BackgroundStreet-connected children and youth in low- and middle-income countries have multiple vulnerabilities in relation to participation in research. These require additional considerations that are responsive to their needs and the social, cultural, and economic context, while upholding core ethical principles of respect for persons, beneficence, and justice. The objective of this paper is to describe processes and outcomes of adapting ethical guidelines for SCCY’s specific vulnerabilities in LMIC.MethodsAs part of three interrelated research projects in western Kenya, we created procedures to (...) address SCCY’s vulnerabilities related to research participation within the local context. These consisted of identifying ethical considerations and solutions in relation to community engagement, equitable recruitment, informed consent, vulnerability to coercion, and responsibility to report.ResultsSubstantial community engagement provided input on SCCY’s participation in research, recruitment, and consent processes. We designed an assent process to support SCCY to make an informed decision regarding their participation in the research that respected their autonomy and their right to dissent, while safeguarding them in situations where their capacity to make an informed decision was diminished. To address issues related to coercion and access to care, we worked to reduce the unequal power dynamic through street outreach, and provided access to care regardless of research participation.ConclusionsAlthough a vulnerable population, the specific vulnerabilities of SCCY can to some extent be managed using innovative procedures. Engaging SCCY in ethical research is a matter of justice and will assist in reducing inequities and advancing their health and human dignity. (shrink)

Volume 20, Issue 5, June 2020, Page 72-74.

Background International collaborators face challenges in the design and implementation of ethical biomedical research. Evaluating community understanding of research and processes like informed consent may enable researchers to better protect research participants in a particular setting; however, there exist few studies examining community perspectives in health research, particularly in resource-limited settings, or strategies for engaging the community in research processes. Our goal was to inform ethical research practice in a biomedical research setting in western Kenya and similar resource-limited settings. Methods (...) We sought to use mabaraza , traditional East African community assemblies, in a qualitative study to understand community perspectives on biomedical research and informed consent within a collaborative, multinational research network in western Kenya. Analyses included manual, progressive coding of transcripts from mabaraza to identify emerging central concepts. Results Our findings from two mabaraza with 108 community members revealed that, while participants understood some principles of biomedical research, they emphasized perceived benefits from participation in research over potential risks. Many community members equated health research with HIV testing or care, which may be explained in part by the setting of this particular study. In addition to valuing informed consent as understanding and accepting a role in research activities, participants endorsed an increased role for the community in making decisions about research participation, especially in the case of children, through a process of community consent. Conclusions Our study suggests that international biomedical research must account for community understanding of research and informed consent, particularly when involving children. Moreover, traditional community forums, such as mabaraza in East Africa, can be used effectively to gather these data and may serve as a forum to further engage communities in community consent and other aspects of research. (shrink)

Рассматривается понимание как специфически человеческий способ существования, как первичный, исходный опыт освоения человеком мира, в котором отсутствует субъект-объективная разделенность, лежащая в основе познавательного отношения. Для специалистов.

This essay some first steps toward the naturalization of what I call rational intentionality or alternatively type II intentionality. By rational or type II intentionality, I mean that full combination of rational powers and content-bearing states that is paradigmatically enjoyed by mature intact human beings. The problem I set myself is to determine the extent to which the only currently extant approach to the naturalization of the intentional that has the singular virtue of not being a non-starter can be aggregated (...) up into an account of rational intentionality. I have in mind a broadly defined family of accounts whose main members are the indicator/information-theoretic approach of Dretske (1988), the asymmetric dependence theory of Jerry Fodor (1987, 1990, 1994) and the teleo-semantics of Ruth Millikan (1984, 1993). Somewhat inaccurately, I will call this family of approaches the information-theoretic family. To be sure, there is only a rough family resemblance among the members of the information-theoretic family. Indeed, several intense quarrels divide the members of that family one from another, but the precise outcome of those internecine struggles is not directly relevant to the aims of this essay. ² Taken collectively, the information-theoretic family yields a compelling picture of the place of at least a crude form of intentionality -- what I call frog-like or type I intentionality -- in the natural order. Though frog-like or type I intentionality is, I think, a genuine species of intentionality, it may subsist in the absence of rational powers. It is that species of intentionality enjoyed by irritable creatures who, following Brandom (1994). (shrink)

Part I of this trilogy, Historical and Scientific Setting, set out a general context for selecting a certain subclass of inter-theoretic relations as achieving appropriate explanatory and ontological unification – hence for properly being labelled reductive. Something of the complexity of these relations in real science was explored. The present article concentrates on the role which identity plays in structuring the reduction relation and so in achieving ontological and explanatory unification.

