Preconception expanded carrier screening (PECS) informs prospective parents about the risk of conceiving a child with a heritable genetic condition. PECS will also, for many, become an important screening test, and websites will likely play a vital role in providing information on this practice. The aim of this article is to examine rationalities in the information on PECS on Dutch websites. The method used is multimodal critical discourse analysis. This method allows an examination of norms and assumptions in the (...) descriptions, as well as of the positions that are discursively made available. The data consist of publicly available material on websites from two genetics departments in the Netherlands. In the results, we present the three main discourses and subject positions that were identified: risk and the couple as possible mediators of severe conditions; the focus on scientific facts and rational conceivers; and severity of the conditions and the responsible couple. In this study, we highlight the importance of acknowledging the interrelation between epistemology and ethics in the discourse on PECS. Finally, it is claimed that the focus on scientific facts in information on PECS risks making existential and ethical dilemmas and choices invisible. (shrink)

This paper provides a comprehensive study of the Epicurean theory of ‘preconception’. It addresses what a preconception is; how our preconception of the gods can be called innata, innate; the role played by epibolai ; and how preconceptions play a semantic role different from that of ‘sayables’ in Stoicism. The paper highlights the conceptual connections between these issues, and also shows how later Epicureans develop Epicurus’ doctrine of preconceptions while remaining orthodox about the core of that doctrine.

In the Netherlands fertility doctors increasingly formulate protocols, which oblige patients to quit their unhealthy lifestyle before they are admitted to IVF procedures. We argue that moral arguments could justify parenting protocols that concern all future parents. In the first part we argue that want‐to‐be parents have moral responsibilities towards their future children to prevent them from harm by diminishing or eliminating risk factors before as well as during the pregnancy. This is because of the future children's potential to become (...) of a certain type, more specifically: a person that will be the want‐to‐be parents' child. Want‐to‐be parents intend to become pregnant and therefore have an additional moral reason to diminish the risks. Also, people who become pregnant unintentionally have the responsibility to prevent their children from harm, unless they become pregnant due to contraception failure. All people not wanting to become pregnant should use contraception methods carefully.In the second part of this paper we translate the want‐to‐be parents' responsibilities into practice. We distinguish four determinants of risk factors: modifiability, chance, severity and effort. We examine some evidence‐based risk factors based on these variables and deduce levels of responsibility.In conclusion, formulating informal requirements for want‐to‐be parents is morally required and therefore also for want‐to‐be parents in need of medical assistance. The protocols developed by fertility doctors in the Netherlands could be seen as the precursor for a general, informal Parenting Protocol that could be developed on the basis of an extended and thoroughly debated risk‐responsibility analysis. (shrink)

Safe and effective methods of preconception gender selection through flow cytometric separation of X- and Y-bearing sperm could greatly increase the use of gender selection by couples contemplating reproduction. Such a development raises ethical, legal, and social issues about the impact of such practices on offspring, on sex ratio imbalances, and on sexism and the status of women. This paper analyzes the competing interests in preconception gender selection, and concludes that its use to increase gender variety in a (...) family, and possibly for selecting the gender of firstborn, might in many instances be ethically acceptable. (shrink)

Le passage de la Lettre à Hérodote consacré au temps (Hrdt. 72-73) est particulièrement obscur. Épicure y affirme explicitement que le mot temps ne renvoie à aucune préconception (prolepse), en tout cas pas au sens habituel qu’a ce terme pour lui, puisqu’il n’existe aucun contenu commun à toutes nos expériences du temps ; et cependant le mot temps n’est pas vide. Cet article vise à résoudre ce paradoxe. Il éclaircit la nature de la perception du temps épicurien et tente de (...) reconstituer le processus cognitif qui la sous-tend. La perception du temps est idiosyncrasique, car elle porte sur une entité de troisième degré : le temps est en effet, selon la formule attribuée à Épicure par Démétrius Lacon, un « accident d’accidents ». Sa perception implique une combinaison d’intuition et de déduction, d’analogie et d’épilogisme, en deçà de la formation d’une préconception – dont nous expliquons l’impossibilité. Elle concerne toujours les durées en tant que nous les rapportons les unes aux autres, selon un « libre jeu » de l’épilogisme et de l’analogie qui ne donne pas lieu à une préconception, mais rend possible de nommer le temps. (shrink)

(2001). Preconception Sex Selection: The Perspective of a Person of the Undesired Gender. The American Journal of Bioethics: Vol. 1, No. 1, pp. 37-38.

