rowland and other later ruling engine builders. This paper brings together what is known about the ruling engines of Rutherfurd and Rogers, their development, the gratings they produced, their quality and the work that was done with them, and assesses and compares their achievements and the impacts of the work of these two men. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BELSEY ON LANGUAGE AND REALISM by Noel Carroll Like much contemporary literary theory, Catherine Belsey's influential Critical Practice1 is antirealist, where "antirealism" refers both to the rejection of a putative literary style and to the espousal of an epistemological stance, the latter ostensibly grounded in a theory of language, adapted from Ferdinand Saussure. Moreover, these two antirealisms are connected in that stylistic antirealism is, in part, advanced as a (...) consequence of epistemological —or perhaps more aptly "linguistic"— antirealism. Belsey's theory is avowedly political, designed to challenge the operation of ideology in literature, particularly realist literature. That is, though Belsey discusses literature of several different periods and of different genres, her primary preoccupation is with something she calls expressive realism, a tendency perhaps best exemplified by the nineteenth-century novel and still pursued by our less experimental writers. Purportedly, expressive realism is underwritten by at least two tenets: (1) realism insofar as it presumes that literature can accurately represent reality, and (2) a variant of expressionism insofar as it presumes we have access to the thoughts and intentions of authors {CP, p. 7). In this note, I shall concentrate exclusively on the linguistic arguments— which Belsey calls "Post Saussurean" — that are mobilized to discredit the first presumption of literary realism, its claim to represent reality. For Belsey, a major problem with expressive realism is that this sort of literature presents itself or is taken as an accurate reflection of reality. Belsey sometimes makes this point by saying that such literature purports to be an accurate representation of reality. At other moments, that which such literature claims to reflect accurately is said to be experiences of reality. But these alternative claims are also segued by 124 Noel Carroll125 saying that what is reflected are experiences of reality which are recognized to be true. Given the text, the variant of the reflection theory that appears to occupy Belsey most is the notion that literature reflects reality — that is, holds a mirror up to nature, as Hamlet might have it. This raises Belsey's political hackles because she believes that a commitment to the plausibility of the goal of reflecting life accurately invests realist literature with the aura of a socially unmediated, transhistorical, "natural" account of human life rather than an ideologically constructed one. In order to forestall this supposedly political repercussion, Belsey, taking advantage of her expanded version of Saussurean linguistics, charges that realism misconstrues the relationship between literature and the world. Indeed, ana this is the crux of her postSaussurean argument, the error here can be traced to something deeper, viz., a misconstrual of the relation between language and the world, of which the pretensions of literary realism are merely but an instance. Stated baldly, Belsey aspires to debunk literature's claims to realism by denying language's claims to realism. This may seem rather like killing a fly by using a cannon. And, in any case, one would have thought that questions about the representational efficacy of language were logically independent of the issue of the ideological operation of literary realism. However, Belsey, like many contemporary literary theorists, mistakenly believes that one contests literary realism by propounding epistemological reservations about language. Belsey claims that her linguistic antirealism derives from Saussure's putative discovery that "far from providing a set of labels for entities which exist independently in the world, language precedes the existence of independent entities, making the world intelligible by differentiating between concepts" {CP, p. 38). That language always precedes the existence of that to which it refers is a truly astounding discovery. And we should wish to know how Saussure, according to Belsey's interpretation, came upon it. For Saussure, language is a system of signs. Signs are composed of two elements: a material element— a sound-image or graphic image— called a signifier, and a conceptual element, what in different jargons is referred to as a meaning, an intension, or a connotation, and which in Saussure's terminology is called a signified. At this point it pays to notice what is missing in this account, viz., what other theorists sometimes call the reference, extension, or denotation of a term, that is, the set of 126Philosophy and... (shrink)

The adaptation of the new municipal entities to present-day social life is a success. The concentration of the local administration with better organized services has left human relations unaffected. The amalgamation of the territory and its administration has effected a more equitable distribution of the casts. Considering the administration, the new municipalities could have been bigger but the human dimensions did not allow such enlargement. In most cases, the amalgamation contributed to the inception of a real social and economie (...) entity. But the deliberations did not always lead to new municipalities that would normally have been required. In view of the rationalisation and improvement of the services the new municipality has succeeded. More goods and services are being distributed for the same cost. The amalgamation of the municipalities led to better organization and more efficiency of the administration.The power to manage increased. Concerning municipal finances, the amalgamation operation has not caused any deficits. The causes of the deficits have to be sought elsewhere : a tendency to extend social benefits and to overstaff, the transformation of the Centers for Public Assistance into Public Centers for Social Welf are, the failure of the national government to fulfil its financial obligations vis-à-vis the municipalities. In addition to these causes, errors in judgment have compromised the finances of many municipalities. On the whole, the amalgamations have been a success. (shrink)

Researchers of non-human animal emotions tend to defend some forms of anthropomorphism and seek ways to make it more critical, self-aware, and useful for scientific purposes. I propose that to achieve this goal, we need first to conduct a Kantian investigation into the deeper structure of anthropomorphism. I argue that we can distinguish at least three levels of anthropomorphising: a narrative level, a cognitive level and an in-between, metatheoretical level which is the deeper structure determining how we anthropomorphise. Because the (...) current debate tends to focus either on the narrative level or on the cognitive level, this paper concentrates on the metatheoretical level, discusses its role in emotion research, the possible errors it may cause, and how we can work on it, drawing on predictive processing-based theories of emotions and an evolutionary approach. The key to being critical in anthropomorphism is to be aware of the complexity of this whole structure, as well as to be able to challenge and put into question all and any of its elements. (shrink)

This article will explore the representation of certain mental and somatic phenomena in Beckett’s trilogy of novels Molloy, Malone Dies and The Unnamable, exploring how his understanding of schizophrenia and psychosis informs his representation of the relationship between mind and body. It will also examine recent phenomenological and philosophical accounts of schizophrenia (Louis Sass, Josef Parnas, Shaun Gallagher) that see the condition as a disorder of selfhood and concentrate in it on the disruption to ipseity, a fundamental and pre-reflective awareness (...) of self that leads to a loss of ‘grip’ (in the term of Merleau-Ponty) on concepts and percepts. Beckett’s writing might, it is argued, make such disruptions more tangible and intelligible. The article will also consider John Campbell’s argument that immunity of the first person to error—Sydney Shoemaker’s foundational philosophical idea that we cannot misspeak the first person pronoun—is revoked in states of psychosis, and relate such states to the moments in Beckett’s writing where this immunity is challenged, and quasi-psychotic experiences represented. (shrink)

What is the nature of truth? This question has been answered by philosophers in quite different ways, while F. H. Bradley asserts that truths have degrees and that no proposition can be stated to be simply true or false. In this paper, I briefly illustrate what he calls the doctrine of degrees of truth and try to address the problems it entails. I first explain what he means by truth and error/falsehood (he does not make a clear distinction between (...) the two terms); then, I concentrate on his criticisms of three theories of truth, followed by a discussion of his own identity theory of truth. I will be focusing on his doctrine of the degrees of truth and highlight its difficulties. I show that his theory faces some insurmountable difficulties, and it should be motivated by a particular form of monism that he insisted on, saying existence monism. (shrink)

We deal with the design problem of nonfragile state estimator for discrete-time genetic regulatory networks with time-varying delays and randomly occurring uncertainties. In particular, the norm-bounded uncertainties enter into the GRNs in random ways in order to reflect the characteristic of the modelling errors, and the so-called randomly occurring uncertainties are characterized by certain mutually independent random variables obeying the Bernoulli distribution. The focus of the paper is on developing a new nonfragile state estimation method to estimate the concentrations of (...) the mRNA and the protein for considered uncertain delayed GRNs, where the randomly occurring estimator gain perturbations are allowed. By constructing a Lyapunov-Krasovskii functional, a delay-dependent criterion is obtained in terms of linear matrix inequalities by properly using the discrete-time Wirtinger-based inequality and reciprocally convex combination approach as well as the free-weighting matrix method. It is shown that the proposed method ensures that the estimation error dynamics is globally asymptotically stable and the desired estimator parameter is designed via the solutions to certain LMIs. Finally, we provide two numerical examples to illustrate the feasibility and validity of the proposed estimation results. (shrink)

