We propose to study the wound healing in Zebrafish by using firstly a differential approach for modelling morphogens diffusion and cell chemotactic motion, and secondly a hybrid model of tissue regeneration, where cells are considered as individual objects and molecular concentrations are described by partial differential equations.

We outline a class of term-languages for epistemic grounding inspired by Prawitz’s theory of grounds. We show how denotation functions can be defined over these languages, relating terms to proof-objects built up of constructive functions. We discuss certain properties that the languages may enjoy both individually and with respect to their expansions. Finally, we provide a ground-theoretic version of Prawitz’s completeness conjecture, and adapt to our framework a refutation of this conjecture due to Piecha and Schroeder-Heister.

It has frequently been suggested that Rawls’s characteristic method of justification, a method crucially involving the notion of reflective equilibrium, is in some sense relativistic in its implications. No sustained development of this suggestion has been undertaken by those who advance it; likewise, no sustained attempt to refute this suggestion has been made by those who are otherwise sympathetic to Rawls’s account of justification. I here attempt to fill these gaps in the already extensive literature associated with the method of (...) reflective equilibrium. At below, I review claims that Rawls’s method has relativistic implications. I also attempt, for purposes of argument, to buttress these claims by citing remarks of Rawls which could be interpreted as relativistic in character. At below, I consider problems of political reasoning as these arise in societies which are ill- and well-ordered in Rawls’s sense. At below, I consider problems of political reasoning as these arise between the members of two or more well-ordered societies, each of which is regulated by a different conception of justice. I also there adapt Williams’s distinction between notional and real confrontations between incompatible systems of beliefs in order to distinguish two kinds of conflict with respect to fundamental political principles. Finally, I show how a notion of broad reflective equilibrium can be deployed in order to solve those problems of political adjudication which may arise between the members of societies which have distinct conceptions of justice. At this point it should be clear that Rawls’s method of justification is not, in intention at least, relativistic in its implications. (shrink)

Bainbridge’s well known “Ironies of Automation” Analysis, design and evaluation of man–machine systems. Elsevier, Amsterdam, pp 129–135, 1983. https://doi.org/10.1016/B978-0-08-029348-6.50026-9) laid out a set of fundamental criticisms surrounding the promises of automation that, even 30 years later, remain both relevant and, in many cases, intractable. Similarly, a set of ironies in technologies for sensor driven self-quantification is laid out here, spanning from instrumental problems in human factors design to much broader social problems. As with automation, these ironies stand in the way (...) of many of the promised benefits of these wearable technologies. It is argued here that without addressing these ironies now, the promises of wearables may not come to fruition, and instead users may experience outcomes that are opposite to those which the designers seek to afford, or, at the very least, those which consumers believe they are being offered. This paper describes four key ironies of sensor driven self-quantification: know more, know better versus no more, no better; greater self-control versus greater social control; well-being versus never being well enough; more choice versus erosion of choice. (shrink)

In this theological tour de force D. Stephen Long addresses a key question in current theological debate: the conditions of the possibility of God-talk, along ...

Mental illness is difficult to reconcile with the Darwinian theory of natural selection. Major psychiatric conditions, such as psychosis and suicidality, often occur in young adults and impair reproductive potential, yet they also appear to be genetically mediated.1 The challenge for evolutionary psychiatry has been to explain not only how such seemingly disadvantageous genes have evaded natural selection, but also how the widespread vulnerability to such conditions ever became established in the human genome in the first place.2In Things Hidden Since (...) the Foundation of the World,3 Girard, with psychiatrist coauthors Oughourlian and Lefort, advanced an account of human evolution in which the scapegoat mechanism... (shrink)