In the Netherlands fertility doctors increasingly formulate protocols, which oblige patients to quit their unhealthy lifestyle before they are admitted to IVF procedures. We argue that moral arguments could justify parenting protocols that concern all future parents. In the first part we argue that want-to-be parents have moral responsibilities towards their future children to prevent them from harm by diminishing or eliminating risk factors before as well as during the pregnancy. This is because of the future children's potential to become (...) of a certain type, more specifically: a person that will be the want-to-be parents' child. Want-to-be parents intend to become pregnant and therefore have an additional moral reason to diminish the risks. Also, people who become pregnant unintentionally have the responsibility to prevent their children from harm, unless they become pregnant due to contraception failure. All people not wanting to become pregnant should use contraception methods carefully.In the second part of this paper we translate the want-to-be parents' responsibilities into practice. We distinguish four determinants of risk factors: modifiability, chance, severity and effort. We examine some evidence-based risk factors based on these variables and deduce levels of responsibility.In conclusion, formulating informal requirements for want-to-be parents is morally required and therefore also for want-to-be parents in need of medical assistance. The protocols developed by fertility doctors in the Netherlands could be seen as the precursor for a general, informal Parenting Protocol that could be developed on the basis of an extended and thoroughly debated risk-responsibility analysis. (shrink)

ZusammenfassungVersuche zur Geschlechtswahl bei der Befruchtung führten in jüngerer Zeit zu anwendbaren, wenngleich noch eingeschränkt erfolgssicheren Techniken. Deren ethische und rechtliche Bewertungen stehen im Mittelpunkt dieser Abhandlung. In Gesellschaften und Kulturen mit traditioneller Bevorzugung männlicher Nachkommenschaft gibt es einerseits ein starkes Interesse für die Geschlechtswahl, andererseits wird in einigen westlichen Ländern der vorgeburtlichen Geschlechtswahl sehr geringe praktische Bedeutung beigemessen. Dabei unterscheidet sich die Verfügbarkeit der entsprechenden reproduktionsmedizinischen Verfahren von freier Zugänglichkeit zu allen Methoden des Fortpflanzungsmedizinmarkts bis hin zu strenger Reglementierung. (...) Es wird anhand der wissenschaftlichen Literatur der Frage nachgegangen, welche für die Begründung rechtlicher Regelung beachtlichen sozialen oder gesundheitlichen Gefährdungen durch präkonzeptionelle Geschlechtswahl verursacht werden könnten, und welche Gründe es andererseits für die Zulässigkeit sozial motivierter präkonzeptioneller Geschlechtswahl gibt. (shrink)

Although it is not their fault, Shors & Matzel's attempt to review the LTP and learning hypothesis suffers from there being no clear published statement of the idea. Their summary of relevant evidence is not without error, however, and it oversimplifies fundamental issues relating to NMDA receptor function. Their attentional hypothesis is intriguing but requires a better systems-level understanding of how attention contributes to cognitive function.

I postulate that the extension of a degree adjective is fixed by implicitly accepted non-analytic reference-fixing principles (“preconceptions”) that combine appeals to paradigmatic cases with generic principles designed to expand the extension of the adjective beyond the paradigmatic range. In regular occasions of use, the paradigm and generic preconceptions are jointly satisfied and determine the existence of an extension/anti-extension pair dividing the adjective’s comparison class into two mutually exclusive and jointly exhaustive subclasses. Sorites paradoxical occasions of use are irregular occasions (...) of use in which the paradigm and generic preconceptions are not jointly satisfied. In them, the relevant degree adjective lacks an extension, and utterances of sentences containing it appearing in sorites arguments do not have truth conditions. I also postulate a probable psychology of paradigm intuitions, used in a psychological explanation of the preference for solutions of the sorites paradox on which paradigm preconceptions retain their intuitive truth-values. (shrink)

The preventative paradigm of preconception care is receiving increasing attention, yet its boundaries remain vague in three respects: temporally; agentially; and instrumentally. Crucially, it remains unclear just who is to be considered a ‘potential parent’, how soon they should take up preconception responsibilities, and how weighty their responsibilities should be.

