Significant advances have recently been made in our understanding of the mechanisms of activation of proteins that require processing. Often this involves endoproteolytic cleavage of precursor forms at basic residues, and is carried out by a group of serine endoproteinases, termed the proprotein convertases. In mammals, seven different convertases have been identified to date. These act in both the regulated secretory pathway for the processing of prohormones and proneuropeptides and in the constitutive secretory pathway, in which a variety of proproteins (...) are activated endoproteolytically. The recently completed sequence of the nematode Caenorhabditis elegans genome affords a unique opportunity to examine the entire proprotein convertase family in a multicellular organism. Here we review the nature of the family, emphasising the structural features, characteristic of the four nematode genes, that supply all of the necessary functions unique to this group of serine endoproteinases. Studies of the C. elegans genes not only provide important information about the evaluation of this gene family but should help to illuminate the roles of these proteins in mammalian systems. BioEssays 22:545–553, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

The heart of this book is the reciprocal relationship between philosophical theories of mind and empirical studies of animal cognition.

As arti® cial intelligence moves ever closer to the goal of producing fully autonomous agents, the question of how to design and implement an arti® cial moral agent (AMA) becomes increasingly pressing. Robots possessing autonomous capacities to do things that are useful to humans will also have the capacity to do things that are harmful to humans and other sentient beings. Theoretical challenges to developing arti® cial moral agents result both from controversies among ethicists about moral theory itself, and from (...) computational limits to the implementation of such theories. In this paper the ethical disputes are surveyed, the possibility of a `moral Turing Test ’ is considered and the computational di culties accompanying the diŒerent types of approach are assessed. Human-like performance, which is prone to include immoral actions, may not be acceptable in machines, but moral perfection may be computationally unattainable. The risks posed by autonomous machines ignorantly or deliberately harming people and other sentient beings are great. The development of machines with enough intelligence to assess the eŒects of their actions on sentient beings and act accordingly may ultimately be the most important task faced by the designers of arti® cially intelligent automata. (shrink)

Should cognitive scientists be any more embarrassed about their lack of a discipline-fixing definition of cognition than biologists are about their inability to define “life”? My answer is “no”. Philosophers seeking a unique “mark of the cognitive” or less onerous but nevertheless categorical characterizations of cognition are working at a level of analysis upon which hangs nothing that either cognitive scientists or philosophers of cognitive science should care about. In contrast, I advocate a pluralistic stance towards uses of the term (...) ‘cognition’ that eschews the urge to treat cognition as a metaphysically well-defined “natural” kind. (shrink)

Knowledge and Reality brings together a selection of Colin McGinn's philosophical essays from the 1970s to the 1990s, whose unifying theme is the relation between the mind and the world. McGinn defends a realist view, but emphasises the epistemological problems that come with it. He has written a new postscript to each essay, placing it in its philosophical context and offering his current reflections on the topic.

The demise of behaviorism has made ethologists more willing to ascribe mental states to animals. However, a methodology that can avoid the charge of excessive anthropomorphism is needed. We describe a series of experiments that could help determine whether the behavior of nonhuman animals towards dead conspecifics is concept mediated. These experiments form the basis of a general point. The behavior of some animals is clearly guided by complex mental processes. The techniques developed by comparative psychologists and behavioral ecologists are (...) able to provide us with the tools to critically evaluate hypotheses concerning the continuity between human minds and animal minds. (shrink)

Agroecology has been proposed as a key building block for food sovereignty. This article examines the meaning, practices and potentials of ‘transformative agroecology learning’ as a collective strategy for food system transformation. Our study is based on our qualitative and action research with the European Coordination of Via Campesina to develop the European Agroecology Knowledge Exchange Network. This network is linked to the global network of La Via Campesina and builds on the strong experiences and traditions of popular education in (...) Latin American peasant movements. Rather than focusing on agroecology education as a process of individual learning, we analyse how a transformative agroecology education can be strengthened as a critical repertoire of action used by social movements to advance food sovereignty. Our analysis contributes a new theory of transformative agroecology learning based on four key characteristics or qualities: horizontalism; diálogo de saberes ; combining practical and political knowledge; and building social movement networks. While these different elements of transformative agroecology learning were present across EAKEN, they were unevenly developed and, in many cases, not systematized. The framework can help to strategically and reflexively systematize and strengthen a transformative agroecology learning approach as a key building block for food sovereignty. (shrink)