Philosophers are intellectual cannibals; they feed on the supposed errors of their colleagues. No harm in that, it might be said. With a sophistical argument like that of the Queen in Alice Through the Looking Glass to support the punishment of the innocent, progress in philosophy might be thought dependent on such voracious activities. The Queen thought that in replying to the claim that punishing the innocent was wrong one could say that if the victim really was innocent then that (...) produced a better universe than one which contained both the pain of the punishment and that of the original crime. In a similar way it might be argued that if the supposed errors of a colleague really exist, then their correction is beneficial; while if the errors do not exist then at least there is underlying agreement among philosophers, though perhaps not harmony. The sophistry, however, arises from the fact that in both cases there are other, and better, alternatives. The Queen unaccountably forgets that it would be still better in the case of innocence not to punish at all; and the philosophical apologist for intellectual cannibalism forgets, unaccountably, that it might be still better to advertise agreement rather than to feed on supposed errors which do not exist. For one thing, in that latter case the spurious conflict might positively conceal the real disagreements. Something of that latter kind happens in Timothy Sprigge’s comments on my views about William James ; James and Bradley:American Truth and British Reality, Open Court, 1994 ). I cannot, however, take much credit for stimulating Sprigge to adopt positions similar to mine for two reasons. First the apparent conflicts which conceal real agreement are relatively few, although quite important; second his own considered general view of James is certainly different from mine and marks the real disagreement between us. Accordingly I take two bites at this particular cherry; first to consider my supposed errors and second to identify the real differences between us. Timothy Sprigge claims to find a number of minor errors in my account, but I concentrate on the two major cases. (shrink)

With his 1951 publication of “Two Dogmas of Empiricism”, W.V.O. Quine launched a series of arguments against the idea that analyticity – “truth in virtue of meaning alone” – could be a philosophically explanatory notion. While his rejection represents a significant philosophical stride in its own right, to which many in the contemporary philosophical scene pay verbal respects, the revolutionary consequences of this insight often go ignored today. Much of current professional philosophy in virtually every sub-discipline carries on as though (...) analyticity were a viable notion, because much of it aims at conceptual analysis – the “discovery” of the meanings of philosophical concepts, such as ‘mind’, ‘truth’, ‘meaning’, ‘person’, and ‘right’. Rejecting analyticity as a viable philosophical notion undermines such efforts insofar as they aim at conceptual analysis. If philosophers give up the notion of analyticity, as they should, they are left with the questions of what goals and methods are viable for the analysis of concepts. One option is to concentrate effort on explication of familiar concepts; explication is an alternative to conceptual analysis in that it does not aim to dig out analytic truths about given concepts. Rather, it identifies what is interesting about a certain vague concept, and generates a new, more rigorous and precise concept to replace the old one. The justification for the replacement, in the most appealing cases, is in the possibilities for understanding that are introduced by the new explication. Examples of explication in my sense are the replacement of ordinary grammatical terms by the operators of first order logic, replacement of ‘game’ with a decision theoretic notion of games in game theory, and replacement of ‘true’ with ‘true-in-L’ in Tarskian semantics. Advances of this sort depart consciously in some ways from ordinary usage of the terms they focus on, but in so departing, they develop new possibilities and perspectives for rigorously understanding the world. In the dissertation that follows, I not only recommend explication as a method, I also put it into practice. I develop an explication of the sameness and difference relations that relies solely on the relation of denotation between a predicate and objects of which it is true. Two things are the same with respect to R just in case there is at least one R-predicate that denotes them in common. I used this explication to develop related explications of similarity and analogy. These latter explications, I use to critique the current fashion of research on similarity and analogy in cognitive psychology. These studies have produced an immense body of interesting and promising work in the past several decades; however, much of the research design and data interpretation harbors philosophical errors and so often imports unjustified prejudices from the researchers themselves. My explication offers alternative formulations of the most salient aspects of these research traditions, formulations that avoid the errors of past research and, more importantly, suggest new research questions and possibilities that would not occur under the previous, philosophically muddled paradigm. The project closes with an application of my explication of analogy to a discussion and critique of the philosophical literature on analogical arguments. While philosophers and logicians have developed workable theories for deductive and inductive reasoning, very little work of promise has been done on analogical arguments. My explication of analogy is used to diagnose the problems of past attempts by philosophers to develop logics for analogical arguments and suggest, in light of the psychological research on analogy and the use of analogies in scientific thought, that philosophers should focus on analogical arguments as creative, heuristic devices, rather than as truth-preserving inference structures. (shrink)

Let us by-pass a lot of disputation by starting with the objections to the dispute itself. It is surely a misfortune, not a gain, both to the biological and the social sciences that a discontinuity has appeared between them over the topic of Human Nature—that the findings of each group seem in important ways alien and unusable for the purposes of the other. To be forced to give up hope of learning anything from a particular source is always a misfortune, (...) it cannot be a cause for triumph. The unity of the world we study calls for free trade in information and in concepts between all the sciences. Autonomy cannot be isolation. Of course each discipline needs to be distinct and to use its own methods. But each also vitally needs to be open to suggestions from its neighbours. Barriers ought not to be raised except against real dangers. In the case before us, I want to say that the suspicions of the social sciences, from which this particular gap largely arises, are misplaced. The contraband article which they fear is real enough, but it is no real part of the physical sciences. It is irrelevant melodrama. What actually is part of the physical sciences cannot be contraband; it is truth which has somehow to be studied and accepted. The workings of prejudice on both sides make this hard, causing contraband sometimes to be exported as fact, and fact sometimes to be rejected as contraband. In this paper I suggest that we concentrate on understanding these prejudices—not because psychoanalysing our errors is any substitute for seeking truth, but because in an ingrained dispute like this it may be the only way to start doing so. (shrink)

In 1972, we proposed a theory of biological pattern formation in which concentration maxima of pattern forming substances are generated through local self- enhancement in conjunction with long range inhibition. Since then, much evidence in various developmental systems has confirmed the importance of autocatalytic feedback loops combined with inhibitory interaction. Examples are found in the formation of embryonal organizing regions, in segmentation, in the polarization of individual cells, and in gene activation. By computer simulations, we have shown that the (...) theory accounts for much of the regulatory phenomena observed, including signalling to regenerate removed parts. These self- regulatory features contribute to making development robust and error-tolerant. Furthermore, the resulting pattern is, to a large extent, independent of the details provided by initial conditions and inducing signals. (shrink)

ObjectiveThe correlation between the performance of coordination movement and brain activity is still not fully understood. The current study aimed to identify activated brain regions and brain network connectivity changes for several coordinated finger movements with different difficulty levels and to correlate the brain hemodynamics and connectivity with kinematic performance.MethodsTwenty-one right-dominant-handed subjects were recruited and asked to complete circular motions of single and bilateral fingers in the same direction and in opposite directions on a plane. Kinematic data including radius and (...) angular velocity at each task and synchronized blood oxygen concentration data using functional near-infrared spectroscopy were recorded covering six brain regions including the prefrontal cortex, motor cortex, and occipital lobes. A general linear model was used to locate activated brain regions, and changes compared with baseline in blood oxygen concentration were used to evaluate the degree of brain region activation. Small-world properties, clustering coefficients, and efficiency were used to measure information interaction in brain activity during the movement.ResultIt was found that the radius error of the dominant hand was significantly lower than that of the non-dominant hand in both clockwise and counterclockwise movements. The fNIRS results confirmed that the contralateral brain region was activated during single finger movement and the dominant motor area was activated in IP movement, while both motor areas were activated simultaneously in AP movement. The Δhbo were weakly correlated with radius errors. Brain information interaction in IP movement was significantly larger than that from AP movement in the brain network in the right prefrontal cortex. Brain activity in the right motor cortex reduces motor performance, while the right prefrontal cortex region promotes it.ConclusionOur results suggest there was a significant correlation between motion performance and brain activation level, as well as between motion deviation and brain functional connectivity. The findings may provide a basis for further exploration of the operation of complex brain networks. (shrink)

