We present a novel method, called graph sparse nonnegative matrix factorization, for dimensionality reduction. The affinity graph and sparse constraint are further taken into consideration in nonnegative matrix factorization and it is shown that the proposed matrix factorization method can respect the intrinsic graph structure and provide the sparse representation. Different from some existing traditional methods, the inertial neural network was developed, which can be used to optimize our proposed matrix factorization problem. By adopting one parameter in the neural network, (...) the global optimal solution can be searched. Finally, simulations on numerical examples and clustering in real-world data illustrate the effectiveness and performance of the proposed method. (shrink)

To correct the misconception that incommensurability implies incomparability, Kuhn lately develops a new interpretation of incommensurability. This includes a linguistic theory of scientific revolutions (the theory of kinds), a cognitive exploration of the language learning process (the analogy of bilingualism), and an epistemological discussion on the rationality of scientific development (the evolutionary epistemology). My focus in this paper is to review Kuhn's effort in eliminating relativism, highlighting both the insights and the difficulties of his new version of incommensurability . Finally (...) I suggest that some of Kuhn's difficulties can be overcome by adopting a concept of rationality that filly appreciates the important role of instruments in the development of science. (shrink)

In this paper we examine the pattern of conceptual change during scientific revolutions by using methods from cognitive psychology. We show that the changes characteristic of scientific revolutions, especially taxonomic changes, can occur in a continuous manner. Using the frame model of concept representation to capture structural relations within concepts and the direct links between concept and taxonomy, we develop an account of conceptual change in science that more adequately reflects the current understanding that episodes like the Copernican revolution are (...) not always abrupt. When concepts are represented by frames, the transformation from one taxonomy to another can be achieved in a piecemeal fashion not preconditioned by a crisis stage, and a new taxonomy can arise naturally out of the old frame instead of emerging separately from the existing conceptual system. This cognitive mechanism of continuous change demonstrates the constructive roles of anomaly and incommensurability in promoting the progress of science. (shrink)

This paper offers a solution to a problem in Herschel studies by drawing on the dynamic frame model for concept representation offered by cognitive psychology. Applying the frame model to represent the conceptual frameworks of the particle and wave theories, this paper shows that discontinuity between the particle and wave frameworks consists mainly in the transition from a particle notion ‘side’ to a wave notion ‘phase difference’. By illustrating intraconceptual relations within concepts, the frame representations reveal the ontological differences between (...) these two concepts. ‘Side’ is an object concept built on spatial relations, but ‘phase difference’ is an event concept built on temporal relations. The conceptual analyses display a possible cognitive source of Herschel’s misconception of polarization. Limited by his experimental works and his philosophical beliefs, Herschel comprehended polarization solely in terms of spatial relations, which prevented him from replacing the object concept ‘side’ with the event concept ‘phase difference’, and eventually resulted in his failure to understand the wave account of polarization.Author Keywords: Herschel; Polarization; Object concept; Event concept; Frame; Cognitive psychology. (shrink)

: This paper offers a preliminary analysis of conceptual change between event concepts. It begins with a brief review of the major findings of cognitive studies on event knowledge. The script model proposed by Schank and Abelson was the first attempt to represent event knowledge. Subsequent cognitive studies indicated that event knowledge is organized in the form of dimensional organizations in which temporally successive actions are related causally. This paper proposes a frame representation to capture and outline the internal structure (...) of event concepts, in particular, their causal connections. The frame representation offers an effective method to analyze the relations between event concepts, and to expose the unique cognitive mechanisms behind conceptual change involved event concepts. Finally this paper shows that the frame representation of event concepts is instrumental to understanding an important historical episode of conceptual change in the context of nineteenth-century optics. (shrink)