Based on research on the increasingly popular unconscious thought effect (UTE), it has been suggested that physicians might make better diagnostic decisions after a period of distraction than after an equivalent amount of time of conscious deliberation. However, published attempts to demonstrate the UTE in medical decision making have yielded inconsistent results. In the present study, we report the results of a meta-analysis of all the available evidence on the UTE in medical decisions made by expert and novice clinicians. The (...) meta-analysis failed to find a significant contribution of unconscious thought to the accuracy of medical decisions. This result cannot be easily attributed to any of the potential moderators of the UTE that have been discussed in the literature. Furthermore, a Bayes Factor analysis shows that most experimental conditions provide positive support for the null hypothesis, suggesting that these null results do not reflect a simple lack of statistical power. We suggest ways in which new studies could usefully provide further evidence on the UTE. Unless future research shows otherwise, the recommendation of using unconscious thought to improve medical decisions lacks empirical support. (shrink)

Louveau, A., S. Shelah and B. Velikovi, Borel partitions of infinite subtrees of a perfect tree, Annals of Pure and Applied Logic 63 271–281. We define a notion of type of a perfect tree and show that, for any given type τ, if the set of all subtrees of a given perfect tree T which have type τ is partitioned into two Borel classes then there is a perfect subtree S of T such that all subtrees of S of type (...) τ belong to the same class. This result simultaneously generalizes the partition theorems of Galvin-Prikry and Galvin-Blass. The key ingredient of the proof is the theorem of Halpern-Laüchli on partitions of products of perfect trees. (shrink)

Um bei einer Wertung der Faktoren, die das Wachstum einer Population beeinflussen, zu einer richtigen Einsicht zu gelangen, empfiehlt es sich, nicht den relativen Wert dieser Faktoren in Bezug auf die in Rede stehende Insektenpopulation auszudrücken, sondern ihre absolute Grösse in Faktoreinheiten zum Ausdruck zu bringen — wie: Wärme in Grad Celsius, Luftfeuchtigkeit in Prozenten, Zahl der im Bevölkerungsmilieu vorgefundenen Raubinsekten oder Parasiten. Auf dieser Grundlage liessen sich Faktoren in folgender Weise aufteilen: Faktoren ersten Grades : Allgemeine Faktoren : Unabhängige (...) Faktoren : nicht mechanische Klimaeinflüsse , chemische Faktoren, Güte der Nahrung. Abhängige Faktoren : die internen Faktoren, die bei einer Zunahme der Dichtigkeit einen Rückgang des Zuwachses bewirken, mit Ausnahme des Kannibalismus, ferner die Menge der Nahrung. Selektive Faktoren : Unabhängige Faktoren : unersättliche Faktoren : mechanische Klimaeinflüsse, weitere mechanische Faktoren, Parasiten und Raubfeinde, die nicht mit töten aufhören, wenn sie gesättigt sind, insofern ihre Bevölkerungsdichte nicht durch die des fraglichen Insektes bedingt wird. ersättliche Faktoren: restliche Raubinsekten und Parasiten, insofern ihre Bevölkerungsdichte nicht durch die des fraglichen Insektes bedingt wird. Abhängige Faktoren : Kannibalismus. Wandelbare Faktoren : Raubinsekten und Parasiten, welche diesem Erfordernis entsprechen, pathogene Pilze und Bakterien. Faktoren zweiten Ranges . Faktoren des dritten Ranges .Afin d'obtenir une notion exacte de la valeur des facteurs qui influencent la croissance d'une population, il vaudra mieux ne pas exprimer ces facteurs en leur valeur relative quant à la population d'insectes en question, mais en unités de facteurs: degrés Celsius, pourcentage de l'humidité de l'air, nombre d'ennemis ou de parasites qui sont présents dans le milieu de la population. Sur cette base on pourra répartir les facteurs de la façon suivante: Facteurs du 1er ordre : Facteurs généraux : influences climatiques non mécaniques , facteurs chimiques, qualité de la nourriture. Facteurs dépendants : les facteurs internes qui font de sorte que la densité de la population diminue quand se présente une plus forte densité, en exceptant le cannibalisme, la quantité de nourriture. Facteurs selectifs ; seule une partie des individus est exposée à leur action; les animaux touchés sont mécaniquement endommagés et, dans la règle, tués. Facteurs indépendants : facteurs insatiables : des influences climatiques mécaniques, d'autres facteurs mécaniques, des parasites et des ennemis qui ne s'arrêtent pas de tuer quand ils sont rassasiés, pour autant que l'intensité de la population de l'insecte en question. facteurs rassasiables: autres ennemis et parasites pour autant que l'intensité de leur population ne se modifie pas sous l'influence de la densité de la population de l'insecte en question. Facteurs indépendants : cannibalisme. Facteurs modifiables : ennemis et parasites qui satisfont à cette exigence, champignons pathogènes, bactéries. Facteurs du 2ième ordre . Facteurs du 3iéme ordre. (shrink)