The accumulation of knowledge concerning the character and transformations of substances from ancient times constitutes progress in chemistry, which has accelerated enormously since the end of the 17th century. The present short article focuses on some themes in the development of theorising and conceptual clarification at the macroscopic and microscopic levels during the 19th and 20th centuries. This covers the general understanding of substances in relation to phase and the general notion of a mixture, the distinction between daltonides and (...) berthollides, and issues connected with the notion of molecular structure. Together with the enormous body of factual material accumulated particularly over the last two centuries, this is progress in chemistry. The epistemological approach seems to give the best account of it amongst philosophical views on progress currently on offer. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Microscope of Experience: Christian Garve’s Translation of Cicero’s De Officiis (1783)Johan van der ZandeDuring the negotiations leading to the Treaty of Teschen of 1779, ending the phony War of Bavarian Succession, Frederick II and his court stayed in Breslau, the capital of Silesia. There, in conversation with Christian Garve, the city’s most famous son, the king strongly recommended a new German translation of Cicero’s On Moral Duties (De (...) Officiis), one of the classical texts of humanist philosophy and his favorite book. Frederick’s faithful subject dutifully obliged his sovereign. Four years later, in the subservient language of a dedication to a royal patron, Garve offered in due obedience to Frederick a result that, “perhaps flawed,” was “vindicated by the efforts directed toward the execution of the command.” 1Yet Garve’s interest in Cicero differed markedly from that of Frederick. After all, as Garve wrote in the preface to the philosophical commentary on his translation, Cicero’s book was written for “persons of the higher classes who participated in the affairs of state” and for whom “moral prescription often transformed into political instruction.” Clearly that was not the world in which Garve lived. The son of an artisan, Garve, after a brief stint as a professor of philosophy in Leipzig in the early 1770s, was forced by his illness to spend the rest of his life as a reclusive private scholar in his hometown. He admitted that Cicero sometimes “condescended to deal with those classes who occupy themselves as educators and scholars.” The producing classes, however, “this vast, indispensable, and valuable part of humankind,” could only find prescriptions [End Page 75] for the virtuous life in Cicero’s work insofar as they were human beings, not in relation to their station in life. In general terms Garve thought that Cicero had neglected to deal sufficiently with domestic duties, a reproach which he also leveled against another intellectual pedigree, Adam Ferguson. This did not mean, however, that Garve reduced the citizen’s actions to the private sphere, where they could be productive economically and concerned only with their own Bildung. On the contrary, for Garve useful citizens were those who committed themselves to sociability and to political engagement. Moral actions were not only to be judged according to their motivation (as Kant asserted) but also on their effects on society at large.This different emphasis, I suggest, was typical of the German popular philosophers, who in the time span between Christian Wolff and Immanuel Kant formulated a philosophy of life and among whom Garve emerged as the foremost representative. As a group they constituted a philosophical movement in their own right and were not merely, as they are usually described, the popularizers of Wolff’s philosophy. Rather, popular philosophy was a characteristic compound of Wolffian rationalism and British empiricism. Some popular philosophers, mostly the older generation, were more inclined to the rationalist and others, among them Garve, to the empirical end of this spectrum. Little concerned with epistemological problems or with the irrational cult of life as were the life philosophies of the nineteenth century, the popular philosophers were primarily interested in the virtuous life, in a philosophical theory of moral and aesthetic action. Theirs was a “science of man,” that is, a combination of practical philosophy and literary skills with the goal of morally educating a literate but non-specialized public to be useful citizens of the absolute state. They wanted to speak with propriety on all themes of human existence rather than pursue those philosophical questions not directly related to human life. 2 I entirely agree with a recent commentator who describes Garve’s concerns as non-bourgeois, or better, pre-bourgeois and deeply rooted in humanist values. 3This approach shows in Garve’s Cicero translation and commentary. In Leipzig he had attended the lectures of the classical philologist Friedrich Wilhelm Reiz, who trained his students in precise, critical scholarship. When Garve became a professor himself, he and Reiz anonymously published a Latin edition of Aristotle’s Rhetoric. Later, Garve wrote that his own philosophy was indebted to Reiz who had pointed out to him the close relationship between linguistic and... (shrink)

It is conventional to try to arrive at the Boltzmann principle and the Second Law starting with the laws of dynamics at the microscopic level. In this article the opposite view is presented: Starting with the Second Law, microscopic properties are derived. A classical result of Wien is developed into a general theorem, and the possibility of deriving the Boltzmann principle as a consequence of Carnot's theorem is discussed.