In a previous article we have shown that Kuhn's theory of concepts is independently supported by recent research in cognitive psychology. In this paper we propose a cognitive re-reading of Kuhn's cyclical model of scientific revolutions: all of the important features of the model may now be seen as consequences of a more fundamental account of the nature of concepts and their dynamics. We begin by examining incommensurability, the central theme of Kuhn's theory of scientific revolutions, according to two different (...) cognitive models of concept representation. We provide new support for Kuhn 's mature views that incommensurability can be caused by changes in only a few concepts, that even incommensurable conceptual systems can be rationally compared, and that scientific change of the most radical sort—the type labeled revolutionary in earlier studies—does not have to occur holistically and abruptly, but can be achieved by a historically more plausible accumulation of smaller changes. We go on to suggest that the parallel accounts of concepts found in Kuhn and in cognitive science lead to a new understanding of the nature of normal science, of the transition from normal science to crisis, and of scientific revolutions. The same account enables us to understand how scientific communities split to create groups supporting new paradigms, and to resolve various outstanding problems. In particular, we can identify the kind of change needed to create a revolution rather precisely. This new analysis also suggests reasons for the unidirectionality of scientific change. (shrink)

In most cases, a wh-question calls for an answer that names an entity in the set denoted by the extension of the wh-complement. However, evidence from questions with necessity modals and questions with collective predicates argues that sometimes a wh-question must be interpreted with a higher-order reading, in which this question calls for an answer that names a generalized quantifier. This paper investigates the distribution and compositional derivation of higher-order readings of wh-questions. First, I argue that the generalized quantifiers that (...) can serve as semantic answers to wh-questions must be homogeneously positive. Next, on the distribution of higher-order readings, I observe that questions in which the wh-complement is singular-marked or numeral-modified can be answered by elided disjunctions but not by conjunctions. I further present two ways to account for this disjunction–conjunction asymmetry. In the uniform account, these questions admit disjunctions because disjunctions may satisfy the atomicity requirement of singular-marking and the cardinality requirement of numeral modification. In the reconstruction account, the wh-complement is syntactically reconstructed, which gives rise to local uniqueness and yields a contradiction for conjunctive answers. (shrink)

: Armed with a photometer originally designed for evaluating telescopes, Richard Potter in the early 1830s measured the re(integral)ective power of metallic and glass mirrors. Because he found significant discrepancies between his measurements and Fresnel's predictions, Potter developed doubts concerning the wave theory. However, Potter's measurements were colored by a peculiar procedure. In order to protect the sensitivity of the eye, Potter made certain approximations in the measuring process, which exaggerated the discrepancies between the theory and the data. Potter's measurements (...) received strong criticisms from wave theorists, not because they felt they needed to defend their theory, but because they believed that Potter was wrong in using the eye as an essential apparatus in the experiments. Potter's photometric measurements and the subsequent debate reveal the existence of two incompatible sets of measuring procedures, each of which consisted of a body of practices concerning how photometric instruments should be used properly. In the debate, the differences regarding measuring procedures shaped the participant's judgments of experimental evidence and eventually their evaluations of the optical theories. (shrink)

_Wh_-questions with the modal verb _can_ admit both mention-some (MS) and mention-all (MA) answers. This paper argues that we should treat MS as a grammatical phenomenon, primarily determined by the grammar of the _wh_-interrogative. I assume that MS and MA answers can be modeled using the same definition of answerhood (Fox in Mention-some interpretations, MIT seminar, 2013 ) and attribute the MS/MA ambiguity to structural variations within the question nucleus. The variations are: (i) the scope ambiguity of the higher-order _wh_-trace (...) and (ii) the absence/presence of an anti-exhaustification operator. However, treating MS answers as complete answers in this way contradicts the widely adopted analysis of uniqueness effects in questions of Dayal (Locality in _wh_ quantification: Questions and relative clauses in Hindi, 1996 ), according to which the uniqueness effects of singular _which_-phrases arise from an exhaustivity presupposition, namely that a question must have a unique exhaustive true answer. To solve this dilemma, I propose that question interpretations presuppose Relativized Exhaustivity: roughly, the exhaustivity in questions is evaluated relative to the accessible worlds as opposed to the anchor/utterance world. Relativized Exhaustivity preserves the merits of Dayal’s exhaustivity presupposition while permitting MS; moreover, it explains the local-uniqueness effects in modalized singular _wh_-questions. (shrink)