AdaBoost has been successfully applied to a number of classification tasks, seemingly defying problems of overfitting. AdaBoost performs gradient descent in an error function with respect to the margin. This method concentrates on the patterns which are hardest to learn. However, this property of AdaBoost can be disadvantageous for noisy problems. Indeed, theoretical analysis has shown that the margin distribution plays a crucial role in understanding this phenomenon. Loosely speaking, some outliers should be tolerated if this has the benefit (...) of substantially increasing the margin on the remaining points. In this paper, we propose new noise robust boosting methods using the concepts of ν-Support Vector Classification and Arc-GV. These methods allow for the probability of a pre-specified fraction ν of points to lie in the margin area or even on the wrong side of the decision boundary. This algorithms can give a nicely interpretable way of controlling the trade-off between minimizing the training error and capacity. (shrink)

The chromosome passenger complex (CPC) localizes to chromosomes and microtubules, sometimes simultaneously. The CPC also has multiple domains for interacting with chromatin and microtubules. Interactions between the CPC and both the chromatin and microtubules is important for spindle assembly and error correction. Such dual chromatin‐microtubule interactions may increase the concentration of the CPC necessary for efficient kinase activity while also making it responsive to specific conditions or structures in the cell. CPC‐microtubule dependent functions are considered in the context (...) of the first meiotic division. Acentrosomal spindle assembly is a process that depends on transfer of the CPC from the chromosomes to the microtubules. Furthermore, transfer to the microtubules is not only to position the CPC for a later role in cytokinesis; metaphase I error correction and subsequent bi‐orientation of bivalents may depend on microtubule associated CPC interacting with the kinetochores. (shrink)

The work of Reiner Schürmann’s which has received the most intense reception has been his monumental book on Heidegger. Both Emmanuel Levinas and Hans-Georg Gadamer have praised it warmly, and it is regarded as an astonishing work, combining both a thorough knowledge of Heidegger’s thought and an original and intriguing philosophical claim. In the following, I shall concentrate primarily on this philosophical claim and not on the question whether Reiner Schürmann’s reconstruction of Heidegger is sufficiently philologically accurate. I do not (...) harbor any doubt in this latter respect, but this lack of doubt on my part does not prove anything, for my knowledge of Heidegger is infinitely less deep than his. My concern will go to the philosophical ideas which he tries to defend, not to determining whether they are genuinely Heideggerian or more representative of Schürmann’s own position. In section one, I shall expose what seems to be essential to me in these ideas. In section two, I shall criticize and try to confute them. If not cogent reasons, personal and social causes must have led, as I see it, Schürmann’s quest in a wrong direction. In section three, I shall analyze these causes, since I believe that they are symptomatic of the best minds of our time. Finally, in section four, it will become possible to evaluate those ideas in more positive terms. In fact, it is always more difficult to see the greatness of an enterprise rather than its errors, and even with regard to the latter one should recognize that certain errors are indispensable and much more important than plain truisms. It is with great grief that I criticize a dead friend with whom I would prefer incomparably more to have this discussion openly. But, besides being an exellent philosopher, Reiner was an extremely noble and fine human being and he would accept the two maxims I have decided to follow in this lecture: Amica veritas, ergo legendus Reinerius; and Omnium hominum amicorum magis amica veritas ipsa. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.2 (2003) 275-276 [Access article in PDF] Zbigniew Janowski. Cartesian Theodicy: Descartes' Quest for Certitude. Dordrecht: Kluwer, 2002. Pp. 181. Cloth, $30.00. Janowski begins this original and erudite work by saying that although "the Meditations have never [before] been interpreted as a theodicy... insofar as theodicy is concerned with examining the relationship between the existence of evil on the one hand and God's (...) omnipotence and benevolence on the other, Descartes's question 'How would the goodness of God not preclude the possibility that nature is deceptive?' is in perfect conformity with, and continues the long tradition of, Christian apologetics" (13). This is not to deny Descartes's primary role in replacing God's causal role in nature with mechanistic science, and his separating religious truth from that of reason. But Descartes also is profoundly concerned with problems of error, evil, God's role in our sins, and Absolute Truth. Janowski is concerned "to show how Descartes' philosophy is derived from the early-seventeenth-century debates over divine and human freedom" by concentrating on the "incongruity between the existence of an omnipotent and benevolent Creator and man's imperfect nature [and] the nature and scope of human freedom" (19). He presents "the problem of error... as the problem of evil; the problem of human will... as the problem of human freedom, and the quest for Certitude... as theodicy, that is, as the vindication of God's goodness and omnipotence" (19-20). His ground for this is his interpretation of Cartesianism as "a kind of epistemological Augustinianism" (20).The view of basic Christian theology is that God is omnipotent and benevolent, and that all his creations are good, so evil is merely the absence of good. According to Descartes, free will makes both error and evil possible. But Augustine says that after the Fall of Man, free will is corrupt and can incline only to evil. So the only good man can do is by way of God's grace, which man cannot resist, for man is not really free to choose between good and evil. But here, Descartes is in disagreement with Augustine. Again, theodicy concerns the problem of the apparent discrepancy between the power of the creator and the imperfections of creation. And the problem is that Descartes's God is an all-powerful being that is absolutely unlimited and creates everything including logical, moral, and legal principles. Descartes's God is not constrained by the principles of non-contradiction (as opposed to St. Thomas's God, who is so constrained). Descartes's argument is that only God is immutable, nothing created is immutable, so no principle created by God, not the Ten Commandments, not the principle of non-contradiction, is immutable.This doctrine of indifferently created eternal truths allies Descartes with the Molinists who argue that God is indifferent in the sense of all powerful, and that humans have a freedom of indifference in that even given grace, they can decide to do either good or evil. This is in opposition to Augustinians and Jansenists who believe that human will corrupted by the Fall of Man can choose only evil until God gives one grace, after which one can choose only good—which, in either case, rules out any notion of freedom of choice between good and evil by an indifferent free will. Descartes believes that we can choose evil even when God gives us grace to choose good. Descartes does follow Augustine in asserting that for God, knowing and willing are the same, in opposition to St. Thomas. But for humans, knowing and willing are separate, and so humans can both err and sin.Descartes's theodicy is that everything depends on God—physics, mathematics, morals, and law. Without God there would be only nihilism. A great difficulty with this doctrine of eternal truths, however, is that it "makes the nature of God completely incomprehensible to man" (102). This is the doctrine of the Hidden God. But in a backhanded way, it saves Descartes's position. He argues that... (shrink)

It will be settled out for the open problem of designing an r-order finite-time state observer for reaction-diffusion genetic regulatory networks with time-varying delays. By assuming the Dirichlet boundary conditions, aiming to estimate the mRNA and protein concentrations via available network measurements. Firstly, sufficient F-T stability conditions for the filtering error system have been investigated via constructing an appropriate Lyapunov–Krasovskii functional and using several integral inequalities and convex technique simultaneously. These conditions are delay-dependent and reaction-diffusion-dependent and can be checked (...) by MATLAB toolbox. Furthermore, a method is proposed to design an r-order F-T state observer, and the explicit expressions of observer gains are given. Finally, a numerical example is presented to illustrate the effectiveness of the proposed method. (shrink)

