Depue & Collins's (D&C's) work relies on extrapolation from data obtained through studies in experimental animals, and needs support from studies of the role of dopamine (DA) neurotransmission in human behaviour. Here we review evidence from two sources: (1) studies of patients with Parkinson's disease and (2) positron emission tomography (PET) studies of DA neurotransmission, which we believe lend support to Depue & Collins's theory, and which can potentially form the basis for a true neurochemistry of personality.

Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

Introduction: the age of reflexion Part I. Romanticism: 1. Romanticism and the sciences David Knight 2. Schelling and the origins of his Naturphilosophie S. R. Morgan 3. Romantic philosophy and the organization of the disciplines: the founding of the Humboldt University of Berlin Elinor S. Shaffer 4. Historical consciousness in the German Romantic Naturforschung Dietrich Von Engelhardt 5. Theology and the sciences in the German Romantic period Frederick Gregory 6. Genius in Romantic natural philosophy Simon Shaffer Part II. Sciences of (...) the Organic: 7. Doctors contra clysters and feudalism: the consequences of a Romantic revolution Nelly Tsouyopoulos 8. Morphotypes and the historical-genetic method in Romantic biology Timothy Lenoir 9. ’Metaphorical mystifications’: the Romantic gestation of nature in British biology Evelleen Richards 10. Transcendental anatomy Philip F. Rehbock 11. Romantic thought and the origins of cell theory L. S. Jacyna 12. Alexander von Humbolt and the geography of vegetation Malcolm Nicholson Part III. Sciences of the Inorganic: 13. Goethe, colour, and the science of seeing Dennis L. Sepper 14. Johann Wilhelm Ritter: Romantic physics in Germany Walter D. Wetzels 15. The power and the glory: Humphrey Davy and Romanticism Christopher Lawrence 16. Oersted’s discovery of electromagnetism H. A. M. Snelders 17. Caves, fossils and the history of the earth Nicholas A. Rupke Part IV. Literature and the Sciences: 18. Goethe’s use of chemical theory in his Elective Affinities Jeremy Adler 19. Kleist’s bedlam: abnormal psychology and psychiatry in the works of Heinrich von Kleist Nigel Reeves 20. Coleridge and the sciences Trevor H. Levere 21. Nature’s book: the language of science in the American Renaissance David van Leer 22. The shattered whole: Georg Buchner and Naturphilosophie John Reddick. (shrink)

The best extant statement of the epistemic regress problem makes assumptions that are too strong. An improved version assumes only that that reasons require support, that no proposition is supported only by endless regresses of reasons, and that some proposition is supported. These assumptions are individually plausible but jointly inconsistent. Attempts to explain support by means of unconceptualized sensations, contextually immunized propositions, endless regresses, and holistic coherence all require either additional reasons or an external condition on support that is arbitrary (...) from the believer's own point of view. (shrink)

Recent scholarship in technology and society studies has given attention to the notion of technological citizenship. This article seeks to further integrate perspectives on this topic with theoretical contributions about the development of moral autonomy. The author challenges the presumption that the strategy of expanding opportunities for participation in technological decision making will in itself develop people's autonomy and citizenship. He argues that concurrent efforts must be made to democratize the political-economic structures of key technologies and to help people prepare (...) morally for citizenship roles in governing these technologies. On this basis, a series of initiatives are suggested. (shrink)

Books reviewed:Mark BevirThe Logic of the History of Ideas.

Recent literature on epistemic innocence develops the idea that a defective cognitive process may nevertheless merit special consideration insofar as it confers an epistemic benefit that would not otherwise be available. For example, confabulation may be epistemically innocent when it makes a subject more likely to form future true beliefs or helps her maintain a coherent self-concept. I consider the role of confabulation in typical cases of interpersonal gaslighting, and argue that confabulation will not be epistemically innocent in such cases (...) even if it does preserve a coherent self-concept or belief-set for the subject. Analyzing the role of confabulation in gaslighting illustrates its role in on-going interpersonal relationships, and augments already growing evidence that confabulation may be quite widespread. The role of confabulation in gaslighting shows that whether confabulation confers epistemic benefits will depend greatly on the interpersonal context in which it is deployed, while whether a coherent self-concept is epistemically beneficial will depend to a great extent on the content of that self-concept. This shows that the notion of an epistemically harmful or beneficial feature of a cognitive process can and should be further clarified, and that doing so has both theoretical and practical advantages in understanding epistemic innocence itself. (shrink)