21세기 학술 연구에서 가장 중요한 개념을 하나 꼽으라면 당연 ‘정보’다. 과거에 “앎은 무엇인가”, “마음이란 무엇인가”, “뜻이란 무엇인가” 등을 물었다면 오늘날에는 “정보란 무엇인가”를 물어야 한다. 현대 정보 개념이 섀넌 등 과학자들에 의해 형성되기 전에 철학자들은 정보 개념 대신에 형상, 인포르마티오, 인텐치오, 관념, 의미, 명제 등과 같은 개념을 사용했다. 이 논문은 다음과 같은 내용을 담고 있다. 첫째, 우리가 “정보”라고 부르는 것은 대부분 “문장” “진술” “명제”로 표현될 수 있다. 둘째, 정보의 내용을 이루는 기본 요소를 흔히 “데이터”라 부르는데 초기 근대철학자는 주체가 받아들여 해석한 데이터를 (...) “관념”이라 불렀고 해석되기 전의 데이터를 “성질”이라 불렀다. 나는 초기 근대철학의 관념이론을 당대의 정보이론으로 여긴 다음 로크, 라이프니츠, 버클리의 정보이론을 요약한다. 셋째, 고대 철학자들이 고안한 형상 개념은 오늘날 물리학과 생물학에서 정보를 다루는 방식과 매우 비슷하다. 결국 철학사의 핵심 개념인 ‘형상’ ‘관념’ ‘명제’는 사실상 ‘정보’의 다른 이름일 뿐이다. 정보를 관념이나 명제처럼 해석의 구성물로 파악하는 나의 이 기초 연구는 심신 문제, 의미의 형이상학, 현대 인식이론, 현대 자연철학 등 다양한 연구 주제들을 새롭게 접근하는 좋은 출발점이다. (shrink)

Name der Zeitschrift: Der Islam Jahrgang: 92 Heft: 1 Seiten: 124-147.

BackgroundDuring a commercial surrogacy arrangement, the event of embryo transfer can be seen as the formal starting point of the arrangement. However, it is common for surrogates to undergo a failed attempt at pregnancy conception or missed conception after an embryo transfer. This paper attempts to argue that such failed attempts can be understood as a loss. It aims to reconstruct the experiences of loss and grief of the surrogates and the intended parents as a consequence of their collective failure (...) to conceive a surrogate pregnancy.MethodsDrawing on a qualitative study conducted over a period of eight months between 2014 and 2015 at two fertility clinics in Delhi and two in Kolkata, India, this paper examines the experiences of the surrogates and the intended parents when faced with missed conceptions or failed conceptions during a surrogacy arrangement.ResultsWe argue that while the surrogate grieves the non-arrival of a ‘good news’ as an uncertain loss, the intended parents experience yet another, failure in addition to the losses they might have incurred during their previous fertility treatments. The body of the surrogate becomes a site of ‘a lost opportunity’. The surrogate embodies a loss in her quest to achieve social mobility and the intended parents experience a disembodied pregnancy loss. This very emotional experience stands in stark contrast to the conceptualisation of such failed attempts as non-events within the discourse of the surrogacy industry. The experience of loss of the intended parents is recognised but their grief is given no space. We argue that such ambiguity around the nature of losses resulting out of a missed or failed conception during surrogacy is an outcome of lack of interpersonal relationship between the surrogate and the intended parents.ConclusionsSince commercial surrogacy is a relational process, the only way in which the experiences of losses and failures of the actors at the preconception stage can be better addressed is through developing close sharing and understanding between each other through an ethics of care. Therefore, to nurture caring relationships, surrogacy needs to be understood as a moral commitment by –the surrogates and intended parents. To enable such a commitment, there is a need to reconsider the pre-defined and legally regulated professional duty of the doctors, agents and agencies. It cannot be a one-sided commitment, but has to have elements of mutuality. (shrink)