I propose a new perspective on the study of scientific revolutions. This is a transformation from an object-only perspective to an ontological perspective that properly treats objects and processes as distinct kinds. I begin my analysis by identifying an object bias in the study of scientific revolutions, where it takes the form of representing scientific revolutions as changes in classification of physical objects. I further explore the origins of this object bias. Findings from developmental psychology indicate that children cannot distinguish (...) processes from objects until the age of 7, but they have already developed a core system of object knowledge as early as 4 months of age. The persistence of this core system is responsible for the object bias among mature adults, i.e., the tendency to apply knowledge of physical objects to temporal processes. In light of the distinction between physical objects and temporal processes, I redraw the picture of the Copernican revolution. Rather than seeing it as a taxonomic shift from a geocentric to a heliocentric cosmology, we should understand it as a transformation from a conceptual system that was built around an object concept to one that was built around a process concept. (shrink)

Previous studies of the history of optics reveal that the confrontation between the emission theory of light and the undulatory theory of light in Britain occupied a considerable period during the early nineteenth century. After the majority of British physicists accepted the undulatory theory in the mid-1830s a few emissionists in Britain did not immediately surrender. They continued to fight a rear-guard action against the undulatory theory, hoping that someday they could reinstate their theory.’ The longevity of the confrontation between (...) the emission and the undulatory theory is consistent with recent philosophical and sociological accounts of science, which expect scientific controversy to last a considerable time. Lakatos’s philosophical account, for example, holds that a degenerating theory does not disappear immediately and may revive at any time through a burst of ‘heuristic power’. But this account only allows one universal standard-the verification of excess empirical content-as the basis for both the generation and the closure of scientific controversies.’ On the other hand, sociological accounts such as actor-network theory have also done much to dispel the impression that rapid closure is inevitable in scientific controversies. But perhaps they risk a new orthodoxy: that controversy itself is inevitable. (shrink)

Histone post-translational modifications play important roles in transcriptional regulation. It is known that multiple histone modifications can act in a combinatorial manner. In this study, we investigated the effects of multiple histone modifications on expression levels of five gene categories in coding regions. The combinatorial patterns of modifications for the five gene categories were also studied in the regions. Our results indicated that the differences in the expression levels between any two gene categories were significant. There were some corresponding differences (...) in multiple histone modification levels among the five gene categories. Multiple histone modifications jointly impacted expression levels of every gene category. Four mutual combinations of histone modifications were found and analyzed. (shrink)

The approach of returning to the original and recovering nature is a typical characteristic of Chinese philosophy. It was founded by the Daoist School and followed by both Daoist and Confucian schools. The precondition of returning to the original and recovering nature is the stillness and goodness within nature integrated into a whole afterwards. Its implementation includes not only returning to the original root so as to achieve the philosophical aim but also restoration to the original nature after it is (...) injured by man’s physical nature and desire. The realization of human nature depends on the work making up for the loss of the original nature. Although there are different methods of realization concerning the return to the original nature, such as returning to the root, seeking the lost mind, extinguishing desire, being good at return, and the self-consciousness of intuitive knowledge, all of these aim at returning to the original nature of stillness and purity. The philosophical value consists in the unceasing pursuit of returning to the original nature. (shrink)

This paper revisits two fundamental issues in question semantics—what does a question mean, and how is this meaning compositionally derived? Drawing on observations with the distribution of wh-words in questions and free relatives as well as quantificational variability effects in question-embeddings, I argue that the nominal meanings of short answers must be derivable from question denotations, which therefore calls for a categorial approach to defining questions, including embedded questions. I provide a novel hybrid categorial approach to compose questions. This approach (...) overcomes the problems with traditional categorial approaches in defining bare wh-indefinites, composing multi-wh questions, and accounting for coordinations of questions. (shrink)