The ongoing conflict in Ukraine constitutes a poignant reminder of the enduring relevance and potential devastation associated with nuclear weapons. For decades, the possibility of such catastrophic conflict has not seemed so imminent as in the current world affairs. -/- This contribution presents a comprehensive analysis of nuclear strategy for the 21st century. By examining the evolving geostrategic landscape the talk illuminates key concepts such as nuclear posture, credible deterrence, first & second strike capabilities, flexible response, EMP , variable yield, (...) counterforce & countervalue, limited war and escalation dominance, thereby providing a nuanced understanding of the delicate balance of power in the nuclear arena in modern conflicts. Furthermore, it concentrates on the era that started with the war in Ukraine, offering insights into how recent geopolitical developments influence nuclear doctrines. -/- Through conceivable real-world scenarios, we gain perspective on the multifaceted challenges posed by newer technologies and potential escalation dynamics involving global nuclear actors. -/- Such scenarios include: -/- 1. A non-weaponised or sub-critical test within Russia to intimidate opponents into understanding Russia’s resolve and capabilities. Prior norms have restricted testing since 2000, apart from North Korea. In case of a full surface test, Russia could detonate in uninhabited areas within its own vast territory with minimal fallout. While clarifying military strength, demonstrations risk hardening resistance without incentivising surrender. -/- 2. Coercive atomic threat to compel Ukraine or its supporters to make concessions. By leveraging the spectre of nuclear warfare, Russia could expect to achieve its objectives through intimidation and fear. However, the effectiveness of such a strategy is questionable, as it may provoke a strong international response and further galvanise support for Ukraine. -/- 3. Demonstration detonation over/under the Black Sea to signal resolve without targeting Ukraine itself; possibly amidst negotiations to gain diplomatic leverage, whilst limiting human casualties to zero or causing a mild, non-destructive tsunami. -/- 4. Ukraine could decide to launch a pre-emptive strike on Russian nuclear facilities or weapons, fearing an imminent attack. Such an action would have a high risk of failure and might even provoke a nuclear retaliation from Russia. It could also lead to a broader conflict, as neighbouring countries might feel compelled to intervene. -/- 5. Limited tactical strike against Ukrainian military or infrastructure to weaken capacity and morale. Russia’s 2000+ non-strategic arsenal could target positions using short-range missiles with 0.3 – 5 kiloton yields. Objectives like crippling Kharkiv defences might create no-go zones hindering advances. However, Ukraine might maintain drone and cyber offensive capabilities regardless. -/- 6. Electromagnetic Pulse attack designed to disable critical infrastructure in Ukraine and NATO countries without radioactive fallout. This aims to hinder the war effort and economy without provoking the same conventional military response as a blast. However, an EMP attack affecting NATO shall still be considered an act of war warranting retaliation. -/- 7. A weapon could be deployed accidentally or without proper authorisation. This could occur due to a technical malfunction, miscommunication, human error, or the actions of rogue elements. The consequences of such an event could be catastrophic, leading to a rapid escalation of the conflict and potentially triggering a global crisis. -/- 8. Sub-strategic offensive targeting NATO in the European theatre, so as to fracture allied resolve, against arms routes in Poland, Baltic stockpiles, British naval bases, American troop concentrations in Germany etc. Putin may perceive defeat or deposition as an existential threat, viewing such an option as self-preservation despite adverse consequences. -/- . (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Cambridge Companion to Galileo ed. by Peter MachamerMartin CurdPeter Machamer, editor. The Cambridge Companion to Galileo. Cambridge: Cambridge University Press, 1998. Pp xii + 462. Cloth, $59.95. Paper, $19.95.The contributions fall into three main areas: Galileo’s work on mechanics, his defense of Copernicus, and his relationship with the church. The relative number of pages devoted to these topics is unusual: the ratio is roughly 3 to 1 (...) to 3.The papers on Galileo’s mechanics and physics are by William Wallace, Peter Machamer, Rivka Feldhay, Wallace Hooper, and Pietro Redondi. Wallace concentrates on unpublished manuscripts from Galileo’s early period, arguing that they reveal Galileo’s intense involvement with Aristotelian philosophy. As in his other writings, Wallace emphasizes the importance of the demonstrative regressus argument for Galileo’s thought, especially for Galileo’s later claim in the Dialogue to have demonstrated the earth’s motion from the phenomenon of the tides. Machamer offers an “Archimedean” [End Page 364] interpretation of Galileo, stressing the Galileo’s use of simple machines, especially the balance, as a model of intelligibility throughout his scientific work. According to Machamer, these machines functioned as something like a Kuhnian exemplar for Galileo, providing the element of necessity and picturability that Galileo deemed essential for scientific explanation. Feldhay explores the role of mathematics in Galileo’s science, arguing that Galileo began to diverge from the Jesuit-Aristotelian tradition once he gave up trying to understand the causes of accelerated motion and focused instead on its geometrical analysis in terms of degrees of velocity. In a useful discussion, Hooper follows the development of Galileo’s inertial mechanics, concluding that even in the Discourses (1638) it is unclear whether Galileo abandoned his pre-Newtonian notion of impetus as the sustaining cause of motion. Redondi examines the relationship of Galileo’s physics to his theology. While Redondi’s conclusion is clear—“Galileo’s physics required God”—his argument is hard to follow, ranging as it does over Galileo’s views on time, atomism, macroscopic and microscopic physics, and cosmogony.Only two articles are directly about Galileo and the Copernican theory but those two pieces, by William Shea and Noel Swerdlow, are models of clarity. Swerdlow focuses on Galileo’s telescopic discoveries 1610–13 while Shea covers the entire period up to the Dialogue of 1632. Unfortunately, this involves repetition of the material about the telescopic discoveries, including some diagrams and illustrations. Tighter editorial control might have avoided this duplication and allowed Shea to devote more time to the fascinating arguments in the Dialogue. What we have is fine, but more would have been better.On Galileo and the church, there are contributions from Ernan McMullin, Richard Blackwell and Marcello Pera. McMullin argues that the seeds of Galileo’s downfall in 1633 were sown in his Letter to the Grand Duchess Christina (1615) in which Galileo endorsed a theory of scriptural interpretation remarkably similar to that contained in Augustine’s commentary on Genesis. McMullin finds a tension in that theory between regarding Scripture and natural science as mutually irrelevant while at the same time giving science priority over the literal reading of Scripture if and only if a demonstration has been provided. Once the demonstration principle was adopted, Galileo’s task of defending the earth’s motion against biblical literalism in the Dialogue became hopeless. Blackwell asks whether there could be another Galileo case in light of the Vatican’s admission of error in 1992. His answer is “Yes.” Blackwell reminds us that while in 1616 it was the Copernican theory that been tried and found heretical, in 1633 the sole issue was Galileo’s obedience to church authority. In Blackwell’s view, there remains the potential for conflict between the church’s “logic of centralized authority” and the democratic, pluralistic methods that give legitimacy to science. Pera, too, concludes that the possibility of conflict remains as long as the church insists that there are truths of faith, necessary for salvation, and those doctrines also have a factual content amenable, at least in principle, to scientific investigation.The book concludes with two pieces: a survey by Michael Segre of the evolution of Galileo’s... (shrink)

Neurofeedback has been suggested as a potential complementary therapy to different psychiatric disorders. Of interest for this approach is the prediction of individual performance and outcomes. In this study, we applied functional connectivity-based modeling using electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) modalities to (i) investigate whether resting-state connectivity predicts performance during an affective neurofeedback task and (ii) evaluate the extent to which predictive connectivity profiles are correlated across EEG and fNIRS techniques. The fNIRS oxyhemoglobin and deoxyhemoglobin concentrations and the (...) EEG beta and gamma bands modulated by the alpha frequency band (beta-m-alpha and gamma-m-alpha, respectively) recorded over the frontal cortex of healthy subjects were used to estimate functional connectivity from each neuroimaging modality. For each connectivity matrix, relevant edges were selected in a leave-one-subject-out procedure, summed into “connectivity summary scores” (CSS), and submitted as inputs to a support vector regressor (SVR). Then, the performance of the left-out-subject was predicted using the trained SVR model. Linear relationships between the CSS across both modalities were evaluated using Pearson’s correlation. The predictive model showed a mean absolute error smaller than 20%, and the fNIRS oxyhemoglobin CSS was significantly correlated with the EEG gamma-m-alpha CSS (r = −0.456, p = 0.030). These results support that pre-task electrophysiological and hemodynamic resting-state connectivity are potential predictors of neurofeedback performance and are meaningfully coupled. This investigation motivates the use of joint EEG-fNIRS connectivity as outcome predictors, as well as a tool for functional connectivity coupling investigation. (shrink)