OBJECTIVE: To apply component analysis, a structured approach to the ethical analysis of risks and potential benefits in research, to published emergency research using a waiver of/exception from informed consent. The hypothesis was that component analysis could be used with a high degree of interrater reliability, and that the vast majority of emergency research would comply with a minimal-risk threshold. METHODS: A Medline search and manual search were done to identify studies using a waiver of/exception from informed consent published between (...) July 1996 and December 2000. A review panel of physicians and bioethicists independently classified nontherapeutic procedures in each study as minimal risk, probably minimal risk, or probably more than minimal risk. RESULTS: Seventy studies using a waiver of/exception from informed consent were identified. A majority of reviewers classified nontherapeutic procedures in 62 studies (88.6%) as minimal risk. Reviewers classified nontherapeutic procedures in six studies (8.6%) as minimal risk or probably minimal risk. In two studies (2.9%), nontherapeutic procedures were classified as probably more than minimal risk. The intraclass correlation coefficient was 0.89 (95% CI = 0.85 to 0.93), indicating very high interrater reliability. CONCLUSIONS: Component analysis can be used with high reliability to review emergency research and may improve the consistency of institutional review board review of emergency research. The vast majority of published emergency research performed using a waiver of/exception from consent complies with a properly-applied minimal-risk threshold. A minimal-risk threshold for nontherapeutic procedures protects subjects better than current U.S. regulations while permitting important emergency research to continue. (shrink)

In the Grundlagen , Frege offers eight main arguments, together with a series of more minor supporting arguments, against Mill’s view that numbers are “properties of external things”. This paper reviews all eight of these arguments, arguing that none are conclusive.

Volume 24, Issue 10, October 2024, Page 113-114.

This paper addresses the question of when and why duties are conditional on compliance on the part of others, by examining the role of reciprocity in Rawls's theory of justice. In particular, it argues that the idea of reciprocity and the relational nature of distributive justice can help explain three otherwise puzzling aspects of Rawls's view: (1) his claim that justice has to be "congruent" with the good; (2) his claim that the justification of a political conception of justice depends (...) on showing that an overlapping consensus of reasonable comprehenisve doctrines is possible, even after the freestanding argument for the political conception has been successfully completed; (3) his claim that there are no global duties of distributive justice, beyond the non-comparative duties of aid and reparation. Each of these arguments has been the subject of controversy partly because of a lack of attention to reciprocity, the paper argues, and the relational nature of Rawls's non-luck-egalitarian position. (shrink)

There are broad commonalities between the projects of Donald MacKinnon (1913–1994) and Stanley Cavell (1926–) sufficient to make the claim that they struck an analogous pose in their respective contexts. This is not to discount their manifest differences. In the milieu of 1960s and 1970s Cambridge, MacKinnon argued in support of a qualified language of metaphysics in the service of a renewed catholic humanism and Christian socialism. At Harvard, Cavell articulated commitments that made him more at home in the world (...) of North American secular political liberalism. Where Nietzsche, Hume, Freud, Heidegger, Emerson and Thoreau were Cavell’s inspirations, Butler, Kant, G. E. Moore, Collingwood and the New Testament were MacKinnon’s. For all the stark differences, commonalities abound and the reason for this can be traced to a shared appreciation of Austin’s contribution to the ‘lingusitic turn’ together with Wittgenstein’s later work. They both developed projects obsessed with the problem of scepticism together with a commitment to a creative re-animation of moral discourse in light of it, with MacKinnon defending a qualified ‘moral realism’, and Cavell, ‘moral perfectionism’. Seen together, a distinctive post-Kantian and post-Wittgensteinian therapeutic moral philosophy is in evidence. (shrink)

Bonhoeffer’s New Beginning investigates Dietrich Bonhoeffer's life-affirming answer to how we begin again after devastation. Combining scholarly rigor and existential honesty, DeCort argues that Bonhoeffer offers an ethical and moral vision of radical hope vis-à-vis the perceived absence of God in the face of devastation.

An argument whose conclusion C is essential evidence for one of its premises can provide its target audience with justification for believing C. This is possible because we can enhance our justification for believing a proposition C by integrating it into an explanatory network of beliefs for which C itself provides essential evidence. I argue for this in light of relevant features of doxastic circularity, epistemic circularity, and explanatory inferences. Finally, I confirm my argument with an example and respond to (...) objections. (shrink)

ABSTRACTMiranda Fricker has characterized epistemic injustice as “a kind of injustice in which someone is wronged specifically in her capacity as a knower” (2007, Epistemic injustice: Power & the e...