Coronavirus disease is having an unprecedented and unpredictable impact on the world's economy. The pandemic has driven the world toward adapting to the current circumstances regardless of the business, sector, or industry. The coronavirus epidemic has affected the global economy and service sector. The purpose of the current study is to assess the effect of COVID-19 on service sector growth and sustainability. Global sectors and industries are trying to anchor themselves amidst the pandemic. The study focuses on the sectors that (...) are badly hit by the outbreak and discussed the strategies and responses different countries are taking to sustain their economies. This study concludes that the vital role of Information Technology and digitization supports the economies in their fight against the pandemic and helps them sustain themselves amid crises. This study also contributes to the body of literature by suggesting IT-based solutions for various industries to elevate effective responsiveness and avoid significant losses. (shrink)

This paper examines older people’s access to care experiences in rural China by integrating anthropological investigation with ethical inquiry. Six months of fieldwork in a post-reform primary hospital show how rural residents struggle to access gerontological and nursing care under socially disadvantageous conditions. This anthropological investigation highlights the unmet needs in medical and nursing care for older people, as well as some social, institutional and structural elements that impede access to care. Centring on protecting the vulnerable as informed by feminist (...) ethics scholarship, this paper argues that the failure to meet older people’s dependency needs is unjust, on the premise that it suggests a denial of the inherent value, rights and dignity of older people. This paper appeals for the provision of greater care and support by the state through putting in place social arrangements that better advance older people’s access to care. Some policy recommendations concerning health and social care reform for older people in rural China are also proposed. (shrink)

In this paper I examine a cognitive mechanism of incommensurability. Using the frame model of concept representation to capture structural relations within concepts, I reveal an ontological difference between object and event concepts: the former are spatial but the latter temporal. Experiments from cognitive sciences further demonstrate that the mind treats object and event concepts differently. Thus, incommensurability can occur in conceptual change across different ontological categories. I use a historical case to illustrate how the ontological difference between an object (...) and an event concept actually caused incommensurability in the context of nineteenth‐century optics. The cognitive and historical analyses indicate that incommensurability can be a local phenomenon and does not necessarily imply incomparability. (shrink)

This discussion seeks to highlight the ability of poetry to combat loneliness, a growing public health problem with significant negative health outcomes that potentially impact millions of Americans. We argue that poetry can play a very relevant role and have an impact in medicine. Through a brief literature review of previous studies on poetry in medicine, we demonstrate that poetry can not only combat loneliness but can also play important roles in helping patients, physicians, and other healthcare professionals/providers. Because of (...) the COVID-19 pandemic, we believe now is the perfect opportunity to utilize poetry because the benefits can be experienced even in solitude, which is why this is such a timely and pertinent issue today. (shrink)

This paper argues that Confucianism had an antiessentialist conception of selfhood. This understanding of self means that they did not have, and could not have had, a concept of “race” in the sense that one's essence determines one's becoming. In the Confucian canon, the embodiment of cultural norms/performance of culturally appropriate actions defines one's human-ness. This account of human agency in becoming human can be seen in the Confucian explanation of moral failure. This assumption of human agency also means that (...) the Confucian understanding of hierarchy is social as opposed to ontological and that differences between peoples are understood to be a result of culture–custom variation. (shrink)

In China's healthcare sector, a popular and socio-culturally distinctive phenomenon known as guanxi jiuyi, whereby patients draw on their guanxi with physicians when seeking healthcare, is thriving. Integrating anthropological investigation with normative inquiry, this paper examines medical guanxi through the lens of patient–physician trust and mistrust. The first-hand empirical data acquired – on the lived experiences and perspectives of both patients and physicians – is based on six months' fieldwork carried out in a county hospital in Guangdong, southern China, which (...) included in-depth interviews with 20 patients and 20 medical professionals. Patients who emphasized the positive effects of guanxi on patient–physician trust believed that it facilitates access to experienced medical specialists, enhances clinical communication, and reduces the financial and medical risks of over diagnosis and overtreatment by physicians. At the same time, these findings reveal patients' strong sense of mistrust, not only towards individual health professionals but also to the medical profession and China's commercialized healthcare industry. While some health professionals in the study responded favourably to medical guanxi, most were opposed to it on the grounds that it undermines professional standards and equitable healthcare. We found that the practice of medical guanxi is not morally justifiable, chiefly because it reinforces the present high levels of patient–physician mistrust and erodes trust between patients and the medical profession as a whole. In China, both the medical profession and the state need to promote patient–physician trust based on medical professionalism and institutional norms, rather than on guanxi or individual relationships. (shrink)