Imbalance in the pH of water reduces this precious resource as an extremely dangerous liquid for human health and plants’ growth. Change in the pH levels of the drinkable water has majorly raised concern towards diverse health issues like heart problems, infant mortality rates, pigmentation of skin, and cholera outbreaks. Therefore, it is necessary to keep a check on essential water quality components that include acidic/basic nature of water. As per the US Environmental Protection Agency, the drinkable water should have (...) a pH level ranging from 6.5 to 8.5. Two sample situates have been identified wherever highly reported pollutants levels were found and have been analyzed through artificial intelligence techniques. It can be observed that wavelet denoised signals fed into the least squares support vector regression and M5 prime regression tree predicted more accurately on the basis of the performance errors that are as follows: root mean squared error ; mean squared error ; mean absolute error. On the basis of these errors, the coefficient of determination/goodness of fit simulated for the prototypes is developed in this study. RMSE outcomes diminish on the whole on applying the training and forecasting data-division via WLSSVR and WM5pRT as compared with fitting the normalized data through LSSVR and M5pRT. These performance measures are essential to analyze the concentration levels of pH in the river streams at the identified sites of study. Thus, the observed pattern from this study may help for future estimation of the quality of water at their sources so that it prohibits the further increase in either acidic or basic salts which prove to be lethal for the environment. Thus, these predictors would be helpful towards formulation of strategies for protection of ecosystem and human health. (shrink)

The aim of this paper is to expose a philosophical analysis of the type and development of a disease that, over time, became a capital sentimental experience in Late modernity: nostalgia. While the Ancient World concentrated on the study and diagnosis of a close disease like melancholy, nostalgia burst into medical manuals as a hybrid pathology between moral error and bodily defect. Its gradual assimilation rooted in a specific experience of temporality with important epistemological, political and existential connotations. throughout (...) this study we set out some fundamental milestones in the establishment of the conditions of possibility of this sentimental experience and we draw some connections with classic references that preluded its diagnosis and the therapy. nostalgia not only has been acquiring a specific centrality in the contemporary world, but it has also been highlighted as a central experience in philosophical literature. (shrink)

This commentary considers experimental material – some new, some from earlier studies – challenging the model presented by Findlay & Walker. It concentrates on the role of voluntary and involuntary visual attention versus fixation in saccade control and on the generation of antisaccades, reflexive prosaccades, and corrective saccades. The data of a large number of subjects are presented to show the systematic relationship between voluntary saccade generation, error production, and error correction in an antisaccade task.

This article identifies already existing theoretical and methodological commonalities between evolutionary biology and phenomenology, concentrating specifically on their common pursuit of origins. It identifies in passing theoretical support from evolutionary biology for present-day concerns in philosophy, singling out Sartre’s conception of fraternity as an example. It anchors its analysis of the common pursuit of origins in Husserl’s consistent recognition of the grounding significance of Nature and in his consistent recognition of animate forms of life other than human. It enumerates and (...) exemplifies five basic errors of continental philosophers with respect to Nature, errors testifying to a philosophical fundamentalism that distorts the intricate interconnections and relationships of Nature in favor of a preferred knowledge rooted in ontological reductionism. It shows that to discover and appreciate the common ground, one must indeed study “the things themselves.”. (shrink)

This commentary continues an exchange on eugenics in Monash Bioethics Review between Anomaly (2018), Wilson (2019), and Veit, Anomaly, Agar, Singer, Fleischman, and Minerva (2021). The eponymous question, “Can ‘Eugenics’ be Defended?”, is multiply ambiguous and does not receive a clear answer from Veit et al.. Despite their stated desire to move beyond mere semantics to matters of substance, Veit et al. concentrate on several uses of the term “eugenics” that pull in opposite directions. I argue, first, that Veit et (...) al. (2021) makes much the same error as does Anomaly (2018) in characterizing eugenics; second, that the paper misunderstands the relationship between eugenics and enhancement; and third, that it distorts the views expressed in my “Eugenics Undefended”. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.2 (2001) 294-295 [Access article in PDF] Schouls, Peter A. Descartes and the Possibility of Science. Ithaca: Cornell University Press, 2000. Pp. x + 171. Cloth, $35.00. There are at least three ways to write the history of philosophy. Truly historical historians of philosophy emphasize the context and development of ideas, concentrating on the intellectual, social, and personal factors that affect the way (...) philosophers have thought about their subject. Analytic philosophers take a critical approach, considering the logic and merit of the arguments of philosophers who have lived in the past almost as if they are engaging in contemporary debates. Another group of philosophers use the ideas of historical figures to support their own philosophical agendas. Peter Schouls' new book on Descartes falls into this third category.Schouls' aim is to present Descartes' philosophy as the origin of modernity. What he means is that "Descartes believed that the world and humanity exist in a relationship which makes it possible for humanity to improve its state through manipulating the world. This manipulation is by means of developing and applying science." Schouls interprets Descartes' notion of progress as leading to "increases in freedom from the drudgery of labor, from the suffering of illness, and from the anxiety of interpersonal and international quarrels,"(ix) arguing that mind-body dualism is necessary for humanity to accomplish these lofty goals.Schouls asks what conditions are needed for humans to develop the science that is a necessary condition for the kinds of progress Descartes sought (and Schouls clearly endorses). Human progress depends on the possibility of science. Descartes founded his science on the pure metaphysics developed in The Meditations. These metaphysical foundations provided the framework for his claim that the human mind can acquire certain knowledge of the world. Central to Descartes' method, Schouls argues, is the view that the imagination must be incorporeal. If this view can be justified, it is a significant departure from the views of most seventeenth-century philosophers who thought that the imagination is a corporeal organ that translates and transmits mechanical impulses to the incorporeal soul. Schouls argues that because the subject-matter of science, especially geometry, involves imagining relationships apart from empirical [End Page 294] experience, it is necessary that the imagination must be incorporeal. Consequently, mind-body dualism is a necessary condition for the kind of science and progress that Descartes sought.There are flaws in this book, some having to do with Schouls' argument and some having to do with its lack of historical context. The two problems are inextricably linked. Schouls reads Descartes without due consideration of historical context. The book's bibliography reveals no primary sources other than the writings of Descartes. Descartes did not write in an intellectual vacuum. He worked within a community of philosophers, and that community provided both the background and audience for his own thoughts. Ignoring this seventeenth-century context causes Schouls to misread the significance of some of Descartes' ideas. For example, he writes that Descartes' philosophy was condemned in both Protestant and Catholic venues "in part because of its assertion of the limitlessness of human freedom" (4). In fact, Descartes' philosophy was banned because he attempted to give a mechanical explanation of the Eucharist. On a related point, Schouls' drive to present Descartes as the origin of modernity causes him to sideline important issues such as the role of theology in Descartes' thought.Similarly, the lack of historical context leads to errors of interpretation. As Alan Gabbey and others have recently demonstrated, terms like "mechanics" and "science" meant something different in the seventeenth century from what they mean today. Even the terms a priori and a posteriori had different meanings in early modern thought. Schouls expresses some mystification about Descartes' use of the term "a priori" in the second Meditiation. This mystification would vanish if he had taken into account early modern usage according to which a priori means reasoning from the one, true cause to an effect rather than acquiring knowledge of the world independently of experience.Schouls' argument sometimes loses... (shrink)

