Childhood adversity is associated with altered or dysregulated stress reactivity; these altered patterns of physiological functioning persist into adulthood. Evidence from both preclinical animal models and human neuroimaging studies indicates that early life experience differentially influences stressor-evoked activity within central visceral neural circuits proximally involved in the control of stress responses, including the subgenual anterior cingulate cortex (sgACC), paraventricular nucleus of the hypothalamus (PVN), bed nucleus of the stria terminalis (BNST) and amygdala. However, the relationship between childhood adversity and the (...) resting-state connectivity of this central visceral network remains unclear. To this end, we examined relationships between childhood threat and childhood socioeconomic deprivation, the resting-state connectivity between our regions of interest (ROIs), and affective symptom severity and diagnoses. We recruited a transdiagnostic sample of young adult males and females (n= 100; mean age = 27.28,SD= 3.99; 59 females) with a full distribution of maltreatment history and symptom severity across multiple affective disorders. Resting-state data were acquired using a 7.2-min functional magnetic resonance imaging (fMRI) sequence; noted ROIs were applied as masks to determine ROI-to-ROI connectivity. Threat was determined by measures of childhood traumatic events and abuse. Socioeconomic deprivation (SED) was determined by a measure of childhood socioeconomic status (parental education level). Covarying for age, race and sex, greater childhood threat was significantly associated with lower BNST-PVN, amygdala-sgACC and PVN-sgACC connectivity. No significant relationships were found between SED and resting-state connectivity. BNST-PVN connectivity was associated with the number of lifetime affective diagnoses. Exposure to threat during early development may entrain altered patterns of resting-state connectivity between these stress-related ROIs in ways that contribute to dysregulated neural and physiological responses to stress and subsequent affective psychopathology. (shrink)

Papers presented at National Seminar on Jainism held in 1998 at Hyderabad?

This book, first published in 1996, introduces students to optimization theory and its use in economics and allied disciplines. The first of its three parts examines the existence of solutions to optimization problems in Rn, and how these solutions may be identified. The second part explores how solutions to optimization problems change with changes in the underlying parameters, and the last part provides an extensive description of the fundamental principles of finite- and infinite-horizon dynamic programming. Each chapter contains a number (...) of detailed examples explaining both the theory and its applications for first-year master's and graduate students. 'Cookbook' procedures are accompanied by a discussion of when such methods are guaranteed to be successful, and, equally importantly, when they could fail. Each result in the main body of the text is also accompanied by a complete proof. A preliminary chapter and three appendices are designed to keep the book mathematically self-contained. (shrink)

The hard problem of consciousness arises in most incarnations of present day physicalism. Why should certain physical processes necessarily be accompanied by experience? One possible response is that physicalism itself should be modified in order to accommodate experience: But, modified how? In the present work, we investigate whether an ontology derived from quantum field theory can help resolve the hard problem. We begin with the assumption that experience cannot exist without being accompanied by a subject of experience (SoE). While people (...) well versed in Indian philosophy will not find that statement problematic, it is still controversial in the analytic tradition. Luckily for us, Strawson has elaborately defended the notion of a thin subject—an SoE which exhibits a phenomenal unity with different types of content (sensations, thoughts etc.) occurring during its temporal existence. Next, following Stoljar, we invoke our ignorance of the true physical as the reason for the explanatory gap between present day physical processes (events, properties) and experience. We are therefore permitted to conceive of thin subjects as related to the physical via a new, yet to be elaborated relation. While this is difficult to conceive under most varieties of classical physics, we argue that this may not be the case under certain quantum field theory ontologies. We suggest that the relation binding an SoE to the physical is akin to the relation between a particle and (quantum) field. In quantum field theory, a particle is conceived as a coherent excitation of a field. Under the right set of circumstances, a particle coalesces out of a field and dissipates. We suggest that an SoE can be conceived as akin to a particle—a SelfOn—which coalesces out of physical fields, persists for a brief period of time and then dissipates in a manner similar to the phenomenology of a thin subject. Experiences are physical properties of selfons with the constraint (specified by a similarity metric) that selfons belonging to the same natural kind will have similar experiences. While it is odd at first glance to conceive of subjects of experience as akin to particles, the spatial and temporal unity exhibited by particles as opposed to fields and the expectation that selfons are new kinds of particles, paves the way for cementing this notion. Next, we detail the various no-go theorems in most versions of quantum field theory and discuss their impact on the existence of selfons. Finally, we argue that the time is ripe for a rejuvenated Indian philosophy to begin tackling the three-way relationship between SoEs (which may become equivalent to jivas in certain Indian frameworks), phenomenal content and the physical world. With analytic philosophy still struggling to come to terms with the complex worlds of quantum field theory and with the relative inexperience of the western world in arguing the jiva-world relation, there is a clear and present opportunity for Indian philosophy to make a worldcentric contribution to the hard problem of experience. (shrink)