A couple of decades after becoming a major area of both public and philosophical concern, animal ethics continues its inroads into main- stream consciousness. Increasingly, philosophers, ethicists, professionals who use animals, and the broader public confront specific ethical issues regarding human use of animals as well as more fundamental questions about animals’ moral status. A parallel, related development is the explo- sion of interest in animals’ mental lives, as seen in exciting new work in cognitive ethology and in the plethora (...) of movies, television commercials, and popular books featuring apparently intelligent animals. -/- As we approach the turn of the twenty-first century, philosophical animal ethics is an area of both increasing diversity and unrealized poten- tial – a thesis supported by this essay as a whole. Following up on an earlier philosophical review of animal ethics (but without that review’s focus on animal research), the present article provides an updated narrative – one that offers some perspective on where we have been, a more detailed account of where we are, and a projection of where we might go. Each of the three major sections offers material that one is unlikely to find in other reviews of animal ethics: the first by viewing familiar territory in a different light (advancing the thesis that the utility-versus-rights debate in animal ethics is much less important than is generally thought); the second by reviewing major recent works that are not very well-known (at least to nonspecialists); and the third by identifying important issues that have been largely neglected. (shrink)

Prior studies provide consistent evidence of deficits for psychopaths in processing verbal emotional material but are inconsistent regarding nonverbal emotional material. To examine whether psychopaths exhibit general versus specific deficits in nonverbal emotional processing, 34 psychopaths and 33 nonpsychopaths identified with Hare's (R. D. Hare, 1991) Psychopathy Checklist-Revised were asked to complete a facial affect recognition test. Slides of prototypic facial expressions were presented. Three hypotheses regarding hemispheric lateralization anomalies in psychopaths were also tested (right-hemisphere dysfunction, reduced lateralization, and reversed (...) lateralization). Psychopaths were less accurate than nonpsychopaths at classifying facial affect under conditions promoting reliance on right-hemisphere resources and displayed a specific deficit in classifying disgust. These findings demonstrate that psychopaths exhibit specific deficits in nonverbal emotional processing. (shrink)

Due to the competitive nature of business as a whole, it is sometimes difficult to develop moral relationships with others. However, though friendships are possible in business, most relationships must be kept on the lower level of business acquaintanceship.

The Units of Selection debate is a dispute about the causes of population change. I argue that it is generated by a particular `dynamical'' interpretation of natural selection theory, according to which natural selection causes differential survival and reproduction of individuals and natural selection explanations cite these causes. I argue that the dynamical interpretation is mistaken and offer in outline an alternative, `statistical'' interpretation, according to which natural selection theory is a fancy kind of `bookkeeping''. It explains by citing the (...) statistical structure of a population and not by citing the causes of survival and reproduction. From the perspective of the statistical interpretation there is no substantive Units of Selection issue. (shrink)

Shepherdson [14] showed that for a discrete ordered ring I, I is a model of IOpen iff I is an integer part of a real closed ordered field. In this paper, we consider integer parts satisfying PA. We show that if a real closed ordered field R has an integer part I that is a nonstandard model of PA (or even IΣ₄), then R must be recursively saturated. In particular, the real closure of I, RC (I), is recursively saturated. We (...) also show that if R is a countable recursively saturated real closed ordered field, then there is an integer part I such that R = RC(I) and I is a nonstandard model of PA. (shrink)

This paper argues that the foundations of our knowledge are the bed-rock certainties of ordinary life, what may be called the Moorean truths. Beyond that are the well-established results within the empirical sciences, and whatever has been proved in the rational sciences of mathematics and logic. Otherwise there is only belief, which may be more or less rational. A moral drawn from this is that dogmatism should be moderated on all sides.

I welcome Mr Kennedy's general approach, but query whether the concept of consumerism is so closely applicable to medical care as he maintains. However, in particular aspects, especially the handling of complaints, his criticisms echo those made by the Patients Association. Finally, I detect some ground for hope in the more enlightened attitude creeping in to the eduction of the medical student.

Recently, certain philosophers of mathematics (Fallis [1997]; Womack and Farach [(1997]) have argued that there are no epistemic considerations that should stop mathematicians from using probabilistic methods to establish that mathematical propositions are true. However, mathematicians clearly should not use methods that are unreliable. Unfortunately, due to the fact that randomized algorithms are not really random in practice, there is reason to doubt their reliability. In this paper, I analyze the prospects for establishing that randomized algorithms are reliable. I end (...) by arguing that it would be inconsistent for mathematicians to suspend judgement on the truth of mathematical propositions on the basis of worries about the reliability of randomized algorithms. (shrink)

It is becoming increasingly common to find phenomena described as emergent. There are two sorts of philosophical analysis of emergence. Ontological analyses ground emergence in real, distinct, emergent properties. Epistemological analyses deny emergent properties and stress instead facts about our epistemic status. I review a standard worry for ontological analyses of emergence, that they entail a surfeit of metaphysics, and find that it can easily be sidestepped. I go on to present a new worry, that ontological emergentism entails a highly (...) implausible ontology, which is harder for the ontological emergentist to avoid. (shrink)

THE FACULTY OF Arts at the University of Sydney is a disaster-area, and not of the merely passive kind, like a bombed building, or an area that has been flooded. It is the active kind, like a badly-leaking nuclear reactor, or an outbreak of foot-and-mouth disease in cattle.