The second International Knowledge and Discourse Conference, held at the University of Hong Kong in June 2002, was the forum for the long-awaited debate between Bruno Latour and Steve Fuller. Bruno Latour counts beyond two. He places the blame for the emphasis in academia on the subject-object distinction on Kant. Latour wants academics to acknowledge that things act, and suggests we look at other traditions, e.g. the Chinese, for alternatives to the subject-object dichotomy. Steve Fuller concentrated on the moral project (...) of science, which is to draw a distinction between the human and the non-human and, to highlight the fact that, as the culmination of the sciences, social science has a particular responsibility to make this distinction. He accused Bruno Latour of evading the moral issue. The debate can be read as a reiteration of the postions of Bruno Latour and Steve Fuller on the question of heterogeneity at the theoretical level, but it did not address the topic at the practical or research level. (shrink)

In this article I critically examine Adam Moore’s claim that the threshold for overriding intangible property rights and privacy rights is higher, in relation to genetic enhancement techniques and sensitive personal information, than is commonly suggested. I argue that Moore fails to see how important advances in genetic research are to social justice. Once this point is emphasised one sees that the issue of how formidable overriding these rights are is open to much debate. There are strong reasons, on grounds (...) of social justice, for thinking the importance of such rights is likely to be diminished in the interests of ensuring a more just distribution of genes essential to pursuing what John Rawls calls a person’s ”rational plan of life’. (shrink)

In this paper, I describe grounds for dissatisfaction with certain aspects of the sciences of animal cognition and argue that a turn toward mathematical modeling of animal cognition is warranted. I consider some objections to this call and argue that the implications of such a turn are not as drastic for ordinary, commonsense understanding of animal minds as they might seem.

Imagination and idealism are particularly important creative epistemic virtues for the medical sciences if we hope to improve the health of the world’s ageing population. To date, imagination and idealism within the medical sciences have been dominated by a paradigm of disease control, a paradigm which has realised significant, but also limited, success. Disease control proved particularly successful in mitigating the early-life mortality risks from infectious diseases, but it has proved less successful when applied to the chronic diseases of late (...) life (like cancer). The time is ripe for the emergence and prominence of a supplementary medical research paradigm, the paradigm of ‘healthy ageing’ which prioritises the goal of rate (of ageing) control rather than disease control. This is the difference between extending the human healthspan versus extending survival by managing (or trying to eliminate) the multi-morbidities, frailty and disability currently prevalent in late life. The idealism of the disease control paradigm is myopic because it ignores the health constraints imposed by the inborn ageing process itself, a biological reality which is already inflicting significant economic and disease burdens on the world’s ageing populations. Unless the medical sciences retard the rate of biological ageing, these problems will continue to be amplified as larger numbers of persons survive into late life. (shrink)

Utilitarianism tells us that actions are morally right and good if and to the extent that they add to human happiness or diminish human unhappiness. And—or, perhaps, therefore—it also tells us that the best action a person can perform is that which of all the possible actions open to him is the one which makes the greatest positive difference to human happiness. Moreover, as everyone will also remember, utilitarianism further tries to tell us, perhaps intending it as a corollary of (...) that first, main claim, that the motive for an action has nothing to do with its moral rightness or goodness. But even if, as utilitarians, we accepted the dubious corollary, it would not follow, as many have thought, that utilitarians have no moral interest in motives. For unless, absurdly, a utilitarian believed either that there was never more than a fortuitous connection between on the one hand what we intended to do and on the other what we did and the consequences of what we did, or that, if there were such connections, we could not know of them, he must believe, as a moralist, that the best motive a person can have for performing an action is likely to be the desire to produce the happiest result. Indeed, utilitarians ought to be morally committed, it would seem, to trying to find out as much as they can about the consequences of our actions, e.g. what connections exist, if any, between how we raise children and what sort of adults they grow up to be. (shrink)