In Part I of this series, we presented the microscopic approach to Souslin-tree constructions, and argued that all known ⋄-based constructions of Souslin trees with various additional properties may be rendered as applications of our approach. In this paper, we show that constructions following the same approach may be carried out even in the absence of ⋄. In particular, we obtain a new weak sufficient condition for the existence of Souslin trees at the level of a strongly inaccessible (...) cardinal. We also present a new construction of a Souslin tree with an ascent path, thereby increasing the consistency strength of such a tree's nonexistence from a Mahlo cardinal to a weakly compact cardinal. Section 2 of this paper is targeted at newcomers with minimal background. It offers a comprehensive exposition of the subject of constructing Souslin trees and the challenges involved. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Microscope of Experience: Christian Garve’s Translation of Cicero’s De Officiis (1783)Johan van der ZandeDuring the negotiations leading to the Treaty of Teschen of 1779, ending the phony War of Bavarian Succession, Frederick II and his court stayed in Breslau, the capital of Silesia. There, in conversation with Christian Garve, the city’s most famous son, the king strongly recommended a new German translation of Cicero’s On Moral Duties (De (...) Officiis), one of the classical texts of humanist philosophy and his favorite book. Frederick’s faithful subject dutifully obliged his sovereign. Four years later, in the subservient language of a dedication to a royal patron, Garve offered in due obedience to Frederick a result that, “perhaps flawed,” was “vindicated by the efforts directed toward the execution of the command.” 1Yet Garve’s interest in Cicero differed markedly from that of Frederick. After all, as Garve wrote in the preface to the philosophical commentary on his translation, Cicero’s book was written for “persons of the higher classes who participated in the affairs of state” and for whom “moral prescription often transformed into political instruction.” Clearly that was not the world in which Garve lived. The son of an artisan, Garve, after a brief stint as a professor of philosophy in Leipzig in the early 1770s, was forced by his illness to spend the rest of his life as a reclusive private scholar in his hometown. He admitted that Cicero sometimes “condescended to deal with those classes who occupy themselves as educators and scholars.” The producing classes, however, “this vast, indispensable, and valuable part of humankind,” could only find prescriptions [End Page 75] for the virtuous life in Cicero’s work insofar as they were human beings, not in relation to their station in life. In general terms Garve thought that Cicero had neglected to deal sufficiently with domestic duties, a reproach which he also leveled against another intellectual pedigree, Adam Ferguson. This did not mean, however, that Garve reduced the citizen’s actions to the private sphere, where they could be productive economically and concerned only with their own Bildung. On the contrary, for Garve useful citizens were those who committed themselves to sociability and to political engagement. Moral actions were not only to be judged according to their motivation (as Kant asserted) but also on their effects on society at large.This different emphasis, I suggest, was typical of the German popular philosophers, who in the time span between Christian Wolff and Immanuel Kant formulated a philosophy of life and among whom Garve emerged as the foremost representative. As a group they constituted a philosophical movement in their own right and were not merely, as they are usually described, the popularizers of Wolff’s philosophy. Rather, popular philosophy was a characteristic compound of Wolffian rationalism and British empiricism. Some popular philosophers, mostly the older generation, were more inclined to the rationalist and others, among them Garve, to the empirical end of this spectrum. Little concerned with epistemological problems or with the irrational cult of life as were the life philosophies of the nineteenth century, the popular philosophers were primarily interested in the virtuous life, in a philosophical theory of moral and aesthetic action. Theirs was a “science of man,” that is, a combination of practical philosophy and literary skills with the goal of morally educating a literate but non-specialized public to be useful citizens of the absolute state. They wanted to speak with propriety on all themes of human existence rather than pursue those philosophical questions not directly related to human life. 2 I entirely agree with a recent commentator who describes Garve’s concerns as non-bourgeois, or better, pre-bourgeois and deeply rooted in humanist values. 3This approach shows in Garve’s Cicero translation and commentary. In Leipzig he had attended the lectures of the classical philologist Friedrich Wilhelm Reiz, who trained his students in precise, critical scholarship. When Garve became a professor himself, he and Reiz anonymously published a Latin edition of Aristotle’s Rhetoric. Later, Garve wrote that his own philosophy was indebted to Reiz who had pointed out to him the close relationship between linguistic and... (shrink)

This paper puts forward the hypothesis that consciousness might be linked to matter in a way which is more sophisticated than the traditional macroscopic Cartesian hypothesis suggests.Advances in the biophysics of the nervous system, not only on the level of its macroscopic functioning but also on the level of individual ion channels, have made the question of how finely consciousness is tied to matter and its dynamics more important. Quantum mechanics limits the attainable resolution and puts into doubt (...) the idea of an infinitely fine-woven attachment. A recent approach to physics rekindles such a rationalist hope. Endophysics focuses on the global implications of microscopic computer simulations of chemical and biophysical processes. A complete artificial universe can be set up in the computer. It produces non-classical and nonlocal effects inside — on the interface that exists between an internal observer (fluid neuron) and the rest of the world. This interface is finer than any brain property to which the status of the mind-body interface has been attributed hitherto. A new class of experiments becomes possible in the artificial world and, by analogy, in the real world. Magnetic resonance imaging experiments, routinely performed under open-loop conditions, can be repeated under psychophysical (closed-loop) conditions — in search for microscopically induced changes in the perceived and measured structure of the world. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:IRBs Under the MicroscopeJonathan D. Moreno (bio)The spring and summer of 1998 were seasons in the sun for institutional review board (IRB) aficionados. Rarely have the arcana of the local human subjects review panels been treated to so much attention in both the executive and the legislative branches of government, not only at the federal but also at the state level. And it looks as if the attention (...) will continue for some time. The spate of interest is due to a series of coincidences: a powerful House of Representatives subcommittee held hearings after its chairman learned about the IRB system during a previous session on research in underdeveloped communities; the Department of Health and Human Services’s Inspector General (DHHS-IG) released a report on IRBs; the National Institutes of Health (NIH) Office of Extramural Research completed a report on clinical trial monitoring; the National Bioethics Advisory Commission (NBAC) readied a report on research involving persons with mental disorders; the states of Maryland and New York completed studies of research with subjects who lack decision-making capacity; and advocacy groups protested a psychiatric research project involving inner city children.Underlying these proximate causes for the IRB blitz is a growing realization that the already considerable clinical trial enterprise will expand significantly over the next few years. Congress is talking about giving the politically popular NIH half again the budget it currently receives, which in turn will stimulate more commercially supported research. The director of the National Cancer Institute is considering a five-fold increase in the number of subjects enrolled in oncology studies over the next several years. Phase I cancer studies are among the most ethically sensitive, so IRBs will have more work cut out for them if this goal is reached. Adding to the rush of interest in IRBs are the government’s recent apology to the survivors of the syphilis study in Tuskegee, continuing congressional dissatisfaction with the way the Pentagon handled its vaccine distribution during the Gulf War, and the controversy about AZT trials in developing countries.On the HillCongressman Christopher Shays, the moderate Connecticut Republican who has developed an interest in human research issues, convened hearings on human [End Page 329] subjects research and the IRB system on 11 June 1998. Shays chairs the House Government Reform/Human Resources Subcommittee. The committee’s ranking minority member is Edolphus Towns of Brooklyn, NY, who shares Shays’s interest in this area.The immediate rationale for the hearings was the release that day of the DHHS-IG report, Institutional Review Boards: A Time for Reform. The subtitle was changed from A System in Jeopardy apparently after some people in DHHS expressed reservations about its seemingly alarmist tone, but the IG staffers who testified before Shays’s subcommittee insisted that they stood behind the message that the IRB system is in trouble if considerable reforms are not undertaken. Among the factors in the research environment cited as support for the bleak forecast: managed care, commercialization, multi-site trials, high IRB workloads, minimal IRB oversight of approved studies, conflicts of interest, insufficient training of IRB members and investigators, and lack of IRB self-studies (DHHS-IG 1998).As is normally the case for congressional oversight hearings, the first panel of witnesses consisted of executive branch officials, including Eric Meslin, Executive Director of the National Bioethics Advisory Commission, and Gary Ellis, Director of the Office for Protection from Research Risks (OPRR). Shays pressed Ellis on the extent to which OPRR conducts on-site investigations of complaints about abuse of human subjects. Admitting that on-site investigations are rare, Ellis suggested that the agency is inadequately staffed to follow up on complaints as quickly as it might wish. The members of Congress who were present at the hearings generally expressed concern about the DHHS-IG’s findings.The second panel that day, which Shays was unable to attend, set a different tone. Four of the panelists—Paul Appelbaum of the University of Massachusetts at Worcester, Robert Levine of Yale University, Angela Bowen of the Western IRB (a private clinical trials review firm), and I—were invited as authorities on the current condition of the IRB system. Bert Spilker... (shrink)

