The immune system can generate an almost infinite number of different antibody specificities, the sum of which is the antibody repertoire. This article considers aspects of the mechanism and control of immunoglobulin variable (V) region gene assembly with a focus on how these factors may affect generation of the antibody repertoire in normal and disease states. New model systems to study the mechanism and control of V gene assembly are described, in particular the introduction of V gene recombination substrates into (...) Abelson murine leukemia virus‐transformed pre‐B cells. Finally, a model is presented which suggests that control of V gene assembly is mediated by regulating accessibility of substrate gene segments to recombinational machinery. (shrink)

In examining the visual culture of Victorian London during the years 1855–1870, Lynda Nead in her book Victorian Babylon explores the difficult and restless narrative of modernization that any of us who have read D. G. Rossetti's “The Burden of Nineveh” will recognize as crucial to the Victorian imagination. As Nead promptly establishes, Babylon for the Victorians was a trope evoking gain and loss, triumph and hubris, future and past ruination. Taking this ancient city as her titular image, then, Nead (...) aims to rearticulate urbanism and modernity, indeed challenging us to reconceive what we mean by “modernity.” Positioning her own arguments against the influential architectonics of Marshall Berman's All That Is Solid Melts into Air and favoring instead the writings of Michel Foucault, Walter Benjamin, and Michel de Certeau, Nead recasts modernity as an “untidy experience,” a “constant struggle with history” . Near her book's end, Nead provocatively claims: “Ruin is the resolution of the contradictory impulses of modernity” .Victorian Babylon explores the spaces of mid‐Victorian London and, more important, the experience of inhabiting those very spaces. This textual tour is divided tidily into three sections: a first on mapping and water, a second devoted to gas and light, and a third on obscenity, which Nead calls “improvement's other” . As Nead herself claims about the metropolitan travel literature she examines, her book speaks well to the eye. Victorian Babylon is a vicarious tour of London thanks to Nead's deft and abundant use of fresh images, which she has culled assiduously from private collections, archives, and especially illustrated nineteenth‐century periodicals. Her study thus takes us to fascinating places: readers travel along with John Hollingshead on his journey down to London's sewers; we are invited into Joseph Paxton's dreamscape of the Great Victorian Way; and we play for a night at Cremorne Pleasure Gardens, witnessing Madame Poitevin's balloon ride. We hesitantly enter the haunted and obscene Holywell Street.The catalogic abundance of Victorian Babylon works both to Nead's advantage and disadvantage. Surely the sheer range of Nead's material proves her points about the frenzy and incomprehensibility of modernity and the promiscuity of Victorian commercial culture. But invariably the variety of topics results in too much cursory analysis—a paragraph on photography followed by a paragraph on the International Health Exhibition; brief excursions into the realms of advertising, illustrated sheet music, and music halls. Subsequently, a reader might grow eager instead for book‐length studies of these issues. Yet the most egregious omission of an adequate treatment is the two‐page cursory overview of the picturesque. Here, Nead misses an opportunity to offer a more extended, theoretical treatment of the “metropolitan picturesque” and how this aesthetic category relates—or not—to the other psycho‐aesthetic touchstones for her work, which are the sublime and the urban uncanny. One might also rue the absence of an extended treatment of the relic versus the ruin at the book's close.The analysis of the book does grow stronger as it unfolds. The Cremorne Gardens in the second section make for interesting reading, and Nead is best at discussing London at night, the uncanny, and what she calls a poetics of gas. The final section on obscenity is most promising, for here the Babylonic polyphony of Victorian London—what Nead calls the twin mission, to build and destroy—hits the reader with full force. One might wish that Nead had spent a bit more time on obscenity before extending her treatment to the more symbolic, architectural expression of obscenity‐cum‐obsolescence, the Temple Bar. However, the fate of the Temple Bar is nicely evocative of the ruin and, thus, takes the reader full circle back to the ambiguities of modernity. (shrink)

The paper investigates the ethical decisions of Millennials, who are not only part of an expanding cohort of the workforce, but also represent potential future managers with a growing influence on work practices and employment relationships. In the conceptual model, we propose that three ethical frames of reference, represented by perceived organisational ethics, perceived employee ethics and reflective moral attentiveness, antecede ethical judgements, which further influence the ethical intentions of Millennials. Using structural equation modelling, we test the model for three (...) different business ethics scenarios: paying a consulting fee, dumping hazardous waste, and running an offensive advertising campaign. The findings confirm the link between ethical judgements and intentions across the board, while the influence of the ethical frames of reference varies among the scenarios. We propose that the differences in the predictive ability of the ethical frames of reference depend on the nature of the ethical issue, which holds important implications for today's managers in their attempts to encourage ethical behaviour of Millennial employees. (shrink)