My paper builds on the conceptual tools from three interrelated philosophical debates that—as I believe—may help structure important if chaotic discussions about surrogates for living human brains and resolve some practical issues related to regulatory matters. In particular, I refer to the discussions about the “moral precautionary principle” in research ethics (Koplin and Wilkinson 2019); about normative uncertainty in ethics (MacAskill, Bykvist, and Ord 2020), and about the inductive risk problem for animal welfare scientists (Birch 2018). I elucidate upon the (...) possible meanings of the phrase “a too good human brain surrogate” used by Henry T. Greely (2021), and I demonstrate that the evaluation of the practical and regulatory implications of the “goodness” of such surrogates created for research purposes should be sensitive to the possible consequences of two types of errors: the under-attribution and over-attribution of moral status to such beings. Many authors writing about this topic (including Greely 2021, but see also, e.g., Koplin and Savulescu 2019) concentrate only on the first type of error, neglecting the negative consequences of the second type, i.e., over-attribution. (shrink)

Independent on Sunday October 2nd One of the country's lead­ing philosophical counsellers, and chairman of the Society for Philosophy in Practice (SPP), Tim LeBon, said it typically took around six 50 ­minute sessions for a client to move from confusion to resolution. Mr LeBon, who has 'published a book on the subject, Wise Therapy, said philoso­phy was perfectly suited to this type of therapy, dealing as it does with timeless human issues such as love, purpose, happiness and emo­tional challenges. `Wise (...) Therapy, is part of a series aimed at promoting an integrative attitude as its ethos. Among all the many perspectives of psychotherapists and counselors, philosophy needs to take its place and needs to find its voice. Tim LeBon has provided an effective means by which counselors can bring philosophy into their work with clients' - APPA journal `Tim Le Bon's Wise Therapy is a comprehensible and well argued book dealing with the practical therapeutic applications of philosophical research that may well be of interest to philosophers but -- as the author himself intends -- will be of most obvious benefit to therapists and counselors, both by informing their dialogue with clients in new ways and by helping them become more informed about ways to resolve the ethical dilemmas arising within the context of their own work' - Metapsychology `A fascinating workshop for therapists and clients, backed up a thorough degree if philosophical acuity' - Journal of the Society for Existential Analysis `I strongly recommend the book for philosophers as well as practitioners, teachers, students and supervisors in counselling and psychotherapy' - Self and Society `Provides some additional and valuable arrows for the therapist's quiver' - Irvin Yalom, author of Love's Executioner `Like Aristotle, Tim LeBon examines what is said and extracts what is best from it…. There are many fascinating exercises designed to bring out and enlighten the client's values, conception of the good life, well-being, happiness, pleasure, and the proper place of reason in life…. Wise Therapy is well written and engaging. The case histories are illuminating examples of therapeutic techniques at work, the thought experiments are well designed, and the philosophical position adapted from the internal debates of the philosophers is level headed…. I recommend it highly to philosophers with an interest in counselling, and psychological counsellors with an interest in philosophy' - Jeff Mason, The Philosophers' Magazine `Tim LeBon has… authored a text which should become a staple on the philosophical counsellor's bookshelf…. Wise Therapy is a concise, well-written book…. His ability to relate philosophical concepts to counselling concerns is admirable and attests to the skill and knowledge he possesses as a working counsellor. But, by far the most important part of Tim LeBon's book to PC is the last chapter, "The Counsellor's Philosophical Toolbox"' - Craig Munns in The Examined Life ` Tim LeBon has done a good job of offering practical approaches to some of the most important and vexing issues that arise in counselling…. Tim LeBon's book contains helpful suggestions, practical information, and useful examples, and would make a good addition to the library of any counsellors willing to allow philosophy to turn mere client sessions into wise therapy' - Peter Raabe, Practical Philosophy Wise Therapy is an original and practical guide to how philosophy can benefit counselling and psychotherapy. Tim LeBon argues that therapy, informed by philosophy, can help clients make better decision and achieve emotional wisdom. He uses philosophical approaches to explore issues of right and wrong, the emotions and reasons, well-being and the meaning of life, and develops a 'counsellor's toolbox' of techniques that can help practitioners apply the wisdom of philosophy to good therapeutic practice. For counsellors who may find philosophical approaches to therapy useful, this work addresses key philosophical topics - the emotions, free will, the meaning of life and ethics. It is jargon-free where possible and assumes no previous philosophical training. From The Independent, 16th November 2004 Plato is my agony aunt It was the end of a love affair that broke her heart. Could the wisdom of the great philosophers show her how to be happy again? Claire Smith tries a novel form of therapy "The unexamined life is not worth living," Socrates said. Nor is the life you're left with after your boyfriend has left you for another woman - at least, that's how it felt in October last year when mine broke rank and went off with an art student from Cleveland, Ohio. We were over there for the opening of his new art exhibition. He'd flown over four days before me and had met her at a party. Supposedly, they "connected". The five months that followed were a roller-coaster of confusion, vitriol and despair. I knew there'd been problems in our relationship. We saw the world very differently; he delighted in the charm of the ordinary, I wanted maximum divinity. He walked; I galloped. He drank tea; I loathed the stuff. But, along the banks of the Thames, we'd made a promise to always stick together. Our love was something unique: "transcendental", I called it. And besides, we recycled. Surely a commitment to save the world would save our relationship? Alas, no. So there I was, a woman scorned. Hell truly hath no greater fury. And what made it worse was that I still believed in our transcendental love. If I wanted to change the way I was feeling, I needed to alter the way I was thinking. But how? A few bottles of wine and a sharp blow to the head might have done the trick. Fortunately, there's an older, more trusted way of turning your head on its head that counsellors are starting to use: philosophy. The idea of employing Plato as an agony aunt was begun in 1981 by the German philosopher Gerd Achenbach. Although philosophy spends a lot of its time asking real-life questions that affect real-life people - What is happiness? And is it always wrong to lie? - most of the debate goes on in ivory towers. What Achenbach and subsequent philosophers including Tim LeBon, the chairman of the UK's Society for Philosophy in Practice, wanted to do was "give practical application" to this gigantic library of great thoughts. So how does it work? Like most types of therapy, you sign up for a set of sessions. "Two would give you a new perspective on one issue; six would help you to make a major life-decision, like a career change; with 12 you can start to rethink your entire life philosophy," explains LeBon. Each session lasts 50 minutes and costs £50 - and, no, you don't have to have any previous knowledge of philosophy. "If you think of Friends, it would suit Ross and Chandler more than Joey," LeBon says. "It's for anyone who wants to make their emotions more intelligent. Or for those who have tried other kinds of therapy, and want something more cerebral." The first session begins with the patient venting off about whatever's troubling them. The rant over, the counsellor then picks out some key concepts that are crucial to the problem - in the case of heartbreak, it is love and happiness that come hurtling to the fore - and then gets the patient to define what they mean. So, what is love? What is happiness? To kick-start the patient's thinking, LeBon describes what a great philosopher had to say about it. In my case, he tells me what Plato wrote about love in his Symposium: that to stop man fighting the gods, Zeus decided to cut each human in two, so they would lose their strength. "This, then, is the source of our desire to love each other," Plato said. "Each of us is a 'matching half' of a human whole, because each was sliced like a flatfish, two out of one, and each of us is always seeking the half that matches him." This method of probing what we might think are "obvious" ideas, such as love and happiness, was devised by Socrates in the squares of Athens. "The only I thing I know is that I know nothing at all," he boasted. What Socrates showed was that although many of the thinkers of his time thought they knew what justice, happiness and goodness meant, their understanding was tied in to their personal agenda and world view, and, what's more, when pushed, their ideas often contradicted themselves. A bit like me on love. Whereas part of my understanding of love was something that gave life meaning, made it worth living and bound us together, I also believed that true love was "transcendental": that it was out of this world, and it didn't matter if the two people who loved each other couldn't get along in the day-to-day. Love was bigger than the mundane. But when it came to the next stage of the therapy, critical thinking - "to check out whether your assumptions stand up to examination" - I walked head first into a contradiction. If