Credibility in a scientific community (sensu Shapin) is a vicarious selector (sensu Campbell) for the reliability of reports by individual scientists or institutions. Similarly, images from a microscope (sensu Hacking) are vicarious selectors for studying specimens. Working at different levels, the process of indirect reasoning and checking indicates a unity to experimentalist and sociological perspectives, along with a resonance of strategies for assessing reliability. The perspective sketched here can open dialogue between philosophical and sociological interpretations of science and resolves at (...) least one tension regarding the "primary" factors by which scientists evaluate claims. (shrink)

The invention in 1986 of scanning force microscopy (SFM) provided a new and powerful tool for the investigation of biological structures. SFM yields a three‐dimensional view at nanometer resolution of the surface topography associated with biological objects. The potential for imaging either macromolecules or biomolecules and cells under native (physiological) conditions is currently being exploited to obtain functional information at the molecular level. In addition, the forces involved in individual bimolecular interactions are being assessed under static and dynamic conditions. (...) In this report we focus on the imaging capability of the SFM. The rather broad spectrum of applications represented is intended to orient the prospective user of biological SFM. (shrink)

The paper presents evidence in bacteria for the utility of Godfrey-Smith’s environmental complexity thesis, using certain kinds of signal transduction systems as proxies for cognitive/behavioral complexity. Microbiologists already accept that the number of signal transduction proteins in a bacterial genome indicates the level of ecological complexity to which the organism is subject: the more signalling proteins, the greater the complexity. Sheer numbers are not always a reliable indicator of behavioral complexity, however. The paper proposes a new, ECT-based procedure for (...) identifying, from genomic sequence and signalling repertoire, novel bacterial candidates likely to exhibit behavioral complexity in response to a complex ecological niche. (shrink)

With the further acceleration of urbanization in China, the proportions of both urban residents’ energy consumption and energy-consuming terminal electricity are showing an increasing trend at the same time. In view of the dynamic and time-varying complex system characteristics of power system, it is of great significance to study the impact mechanism of urbanization residents’ electricity consumption on the realization of demand-side management and environmental protection. Based on the one-year follow-up survey data obtained from household meter reading, this paper studies (...) the impact mechanism of urban residents’ electricity consumption in different seasons and terminals by descriptive analysis and multiple linear regression model. The results show that, on the whole, electricity is a necessity for urban households and does not change significantly with changes in income. At the turn of summer and autumn and the turn of winter and spring, high-income families tend to use higher levels of energy in pursuit of comfort, while low- and middle-income families do not have luxury consumption. In different seasons, the influence mechanism of household electricity consumption at different terminals is different. (shrink)

The causal exclusion argument supports the notion that causation should be thought of as a purely low-level affair. Here we argue instead in favour of high-level causation as a natural and meaningful notion that may even be more useful than causation at more fundamental physical levels. Our argument is framed in terms of a broadly interventionist conception of causation. Its essence is that causal relations at an appropriately high level can in a certain sense be less sensitive (...) than those at a fundamental, microscopic level. This means that in settings where causal relations at the physical level are not considered in the context of some suitable macro-level interpretation, statements concerning the low-level relations may be highly sensitive with respect to changes in background conditions. Using an example of accelerator experiments in particle physics, we consider what it means to characterize extremely sensitive low-level events as causal. (shrink)

The different sciences furnish us with a wide variety of explanations: some work at macroscopic scales, some work at microscopic scales, and some operate across different levels. How do these different explanatory levels relate to one another, and what is an explanatory level in the first place? Over the last 50 years, more and more philosophers—both reductionists and anti-reductionists—no longer subscribe to the idea that the best explanation resides at the fundamental physical level. New challenges arise from (...) the success of scientific explanations employing multi-level models which mix levels of explanation, from distinctive differences between levels structures in biology, cognitive science, and social science, from the apparently radical reimagining of the explanatory role of spacetime in our current best theories of fundamental physics, and from the enduring mystery of how higher-level explanations are possible in the first place. These questions naturally connect to classic philosophical ways of thinking about the relationships between levels: reduction, emergence, and fundamentality. This volume presents a snapshot of cutting-edge research on explanatory levels, from their conceptual foundations to the details of how they are used in scientific practice. (shrink)

According to influential views the probabilities in classical statistical mechanics and other special sciences are objective chances, although the underlying mechanical theory is deterministic, since the deterministic low level is inadmissible or unavailable from the high level. Here two intuitions pull in opposite directions: One intuition is that if the world is deterministic, probability can only express subjective ignorance. The other intuition is that probability of high-level phenomena, especially thermodynamic ones, is dictated by the state of affairs (...) in the world. We argue in support of this second intuition and we show that in fact there are two different ways in which high-level probability describes matters of fact, even if the underlying microscopic reality is deterministic. Our analysis is novel, but supports approaches by, e.g., Loewer, Albert, Frigg and Hoefer, List and Pivato. In particular, the reductive view we propose here can be seen as a naturalization of the above approaches. We consider consequences of our result for nonreductive physicalist approaches, such as functionalism, that admit multiple realization of the kinds that appear in the special sciences by physical kinds. We show that nonreductive physicalism implies the existence of nonphysical matters of fact. (shrink)

Relationships of counterfactual dependence have played a major role in recent debates of explanation and understanding in the philosophy of science. Usually, counterfactual dependencies have been viewed as the explanantia of explanation, i.e., the things providing explanation and understanding. Sometimes, however, counterfactual dependencies are themselves the targets of explanations in science. These kinds of explanations are the focus of this paper. I argue that “micro-level model explanations” explain the particular form of the empirical regularity underlying a counterfactual dependency by (...) representing it as a physical necessity on the basis of postulated microscopic entities. By doing so, micro-level models rule out possible forms the regularity could have taken. Micro-model explanations, in other words, constrain empirical regularities and their associated counterfactual dependencies. I introduce and illustrate micro-level model explanations in detail, contrast them to other accounts of explanation, and consider potential problems. (shrink)