Mechanisms to engage lay citizens in science and technology are currently in vogue worldwide. While some engagement exercises aim to influence policy making, research suggests that they have had little discernable impacts in this regard. We explore the potentials and challenges of facilitating citizen engagement in nanotechnology from the “topdown,” addressing the following questions: Can academics and others within institutions initiate meaningful engagement with unorganized lay citizens from the top-down? Can they facilitate effective engagement among citizens, scientists, and policy makers (...) while building citizen engagement capacities? Is it possible to create independent bottom-up citizen engagement in scientific and technological issues from the top-down, and what are the challenges in doing so? Our experiences show that although academics can build citizens' individual, collective, and political capacities to engage with each other, scientists, and policy makers, this work is enormously time and energy intensive, and institutional support is needed to sustain it. (shrink)

Donald Griffin has suggested that cognitive ethologists can use communication between non-human animals as a "window" into animal minds. Underlying this metaphor seems to be a conception of cognition as information processing and communication as information transfer from signaller to receiver. We examine various analyses of information and discuss how these analyses affect an ongoing debate among ethologists about whether the communicative signals of some animals should be interpreted as referential signals or whether emotional accounts of such signals are adequate. (...) We discuss the food-calling behavior of a group of rhesus monkeys to develop these issues. (shrink)

Cambridge Quarterly of Healthcare Ethics. What values and principles should inform the regulation of new human genetic technologies? To adequately answer this question we need an account of genetic justice. That is, an account of what constitutes a fair distribution of genetic endowments that influence our expected life-time acquisition of natural primary goods. These are goods that every rational person has an interest in. The decisions we now make regarding the regulation of human genetic technologies will determine how quickly and (...) effectively these benefits are brought into existence, as well as who receives these benefits. In this paper I argue that a necessary condition of a defensible account of genetic justice is that it must track genetic complexity. Genetic complexity encompasses phenomena such as polygenetic traits, gene-gene interactions and complex environmental influences. More specifically, I argue that pluralistic prioritarianism is a theoretical position well-suited for tracking genetic complexity. (shrink)

Nanotechnology thrives in the realm of the virtual. Throughout its history, the field has been shaped by futuristic visions of technological revolution, hyperbolic promises of scientific convergence at the molecular scale, and science fiction stories of the world rebuilt atom by atom. Even today, amid the welter of innovative nanomaterials that increasingly appear in everyday consumer products—the nanoparticles enhancing our sunscreens, the carbon nanotubes strengthening our tennis rackets, the antimicrobial nano-silver lining our socks, the nanofilms protecting our wrinkle-free trousers—the public (...) rhetoric of nanotechnology constantly reminds us that such precision-engineered materials merely represent a trace or a premonition of the amazing future still to come... (shrink)

A principal goal of the discipline of artificial morality is to design artificial agents to act as if they are moral agents. Intermediate goals of artificial morality are directed at building into AI systems sensitivity to the values, ethics, and legality of activities. The development of an effective foundation for the field of artificial morality involves exploring the technological and philosophical issues involved in making computers into explicit moral reasoners. The goal of this paper is to discuss strategies for implementing (...) artificial morality and the differing criteria for success that are appropriate to different strategies. (shrink)

This book brings together contributors from the different member states of the European Union in order to understand the different degrees of subscription to the concept of Europe and the role education plays in such a process. This second edition includes the new countries which have become part of the union and also considers recent developments in policy and practice. Countries covered are: Austria; Belgium; Denmark; Finland; France; Germany; Greece; Ireland; Italy; Luxembourg; Netherlands; Portugal; Spain; Sweden and the UK. All (...) sectors of education are dealt with in each case and the central theme of the European dimension is examined throughout. (shrink)

Kaur (2012) raises the question, how can education be more inclusive and representative when catering to diverse groups and students? Does our entitlement to human kindness cease once incarcerated, and are we to be forever banished to the outskirts of society? The majority of offender education research assesses success or failure through mechanistic, objective and calculated criteria. Statistically, offenders repeatedly underachieve in primary and secondary education; offenders who partake in some form of adult and post-release learning continue this pattern, and (...) face other non-learning barriers that impact on participation and accreditation outcomes (Prison Education Trust, 2018). Departing from conventional modes and methods of teaching, this article examines the transformative journeys of former offenders, and considers the role of education in supporting them to lead more productive and meaningful lives. (shrink)

dynamic ontologies must be inferred and populated in part from the reference corpora themselves, but ontological rela-.

