Chemotherapy is an important therapeutic approach for cancer treatment. However, drug resistance is an obstacle that often impairs the successful use of chemotherapies. Therefore, overcoming drug resistance would lead to better therapeutic outcomes for cancer patients. Recently, studies by our own and other groups have demonstrated that there is an intimate correlation between the loss of the F‐box and WD repeat domain‐containing 7 (FBW7) tumor suppressor and the incurring drug resistance. While loss of FBW7 sensitizes cancer cells to certain drugs, (...) FBW7‐/‐ cells are more resistant to other types of chemotherapies. FBW7 exerts its tumor suppressor function by promoting the degradation of various oncoproteins that regulate many cellular processes, including cell cycle progression, cellular metabolism, differentiation, and apoptosis. Since loss of the FBW7 tumor suppressor is linked to drug resistance, FBW7 may represent a novel therapeutic target to increase drug sensitivity of cancer cells to conventional chemotherapeutics. This paper thus focuses on the new functional aspects of FBW7 in drug resistance. (shrink)

We study the notion of polynomial-time relation reducibility among computable equivalence relations. We identify some benchmark equivalence relations and show that the reducibility hierarchy has a rich structure. Specifically, we embed the partial order of all polynomial-time computable sets into the polynomial-time relation reducibility hierarchy between two benchmark equivalence relations Eλ and id. In addition, we consider equivalence relations with finitely many nontrivial equivalence classes and those whose equivalence classes are all finite.

We define some variations of the Scott rank for countable models and obtain some inequalities involving the ranks. For mono-unary algebras we prove that the game rank of any subtree does not exceed the game rank of the whole model. However, similar questions about linear orders remain unresolved.

How individuals reason deductively has concerned researchers for many years. Yet, it is still unclear whether, and if so how, participants’ reasoning performance changes over time. In two test sessions one week apart, we examined how the syllogistic reasoning performance of 100 participants changed within and between sessions. Participants’ reasoning performance increased during the first session. A week later, they started off at the same level of reasoning performance but did not further improve. The reported performance gains were only found (...) for logically valid, but not for invalid syllogisms indicating a bias against responding that ‘no valid conclusion’ follows from the premises. Importantly, we demonstrate that participants substantially varied in the strength of the temporal performance changes and explored how individual characteristics, such as participants’ personality and cognitive ability, relate to these interindividual differences. Together, our findings contradict common assumptions that reasoning performance only reflects a stable inherent ability. (shrink)

In the midst of the coronavirus (COVID-19) pandemic, new unexpected and extraordinary scenes and sounds of aesthetical biblical and apocalyptic proportions are witnessed. Community and religious gatherings in public spaces are prohibited. Modern, conventional and traditional human achievements have become futile. One can describe the COVID-19 pandemic, and this new search for meaning as a juxtaposed tension of metaphorical apocalyptic vistas and metaphorical biblical vistas. The Bible holds the same juxtaposed tension which may help humanity to rediscover the semantics of (...) biblical truth and hope – but it also espouses a metaphorical liberational vista of transcendence. Coronavirus could be a metaphor for something with extraordinary new possibilities. The biblical metaphors are being amplified in different metaphorical vistas to make it more discerning or accessible to the world population today. As a metaphorical liberation vista, it may offer new hope for a new kind of living, a new kind of humanity, a new kind of knowing and believing and a new kind of world order.Contribution: This article offers a Practical Theological contribution to the significance of the Bible within the COVID-19 pandemic context. Human suffering and divine metaphorical vistas encapsulate prospects for truth, hope and new meaning for the liberation of humanity. (shrink)

The ecological crisis in the world necessitates the reconfiguration of the hegemony of modern science, theology, politics, economics and technology – the root cause of a pending ecological catastrophe. The aim is to redress a growing culture of apathy in the context of devastating weather conditions, social and political discord, and unrelenting violent wars. Public theology serves as a conceptual framework with transversal rationality as an interlocutor between the different theological (systematic, ethics, pastoral care and eco-theology), religious and philosophical perspectives. (...) The theological ontology of care is presented followed by the role of communities of critical prophetic discourse. The notion of earth as a community leads to the prospect of a new eco-theology. Finally, the pending ecological catastrophe is reconceptualised in and through Christian eschatology. This is an inter- and intra-disciplinary discussion on the disastrous consequences of modernity and anthropocentric behaviour in terms of the current environmental crisis. Various scholars offer valuable insights into what the problem is, who responsible is for the environmental crisis, and how Christian communities should forge an accountability of care for the earth and vulnerable human beings. The eschatological reality of God’s preferred future remains a constant of hopeful and sustainable life in the Anthropocene age. It is recommended that we change the way we exist by transforming modernity as developed and sustained through theology, socio-political, economic and technological ‘advances’. Contribution: This article focussed on the ecological crisis because of anthropocentrism and distorted theological, political and socio-economic paradigms to serve human interests despite the consequences for the earth. We need to reconfigure interdisciplinary and intradisciplinary scientific approaches to embrace earth as a key scientific interlocutor. The ecological crisis should be conceptualised within the reality of Christian eschatology – Jesus Christ is ultimately, the eschaton. (shrink)