This report reviews what quantum physics and information theory have to tell us about the age-old question, How come existence? No escape is evident from four conclusions: (1) The world cannot be a giant machine, ruled by any preestablished continuum physical law. (2) There is no such thing at the microscopic level as space or time or spacetime continuum. (3) The familiar probability function or functional, and wave equation or functional wave equation, of standard quantum theory provide mere (...) continuum idealizations and by reason of this circumstance conceal the information-theoretic source from which they derive. (4) No element in the description of physics shows itself as closer to primordial than the elementary quantum phenomenon, that is, the elementary device-intermediated act of posing a yes-no physical question and eliciting an answer or, in brief, the elementary act of observer-participancy. Otherwise stated, every physical quantity, every it, derives its ultimate significance from bits, binary yes-or-no indications, a conclusion which we epitomize in the phrase, it from bit. (shrink)

I defend what may loosely be called an eliminativist account of causation by showing how several of the main features of causation, namely asymmetry, transitivity, and necessitation, arise from the combination of fundamental dynamical laws and a special constraint on the macroscopic structure of matter in the past. At the microscopic level, the causal features of necessitation and transitivity are grounded, but not the asymmetry. At the coarse-grained level of the macroscopic physics, the causal asymmetry is grounded, (...) but not the necessitation or transitivity. Thus, at no single level of description does the physics justify the conditions that are taken to be constitutive of causation. Nevertheless, if we mix our reasoning about the microscopic and macroscopic descriptions, the structure provided by the dynamics and special initial conditions can justify the folk concept of causation to a significant extent. I explain why our causal concept works so well even though at bottom it is comprised of a patchwork of principles that don't mesh well. (shrink)

Nehemiah Grew (1641–1712) devoted more than 10 years of his life to developing a science of plants and vegetation, a project in which observation (often at the microscopic level) and experimentation played a prominent role. Grew started by composing a natural history of plants that was concerned with their anatomical structure and functioning, but, as I suggest, he also aimed to use observations and experiments to develop an experimental science that investigated the causes and principles of vegetation. Apart (...) from studying the structure of plants, Grew also treated them as instruments in which different chemical operations took place (such as filtration, digestion, fermentation, and the separation of particles of matter). At a methodological level, the science of plants and vegetation is a project based on experimental comparisons, variations, and extensions that, in some cases, led Grew to revise his explicative hypothesis. (shrink)

Many features of quantum mechanics (QM) suggest that, at the microscopic level, objects sometimes fail to determinately instantiate their properties. In recent years, many have argued that this phenomenon indicates the existence of an ontological kind of indeterminacy, often called metaphysical indeterminacy, which is supposed to affect the ontology of QM. As insisted by Glick ('Against Quantum Indeterminacy), however, once we look at the major realist approaches to QM we learn that the indeterminacy disappears from the description of (...) the world at its most fundamental level. This absence might be taken as a good reason for adopting some form of eliminativism towards quantum mechanical indeterminacy. The aim of this paper is to distinguish three ways of defending eliminativism, and to argue that none of them eventually succeeds. The upshot is that QM does in fact suggest the existence of metaphysical indeterminacy, although only as an emergent phenomenon. (shrink)

This paper deals with the dependence of directionality in the course of events-or our claims concerning such directionality-on the modes of description we use in speaking of the events in question. I argue that criteria of similarity and individuation play a crucial role in assessments of directionality. This is an extension of Davidson's claim regarding the difference between causal and explanatory contexts. The argument is based on a characterisation of notions of necessity and contingency that differ from their modal logic (...) counterparts on the one hand, and from causality and chance on the other. I show that some types of directionality are perfectly compatible with both determinism and indeterminism at the microscopic level, and that there is no likelihood of, or advantage to, reducing such directionality to other laws or causal processes. (shrink)

In various documents the view emerges that contemporary biotechnosciences are currently experiencing a scientific revolution: a massive increase of pace, scale and scope. A significant part of the research endeavours involved in this scientific upheaval is devoted to understanding and, if possible, ameliorating humankind: from our genomes up to our bodies and brains. New developments in contemporary technosciences, such as synthetic biology and other genomics and “post-genomics” fields, tend to blur the distinctions between prevention, therapy and enhancement. An important dimension (...) of this development is “biomimesis”: i.e. the tendency of novel technologies and materials to mimic or plagiarize nature on a molecular and microscopic level in order to optimise prospects for the embedding of technological artefacts in natural systems such as human bodies and brains. In this paper, these developments are read and assessed from a psychoanalytical perspective. Three key concepts from psychoanalysis are used to come to terms with what is happening in research laboratories today. After assessing the general profile of the current revolution in this manner, I will focus on a particular case study, a line of research that may serve as exemplification of the vicissitudes of contemporary technosciences, namely viral biomaterials. Viral life forms can be genetically modified (their genomes can be rewritten) in such a manner that they may be inserted in human bodies in order to produce substances at specific sites such as hormones (testosterone), neurotransmitters (dopamine), enzymes (insulin) or bone and muscle tissue. Notably, certain target groups such as top athletes, soldiers or patients suffering from degenerative diseases may become the pioneers serving as research subjects for novel applications. The same technologies can be used for various purposes ranging from therapy up to prevention and enhancement. (shrink)

The ArgumentThe paper is divided into the two parts. In the first, I examine the relations among molecular biology, gene technology, and medicine as some aspect of the consequences of these relations with respect to the human genome project of the consequences of these relations with respect to the human genome project. I argue that the prevailing momentum of early molecular biology resided in argue that the prevailing momentum of relay molecular biology resided in crating the technical means for an (...) extracellular representation of intracellular configurations. Assuch, its medical impact was rather limited. With the advent of recombinant DNA technology is based on the prospects of an intracellular representation of extracellular projects—the “rewriting” of life. Its medical impact is potentially unlimited. In the second part, I question the very opposition between nature and culture that implicitly underlies the notion of medicine as a “cultural system.” I argue that both on a macroscopic level and on a microscopic level, the “natural” and the “social” are no longer to be seen as ontologically different.In its uncanny oscillation between retrospection and foresight, between description and proclamation, and between assertion and hesitation, this essay translates an uneasiness that I have not been able to overcome while writing it. The essay conveys the tangled views of a hybrid author who himself cannot but oscillate between the perspectives of an actor in the field of molecular biology, a participant in the field of science studies, and a citizen. (shrink)

To explain phenomenon R by showing how mechanism M yields output R each time it is triggered by circumstances C, is to give a causal explanation of R. This paper analyses what mechanistic analysis can contribute to our understanding of causation in general and of downward causation in particular. It is first shown, against Glennan, that the concept of causation cannot be reduced to that of mechanism. Second it is shown, against Craver and Bechtel, that mechanistic explanation allows us to (...) make sense of causal processes that cut across levels, either in bottom-up direction where a change in a part of a system causes a change in the whole, or in downward direction where a change at the level of the system causes a change at the level of its parts. I suggest construing a decision's influence on molecules in muscle cells as a global constraint. Microscopic laws determine the detailed evolution of muscle cells and glucose molecules, but this evolution is constrained by the fact that it must be compatible with the action caused by the decision. (shrink)