1.What do you do when you argue a case? -- Claims and conclusions -- Reasons and inference -- Titles as questions -- Support for a conclusion -- 2.How will you make yourself clear? -- Vagueness and definition -- Assumptions -- Ambiguity and conflation -- Ordering and indicating -- 3.What case have others made? -- Counter-claims -- Counter-argument -- Selection and evaluation of sources -- Reputation and expertise -- 4.What do you make of these arguments? -- Overstatement and straw man -- (...) Causes and conditions -- Appeals to the past -- Appeals to feelings -- 5.How will you support your case? -- Examples and anecdotes -- Facts and factual claims -- Statistical evidence -- Credibility and corroboration -- 6.How much can you be sure about? -- Certainty and plausibility -- Deductive argument -- Conditional claims -- Logic and truth -- 7.How much is a matter of belief? -- Point of view -- Belief and opinion -- Bias and neutrality -- Values and principles -- 8.Are you over-simplifying the issue? -- Ad hominem and tu quoque ploys -- False dichotomy -- Over-generalization -- Analogy and slippery slope -- 9.Does your argument hang together? -- Contradiction -- Consistency and coherence -- Changing the subject -- Begging the question -- 10.How will you lay out your case? -- Structure of reasoning -- Intermediate conclusion -- Alternative inferences -- Quotation and referencing. (shrink)

People’s perception of their own efficacy is a critical precursor for adaptive behavioural responses to the threat posed by climate change. The present study investigated whether components of climate efficacy could be enhanced by short video messages. An online study (N = 161) compared groups of participants who received messages focusing on individual or collective behaviour. Relative to a control group, these groups showed increased levels of response efficacy but not self-efficacy. However, this did not translate to increased climate commitment; (...) mediation analysis suggested that the video messages, while increasing efficacy, may also have had a counterproductive effect on behavioural intentions, possibly by reducing the perceived urgency of action. This finding reinforces the challenge faced by climate communicators seeking to craft a message that boosts efficacy and simultaneously motivates adaptive responses to the climate crisis. (shrink)

This two volume Handbook contains chapters on the main areas to which Post-Keynesians have made sustained and important contributions. These include theories of accumulation, distribution, pricing, money and finance, international trade and capital flows, the environment, methodological issues, criticism of mainstream economics and Post-Keynesian policies. The Introduction outlines what is in the two volumes, in the process placing Post-Keynesian procedures and contributions in appropriate contexts.

βριс φυτεει τραννον βριс κτλ. Thus the MSS, Schol. and Stobaeus 4.8. 11 . βριν φυτεει τυραννον βριс κτλ. Thus Blaydes, followed recently by R. P. Winnington-Ingram, JHS 91 , 126 = Sophocles. An interpretation , p. 192 ; R. D. Dawe, Sophoclis Tragoediae , i. 156 and Sophocles. Oedipus Rex , pp. 18, 61,182 f. ; R. W. B. Burton, The Chorus in Sophocles' Tragedies , p. 164 ; J. Diggle, CRn.s. 32, 14.

Corporate environmental ethics has moved from a niche issue within business strategy to a potential source of competitive advantage. Firms, however, are comprised of individuals who vary in their personal beliefs regarding environmental responsibility. Environmental stewards are those employees whose attitudes and actions reflect environmental concern. Top management can convey similar environmental values through the creation of eco-capabilities. Applying logic from the natural resource-based view of the firm, we build a model to test how the alignment of environmental values impacts (...) multiple outcomes. We conduct a time-lagged examination using multi-level data from frontline employees, their managers, and their customers. We find that firms can ‘activate’ their corporate environmental ethics through eco-capabilities. Specifically, environmental stewards find more meaning in their work when managers perceive high levels of eco-capabilities within the firm. This meaningful work increases employee brand advocacy and customer satisfaction. Together, we demonstrate how corporate environmental ethics translates to the frontline and the customers they serve. (shrink)