According to the desire-satisfaction theory of well-being, your life goes well to the extent that your desires are satisfied. This theory faces the problem of prudential neutrality: it apparently cannot avoid saying that, from the point of view of prudence or self-interest, you ought to be neutral between satisfying an existing desire of yours and replacing it with an equally strong desire and satisfying the new desire. It also faces the problem of remote desires: it regards as directly relevant to (...) your well-being even desires whose objects are intuitively too irrelevant to (or ‘remote’ from) your life to affect your welfare. In this article, I argue that desire theorists can answer both objections by appealing to hidden desires – ones that it is psychologically realistic to attribute to the agents in the cases on which the two problems are based, even though they are not mentioned in descriptions of those cases. (shrink)

This volume brings the first English translation of the Confucian classics Four Books for Women, with extensive commentaries, to the English-speaking world. Written by women for women's education, this work provides an invaluable look at the tradition of Chinese women's writing, education, history, and philosophy, from the 1st to the 16th century.

Surveys of public opinions on climate change found that a majority of American respondents regarded global warming as a critical or an important threat . Given this consensus, one might expect that a majority of Americans are ready to take immediate action to deal with the environmental crisis. However, when they were asked whether we should begin taking steps now, only 43% of American respondents said yes; 54% of them chose either the option “until we are sure that global warming (...) is really a problem, we should not take any steps that would have economic costs,” or the option “global warming should be addressed, but its effects will be gradual, so we can deal with the problem .. (shrink)

I propose a new perspective with which to understand scientific revolutions. This is a conversion from an object-only perspective to one that properly treats object and process concepts as distinct kinds. I begin with a re-examination of the Copernican revolution. Recent findings from the history of astronomy suggest that the Copernican revolution was a move from a conceptual framework built around an object concept to one built around a process concept. Drawing from studies in the cognitive sciences, I then show (...) that process concepts are independent of object concepts, grounded in specific regions of the brain and involving unique representational mechanisms. There are cognitive obstacles to the transformation from object to process concepts, and an object bias—a tendency to treat processes as objects—makes this kind of conceptual change difficult. Consequently, transformation from object to process concepts is disruptive and revolutionary. Finally, I explore the implications of this new perspective on scientific revolutions for both the history and philosophy of science.Keywords: Scientific revolutions; Process concepts; Object concepts; Object bias; Copernican revolution. (shrink)

The application of algorithms in organizations is becoming more widespread. Previous research has aimed to enhance employees’ perceptions of algorithmic fairness by focusing on technical features. However, individuals often struggle to observe and comprehend these features, hindering their ability to form rational fairness judgments. Drawing upon fairness heuristic theory, this study explores how individuals perceive algorithmic fairness when technical features are invisible because of algorithmic opacity. Research conducted with food delivery riders in China suggests that, in the absence of transparent (...) algorithmic information, riders heuristically form perceptions of algorithmic fairness based on more salient and accessible distributive fairness information. These heuristic perceptions of algorithmic fairness further predict outcomes such as task performance and helping behavior. We also found that different distributive fairness information holds varying importance in the process of shaping heuristic perceptions of algorithmic fairness and that algorithmic transparency perceptions and tenure moderate this process. The findings extend fairness heuristic theory and have practical implications. (shrink)

Problem and Project Based Learning (PBL) has been used as an educational philosophy and methodology in the construction of a student centered and contextualized learning environment. PBL is also regarded as an effective method in producing engineering graduates who can not only meet the needs of professional competences but are also prepared for new challenges in the globalized and technological context. However, can PBL be a solution to the challenge of a general lack of university students studying engineering and technology (...) in many countries? Gender and Diversity in a Problem and Project Based Learning Environment presents an ethnographical study on the learning experiences of engineering students in the PBL environment in Denmark, and it attempts to question the issue of diversity in engineering education via the exploration of which ways the PBL environment is friendly to diverse groups of learners such as women. (shrink)