Through the introduction of his ‘common cause principle’ [The Direction of Time, 1956], Hans Reichenbach was the first to formulate a precise link relating causal claims to statements of probability. Despite some criticism, the principle has been hugely influential and successful—a pillar of scientific practice, as well as guiding our reasoning in everyday life. However, Bell’s theorem, taken in conjunction with quantum theory, challenges this principle in a fundamental sense at the microscopic level. For the same reason, the (...) celebrated causal model framework pioneered by Pearl, as well as by Spirtes, Glymour and Scheines, defies satisfactory causal explanations of quantum correlations—the role of the ‘causal Markov condition’ in this framework amounts to a generalisation of Reichenbach’s principle. Much effort has been devoted to the development of quantum causal models to overcome this challenge and to study whether a principled way of causal reasoning, albeit adjusted in its terms, can be maintained when it comes to quantum physics. A clarification of what quantum causal relations are supposed to be is also a much needed step in light of the hotly debated topic of causality in foundations of quantum theory, e.g. in the study of ‘indefinite causal structures’. This paper reports and discusses a framework of quantum causal models and argues that it is promising and interesting for two main reasons. First, it can be seen as a prime example of a recent research programme that took direct and fruitful inspiration from ideas first formulated by Reichenbach—it began by asking, and giving an answer to, how the common cause principle could be generalised appropriately to quantum theoretical terms. Second, the framework did not only facilitate generalisations of the core theorems of the classical framework of causal models, but, above all, it has a theorem at its center that justifies the ‘quantum causal Markov condition’ on the basis of what arguably is a natural definition of causal relations in quantum theory. This provides a conceptually clear grounding of the framework, as well as a proposal for the needed clarification of quantum causal relations in the foundations of quantum theory more generally. (shrink)

I defend what may loosely be called an eliminativist account of causation by showing how several of the main features of causation, namely asymmetry, transitivity, and necessitation, arise from the combination of fundamental dynamical laws and a special constraint on the macroscopic structure of matter in the past. At the microscopic level, the causal features of necessitation and transitivity are grounded, but not the asymmetry. At the coarse-grained level of the macroscopic physics, the causal asymmetry is grounded, (...) but not the necessitation or transitivity. Thus, at no single level of description does the physics justify the conditions that are taken to be constitutive of causation. Nevertheless, if we mix our reasoning about the microscopic and macroscopic descriptions, the structure provided by the dynamics and special initial conditions can justify the folk concept of causation to a significant extent. I explain why our causal concept works so well even though at bottom it is comprised of a patchwork of principles that don't mesh well. (shrink)

On a macroscopic level we take general relativity as the appropriate theory of space-time and gravity. We will argue that, on a more microscopic level, in the Compton wavelength regime of elementary particles, there are good reasons for suspecting the presence of a torsion of space-time. A corresponding gaugetheoretical formalism related to the Poincaré group is reviewed, and the kinematical consequences of the presence of a torsion are worked out. In particular we discuss the operational meaning and (...) the measurability of torsion. The dynamics of torsion is left for a forthcoming article. (shrink)

Einstein's early thoughts about superconductivity are discussed as a case study of how theoretical physics reacts to experimental findings that are incompatible with established theoretical notions. One such notion that is discussed is the model of electric conductivity implied by Drude's electron theory of metals, and the derivation of the Wiedemann-Franz law within this framework. After summarizing the experimental knowledge on superconductivity around 1920, the topic is then discussed both on a phenomenological level in terms of implications of Maxwell's (...) equations for the case of infinite conductivity, and on a microscopic level in terms of suggested models for superconductive charge transport. Analyzing Einstein's manuscripts and correspondence as well as his own 1922 paper on the subject, it is shown that Einstein had a sustained interest in superconductivity and was well informed about the phenomenon. It is argued that his appointment as special professor in Leiden in 1920 was motivated to a considerable extent by his perception as a leading theoretician of quantum theory and condensed matter physics and the hope that he would contribute to the theoretical direction of the experiments done at Kamerlingh Onnes' cryogenic laboratory. Einstein tried to live up to these expectations by proposing at least three experiments on the phenomenon, one of which was carried out twice in Leiden. Compared to other theoretical proposals at the time, the prominent role of quantum concepts was characteristic of Einstein's understanding of the phenomenon. The paper concludes with comments on Einstein's epistemological reflections on the problem. (shrink)

The rigid recoil of a crystal is the accepted mechanism for the Mössbauer effect. It’s at odds with the special theory of relativity which does not allow perfectly rigid bodies. The standard model of particle physics which includes QED should not allow any signals to be transmitted faster than the speed of light. If perturbation theory can be used, then the X-ray emitted in a Mössbauer decay must come from a single nuclear decay vertex at which the 4-momentum is exactly (...) conserved in a Feynman diagram. Then the 4-momentum of the final state Mössbauer nucleus must be slightly off the mass shell. This off-shell behavior would be followed by subsequent diffusion of momentum throughout the crystal to bring the nucleus back onto the mass shell and the crystal to a final relaxed state in which it moves rigidly with the appropriate recoil velocity. This mechanism explains the Mössbauer effect at the microscopic level and reconciles it with relativity. Because off-mass-shell quantum mechanics is required, the on-mass-shell theories developed originally for the Mössbauer effect are inadequate. Another possibility is that that the recoil response involves a non-perturbative effect in the standard model which could allow for a non-local instantaneous momentum transfer between the crystal and the decay, as proposed for example by Preparata and others in super-radiance theory. The recoil time of the crystal is probably not instantaneous, and if it could be measured, one could distinguish between various theories. An experiment is proposed in this paper to measure this time. The idea is to measure the total energy radiated due to bremsstrahlung from a charged Mössbauer crystal which has experienced a recoil. Using Larmor’s formula, along with corrections to it, allows one to design an experiment. The favored idea is to use many small nano-spheres of Mössbauer-active metals, whose outer surfaces are charged. The energy radiated then varies as the charge squared divided by the recoil time. This can then be measured with the extreme sensitivity available in Mössbauer experiments. If it turns out that experiments prove the need for off-mass-shell theory, then this would have profound implications for all of condensed matter physics. It would mean that an off-mass-shell theory like those considered by Stueckelberg, Horwitz, Piron, Greenberger, and many others are required to describe nature. The inclusion of these would be a major shift in the foundations. It would mean that there are new dynamic variables—the rest masses of particles. The ability to measure the diffusion relaxation time should prove useful also in chemical analysis, and provide a new class of analytical methods for material science. This problem is also interesting because the Mössbauer effect is a phenomenon where the solid-state environment dramatically and indisputably influences the probability of a nuclear process. (shrink)

