Type II DNA topoisomerases (Topo II) are essential enzymes implicated in key nuclear processes. The recent discovery of a novel kind of Topo II (DNA topoisomerase VI) in Archaea led to a division of these enzymes into two non‐homologous families, (Topo IIA and Topo IIB) and to the identification of the eukaryotic protein that initiates meiotic recombination, Spo11. In the present report, we have updated the distribution of all Topo II in the three domains of life by a phylogenomic approach. (...) Both families exhibit an atypical distribution by comparison with other informational proteins, with predominance of Topo IIA in Bacteria, Eukarya and viruses, and Topo IIB in Archaea. However, plants and some Archaea contain Topo II from both families. We confront this atypical distribution with current hypotheses on the evolution of the three domains of life and origin of DNA genomes. BioEssays 25:232–242, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Many common arguments for physicalism begin with the principle that the cosmos is “causally closed.” But how good are the arguments for causal closure itself? I argue that the deductive, a priori arguments on behalf of causal closure tend to beg the question. The extant inductive arguments fare no better. They commit a sampling error or a non-sequitur, or else offer conclusions that remain compatible with causal openness. In short, we have no good arguments that the physical world is causally (...) closed. (shrink)

Karl Buhler (1879-1963) was one of the leading theoreticians of language of the twentieth century. This is an English translation of Buhler's theory that begins with a survey on 'Buhler's legacy' for modern linguistics (Werner Abraham), followed by the Theory of Language, and finally with a special 'Postscript: Twenty-five Years Later!'.

Im vorliegenden Aufsatz unterscheide ich verschiedene Weisen, in denen Interpretationen richtig oder falsch sein können. Ich komme zu dem Resultat, dass Interpretationen richtig oder falsch sind, sofern ihr deskriptiver Inhalt hinreichend bestimmt ist. Die Richtigkeit oder Falschheit der Interpretation hängt dabei davon ab, ob der deskriptive Inhalt wahr oder falsch ist.

First published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

The meaning of the term logagogy is elucidated, and logagogic practices are outlined in the history of medicine. It is shown how the traditional medicine of India, Ayurveda, shows signs of logagogic practices(sattvavajaya), and that not only Ayurveda but also the famous Greek physician Galenus emphasize a philosophical approach to medicine. As Galenus’s logagogic practices have their roots in the tradition of practical philosophy in Greek antiquity, the most important Greek schools of thought that are relevant to logagogic approaches are (...) sketched. It is shown that the Stoics created a rationalistic system emphasizing the importance of the logos for human beings, and that Epicurus made advances in psychoeducation and cognitive reframing that are important for logagogic practices. These logagogic approaches of antiquity have been taken up by modern counseling in philosophical practices. The article closes with an outline of a clinical logagogy. (shrink)

ABSTRACTDeliberative and decisional groups play crucial roles in most aspects of social life. But it is not obvious how to organize these groups and various socio-cognitive mechanisms can spoil debates and decisions. In this paper we focus on one such important mechanism: the misrepresentation of views, i.e. when agents express views that are aligned with those already expressed, and which differ from their private opinions. We introduce a model to analyze the extent to which this behavioral pattern can warp deliberations (...) and distort the decisions that are finally taken. We identify types of situations in which misrepresentation can have major effects and investigate how to reduce these effects by adopting appropriate deliberative procedures. We discuss the beneficial effects of holding a sufficient number of rounds of expression of views; choosing an appropriate order of speech, typically a random one; rendering the deliberation dissenter-friendly; having agents express fined-grained views. These applicable procedures help improve deliberations because they dampen conformist behavior, give epistemic minorities more opportunities to be heard, and reduce the number of cases in which an inadequate consensus or majority develops. (shrink)

This article presents a community-based account of salience as an alternative and a complement to the ‘natural salience’ approach which is endorsed by almost all game theorists who use this concept. While in the naturalistic approach, salience is understood as an objective and natural property of some entities, the community-based account claims that salience is a function of community membership. Building on David Lewis’s theory of common knowledge and on some of its recent refined accounts, I suggest that salience acts (...) as a correlating device in a correlated equilibrium. What is constitutive of salience is common understanding, the fact that agents have common knowledge that they share the same modes of reasoning with respect to a well-identified set of events. I argue that the basis for common understanding is community membership. The relevance of this account stems from the fact that it answers the objection that salience is either unnecessary or unable to account for coordination between rational agents. (shrink)

According to Woodward’s causal model of explanation, explanatory information is relevant for manipulation purposes and indicates by means of invariant causal relations how to change the value of certain target explanandum variables by intervening on others. Therefore, the depth of an explanation is evaluated through the size of the domain of invariance of the generalization involved. In this article, I argue that Woodward’s account of explanatory relevance is still unsatisfactory and claim that the depth of an explanation should be explicated (...) in terms of the size of the domain of circumstances which it designates as leaving the explanandum unchanged. (shrink)

This paper evaluates how Amartya Sen’s critique of revealed preference theory stands against the latter’s contemporary, ‘neo-Samuelsonian’ version. Neo- Samuelsonians have argued that Sen’s arguments against RPT are innocuous, in particular once it is acknowledged that RPT does not assume away the existence of motivations or other latent psychological or cognitive processes. Sen’s claims that preferences and choices need to be distinguished and that external factors need to be taken into account to analyze the act of choice then appear to (...) be irrelevant. However, while it is true that contemporary revealed preference theory partially evades Sen’s critique, I show that the latter is still relevant outside the restricted areas of consumer choice and market dynamics. In particular, Sen’s views regarding the importance of incomplete preferences and the multiplicity of levels of agency can hardly be integrated into the framework of CRPT. This is a significant limit, given the imperialistic claims of some of the proponents of the latter. (shrink)

Cyril Smith shows that Marx developed a far richer and liberatory vision of humanity and the alternative to capital than that which has characterized his followers, and he makes a powerful argument that it is essential to return to Marx's original body of thought in order to reconstitute a viable critique of existing capitalist society.

First Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.

An introduction to the ethnography and human geography of non-European peoples, this book deals with the economic and social life of a number of groups at diverse levels of cultural achievement and in different regions of the world. International in its scope the book covers: Malaysia, Africa, North America, Canada, Siberia, the Amazon, Eastern Solomon Islands, India, Central Asia and the Middle East. Originally published in 1934. This re-issues the seventh edition of 1949.

Economic theories of team reasoning build on the assumption that agents can sometimes behave according to beliefs or preferences attributed to a group or a team. In this paper, I propose a different framework to introduce collective intentionality into game theory. I build on John Searle’s account, which makes collective intentionality constitutive of institutional facts. I show that as soon as one accepts that institutions are required to solve indetermination problems in a game, it is necessary to assume a form (...) of collective intentionality that comes from what I call a common understanding of the situation among the players. This common understanding embodies the epistemic requirements for an institution to be a correlated equilibrium in a game. As a consequence, I question recent claims made by some economists according to which game-theoretic accounts of institutions do not need to assume collective intentionality. (shrink)

This paper pursues a naturalist endeavor in social ontology by arguing that the Beliefs-Rules-Equilibrium account of institutions can help to advance the debate over the nature of social kinds. This account of institutions emerges from a growing number of works in economics that use game theory to study the role and the functioning of institutions in human societies. I intend to show how recent developments in the economic analysis of rules and institutions can help solve issues that are generally considered (...) constitutive of any ontological inquiry. I argue that the Beliefs-Rules-Equilibrium account of institutions can contribute to advancing the debate on an issue of particular importance, regarding the specific form of dependence characterizing the relation between institutions and individuals’ attitudes about them. I tackle this issue by taking Francesco Guala's claims about the nature of institutions made in his book “Understanding Institutions” as a point of departure. In particular, I reject Guala’s functionalism about institutions. On the basis of the Beliefs-Rules-Equilibrium account, I claim that it is futile to search for constitutive features of general institutions (money, property rights, family…) and that the best we can have is a knowledge of what are the rules within a specific institution, which the agents consider to be essential in their institutional practice. (shrink)

Using panel data of 4,244 company years, we examine whether and how corporate social performance affects a firm's capacity to achieve profitable sales in foreign markets. Based on our extension of instrumental stakeholder theory into the international arena, we hypothesized a U-shaped relationship between CSP and multinationality. Results supported our contention that multinational enterprises need to be substantially committed to social performance objectives if they are to recoup the cost of their CSP investments, and improve their capacity to compete in (...) foreign markets. MNEs engaged in intermediate levels of CSP achieve lower levels of multinationality than firms operating at either anchor of the social performance continuum. In addition, this study demonstrates that CSP moderates a well-established relationship in international business literature - the relationship between R&D investment and a firm's multinationality. Implications for research and practice are discussed. (shrink)

In this overview, I begin by situating De-Moralizing Gay Rights within the field of queer studies/queer theory. I then delineate the book’s principal arguments. The book critically interrogates three sets of distortions in 21st century public discourse on LGBT+ rights in the United States. The first relates to the critique of pinkwashing, often advanced by scholars who claim to be proponents of a radical politics. I suggest that this critique sometimes suffers from analytical overreach. The second concerns a recent US (...) Supreme Court decision, Obergefell v. Hodges (2015), a judgment that established marriage equality across the 50 states. I argue that this judgment mobilizes the Court’s endorsement of two elements of homonormativity: amatonormativity and repronormativity. Instead of endorsing homonormativity, the Court should have employed an approach based on decisional minimalism. The third distortion occurs in Kenji Yoshino’s theorization of the concept of gay covering. Yoshino’s calls to dismantle cultural demands for gay covering turn out, I argue, to constitute an oppressive command to ‘gay-flaunt.’. (shrink)

Albert O. Hirschman est surtout connu pour ses travaux sur le développement économique et des publications comme Exit, Voice and Loyalty (1970), The Passions and the Interests (1977) ou encore The Rhetoric of Reaction (1991). Il l’est beaucoup moins pour sa défense du possibilisme qui représente sa conception méthodologique des sciences sociales. Nous en présentons l’origine et ses principales caractéristiques dans cet article. Codes JEL : B31, B40.

Various errors can affect scientific code and detecting them is a central concern within computational science. Could formal verification methods, which are now available tools, be widely adopted to guarantee the general reliability of scientific code? After discussing their benefits and drawbacks, we claim that, absent significant changes as regards features like their user-friendliness and versatility, these methods are unlikely to be adopted throughout computational science, beyond certain specific contexts for which they are well-suited. This issue exemplifies the epistemological heterogeneity (...) of computational science: profoundly different practices can be appropriate to meet the reliability challenge that rises for scientific code. (shrink)