Many empirical studies have been conducted to investigate self-regulated learning in the Western countries. Less well investigated is the SRL in the Chinese Mainland students and how it affects their academic achievement. On the basis of PISA 2009, this paper is aimed at exploring the SRL of 15-year-old Shanghai students, as measured by cognitive strategy, metacognition, and motivational belief. In the aspect of SRL nature, the results reveal that 15-year-old students in Shanghai use elaboration strategy frequently and seldom use memorization (...) strategy, and that they have high metacognition in understanding, remembering, and summarizing but have low control strategy, and that their enjoyment of reading is relatively high. In the aspect of SRL’s consequence for reading literacy, findings from multilevel linear regression corroborate previous evidence from the Western countries about the effect of SRL on academic achievement. Specifically, elaboration strategy, metacognition in understanding and remembering, metacognition in summarizing, control strategy, and enjoyment of reading are conducive to students’ reading literacy, while memorization strategy exerts a significantly negative effect on reading literacy. The findings could be useful in helping us to gain a better understanding of Shanghai students’ SRL. (shrink)

The overwhelming motif of nineteenth century anti-Semitic discourse is the metaphor of the Jew as a ghost. In all cultures, the ghost represents the antithesis of what is categorically human: it represents the other par excellence. By using the heuristic of the ghost to interpret how Enlightenment discourse has dealt with the other, this article will argue that the Enlightenment model of the self and its relation to others was a contributing factor to Modern Racism. Enlightenment discourse on subjectivity finds (...) its counterpart in Confucian notions of subjectivity. By looking at how ghosts are understood within Confucian discourse and how they are evoked in popular literature, I argue that Confucian philosophy’s model of subjectivity contributed to the success of the Chinese empire’s assimilation project. (shrink)

In this article I explain why scientists cannot always resolve their disagreements about experiments even if they do not hold conflicting theoretical assumptions, and how incommensurability in experiments can occur even if experiments are not deeply encumbered by theoretical assumptions. On the basis of recent discoveries in cognitive psychology and an extended analysis of a historical case, I explore a cognitive mechanism that may generate incommensurability in experiment appraisal. I find that, because of the involvement of goal-derived categories, incommensurability in (...) experiments may result from the conflict of goals that scientists pursue in their researches, from the differences of goal-derived classification schemata that they employ in analyzing experiments, and from discrepancies between skills that they have developed in their practices. This account differs from the conventional interpretation of Kuhn’s thesis, which attributes the cause of incommensurability solely to theoretical differences. In the conclusion, I further discuss the implications of this new account of incommensurability for both philosophical and historical studies of science. (shrink)

The student management work model in colleges and universities is an effective plan for college student management, but the traditional college student management work is not very good in terms of student psychology, resulting in negative attitudes such as low learning desire, low learning efficiency, and inactive learning. In recent years, with the development of artificial intelligence technologies such as sentiment analysis and incentive theory, emotional management and incentive theory have been applied to the management of college students. The emotional (...) management and incentive model is a way to help college students get rid of psychological obstacles and guide students to establish positive and correct values by predict and analyze the psychological state of college students through language emotion recognition and BP neural network. This paper compares the college student management work model based on emotional management and incentives with the traditional college management work mode through experiments. The results show that the students’ learning enthusiasm is better than the traditional college student management work mode based on emotional management and incentives. The student management work model in colleges and universities is 15.8% better, and the students’ grades have improved by 12.5%; the college student management work model based on emotional management and incentives also has a positive role in helping students’ mental health. The way of emotional management and motivation can make better use of college students’ psychology to effectively manage students and guide students to develop in a good direction. (shrink)