Suppose a physician advises a woman to delay her planned pregnancy for a few months in order to significantly reduce the likelihood that her baby will suffer with Spina Bifida. If the woman chooses to ignore this advice and conceives soon after, I believe most people would consider it a matter of common sense that the child thus born is a victim of this woman’s negligence, even if it is fortunate enough to not be burdened with Spina Bifida. This common (...) sense judgement appeared to have been done in by the fact that the timing of conception can be identity-influencing, and so the child that is born only exists because of its mother’s decision to ignore her physician’s advice. However, recently, contemporary contractualist theories have been used to make sense of preconception negligence towards persons whose existence is a result of that same negligence. I will briefly discuss this interesting development and then show how this retrieval of the common sense judgement comes at a great cost to prenatal reproductive autonomy. (shrink)

The paper deals with one of the key notions in Epicurean epistemology, preconception. Together with perceptions, preconceptions are the second criterion of truth. The aim of the paper is to explore their epistemological status on the basis of their origin and formation. I argue that the process of formation of preconception is purely empirical, since they are produced through repeated perceptions of individual instances of a particular type of thing. Given the way they are formed, I claim that (...) preconceptions are the means by which we recognize types of object and as such are fundamental to Epicurus’ account of how we gain knowledge of things. Exactly this gives them a distinctive criterial role, since preconceptions––unlike perceptions––enable us to engage in the process of interpretation of perceptual content. (shrink)

A number of late Stoic sources describe either ethical concepts or a supposed universal belief in gods as being innate in the human animal. Though Chrysippus himself is known to have spoken of "implanted preconceptions" (ἔμφυτοι προλήψεις) of good and bad, scholars have typically argued that the notion of innate concepts of any kind would have been entirely incompatible with his theory of knowledge. Both Epictetus' notion of innate concepts of good and bad and the references to an innate belief (...) in gods by other philosophers of the Roman era are thus generally held to be later developments, probably owing to a Platonist-Stoic syncretism. Review of the evidence, however, shows that Chrysippus, like Epictetus, held ethical concepts to represent a special category of conception in that their formation was guaranteed by oikeiôsis. Unlike other concepts, that is, these represent a formal conceptualization of an innate tendency to distinguish between things fitting for one's constitution and things not fitting that all animals, according to the Stoics, bring to their empirical experiences. While the notion that human belief in gods is similarly innate does seem to have been a later development, it too was explained with reference to oikeiôsis rather than resulting from a simple "syncretism.". (shrink)

The author reflects upon her role as a public health nurse striving to attain practice authenticity. Client assessment and nursing interventions were seemingly sufficient until she became curious about ‘Who is this person sitting across from me?’ and ‘What are her experiences in the world as a lone parent living in poverty at the margins of society?’ The author begins to think that she could shift from mere client investigation to pure wonderment about the Other by imagining herself as a (...) researcher, an explorer of another's life world. Ultimately this process enables her to enhance the ‘caring’ in her practice with the knowledge gained of the perceptions and meanings impoverished clients assigned to their everyday lives. Jurgen Habermas’ theory of communicative competence serves as the reference map guiding exploration. The author uses Habermas’ theoretical principles of intersubjective mutuality – the validity claims of comprehensibility, truth, sincerity, and legitimacy. Comprehensibility embodies understanding, an attitude of unconditional acceptance, and care respect of another's individual person and self‐defined reality. Intersubjective mutuality also requires that one dwell in the moment with the Other, satisfied that communication is founded on truth. Sincerity implies fostering the Other's expression of authentic self apart from oppressive distracters. Lastly, legitimacy reconciles the author's altruistic pursuit to know the Other's ontological truth with the reality of the present world. (shrink)

Ed. by John J. Cleary and Gary M. Gurtler ( this volume contains papers and commentaries presented to the Boston Area Colloquium in Ancient Philosophy during the academic year 2006-7).