This chapter contains sections titled: Introduction Investigating Consciousness and Consciousness Expansion The Cannabis Experience.

Theology, Fantasy, and the Imagination analyzes theological, religious, and philosophical themes in classical Christian fantasy, contemporary “post-Christian” fantasy, and fantasy at play in table top games such as Dungeons and Dragons and Magic: the Gathering.

Aristotle is essentially human; that is, for all possible worlds metaphysically consistent with our own, if Aristotle exists, then he is human. This is a claim about the essential property of an object. The claim that objects have essential properties has been hotly disputed, but for present purposes, we can bracket that issue. In this essay, we are interested, rather, in the question of whether properties themselves have essential properties (or features) for their existence. We call those who suppose they (...) do “property essentialists”; those who do not, “property anti-essentialists,” or “quidditists.” We offer two complementary arguments. Our total argument is under-girded by two assumptions: transworld identity theory and “received view” counterfactual semantics, a la David Lewis. We then argue that, if one presumes that these are true, then one risks running headlong into paradox if one also accepts property anti-essentialism. That's the first argument. By contrast, if one accepts these same assumptions in conjunction with property essentialism, then the paradox is avoided. This is the second argument. We take it that our arguments work to show that, between property essentialism and quidditism, the property essentialist is on better footing. Plausibly, properties themselves do have essential properties for their existence. (shrink)

The problem of the criterion says that we can know a proposition only if we first know a criterion of truth and vice versa, hence, we cannot know any proposition or any criterion of truth. The epistemic levels response says that since knowledge does not require knowledge about knowledge, we can know a proposition without knowing a criterion of truth. This response (advocated by Chisholm and Van Cleve) presupposes that criteria of truth are epistemic principles. In general, however, criteria of (...) truth are not epistemic principles, so the epistemic levels response to the problem of the criterion fails. (shrink)

This essay is an attempt to demonstrate that Charles Taylor’s “social imaginaries” should not be viewed as sources of identity. For Taylor, making sense of society’s practices allows an individual to develop a conception of the self – an idea Taylor borrows from Hegel. I therefore suggest that Kierkegaard’s critiques against Hegel may similarly be used against Taylor’s conception of identity. Kierkegaard’s critiques of Hegel are applicable to Taylor’s social imaginaries for two reasons. First, Hegel’s system only provides approximations—mediation in (...) the ethical nullifies the individual’s subjective relation to Kierkegaard’s “Absolute” by objectivizing the relation. Thus, despair ensues. Second, if knowledge of the Absolute is mediated through social imaginaries, the individual’s responsibility to perpetually renew faith in her constituting power is diminished. Taylor’s “system” is therefore insufficient for achieving a positive view of existence because selfhood is properly understood through the inward subjectivity of one’s relation to her constituting power. (shrink)

BonJour has proposed background conditions on internalist justification, which Kornblith argues are inconsistent with a core internalist ‘credo’ – that subjects internally alike are justificationally alike – signaling the ‘death’ of internalism. The funeral arrangements are premature, though more systematic consideration of background conditions is needed. The majority of BonJour's conditions are not background conditions as their failure makes an epistemically relevant internal difference. This neutralizes Kornblith's criticisms and reveals how the proposed conditions are not departures from internalism. BonJour's background (...) conditions are simply conditions, the credo remains intact, and Kornblith's objections do not spell problems for internalism, let alone death. (shrink)

Kriegel described the problem of intentional inexistence as one of the ‘perennial problems of philosophy’, 307–340, 2007: 307). In the same paper, Kriegel alluded to a modal realist solution to the problem of intentional inexistence. However, Kriegel does not state by name who defends the kind of modal realist solution he has in mind. Kriegel also points out that even what he believes to be the strongest version of modal realism does not pass the ‘principle of representation’ and thus modal (...) realism is not an adequate solution to the problem of intentional inexistence. In this paper, I respond to Kriegel by defending a modal realist solution that he did not consider in 2007, called ‘extended modal realism’. EMR is a version of modal realism where possible worlds are not completely isolated as they are under the Lewisian model. Rather, under EMR worlds are, in a way, spatiotemporally related. The fact EMR worlds are related allows EMR to sufficiently pass the principle of representation and thus can be deemed a legitimate solution to the problem of intentional inexistence. I conclude that either EMR can pass the principle of representation in some cases or, and I think the more sensible option, we give up on the principle of representation altogether. (shrink)