. Ably marshalling ideas from theology, philosophy, and neurology, personality theorist Joseph F. Rychlak criticizes mechanistic psychologists' neglect of will and responsibility; these human qualities involve dialectically considering alternatives. I disagree with Rychlaks suggestion of fundamental mystery in the minds transcendence of the body and believe transcendent mind is intimately related to biological evolution and the brain. For example, dialectics, seen in simpler forms in lower animals, may require neural inhibition, feedback circuits, and topographic mappings. However, epistemologically speaking, neuroscientists strongly (...) need the human insights of work such as Rychlak's to understand the alternatives, in planning investigation at more microscopic levels. (shrink)

The received view on the nature of legal authority contains the idea that a sound account of legitimate authority will explain how a legal authority has a right to command and the addressee a duty to obey. The received view fails to explain, however, how legal authority truly operates upon human beings as rational creatures with specific psychological makeups. This book takes a bottom-up approach, beginning at the microscopic level of agency and practical reason and leading to the (...) justificatory framework of authority. The book argues that an understanding of the nature of legal normativity involves an understanding of the nature and structure of practical reason in the context of the law, and advances the idea that legal authority and normativity are intertwined. This point can be summarised thus: if we are able to understand both how the agent exercises his or her practical reason under legal directives and commands and how the agent engages his or her practical reason by following legal rules grounded on reasons for actions as good-making characteristics, then we can fully grasp the nature of legal authority and legal normativity. Using the philosophies of action enshrined in the works of Elisabeth Anscombe, Aristotle and Thomas Aquinas, the study explains practical reason as diachronic future-directed intention in action and argues that this conception illuminates the structure of practical reason of the legal rules' addressees. The account is comprehensive and enables us to distinguish authoritative and normative legal rules in just and good legal systems from 'apparent' authoritative and normative legal rules of evil legal systems. At the heart of the book is the methodological view of a 'practical turn' to elucidate the nature of legal normativity and authority. (shrink)

Arguments pertaining to the mind-brain connection and to the physical effectiveness of our conscious choices have been presented in two recent books, one by John Searle, the other by Jaegwon Kim. These arguments are examined, and it is explained how the encountered difficulties arise from a defective understanding and application of a pertinent part of contemporary science, namely quantum mechanics. The principled quantum uncertainties entering at the microscopic levels of brain processing cannot be confined to the micro level, (...) but percolate up to the macroscopic regime. To cope with the conflict between the resulting macroscopic indefiniteness and the definiteness of our conscious experiences, orthodox quantum mechanics introduces the idea of agent-generated probing actions, each of which specifies a definite set of alternative possible empirically/experientially distinguishable outcomes. Quantum theory then introduces the mathematical concept of randomness to describe the probabilities of the various alternative possible outcomes of the chosen probing action. But the agent-generated choice of which probing action to perform is not governed by any known law or rule, statistical or otherwise. This causal gap provides a logical opening, and indeed a logical need, for the entry into the dynamical structure of nature of a process that goes beyond the currently understood quantum mechanical statistical generalization of the deterministic laws of classical physics. The well-known quantum Zeno effect can then be exploited to provide a natural process that establishes a causal psychophysical link within the complex structure consisting of a stream of conscious experiences and certain macroscopic classical features of a quantum mechanically described brain. This naturally created causal link effectively allows consciously felt intentions to affect brain activity in a way that tends to produce the intended feedback. This quantum mechanism provides an eminently satisfactory alternative to the classical physics conclusion that the physical present is 1 completely determined by the physical past, and hence provides a physicsbased way out of the dilemma that Searle and Kim tried to resolve by philosophical analysis.. (shrink)

Cybernetic Bacteria is an ongoing transdisciplinary investigation that brings together art, philosophy, microbiology and digital technology to examine the relationship of the emerging science of bacterial communication to our own digital communications networks, looking in particular at ‘packet data’ and bacterial quorum sensing. The project seeks to compare philosophical notions of the sublime with a kind of bacterial sublime, demonstrating the greater complexity of the interactions taking place at a microscopic level, when compared to human communication technologies such (...) as the World Wide Web (with particular focus on scale-free networks). The first artwork in the series employed a clear plastic tube of liquid agar jelly planted into earth to allow the soil bacteria beneath to grow upwards and become visible. A total of 100 µL of Homoserine Lactone, a hormone used by bacteria for quorum sensing (a form of bacterial communication), was then added by the artist as part of a performance lecture, with her in effect saying: ‘I’m here’ to the bacteria below. The microbes that have been communicated to then pass the signal on to their neighbours and so on. In theory this enables the signal to travel around the planet. However, the main issue with this work is one of Hermeneutics; the bacteria, which receive the communication, will not identify the artist as human – simply as another (albeit very large) bacterium. The project has subsequently evolved into a multiple screen digital artwork showing network traffic taking place in real time (web traffic, RFID and Bluetooth), a film of bacterial communication in progress (using two strains of genetically modified bacteria) and an interactive conceptualisation of the data from both sources generated using artificial life. The project continues. (shrink)

Many apparently complex mechanisms in biology, especially in embryology and molecular biology, can be explained easily by reasoning at the level of the “efficient cause” of the observed phenomenology: the mechanism can then be explained by a simple geometrical argument or a variational principle, leading to the solution of an optimization problem, for example, via the co-existence of a minimization and a maximization problem . Passing from a microscopic level to the macroscopic level often involves an (...) averaging effect that gives birth to a global functional feature . We will illustrate these general principles by building in four different domains of application “a minima” models and showing the main properties of their solutions: extraction of a minimal RNA structure functioning as the first “peptidic machine,” a kind of ancestral ribosome; study of a genetic regulatory network of Drosophila centred on Engrailed gene and expressing successively two genes inside a limit cycle; study of a genetic network regulating neural activity and proliferation in mammals; and study of a simple geometric model of epiboly in zebrafish. (shrink)