Gary Zukav suggested that we consider reality what we take to be true, what we believe and that is based on our perception (1979). If we assume that this is the case, then we might try to use tangible and intangible tools to reframe our preconception. As human beings we are trying to maintain the relation between our body and soma. In the same way someone might try to understand the body–mind coupling as oneness of duality, in other words (...) not two and not one. Furthermore, we can only use our senses to fulfil what is the present, the now. The now action will lead us to a specific scenario. As history has taught us, social and technological innovations have driven human beings to often perceive themselves as the spark of industrial revolution: an ideal salvation for the most urgent issues. Then, it might be acceptable to consider the marriage between art and science as a tool to achieve a sort of soteriological reward. In the same way, if additive art is object oriented then we might be allowed to explore how the applied arts under the design dimension, as practice and research, are struggling in the search for a new spirituality. Moreover the quest for design education, combined with the analysis of post-dramatic theatre and participatory design, has raised the question of how an alternative basic design course could heighten self- and collective consciousness through an approach based on the relation of body–soma. It is noted that design education, since the initiation of Bauhaus Art School, was considered the ideal path to deliver a physical outcome that represented the balance between art, technology and science, while from a philosophical point of view we can recognise the following as a subtle suggestion on what design education should expand its search: ‘to perceive, to conceive, to image: such are indeed the three types of consciousness by which the same object can be given to us’ (Sartre 1940: 8). Tracing connections between Sartre’s idea and the blend of post-dramatic theatre with participatory design into arts education, this article will describe experiments that aim to break down design students’ preconception: a dimension where the process of fabricated realities became the main outcome, the body–soma dialogues struggling to gain the perpetual unbalance. Experiments were conducted at the micro–macro scale, in a non-tactile society, where, for most people, the practice of Buddhism is embedded in daily life. This article aims to underline how an alternative approach to design education in South East Asia could be the building blocks to develop a reflection, an open-ended dialogue on network effect and the self. (shrink)

Endeavors have been made to found and incorporate ethical values in most aspects of healthcare, including health technology assessment. Health technologies and their assessment are value-laden and could trigger problems with dissemination if they contradict societal norms. Per WHO definition, preconception expanded carrier screening is a new health technology that warrants assessment. It is a genetic test offered to couples who have no known risk of recessive genetic diseases and are interested pregnancy. A test may screen for carrier status (...) of several autosomal recessive diseases and X-linked at one go. The technique has been piloted in the Netherlands and is discussed in other countries. The aim of the study was to examine values and value conflicts that healthcare experts recounted in relation to the discussion of implementation and use of preconception ECS in Sweden. We interviewed ten experts, who were associated with influencing health policymaking in Sweden. We employed systematizing expert interviews, which endeavor to access experts’ specialist knowledge. There were four female and six male informants, of which four were physicians, three bioethicists, one a legal expert, one a theologian and one a political party representative in the parliament. The participants functioned as members of two non-governmental bodies and three governmental organizations. We employed thematic analysis to identify themes, categories and subcategories. Two main themes surfaced: values and value conflicts. The main categories of Respect for persons, Solidarity, Human dignity, Do no harm, Health and Love formed the first theme, while values conflicting with autonomy and integrity respectively, constituted the second theme. Concepts relating to respect for persons were the most commonly mentioned among the participants, followed by notions alluding to solidarity. Furthermore, respondents discussed values conflicting with Swedish healthcare ones such as equality and solidarity. The experts highlighted values and concepts that are distinctive of welfare states such as Sweden and delineated how preconception ECS could challenge such values. Moreover, the analysis revealed that certain values were deemed more substantive than others, judging by the extent and detail of inference; for example, respect for persons and solidarity were on top of the list. (shrink)

ABSTRACT In 1956 the biomedical world was surprised to hear a report that human cells each contained forty six chromosomes, rather than the forty eight count that had been documented since the 1920s. Application of available techniques to culture human cells in vitro, halt their division at metaphase, and disperse chromosomes in an optical plane permitted perception of visual images not seen before. Researchers continued to obtain the preconceived forty eight counts until reeducation with these novel epistemic ‘chromosomes’ convinced them (...) that they could confidently report forty six chromosomes per cell. Within only a few years, and virtually without dissent, the social community of human cytogeneticists agreed upon a shared visual culture of human chromosome count and morphology. The initial forty six count proved not to be an anomaly. A new comparison of historical and ethnomethodological studies has suggested a better understanding of how applied technologies coupled with altered human perceptions established a new science. Human cytogenetics then collaborated with medical genetics to correlate changes in the new human karyotype with disorders of clinical significance. (shrink)