Chronic and current epistemological controversies, with particular attention to the development of pragmatist/historicist/constructivist reconceptions of knowledge and science in the 20th century and the scandalized responses to them by defenders of more traditional rationalist/objectivist/realist conceptions. Individual chapters deal with complex and confused relations among epistemic skepticism, relativism, and constructivist epistemology ; 20th-century "postmodern" relativism and anti-relativism; Ludwik Fleck and constructivist views of truth, science, and knowledge; attacks on and disavowals of constructivism and/or relativism by established and feminist philosophers; the Science (...) Wars and fraught relations between the humanities and the sciences; the problematic claims of Evolutionary Psychology; and chronic problems and contemporary views of animal-human relations. (shrink)

This paper is about the semantic analysis of referentially opaque verbs like seek and owe that give rise to nonspecific readings. It is argued that Montague's categorization (based on earlier work by Quine) of opaque verbs as properties of quantifiers runs into two serious difficulties: the first problem is that it does not work with opaque verbs like resemble that resist any lexical decomposition of the seek ap try to find kind; the second one is that it wrongly predicts de (...) dicto (i.e. narrow scope) readings due to quantified noun phrases in the object positions of such verbs. It is shown that both difficulties can be overcome by an analysis of opaque verbs as operating on properties. This is a strongly modified version of a paper entitled lsquoDo We Bear Attitudes towards Quantifiers?rsquo that I have presented at conferences in Gosen (Gesellschaft für Sprachwissenschaft), Ithaca (SALT I), and Konstanz (Lexikon). I owe a special debt to Hans Kamp and Arnim von Stechow for shaping my views on the subject of this paper during the past ten years or so. Comments from and discussions with the following friends and colleagues have also led to considerable improvements: Heinrich Beck, Steve Berman, David Dowty, Veerle van Geenhoven, Fritz Hamm, Irene Heim, Wolfgang Klein, Angelika Kratzer, Michael Morreau, Barbara Partee, Mats Rooth, Roger Schwarzschild, Wolfgang Sternefeld, Emil Weydert, Henk Zeevat, and three referees. (shrink)

This collection breaks new ground in four key areas of feminist social thought: the sex/gender debates; challenges to liberalism/equality; feminist ethics; and feminist perspectives on global ethics and politics in the 21st century. Altogether, the essays provide an innovative look at feminist philosophy while making substantive contributions to current debates in gender theory, ethics, and political thought.

Although corporate decision makers may justify charitable contributions on strategic grounds, extremely large corporate philanthropic contributions may beperceived by shareholders as unnecessary. If stockholders attempt to limit corporate philanthropy, then governance mechanisms should put a cap on giving amounts. Using a matched-paired sample to control for industry and company size, theauthors compared big givers and small givers. The authors find that blockholders and institutional owners limit corporate philanthropy. This suggests that high levels of corporate philanthropy may be perceived as excessive (...) by influentialstockholders, and some governance mechanisms act to curtail it. (shrink)

Partee (1973) discussed quotation from the perspective of the then relatively new theory of transformational grammar.2 As she pointed out, the phenomenon presents many curious puzzles. In some ways quotes seem quite separate from their surrounding text; they may be in a different dialect, as in her example in (1), (1) ‘I talk better English than the both of youse!’ shouted Charles, thereby convincing me that he didn’t. [Partee (1973):ex. 20] or even in a different language, as in (2): (2) (...) Louise said ‘Je voudrais un auto-da-f´e’, but I didn’t know what she meant. (shrink)

This collection of essays by Robert Brandon spans two decades and most of the important problems in the philosophy of biology. Four of his five most important contributions to the philosophy of biology can be found here: the concept of relative adaptedness and its role in the propensity interpretation of fitness; the principle of natural selection; the use of the screening-off relation in defense of organismic selection; and the distinction between units of selection and levels of selection. The fifth major (...) contribution, an analysis of the concept of "environment," mentioned briefly in an essay on the co-evolution of organisms and environment, is given an extended treatment in his 1990 book, Adaptation and Environment. (shrink)

Being White, Being Good focuses on white complicity and white complicity pedagogy. It examines the shifts in our conceptualization of the subject, language and moral responsibility that are required for understanding white complicity and draws out implications for social justice pedagogy.