Mammalian neural cells contain at least two forms of brain spectrin: brain spectrin (240/235) which is located primarily in the axons and presynaptic terminals of neurons, and brain spectrin (240/235E) which is found in the cell bodies, dendrites and postsynaptic terminals of neurones. Brain spectrin (240/235E) is also found in certain glial cell types. Antibodies against red blood cell spectrin detect only brain spectrin (240/235E), while antibodies against brain spectrin isolated from axonal and synaptic membranes detect brain spectrin (240/235). Previous (...) apparent discrepancies in the literature concerning brain spectrin localization at the light microscope level were undoubtedly due to different laboratories detecting distinct brain spectrin subtypes, based on the particular antibody being utilized for immunohistochemistry. In this review we (1) discuss the data supporting the presence of at least two distinct subtypes of mammalian brain spectrin, (2) explain how these results reconcile previous discrepancies concerning the localization of spectrin within neural cells, and (3) suggest the future implications of these findings. (shrink)

The hydrodynamical formalism for the quantum theory of a nonrelativistic particle is considered, together with a reformulation of it which makes use of the methods of kinetic theory and is based on the existence of the Wigner phase-space distribution. It is argued that this reformulation provides strong evidence in favor of the statistical interpretation of quantum mechanics, and it is suggested that this latter could be better understood as an almost classical statistical theory. Moreover, it is shown how, within this (...) context, the Wigner and the Margenau-Hill functions are not equivalent, and that the latter is essentially unsatisfactory, as well as the associated symmetrization rule. Arguments in favor of a stochastic picture of the phenomena at the microscopic level are also presented. (shrink)

Spectroscopy is a scientific topic at the interface between Chemistry and Physics, which is taught at high school level in relation with its fundamental applications in Analytical Chemistry. In the first part of the paper, the topic of spectroscopy is analyzed having in mind the well-known Johnstone’s triangle of chemistry education, putting in evidence the way spectroscopy is usually taught at the three levels of chemical knowledge: macroscopic/phenomenological, sub-microscopic/molecular and symbolic ones. Among these three levels, following Johnstone’s recommendations (...) the macroscopic one is the most useful for high school students who learn spectroscopy for the first time. Starting from these premises, in the second part of the paper, we propose a didactic sequence which is inspired by the historical evolution of spectroscopic instruments from the first spectroscopes invented by Gustav Kirchhoff and Robert Bunsen in 1860 to the UV–vis spectrophotometers which became common since the 1960s. The idea behind our research is to analyze the conceptual advancements through the history of spectroscopy and to identify the key episodes/experiments and spectroscopic instruments. For each of them, a didactic activity, typically an experiment, is then proposed underlining the relevant aspects from the chemistry education point of view. The present paper is the occasion to reflect on the potentialities of an historical approach combined with a laboratorial one, and to discuss the role of historical instruments and related technological improvements to teach spectroscopy. (shrink)

The purpose of this paper is to show that the Lorentz contraction of a rod is possible only if the rod’s world path is a real four-dimensional object. This result demonstrates that special relativity does require reality at the microscopic level to be a four-dimensional world represented by Minkowski spacetime.

Gestalt theory is discussed as one main precursor of synergetics, one of the most elaborated theories of self-organization. It is a precursor for two reasons: the Gestalt theoretical view of cognitive order-formation comes dose to the central ideas of self-organization. Furthermore both approaches have stressed the significance of non-linear perceptual processes (such as multistability) for the solution of the mind-brain problem. The question of whether Gestalt theory preferred a dualistic or a monistic view of the mind-body relation is answered in (...) that there was a preference for dualism in epistemological questions and for monism in the mind-brain relation. The latter was attained by the concept of psychophysical isomorphism. This concept, although widely misunderstood in many respects, was criticized on the basis of neurobiological findings. One main objection was the neglect of the importance of the elementary neurophysiological processes. A distinction between macroscopic and microscopic brain processes seemed to be required. This idea was taken up in synergetics which postulates a bottom-up and top-down interaction between these two levels. Macroscopic order emerges from elementary brain processes and, at the same time, has a backward slaving effect to the microscopic level In the light of such holistic emergentism, the question whether macroscopic order states might be attractors for psychological meanings is discussed. (shrink)

Non-relativistic quantum mechanics is incompatible with our everyday or ‘classical’ intuitions about realism, not only at the microscopic level but also at the macroscopic level. The latter point is highlighted by the ‘cat paradox’ presented by Schrödinger. Since our observations are always made at the macroscopic level — even when applying the formalism to the microscopic level — the failure of classical realism at the macroscopic level is actually more fundamental and crucial.

One of the recurrent problems in the foundations of physics is to explain why we rarely observe certain phenomena that are allowed by our theories and laws. In thermodynamics, for example, the spontaneous approach towards equilibrium is ubiquitous yet the time-reversal-invariant laws that presumably govern thermal behaviour in the microscopic level equally allow spontaneous departure from equilibrium to occur. Why are the former processes frequently observed while the latter are almost never reported? Another example comes from quantum mechanics (...) where the formalism, if considered complete and universally applicable, predicts the existence of macroscopic superpositions—monstrous Schr¨odinger cats—and these are never observed: while electrons and atoms enjoy the cloudiness of waves, macroscopic objects are always localized to definite positions. (shrink)

My goal is to conceive how the reality would look like for hypothetical creatures that supposedly perceive on time scales much faster or much slower than that of us humans. To attain the goal, I propose modelling in two steps. At step one, we have to single out a unified parameter that sets time scale of perception. Changing substantially the value of the parameter would mean changing scale. I argue that the required parameter is duration of discrete perceptive frames, or (...) snapshots, whose sequencing constitutes perceptive process. I show that different standard durations of perceptive frames is the ground for differences in perceptive time scales of various animals. Abnormally changed duration of perceptive frames is the cause of the effect of distorted subjective time observed by humans under some conditions. Now comes step two of the modelling. By inserting some arbitrary duration of a perceptive frame, we set a hypothetical scale and thus emulate a viewpoint for virtual observation of the reality in a wider or narrower angle of embracing events in time. Like changing lenses of a microscope, viewing reality in different temporal scales makes certain features of reality manifested, others veiled. These are, in particular, features of life. If we observe an object in an inappropriate interval, we may not notice the very essence of a process it is undergoing. (shrink)

This book, the first in the Chicago Series in Biology, is an informal attempt to enrich ecological theory with some useful and general concepts. The author's purpose is to escape the "microscopic" level of analysis, that is, the level of interaction between a predator and its prey and of population response to changes in the environment, and to take a "macroscopic" point of view. He does this by first interpreting ecological relationships in terms of cybernetic theory. For (...) example, he takes "information" to be something brought about within the system by its own operation, which in turn influences its future. "Energy gates" are aspects of the system which involve transfer of information from the less organized sub-system to the more organized. Then he takes a cybernetic look at succession, maturity, and exploitation, illustrating his analysis with examples from his speciality of marine biology. He emphasizes that, since we are dealing with a dynamic system, it is important to work with trends and gradients rather than with point values. Finally, he considers evolution as a process going on in an ecosystem. An intellectual synthesis of the paleontological picture of evolution and the contemporary picture of succession should give us working principles for understanding the history of life. As an illustration, he suggests conditions which might have fostered man and his culture. This is a brilliant little book, simply written and absorbing.--L. G. (shrink)