Why does the world have the pattern of patriarchy it currently possesses? Why have patriarchal practices and institutions evolved and changed in the ways they have tended to over time in human societies? This paper explores these general questions by integrating a feminist analysis of patriarchy with the central insights of the functionalist interpretation of historical materialism advanced by G. A. Cohen. The paper has two central aspirations: first, to help narrow the divide between analytical Marxism and feminism by redressing (...) the former's neglect of the important role female labor has played, and continues to play, in shaping human history. Second, by developing the functionalist account of historical materialism in order to take patriarchy seriously, we can derive useful insights for diagnosing the emancipatory challenges that women face in the world today. The degree and form of patriarchy present in any particular society is determined by the productive forces it has had at its disposal. According to historical materialism, technological, material, and medical advances that ease the pressures on high fertility rates (such as the sanitation revolution, vaccinations, birth control, and so on) are the real driving forces behind the positive modulations to patriarchy witnessed in the twentieth century. (shrink)

In Michael Sandel's latest book entitled ican republicanism, Aristotle, and Hegel, com- Democracy's Discontent (1996), he argues munitarians are critical of the individualistic that the prevailing public philosophy (what he methodology liberalism employs. Such a methcalls the procedural republic) that informs..

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . (...) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . (shrink)

Recent advances in genetic research pose many complex problems for moral and political philosophers. On the one hand, these advances promise great things. Genetic enhancement techniques might allow us to prevent or cure a variety of debilitating diseases. But on the other hand, talk about intervening in people's genetic make-up conjures up memories of the sinister episodes of past eugenic movements. Such movements violated the most basic principles of justice. How can society capitalize on the benefits of genetic intervention and (...) yet avoid the injustices of past eugenic movements? What basic moral principles should guide public policy and individual choice concerning the use of genetic interventions? These important questions are tackled by Allen Buchanan, Dan Brock, Norman Daniels, and Daniel Wikler in From Chance to Choice: Genetics and Justice. This book brings together the thoughts of leading scholars in the field and is likely to set the agenda for serious debate on this topic. (shrink)

It is widely agreed, claims John Horton, “that the core of the concept of toleration is the refusal, where one has the power to do so, to prohibit or seriously interfere with conduct one finds objectionable”.1 Liberals champion toleration as one of the main political virtues of a just society. The tolerant society is one which protects a diverse array of fundamental freedoms ranging from freedom of conscience and religion to freedom of expression and freedom of association. Secure in the (...) knowledge that the constitution guarantees these various freedoms, citizens can freely pursue the lifestyles they find most fulfilling, regardless of the fact that the majority of people may or may not find their.. (shrink)

(forthcoming) Journal of Medical Licensure and Discipline. Rapid advances in human genetics raise the prospect that one day we may be able to develop genetic enhancements to promote a diverse range of phenotypes (e.g. health, intelligence, behaviour, etc.). Perhaps the biggest challenge that genetic enhancements pose for medical practitioners is that they will compel us to re-think a good deal of the conventional wisdom of the status quo. Radical enhancements are likely to have this affect for a variety of reasons. (...) Firstly, the status quo is premised (at least in large part) on a sharp distinction between treatment and enhancement; a distinction that at least some genetic enhancements will call into question. Secondly, the prospect of radical enhancements requires us to keep an open mind concerning how we conceive of the harm of non-intervention (i.e. the harm of the status quo). And thirdly, some enhancements might compromise the preservation of personal identity. All of these issues may have important consequences for State Medical Boards, ranging from the way we view the aspiration to prevent harm and ensure reasonable standards of care, to malpractice, continuing competency and medical specialization. (shrink)

“Three Wishes” is an exercise in what could be called interactive philosophy. It challenges the reader to discern for herself what lessons we can take from the fable, rather than explicitly laying these out beforehand. Engaging in this intellectual exercise should prove fruitful as it compels one to reflect critically upon the interconnection between distinct laudable goals as well as appreciate the role that perceived feasibility constraints play in our determination of what the fundamental principles of distributive justice are and (...) how they should be ordered. (shrink)