I think love's purpose is to make life worth living, but then say it's irrelevant to daily life, surely my two ideas of love are not compatible? As the cogs in my brain start to creak into motion, I feel myself taking a step back from my predicament: thinking about how I've been thinking. This idea I had of transcendental love might have started off as a romantic dream. But when the relationship stopped working, and I found myself feeling trapped and frustrated, I used it to justify the mechanics of a relationship that just didn't work in the daily grind. I used it to lie to myself. In the final stage, LeBon gets me to start thinking about how to go forward. "You can't change what has happened," he says. "You can't change that he's left you, or how you behaved in the relationship. So, as the Stoics did, let's work on controlling the controllables: the things that you can change." To work out what can be changed, he gets me to try out a thought experiment, a method often used in philosophy to imagine other worlds where people can have different codes of behaviour. Thought experiments shatter your preconceived ideas of how the world should be and let your imagination run wild to how the world could be. "I find Viktor Frankl very useful here, the Austrian psychiatrist and concentration-camp survivor who actually believed that everything in life happens for a purpose," LeBon says. "Suppose this break-up did happen for a reason that will work to your benefit," he suggests. "What might that be? The answer might be that you can now focus on something important that was denied in the relationship. Or - the Hollywood version - so you'll meet someone who is really right for you." Temporarily freed of any sense of responsibility for the relationship that was, and its sorry demise, the list came fast. I could now travel more; he didn't like me travelling on my own, but too often he didn't want to go anywhere, preferring to stay in his studio and make art. I'd love to meet someone with a similar sense of adventure to mine. For the first time in two years, I was being honest with myself about what I really wanted - listening to those voices that we all have inside our heads, and too often try to muzzle. So did philosophy save me? Well, I'm now dating a travel writer I have to run to keep up with. I still haven't got over the fact that my replacement came from Cleveland, Ohio. But I guess I never will. Tim LeBon can be reached by e-mail at [email protected] A FEW WORDS FROM THE WISE Compiled by Ed Caesar · "At the touch of love, everyone becomes a poet" - Plato · "There is always some madness in love. But there is also always some reason in madness" - Friedrich Nietzsche · "That man shall live as his own master and in happiness who can say each day 'I have lived'" - Horace · "The good of man is the active exercise of his soul's faculties in conformity with excellence or virtue... Moreover this activity must occupy a complete lifetime; for one swallow does not make spring, nor does one fine day; and similarly one day or a brief period of happiness does not make a man supremely blessed and happy" - Aristotle · "There is nothing on this earth more to be prized than friendship" - Thomas Aquinas · "Whatever you do... love those who love you" - Voltaire · "Happiness is not an ideal of reason but of imagination" - Immanuel Kant · "Happiness is a state of which you are unconscious. The moment you are aware that you are happy, you cease to be happy" - Jiddu Krishnamurti · "Love is an ideal thing. Marriage is a real thing" - Johann Wolfgang von Goethe I shrink, therefore I am Therapy has many answers, but some questions require the help of a philosopher, says Clint Witchalls Sunday November 21, 2004 The Observer Danny had worked in the City of London for 10 years. As a research analyst, stockbroker and fund manager, he'd made a lot of valuable contacts, earnt a lot of cash, and learnt some important business skills. However, as he approached his mid-thirties, he no longer felt good about himself or what he did for a living, and he found his colleagues cold and unfriendly. A chronic illness made him realise his mortality, and he began to reassess his priorities. Danny had been struggling with his career conundrum for nearly five years when he met David Arnaud, a philosophical counsellor. After a few soul-searching sessions, Danny arrived at a decision. Today, he teaches economics to sixth-formers, and he loves it. 'It's a much better lifestyle,' he says. Many people are turning to philosophical counsellors to get answers to questions such as: 'How do I make sense of myself?' 'What is important to me?' 'Where am I going?' These are perhaps not the sort of questions that require psychiatric intervention, but Arnaud, who recently completed the first empirical study of philosophical counselling in the UK, has found that within just five sessions the majority of clients, with important decisions to make, tend to move from a state of concern and confusion to a resolution. Modern philosophical counselling can be traced back to 1981, when the philosopher Gerd Achenbach opened the first practice near Cologne. Achenbach referred to the new discipline as 'therapy for the sane.' Today, there are hundreds of philosophical counsellors around the world, with the movement particularly strong in the US, Britain and the Netherlands. 'The dilemmas people face aren't always primarily psychological,' says Alex Howard, a philosophical counsellor from Newcastle. 'If people face problems that are social or economic, it doesn't make sense to define their problems in purely psychological terms.' Tim LeBon, a founder member of the Society for Philosophy in Practice (SPP) and author of Wise Therapy, adds: 'We are faced with far more life choices than our grandparents, yet have far fewer resources to deal with them. Our grandparents may have gone to a priest or to other family members for advice; most people don't trust these solutions any more and so want to make their own well-informed, well thought-out choices. Philosophical counselling can help these people - people in mid-life crises who are wondering how to make the most of the rest of their life. People who want to take stock of their values.' Where stressed executives might once have been prescribed a course of tranquillisers or antidepressants, they can now get a dose of Bertrand Russell instead: 'Success is too dearly purchased if all the other ingredients have been sacrificed to obtain it.' While some philosophical counsellors do recommend books for their clients to read, most sessions are about helping the client identify faulty thoughts. For example, a briefing in Aristotelian logic might show a client why their beliefs are erroneous. The person might infer that they're a screw-up because they've screwed up. The counsellor could point out that they're making an error called 'fallacy of composition' - that is, what's true of the part isn't necessarily true of the whole. In philosophical counselling, problems aren't pathologised as they are by the psychiatric profession, and the dialogue between client and counsellor is more like a meeting of equals, compared to many therapies where the client is treated like a patient and seen as someone who is, in some way, inadequate. 'Anybody can benefit from philosophical counselling,' says Howard. 'But it does require someone who is willing to take stock.' Lou Marinoff, author of international bestseller Plato Not Prozac! has done much to promote philosophical counselling. 'Some people who have stabilised their neurochemistry and validated their emotions now wish to examine or re-examine the criteria of their beliefs, the principles of their conduct, or the meaning of their lives,' he says. 'With whom shall they do this? Psychologists and psychiatrists can shed light on such issues - as can rabbis, priests, imams and gurus. Philosophers are now rejoining the ranks of helpers.' LeBon believes certain therapies (such as cognitive behavioural therapy) don't go far enough in helping their clients. 'For instance, if you are anxious about your relationship, a cognitive therapist would try to dispute your catastrophising and jump to conclusions to make you feel less anxious,' says LeBon. 'A philosophical counsellor would do this, but would also look for existential meaning in your anxiety - perhaps you really don't want to be in the relationship and that is what your anxiety is telling you.' LeBon also gives short shrift to psychoanalysts. 'There's very little evidence for the Freudian unconscious, and it's time to move on to more intellectually satisfying and helpful therapies,' he says. However, Alain de Botton, the man who popularised philosophy as self-help, isn't ready to bury psychologists and their ilk just yet. 'The truth is that psychoanalysis grew out of philosophy - it's not some completely new idea, and in fact, done properly, psychoanalysis is philosophical anyway. It may even be dangerous to the mental health of some people to suggest a philosopher rather than a properly trained analyst. The knowledge of analysts when it comes to many emotional problems is now much greater than that of most philosophers.' Guardian Unlimited © Guardian Newspapers Limited 2004. (shrink)

This paper argues against the unity of the virtues, while trying to salvage some of its attractive aspects. I focus on the strongest argument for the unity thesis, which begins from the premise that true virtue cannot lead its possessor morally astray. I suggest that this premise presupposes the possibility of completely insulating an agent’s set of virtues from any liability to moral error. I then distinguish three conditions that separately foreclose this possibility, concentrating on the proposition that there (...) is more to morality than virtue alone—that is, not all moral considerations are ones to which some virtue is characteristically sensitive. If the virtues are not unified, the situationist critique of virtue ethics also turns out to be more difficult to establish than some have supposed. (shrink)