In this paper we distinguish two issues that are often run together in discussions about physicalism. The first issue concerns levels. How do entities picked out by non-physical terminology, such as biological or psychological terminology, relate to physical entities? Are the former identical to, or metaphysically supervenient on, the latter? The second issue concerns physical parts and wholes. How do macroscopic physical entities relate to their microscopic parts? Are the former generally determined by the latter? We argue that views (...) on these two issues are independent of one another and should not be conflated. (shrink)

QED is a fundamental microscopic theory satisfying all the conservation laws and discrete symmetries C, P, T. Yet, dissipative phenomena, organization, and self-organization occur even at this basic microscopic two-body level. How these processes come about and how they are described in QED is discussed. A possible new phase of QED due to self-energy effects leading to self-organization is predicted.

This paper concerns how motor actions are neurally represented and coded. Action planning and motor preparation can be studied using a specific type of representational activity, motor imagery. A close functional equivalence between motor imagery and motor preparation is suggested by the positive effects of imagining movements on motor learning, the similarity between the neural structures involved, and the similar physiological correlates observed in both imaging and preparing. The content of motor representations can be inferred from motor images at a (...) macroscopic level, based on global aspects of the action (the duration and amount of effort involved) and the motor rules and constraints which predict the spatial path and kinematics of movements. A more microscopic neural account calls for a representation of object-oriented action. Object attributes are processed in different neural pathways depending on the kind of task the subject is performing. During object-oriented action, a pragmatic representation is activated in which object affordances are transformed into specific motor schemas (independently of other tasks such as object recognition). Animal as well as human clinical data implicate the posterior parietal and premotor cortical areas in schema instantiation. A mechanism is proposed that is able to encode the desired goal of the action and is applicable to different levels of representational organization. (shrink)

Lynne Rudder Baker presents and defends a unique account of the material world: the Constitution View. In contrast to leading metaphysical views that take everyday things to be either non-existent or reducible to micro-objects, the Constitution View construes familiar things as irreducible parts of reality. Although they are ultimately constituted by microphysical particles, everyday objects are neither identical to, nor reducible to, the aggregates of microphysical particles that constitute them. The result is genuine ontological diversity: people, bacteria, donkeys, mountains and (...) microscopes are fundamentally different kinds of things - all constituted by, but not identical to, aggregates of particles. Baker supports her account with discussions of non-reductive causation, vagueness, mereology, artefacts, three-dimensionalism, ontological novelty, ontological levels and emergence. The upshot is a unified ontological theory of the entire material world that irreducibly contains people, as well as non-human living things and inanimate objects. (shrink)

Our aim in this paper is to put the concept of moral responsibility under a microscope. At the lowest level of magnification, it appears unified. But Gary Watson has taught us that if we zoom in, we will find that moral responsibility has two faces: attributability and accountability. Or, to describe the two faces in different terms, there is a difference between being responsible and holding responsible. It is one thing to talk about the connection the agent has with (...) her action; it is quite another to talk about the potential interaction the agent might have with her moral community. It turns out, though, that the faces of moral responsibility can themselves be viewed under an even higher level of magnification. If moral responsibility has two faces, then our aim in this paper is to examine their features. To do so reveals subtle distinctions in our concept of moral responsibility and its interaction with surrounding issues that, we argue, can help illuminate various debates in the literature. (shrink)

Do political concerns belong in psychodynamic treatment? How do class and politics shape the unconscious? The effects of an increasingly polarized, insecure and threatening world mean that the ideologically enforced split between the political order and personal life is becoming difficult to sustain. This book explores the impact of the social and political domains at the individual level. The contributions included in this volume describe how issues of class and politics, and the intense emotions they engender, emerge in the (...) clinical setting and how psychotherapists can respectfully address them rather than deny their significance. They demonstrate how clinicians need to take into account the complex convergences between psychic and social reality in the clinical setting in order to help their patients understand the anxiety, fear, insecurity and anger caused by the complex relations of class and power. This examination of the psychodynamics of terror and aggression and the unconscious defences employed to deny reality offers powerful insights into the microscopic unconscious ways that ideology is enacted and lived. _Psychoanalysis, Class and Politics_ will be of interest to all mental health professionals interested in improving their understanding of the ideological factors that impede or facilitate critical and engaged citizenship. It has a valuable contribution to make to the psychoanalytic enterprise, as well as to related scholarly and professional disciplines. (shrink)

Special sciences (such as biology, psychology, economics) describe various regularities holding at some high macroscopic level. One of the central questions concerning these macroscopic regularities is how they are related to the laws of physics governing the underlying microscopic physical reality. In this paper we show how a macroscopic regularity may emerge from an underlying micro- scopic structure, and how the appearance of multiple realizability of the special sciences by physics comes about in a reductionist-physicalist framework. On this (...) basis we explain how complexity at the high level can arise due to a sort of harmony between the microscopic dynamics and observer-dependent macroscopic properties. We show that observer-dependent properties, which underlie the emergence of macroscopic properties and of macroscopic complexity, are objective physical facts. We argue that such physical properties remove the mystery from the multiple realizability of special sciences’ kinds, since the latter are grounded in shared physical properties. Finally we explain how and in what sense in our reductive physicalist approach the special sciences are still autonomous after all. (shrink)

This book presents the life and personality, the scientific and philosophical work of Ludwig Boltzmann, one of the great scientists who marked the passage from 19th- to 20th-Century physics. His rich and tragic life, ending by suicide at the age of 62, is described in detail. A substantial part of the book is devoted to discussing his scientific and philosophical ideas and placing them in the context of the second half of the 19th century. The fact that Boltzmann was the (...) man who did most to establish that there is a microscopic, atomic structure underlying macroscopic bodies is documented, as is Boltzmann's influence on modern physics, especially through the work of Planck on light quanta and of Einstein on Brownian motion. Boltzmann was the centre of a scientific upheaval, and he has been proved right on many crucial issues. He anticipated Kuhn's theory of scientific revolutions and proposed a theory of knowledge based on Darwin. His basic results, when properly understood, can also be stated as mathematical theorems. Some of these have been proved: others are still at the level of likely but unproven conjectures. The main text of this biography is written almost entirely without equations. Mathematical appendices deepen knowledge of some technical aspects of the subject. (shrink)