ABSTRACT This paper draws upon transitivity and Appraisal within Systemic Functional Linguistics to study the traumatic discourse of Nanjing Massacre in Chinese Mainland’s and Japan’s history textbooks. Through corpus analysis, this research finds that the Chinese discourse mainly uses effective process, relational process, verbal process to construe Japan’s victimizering experience and China’s victimhood, and employs negative Affect, opposite values of Judgment, negative Appreciation, Expand, Raise and Sharpen to construct a critical voice for the Japanese army and a sympathic tone for (...) the Chinese. By contrast, the Japanese discourse largely uses pseudo-effective and middle processes, mental and existential processes to cover up Japan’s victimizering experience, and employs negative Judgment, positive Appreciation, Contract and Raise to construct an almost uncritical voice for the Japanese army and the massacre. The difference in the representation and evaluation of Nanjing Massacre results from the politics of official memories in both countries. As China endeavors to strengthen its patriotic education by using Nanjing Massacre as an ideological weapon for national solidarity, Japan expedites its nationalist historiography move to recreate its normal national image by marginalizing the massacre. (shrink)

The time-scale dynamic equations play an important role in modeling complex dynamical processes. In this paper, the Mei symmetry and new conserved quantities of time-scale Birkhoff’s equations are studied. The definition and criterion of the Mei symmetry of the Birkhoffian system on time scales are given. The conditions and forms of new conserved quantities which are found from the Mei symmetry of the system are derived. As a special case, the Mei symmetry of time-scale Hamilton canonical equations is discussed and (...) new conserved quantities for the Hamiltonian system on time scales are derived. Two examples are given to illustrate the application of results. (shrink)

Through a key passage (Xici 2.2) from the Book of Changes, this paper shows that Ernst Cassirer’s philosophy of symbolic forms shares similarities with the canonical account of symbolic formation in the Chinese tradition: the genesis of xiang (象), often translated as image or symbol. xiang became identified with the origins of culture/civilisation itself. In both cases, the world is understood as primordially (phenomenologically) meaningful; the expressiveness of the world requires a human subject to consummate it in a (...) symbol, whilst the symbol in turn gives us access to higher orders of meaning. It is the self-conscious creation of the symbol that then allows for the higher forms of culture. For both the Xici and Cassirer, symbols and the symbolic consciousness that comes with it is the pre-condition for the freedom, ethics and the cultivation of agency. As for both the Xici and Cassirer, it is human agency that creates these symbols, it will be argued that the Xici is making a Cassirerian argument about the (ethical) relationship between human agency, symbols and ethics/freedom. (shrink)

The direction and specificity of endolysosomal membrane trafficking is tightly regulated by various cytosolic and membrane‐bound factors, including soluble NSF attachment protein receptors (SNAREs), Rab GTPases, and phosphoinositides. Another trafficking regulatory factor is juxta‐organellar Ca2+, which is hypothesized to be released from the lumen of endolysosomes and to be present at higher concentrations near fusion/fission sites. The recent identification and characterization of several Ca2+ channel proteins from endolysosomal membranes has provided a unique opportunity to examine the roles of Ca2+ and (...) Ca2+ channels in the membrane trafficking of endolysosomes. SNAREs, Rab GTPases, and phosphoinositides have been reported to regulate plasma membrane ion channels, thereby suggesting that these trafficking regulators may also modulate endolysosomal dynamics by controlling Ca2+ flux across endolysosomal membranes. In this paper, we discuss the roles of phosphoinositides, Ca2+, and potential interactions between endolysosomal Ca2+ channels and phosphoinositides in endolysosomal dynamics. (shrink)

This paper analyses the text Vital Dispositions Come Via Mandate (Xing Zi Ming Chu, 性自命出) and argues that central to its account of the cultivation of inner virtue are the affections (qing, 情), the heart-mind (xin, 心), and the techniques of the heart-mind (xinshu, 心术; or simply ‘culture’). Qing, it is argued, are intersubjective, socio-culturally produced non-sensory data that act on the heart-mind and serve as the foundation for moral behavior. Qing is encoded in cultural forms such as Music and (...) poetry. Hence, there is an internal relationship between qing, xin, and xinshu. Correctly understanding the connection between these and how they shape the human being will help elucidate the nature of the Confucian moral program. In foregrounding qing, this paper presents Confucian moral philosophy as grounded in a hermeneutic and sympathetic understanding of the perspective of the other. (shrink)