It is not an easy work to read, the phrasing being rather complicated, and the topics at times repetitious and intertwined; but great works do not have to be easy texts. It is the first of a proposed pair, its role being indicated by the sub-title: Problems in the Logic of Scientific Explanation. The next volume is to deal with the analysis of scientific concepts and inference. In the present work we may distinguish three groups of chapters. The first group (...) centers around certain structural concepts, particularly science, explanation and law. The second concerns problems of the physical sciences and the third is about social and biological sciences. It is entirely absurd to attempt a thorough review of the whole work in less than a work of comparable length particularly in view of the highly technical character of substantial parts of it. Another reviewer has already decided on the same grounds to restrict his attention to the second part. I shall concentrate on the first and third. I am particularly sensible that the comments which follow, when critical, are reflections of an alternative possible construal rather than objective demonstrations of error. (shrink)

The Libros del Saber de Astronomia is a compilation of various Arabic astronomical works translated into Castilian in the second half of the thirteenth century, under the direction of King Alfonso X of Spain. A section describing a mercury clock has been suggested to be of particular significance in view of the likely invention of the mechanical clock around this period, so a new translation into modern technical English has been prepared. The clock is shown to consist essentially of an (...) annulus of mercury-filled chambers separated by narrow partitions, each partition being perforated by a very small hole. This annulus is attached concentrically to a pulley wheel around which a cord is wrapped, and a fixed weight hung upon the cord. The torque raises the mercury on the opposite side, but as the resulting hydrostatic head then causes it to percolate through the holes connecting the chambers the wheel slowly rotates to maintain its equilibrium. The weight therefore gradually descends in a controlled manner. It is claimed that, by suitable adjustment of the driving weight, the wheel could be made to turn once in 4 hours. A 6:1 reduction gear therefore enabled the rete of an astrolabe to be rotated once in 24 hours, modelling the real sky so that the time could be read off directly against the plate.A working model has been constructed on these principles, but utilizing modern materials to contain the mercury. It does work, but the range of rotation periods is quite limited and the reproducibility poor . It is shown that this is a consequence of the compounding of errors in what amounts to a ring of ‘mercury glasses’ joined end-to-end, for a single ‘mercury glass’ has a standard deviation of ±1.7 per cent and five or six are in use at any one time. Errors and omissions in the Castilian account suggest that the translator had never seen the instrument they attempt to describe.The mercury clock of the Libros is not isochronous, and its constant unidirectional rotation contrasts with the oscillators that are the hallmark of all advanced timekeepers. It is concluded that, although an interesting experiment, it had no influence on the evolution of clockwork in the western world. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:REID' S CRITICISM OF HUME'S THEORY OF PERSONAL IDENTITY One of the most interesting philosophical controversies is that between Reid and Hume, considered as representatives of two different sorts of empiricism. Hume, for these purposes, represents 'radical' empiricism, and the attempt to base knowledge solely on experience and what can be validly inferred from it, regardless of how far this leads one from everyday notions and beliefs. Reid, in (...) contrast, represents 'common sense' empiricism, and the view that the. results of experience and deduction must conform to a number of 'first principles or intuitive judgments' (Essays on the intellectual powers of man, VI, 4), which aie unprovable, but which no one can avoid accepting. It is important to be clear about the status of Reid' s 'intuitive judgments', or 'principles of common sense'. They are not merely the general beliefs of a particular culture, which could be 'vulgar errors or preJUdICeS''. Nor are they merely beliefs generally held by people uncorrupted by philosophy. They are assumptions which have to be made if theoretical or practical activity is to be possible at all, principles which are always accepted in practice even by those who deny them in theory. For example, although the uniformity of nature is not a logically necessary truth, everybody always thinks and acts in ways that presuppose that it is true: 'Nature is governed by fixed laws, and if it were not so, there could be no such thing as prudence in human conduct.... the whole fabric of natural philosophy is built upon this principle.' (Essays, VI, 5) Again, everyone, even a theoretical determinist, makes moral judgments and deliberates what to do; and these activities presuppose a belief in human free will. (Essays, ibid.) Hume himself, as Reid was aware, accepted the validity of some principles of this sort, notably of the 42. uniformity of nature. But Reid was dissatisfied with Hume's account, partly because he thought Hume had rejected far too much, and partly because of the grounds Hume gives for accepting, for example, the validity of induction, and the existence of the external physical world. Hume regards these beliefs as non-rational, and deriving from our psychological make-up; it is nature and not reason which causes the belief in an ordered physical reality. In Hume's eyes this is a sufficient justification: if our nature compels us to believe something, this is as good a ground for believing it as any other. Reid, on the other hand, believed, first, that there were many more principles of this sort than Hume had acknowledged, and secondly, that the justification of them was rational, and not merely psychologically determined, since it was based on the impossibility of thinking and acting coherently without them. Hence, even though Hume builds up with one hand what he pulls 'down with the other, and destroys the rational basis for belief only to replace it by one based on human nature and psychology, Reid continues to treat him as the archsceptic. In constructing his list of first principles in Essays, VI, 5, Reid explicitly or implicitly attacks Hume's 'scepticism' on five points - the existence of the mind; the existence of the physical world and the reliability of our senses; the reliability of memory; the reliability of reason; and the uniformity of nature. Against this scepticism he deploys three types of argument. The first is the argument from the universal beliefs of mankind, particular!/ as displayed in the structural features supposedly common to all languages. The second is the argument that the position of the sceptic is, when its consequences are worked out, either self-contradictory or incoherent. And the third is the argument already mentioned, that this position is inconsistent with other beliefs which the sceptic inevitably holds, since he thinks and acts in ways which are 43. inconsistent with their falsity, and cannot avoid doing so. To assess the force of Reid' s attacks, we have to consider both the strength of arguments of this sort in general and whether they apply in all these five cases. In this article, I want to concentrate on the first issue of the five, that of personal identity. Apart from displaying Reid... (shrink)

A diploid human genome contains approximately six billion nucleotides. This enormous amount of genetic information can be replicated with great accuracy in only a few hours. However, because DNA strands are oriented antiparallel while DNA polymerization only occurs in the 5′ → 3′ direction, semi‐conservative replication of double‐stranded DNA is an asymmetric process, i.e., there is a leading and a lagging strand. This provides a considerable opportunity for non‐random error rates, because the architecture of the two strands as well (...) as the DNA polymerases that replicate them may be different. In addition, the proteins that start or finish chains may well be different from those that perform the bulk of chain elongation. Furthermore, while replication fidelity depends on the absolute and relative concentrations of the four deoxyribonucleotide precursors, these are not equal in vivo, not constant throughout the cell cycle, and not necessarily equivalent in all cell types. Finally, the fidelity of DNA synthesis is sequence‐dependent and the eukaryotic nuclear genome is a heterogeneous substrate. It contains repetitive and non‐repetitive sequences and can actually be considered as two subgenomes that differ in nucleotide composition and gene content and that replicate at different times. The effects that each of these asymmetries may have on error rates during replication of the eukaryotic genome are discussed. (shrink)

Austin's lecture on this topic contributes little to the problem of freedom of the will, and so in my discussion of his ideas I shall stop short of the difficult part of that problem. His most important positive suggestion is that hypotheticals should be divided into two classes, conditionals and pseudo-conditionals. He claims that neglect of this distinction has been the cause of mistakes in certain forms of the dispositional analysis of the statement that an agent could have acted otherwise, (...) and he then goes on to criticise all forms of that analysis using arguments which do not depend on the difference between the two kinds of hypothetical.This discussion will be in two parts. In the first I shall take up Austin's distinction between conditionals and pseudos and criticise it and develop it at length, because it seems to me to be the most important thing in his lecture. Since I shall not have space for comment on fortuitous errors made by defenders of the dispositional analysis of the claim that an agent could have acted otherwise, I shall concentrate on the essential features of that analysis. (shrink)