Hospitals are places where patients are unwell, where patients and their families may be upset, confused, frustrated, in pain, and vulnerable. The likelihood of these experiences and emotions manifesting in anger and aggressive behaviour is high. In this paper, we describe the involvement of a clinical ethics service responding to a request to discuss family aggression within a rehabilitation department in a large paediatric hospital in Australia. We suggest two key advantages of involving a clinical ethics service in discussions about (...) how to respond to family aggression. First, the process of ethics deliberation provides an opportunity for clinicians to be involved in the solution by articulating their perspectives, tolerance levels, and general concerns about the effects of family aggression towards staff. Second, supporting clinicians to articulate and identify the impact of parental aggression directly counters the disadvantages of the more blunt zero-tolerance policy response, which is necessarily imposed from the top down. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:A Time of Novelty: Logic, Emotion, and Intellectual Life in Early Modern India, 1500-1700 C.E. by Samuel WrightAnusha Rao (bio)A Time of Novelty: Logic, Emotion, and Intellectual Life in Early Modern India, 1500-1700 C.E. By Samuel Wright. Oxford: Oxford University Press, 2021. Pp. xxi + 278. Paper $99.00, isbn 978-0-197568-16-3Samuel Wright's A Time of Novelty examines the discipline of Nyāya, or Sanskrit logic, between 1500 and 1700 CE (...) and argues that novelty, both as an intellectual and affective category, was the structuring principle through which Nyāya intellectuals built a philosophical community in early modernity. Wright uses a set of essays and commentaries by Nyāya philosophers on a range of topics to reflect on how intellectual life in this period was shaped by critical inquiry, emotion, and manuscript culture.The book studies a very fruitful, if contentious, period within the history of Sanskrit intellectual disciplines. Sheldon Pollock's "Sanskrit Knowledge Systems on the Eve of Colonialism" (SKSEC project) was the first to draw attention to this period as early modernity in India. Pollock has pointed to both parallels with and differences from modernity in Europe. Since then, scholarly attention has been directed to how periodizing techniques were used by Nyāya intellectuals, and to the relationship that these "new" Nyāya intellectuals had with the tradition. While Wright is in general agreement with the aims of the SKSEC project, he argues against focusing exclusively on intellectual historical change without understanding the values and sentiments that underwrite intellection. For this reason, the book undertakes the challenging task of linking a set of understudied Nyāya arguments with philosophy of emotions to understand affective novelty. This offers interesting insights into the emotional concerns behind Nyāya intellection in a way that earlier scholarship has been unable to, but it has the disadvantage of imposing frameworks alien to Nyāya philosophers onto their arguments--such as Wright's arguments about how space is produced in chapter 3.The book is organized into six chapters, each of which deals with an important topic within Nyāya arguments in early modern India. While the first four chapters, titled "Doubt," "Objectivity," "Happiness," and "Dying," directly deal with these contentious issues and debates around them by Nyāya thinkers, in the last two chapters, "Space" and "Time," Wright does not take up specific arguments from primary texts, but focuses on how we can best understand the space that Nyāya intellectuals inhabited and how novelty can be conceptualised in time. [End Page 1]In the first chapter on doubt, Wright zooms in on arguments about how doubting cognitions emerge, focusing particularly on Raghunātha Śiromaṇi and how commentators present his novel position on the issue. Earlier Nyāya intellectuals argued that speech and other indirect forms of perception could not generate doubting cognitions. Instead, they advanced a theory of apperceptive doubt, where doubt arises in a subsequent, remembering cognition. Raghunātha, on the other hand, argues that doubting cognitions can arise directly from speech, and he substantially changes the definition of doubt, a change which is noted and carefully explained by his commentators. Beginning with the theory of doubt allows Wright to then examine how the new definition of doubt leads to structural changes in the crafting of Nyāya debates, particularly in genres such as the short essay (vāda), where the topic of contention is stated in the newly developed format. Wright also links this debate with the notion of trust. Careful attention to how the debate is framed by commentators also underscores the emotional underpinnings of the argument--the "old" view is not to be trusted, since it does not stand up to reasoning (p. 60). Doubting cognitions are not ignored in Nyāya, but become the beginning point of debates and discussions, demonstrating that Nyāya philosophers in early modern India were fashioning a community that engaged peers through new ways of understanding and caring about critical inquiry.The second chapter focuses on arguments around objectivity and deals at greater length with the periodizing techniques used by Nyāya thinkers in the early modern period. This... (shrink)

This is an in-depth review of "The Embodied Mind: Cognitive Science and Human Experience" by Francisco Varela, Evan Thompson and Eleanor Rosch.

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

It has been suggested that early cry parameters are connected to later cognitive abilities. The present study is the first to investigate whether the acoustic features of infant cry are associated with cognitive development already during the first year, as measured by oculomotor orienting and attention disengagement. Cry sounds for acoustic analyses (fundamental frequency; F0) were recorded in two neonatal cohorts at the age of 0-8 days (Tampere, Finland) or at 6 weeks (Cape Town, South Africa). Eye tracking was used (...) to measure oculomotor orienting to peripheral visual stimuli and attention disengagement from central stimuli at 8 months (Tampere) or at 6 months (Cape Town) of age. Only a marginal positive correlation between fundamental frequency of cry (F0) and visual attention disengagement was observed in the Tampere cohort, but not in the Cape Town cohort. This correlation indicated that infants from the Tampere cohort with a higher neonatal F0 were marginally slower to shift their gaze away from the central stimulus to the peripheral stimulus. No associations between F0 and oculomotor orienting were observed in either cohort. We discuss possible factors influencing the current pattern of results suggesting a lack of replicable associations between neonatal cry and visual attention and suggest directions for future research investigating the potential of early cry analysis in predicting later cognitive development. (shrink)