The article argues that the relationship to time is at the root of what makes us human and that culture arises with and from efforts to transcend death, change and the rhythmicity of the physical environment. Time can be tracked through systems of time measurement and later transformed from a process of nature into clock time, a time to human design that is abstracted from context and content. In this form time can be traded with all other times. With contemporary (...) science and new information and communications technologies, which operate in a new all-encompassing temporal spectrum that extends from nanoseconds to millennia, clock time is no longer appropriate to the associated present-oriented transactions and futures are traversed in the dual sense of the word. By historically locating temporal relations, the article provides both a new understanding of socio-cultural relations and a perspective on social change. (shrink)

Prenatal screening and testing are preference‐based health care options. They are offered so that pregnant women and their partners can learn genetic information about the developing fetus. In this literature review, I summarize studies of women’s and their partners’ psychological responses to prenatal testing and screening. These studies investigate the experiences of pregnant women, largely in the United States, who have access to health care services. Although the results indicate that these women are receptive to prenatal testing and screening and (...) seem to have limited negative psychological consequences, pregnant women without access to these services are not represented and may have different experiences. With that caveat in mind, based on the evidence, women generally do well psychologically as they manage the options that arise for them in the prenatal context. (shrink)

In 1960, a relatively new ‘syndrome’ began appearing with growing frequency in psychiatric hospitals and in doctors’ offices. Eventually termed ‘delicate self-cutting’, this new model for typical self-mutilative behavior was developed in conjunction with a description of the ‘typical’ self-mutilator: young (adolescent to just post-adolescent), female, and almost always attractive. This article contends that, despite recent efforts to change the nature of research on self-mutilation, the myth of a typical mutilator, developed from a particular historical bias, continues to work in (...) popular and medical discourses on the subject. I will begin with a detailed discussion of the medical discourse in an effort to ask how the myth was made. Noting that the female body, here, is singled out as pathological at a time when, specifically in the USA, the emergent Women’s Movement was beginning to contest certain gender lines, I would like to examine how the medical discourse and material bodies interrelate and interact with each other and with the cultural narratives around them. Finally, I end with examples from the 1999 film Girl, Interrupted, as well as other recent popular and medical accounts, to illustrate not only the perpetuation of the myth of the ‘typical’ self-mutilator but also the inability or refusal to recognize the biased nature of the medical discourse in the instance on self-mutilation. (shrink)

This paper presents problems for Stalnaker’s common ground theory of presupposition. Stalnaker (Linguist and Philos 25:701–721, 2002) proposes a 2-stage process of utterance interpretation: presupposed content is added to the common ground prior to acceptance/rejection of the utterance as a whole. But this revision makes presupposition difficult to distinguish from assertion. A more fundamental problem is that the common ground theory rests on a faulty theory of assertion—that the essence of assertion is to present the content of an utterance as (...) new information. Many examples are presented of utterances which are felicitous but not informative in this way. (shrink)

Over the past two decades, modal epistemology has turned its attention to ordinary modal knowledge. This paper brings to the fore a neglected but central form of ordinary modal knowledge: knowledge of agentive modality, and in particular of our own abilities, which I call ‘ability knowledge’. I argue that modal epistemology as it is does not account for ability knowledge, by looking at the most promising candidate theories: perception-based, counterfactual-based, and similarity-based modal epistemologies. I then outline a more promising epistemology (...) for our ability knowledge, which relies on the experience of our own agency, and draw out some lessons for modal epistemology in general. (shrink)

This paper examines nurses’ international migration within the broader context of female migration, particularly against more studied groups of women who have migrated for employment in care‐giving roles. We analyze the similarities and differences between skilled professional female migrants (nurses) and domestic workers (nannies and in‐home caretakers) and how societal expectations, meanings, and values of care and ‘women's work’, together with myriad social, cultural, economic and political processes, construct the female migrant care‐giver experience. We argue that, as the recruitment of (...) foreign workers gains visibility, strategies are introduced to better prepare female migrant care‐givers for the marketplace. Language, specifically command of English and accent modification, is highlighted as one means to assimilate migrant care‐givers to host communities. (shrink)