The furore over the retention of organs at postmortem examination, without adequate consent, has led to a reassessment of the justification for, and circumstances surrounding, the retention of any human material after postmortem examinations and operations. This brings into focus the large amount of human material stored in various archives and museums, much of which is not identifiable and was accumulated many years ago, under unknown circumstances. Such anonymous archival material could be disposed of, used for teaching, used for research, (...) or remain in storage. We argue that there are no ethical grounds for disposing of the material, or for storing it in the absence of a teaching or research rationale. Nevertheless, with stringent safeguards, it can be used even in the absence of consent in research and teaching. Regulations are required to control the storage of all such human material, along the lines of regulations governing anatomy body bequests. (shrink)

The point of education is to support students to be able to live meaningful, autonomous lives, filled with rich experiences. The arts and aesthetic education are vital to such flourishing lives in that they afford bold, beautiful, moving experiences of awe, wonder and the sublime that are connected to the central human functional capability Nussbaum labels senses, imagination and thought. Everyone ought to have the opportunity to learn about art, to appreciate and create art, to critique art and to understand (...) how we are connected to the culture of our society. A life without art is unimaginable, and to the extent that people lack aesthetic experiences, their lives are impoverished, not ‘fully human’. Given that the distinctive value of art objects is that they afford aesthetic experience, it is upon this foundation that an argument ought to be mounted as to why schooling needs the arts, specialised teachers, and all students deserve aesthetic education. Therefore, in this paper, I offer a defence of compulsory aesthetic education across the curriculum on the basis of the aesthetic experiences the arts afford, and the central role such experiences play in eudaimonia—the flourishing life. (shrink)

We investigate the semantics of the logical systems obtained by introducing the modalities and into the family of substructural implication logics (including relevant, linear and intuitionistic implication). Then, in the spirit of the LDS (Labelled Deductive Systems) methodology, we "import" this semantics into the classical proof system KE. This leads to the formulation of a uniform labelled refutation system for the new logics which is a natural extension of a system for substructural implication developed by the first two authors in (...) a previous paper. (shrink)

"Some patients find it difficult to be in the present because they are stuck in the past; others, by contrast, struggle to remain connected with the past and are suspended in a so-called present that is effectively atemporal, that is out of time”.1 For psychoanalysts, the most profound and ultimately ethical way that we can help individuals, is by helping them know themselves. This involves discovering how they were shaped by their past and how their ongoing self-experience cannot be understood (...) in isolation from its constitutive contexts. Psychoanalysts help patients explore foundational questions such as: ‘Who am I?’ ‘How did I get here?’ ‘How am I implicated in my own suffering?’ ‘How can I grow and flourish and truly engage with my life?’. The answers to these questions emerge from a detailed exploration of the persons lived relational history, their current social and relational context and the political systems within which they are embedded. It is via this expansion of self-awareness that individuals can access agency and true freedom of choice. The clinical approach presented by Notini et al 2 is grounded in a completely different, radically decontextualised understanding of human experience. Their conceptualisation of Phoenix’s gender identity is ahistorical and atemporal: it is indeed ‘out of time’. For these authors, gender identity is assumed to be an immutable core essence, much like Ehrensaft’s3 ‘true gender self….there from birth’. It simply ‘is’. This is a …. (shrink)

Nos tempos modernos, a doutrina do direito natural tem sido negada por muitos autores. Não foi assim entre os medievais e entre os antigos. Tomás de Aquino, em diversas partes de sua obra, trata do tema e mostra como a própria racionalidade do homem o leva a descobrir algo que está insito no mais intimo de sua natureza.