Purpose This paper aims to analyze some of the epistemically pernicious effects of the use of the internet and social media. In light of this analysis, it introduces the concept of epistemic pornography and argues that epistemic agents both can and should avoid consuming and sharing epistemic pornography. Design/methodology/approach The paper draws on research on epistemic virtue, cognitive biases, social media use and its epistemic consequences, fake news, paternalistic nudging, pornography, moral philosophy, moral elevation and moral exemplar theory to analyze (...) the epistemically pernicious effects of the internet and social media. Findings There is a growing consensus that the internet and social media activate and enable human cognitive biases leading to what are here called “failures of epistemic virtue.” Common formulations of this problem involve the concept of “fake news,” and strategies for responding to the problem often have much in common with paternalistic “nudging.” While fake news is a problem and the nudging approach holds out promise, the paper concludes that both place insufficient emphasis on the agency and responsibility of users on the internet and social media, and that nudging represents a necessary but not sufficient response. Originality/value The essay offers the concept of epistemic pornography as a concept distinct from but related to “fake news” – distinct precisely because it places greater emphasis on personal agency and responsibility, and following recent literature on moral elevation and moral exemplars, as a heuristic that agents might use to economize their efforts at resisting irrational cognitive biases and attempting to live up to their epistemic duties. (shrink)

This paper highlights areas of concern in the assessment of pragmatics, with the intent of stimulating fresh thinking about the assessment of pragmatics both for research purposes and as a part of classroom instruction. It starts by considering what aspects of ability in pragmatics to assess, and then contrasts the trade-off between the feasibility of obtaining data and the ultimate importance of the data. Next, the conspicuous lack of assessment of ability in L2 pragmatics in language classes is noted. Then (...) follow sections on topics all relating primarily to the assessment of pragmatics for research purposes – the use of mixed methods, data elicitation procedures, and norms used in determining the appropriateness of any given performance in pragmatics. The last two topics deal, respectively, with the perceived relevance of the given assessment by the learners and with the value of collecting verbal report data from the respondents as a means for validating the assessment measures. Finally, considerations regarding the most prominent of these issues are provided. (shrink)

Zika infection in pregnant women is associated with an elevated probability of giving birth to a child with microcephaly and multiple other disabilities. Public health messaging on Zika prevention has predominantly targeted women who know they are pregnant or intend to become pregnant, but not teenage females for whom unintended pregnancy is more likely. Vulnerabilities among this population to reproductive risks associated with Zika are further amplified by restrictive abortion laws in several Zika-impacted states. Key to prevention is enhanced, targeted (...) public health messaging centered on teens nationally and particularly in certain high-risk regions. (shrink)

This exploratory study set out to pilot use of a Risk Innovation approach to support the development of advanced biopreservation technologies, and the societally beneficial development of advanced technologies more broadly. This is the first study to apply the Risk Innovation approach — which has previously been used to help individual organizations clarify areas of value and threats — to multiple entities involved in developing an emerging technology.

Progress in emergency and critical care requires that clinical research be performed on patients who are incapable of granting consent for research participation. Analyses of the ethics of such research have left some questions incompletely answered. Why should we be permitted to expose vulnerable patients to research risks without their consent? In particular, how do we justify research interventions that have no potential benefit for participants (nontherapeutic interventions)? This article presents a moral justification for nontherapeutic interventions in emergency research. By (...) relying on a framework for assessing research risks, and by drawing on the example of pediatric research, this justification is founded in how institutional review boards, and society in general, analyze risk. Our justification for emergency research also suggests additional protections for emergency research participants, including a stringent threshold for research risk, that still permit important research to proceed. (shrink)

The notion of function is indispensable to our understanding of distinctions such as that between being broken and being in working order (for artifacts) and between being diseased and being healthy (for organisms). A clear account of the ontology of functions and functioning is thus an important desideratum for any top-level ontology intended for application to domains such as engineering or medicine. The benefit of using top-level ontologies in applied ontology can only be realized when each of the categories identified (...) and defined by a top-level ontology is integrated with the others in a coherent fashion. Basic Formal Ontology (BFO) has from the beginning included function as one of its categories, exploiting a version of the etiological account of function that is framed at a level of generality sufficient to accommodate both biological and artifactual functions. This account has been subjected to a series of criticisms and refinements. We here articulate BFO’s account of function, provide some reasons for favoring it over competing views, and defend it against objections. (shrink)