"Nothingness lies coiled in the heart of being like a worm."The John Donne of "A Valediction: Of Weeping" prefers the picture to the real. For Donne and for Jean-Paul Sartre, with whom he is aligned in this essay, the preference principally involves issues of control. As Sartre writes, "It's not enough that a certain picture which I have in mind should exist; it is necessary as well that it exist through me."1 While the more conventional predilection for the virtual over (...) the actual assumes the durability of art, Donne's sequential portraits in the poem confirm, as Sartre puts it, that "man's relation with being is that he can modify it". The vanishing... (shrink)

Abstract:Recent work on the subject speaks to the importance trust has for firm performance (e.g., Hagen and Choe, 1999; Hill, 1995). Yet little work has been done to show how context affects the ability of firms to create trust in relationships with key stakeholders. This paper looks at how the institutional environment may affect the performance of different strategies for managing firm-stakeholder relationships, and in turn, how this affects firm performance. The authors put forward propositions that build on these theoretical (...) insights and offer prospects for future empirical work. (shrink)

Contemporary organizations often reciprocate to society for using resources and for affecting stakeholders by engaging in corporate social responsibility. It has been shown that CSR has a positive impact on employee attitudes. However, not all employees may react equally strongly to CSR practices. Based on socio-emotional selectivity theory, we contend that the effect of CSR on employee satisfaction will be more pronounced for older than for younger employees, because CSR practices address those emotional needs and goals that are prioritized when (...) people’s future time perspective decreases. In one multi-source field study and one experimental study, we demonstrate that CSR indeed has a stronger positive effect on employee satisfaction for older relative to younger employees. Accordingly, engaging in CSR can be an attractive tool for organizations that aim to keep their aging workforce satisfied with their job. (shrink)

The excessive faith liberal theorists have had in the power of rights and rights discourse can have deleterious consequences for children. As vulnerable and dependent beings, children need to be nurtured with love and affection in a setting in which intimate relationships between parents and children can flourish. A rights‐based discourse is conceptually ill‐equipped to accommodate the importance of establishing and supporting caring relationships. An ethic of care, emphasizing responsibilities over rights, provides a better way of conceptualizing and responding to (...) the interests of children than thinking of children as proto‐adults with rights especially that to autonomy. (shrink)

Despite three major reform movements over the last 300 years, the mental health system has been remarkably resistant to change. Today, another period of reform is underway, only this time, new players - dissatisfied ex-psychiatric patients - are organizing to affect the process of change. This paper discusses characteristics of previous movements and examines their similarity to and difference from the present consumer and psychiatric survivor movement. It appears that the new participants have shaped the rhetoric of reform but it (...) remains to be seen if they can affect the reality. (shrink)

In this paper, my aim is to understand the origin of experimental and scientific models of pathogeny of the diseases of the nervous system in the Salpêtrière (Paris). I will analyse the role of the contexts of cell theory, microscopy and the advances in histological techniques in the creation of various pathogenic models, based on the concept of the cell, the Wallerian degeneration and the neurone concept. I argue that, as medicine and pathology remain autonomous in their methods and goals, (...) because of the evident degree of complexity of diseases, close and reciprocal interactions with sciences, their practices and theories, make it possible to establish convergences between clinical observations, pathological data and those from the experimental models of pathologies. The search for pathogenic models behaves like an engine, which is efficient in assembling facts, in testing pathogeneses and reforming nosologies, combined with the breakthroughs in biology. This paper is a case study showing the emergence of such interactions in the last decades of the nineteenth-century in Paris. (shrink)

Many organisms face a dilemma rooted in the unequal numbers of X chromosomes carried by the two sexes and the need to maintain equivalent expression of X‐linked genes. Several strategies have arisen to cope with this problem. All rely on accurately targeting epigenetic modifications to entire chromosomes. Targeting results from the action of recognition elements that attract modification and may rely on spreading of modification in cis along the affected chromosome. A recent report describing the first X chromosome recognition element (...) from C. elegans opens the way to defining the relative contributions of these factors to the compensation of X‐linked gene expression in worms.1 Extrachromosomal arrays composed of a C. elegans recognition element attract proteins that modify the C. elegans X chromosomes and interact genetically with mutations disrupting compensation. Moreover, examination of X:A translocations provides the first evidence for spreading of modification along C. elegans X chromosomes. BioEssays 26:707–710, 2004. © 2004 Wiley Periodicals, Inc. (shrink)