This paper aims to explain how semiotics and constructivism can collaborate in an educational epistemology by developing a joint approach to prescientific conceptions. Empirical data and findings of constructivist research are interpreted in the light of Peirce’s semiotics. Peirce’s semiotics is an anti-psychologistic logic and relational logic. Constructivism was traditionally developed within psychology and sociology and, therefore, some incompatibilities can be expected between these two schools. While acknowledging the differences, we explain that constructivism and semiotics share the assumption of realism (...) that knowledge can only be developed upon knowledge and, therefore, an epistemological collaboration is possible. The semiotic analysis performed confirms the constructivist results and provides a further insight into the teacher-student relation. Like the constructivist approach, Peirce’s doctrine of agapism infers that the personal dimension of teaching must not be ignored. Thus, we argue for the importance of genuine sympathy in teaching attitudes. More broadly, the article also contributes to the development of postmodern humanities. At the end of the modern age, the humanities are passing through a critical period of transformation. There is a growing interest in semiotics and semiotic philosophy in many areas of the humanities. Such a case, on which we draw, is the development of a theoretical semiotic approach to education, namely edusemiotics. (shrink)

The necessity for a clear understanding of the dual character of scientific method and of its applicability in social study as in the physical and biological sciences, can hardly receive too much emphasis at the present stage of development. Such an understanding, however, merely provides the proper beginning or orientation in the organization of any scientific discipline. That which is a common element in all scientific procedure can hardly serve to differentiate one science from another.

No one denies that in his research the historian, whether consciously or not, guides himself by already acquired knowledge of reality past and present that has undergone certain interpretation. It is usually said that he possesses a certain "view of the world." a certain understanding of the historical process, a certain theory , i.e., conceptions from which he cannot detach himself in the course of his research. Some regard this situation as a kind of "inevitable evil" inherent primarily in the (...) social sciences and demand "pure," "objective" research, i.e., for historical research, that it not be guided by anything but the sources actually employed. There are others who are not disturbed by this situation, for they recognize that "pure" research does not exist even in the natural sciences. And if they make certain demands in this regard, it is not for elimination of the researcher's particular standpoint, guided by the knowledge already acquired, but rather enrichment and perhaps qualitative reconstruction of the knowledge he employs in his research. This knowledge is treated in the given case as a kind of governing mechanism in the process of research. The proponents of both points of view strive for a particular goal: attainment of research results as adequate to reality as possible in a given field, with the only difference that they suggest different paths for attainment of this goal. It may even be stated that these standpoints are not debatable, for adherents of the second point of view will undoubtedly agree that in order to enrich and perhaps reorganize the knowledge used in the research it is necessary to eliminate from it elements of low quality, i.e., speculative, unsupported knowledge that impedes the research. Adherents of the former point of view, however, would not maintain too extreme a position if the knowledge they want to eliminate proves to be scientific knowledge, i.e., confirmed knowledge or, to put it differently, true knowledge. Naturally, this does not mean that no differences exist between these viewpoints. (shrink)

O objetivo desse texto é apresentar uma reflexão sobre a filosofia enquanto práxis humana, na perspectiva da superação do preconceito de que a filosofia é uma atividade do pensamento, deslocada da vida e de suas relações com o contexto social, partindo do pressuposto de que a filosofia é uma reflexão, um conhecimento crítico da realidade. O foco de nossa reflexão destaca a pergunta filosófica como instrumento mobilizador da formação da consciência crítica do sujeito, como processo de criação e superação do (...) preconceito de que a filosofia é uma atividade para alguns iluminados. (shrink)

“Over a hundred years ago Thorstein Veblen expressed the view that the ontological or ‘metaphysical’ presuppositions of economics needed to be more realistic, a view that was a necessary part of his support for evolutionary thinking. When he was writing, though, evolutionary theorising in economics had been introduced in a rather incoherent manner resulting in an ontological mishmash - of a sort that led Veblen to coin the label neoclassical for those involved. As it happened evolutionary thinking never really took (...) off in a coherent way in economics, and social ontological reasoning itself became somewhat marginalised. As I write, however, there are once more groups of scholars including economists developing systematic projects in social ontology. Now, however, the branch of non-social science attracting the most attention is quantum mechanics. An issue of interest that is explored here is whether the growing concern of economists with quantum insights will finally allow the specific ontological conception supported by Veblen to become established, facilitating, amongst other things, a turn to a coherent form of evolutionary thinking, or whether, as argued by some, it is more likely to lead to support for the ontological mix-up sustained by those Veblen labelled neoclassical.”. (shrink)