One of the most common contemporary approaches for developing an ethics of artificial intelligence (AI) involves elaborating guiding principles. This essay explores the limitations of this approach, using the history of bioethics as a comparative case. The examples of bioethics and recent AI ethics suggest that principles are difficult to implement in everyday practice, fail to direct individual action, and can frequently result in a pure proceduralism. The essay encourages an additional attention to virtue, which forms the dispositions of actors, (...) directs them to valued ends, and encourages right action in particular situation to complement principles. Practices and professions like medicine or warfighting that already have rich traditions of reflection on virtue ethics will be especially fruitful fields for developing an AI ethics of virtue. (shrink)

Since the inception of the Pastoral Care Movement, the approach to pastoral care has evolved from the traditional shepherd model to a more clinical, client-centred method. This evolution requires a thorough analysis of recent trends and dynamics in pastoral care, especially in relation to key theological theories and the Church’s role in providing support. Today, the landscape of pastoral care covers a range of topics, including ecotheology, global existential crises and the Church’s involvement in addressing these issues. Additionally, this examination (...) reveals conclusions about theological shortcomings and inconsistencies in emphasis within pastoral care.Contribution: This article provides a critical overview of pastoral care in its current form and context, examining its relevance to the existential needs of the postmodern social milieu and its role in the church today. It offers a critical evaluation of pastoral care within contemporary culture. (shrink)

Le mancagne, langue atlantique parlée au Sénégal et en Guinée-Bissau, est une langue SVO à riche morphologie qui comporte un nombre important d’emprunts. La présente étude est basée sur un corpus recueilli sur le terrain entre 2016 et 2018. L’article analyse les procédés d’appropriation des emprunts lexicaux au créole de Bissau par le mancagne. Il décrit, de ce fait, le processus d’appropriation des emprunts qui tournent essentiellement autour des classes nominales. L’intégration se fait alors selon trois grands procédés : (i) (...) lorsque la première syllabe du mot emprunté est semblable à un préfixe, (ii) quand la syllabe initiale identique à un préfixe de classe est remplacée par un authentique préfixe et (iii) le cas où la syllabe initiale ne correspond à aucune classe. (shrink)

This article aims to illustrate how racism could be addressed. Three pedagogies - a dangerous pedagogy as courageous dialogue, a pedagogy of discomfort and a critical pedagogy - are presented as examples to reframe the issue of racism. The contribution of James Cone is applied as a broad descriptive theoretical framework. Cone's views in this article resonate with the history of contemporary racism in South Africa and will therefore be juxtaposed by the contribution of South African theologians. A fourth pedagogy, (...) namely, a pedagogy of freedom and healing, is introduced to address gaps in the first three pedagogies. The objective is to realise freedom or healing between people of different races. (shrink)

The inability of government, communities and churches to deal with complex HIV and AIDS challenges may foster pathological psychosocial and systemic dysfunctionalities. The reframing of pathological and disempowering pastoral therapeutic and health promotion praxes are sought. The objective was to construct a new pastoral and social therapeutic methodology. It should develop in line with health promotion praxes in strengthening both ecclesial and community health praxes. Reframing agents such as pastoral therapeutic and health praxes, as well as ecclesial and community systems, (...) could ultimately engender a transformative process in transforming pathological HIV and AIDS praxes. (shrink)

Laozi zhe xue -- Zhuangzi zhe xue za lun -- Xian Qin zhu zi yan jiu wen xian mu lu.

Di 1 juan. Zhe xue di chuang xin -- di 2 juan. Zhe xue di ao mi -- di 3 juan. Zhe xue si wei fang shi bian ge -- di 4 juan. Chuan tong zhe xue dao xian dai zhe xue -- di 5 juan. Zhe xue ti xi gai ge -- di 6 juan. Zhe xue zai zou xiang wei lai.

This essay introduces this special issue on virtue ethics in relation to military AI. It describes the current situation of military AI ethics as following that of AI ethics in general, caught between consequentialism and deontology. Virtue ethics serves as an alternative that can address some of the weaknesses of these dominant forms of ethics. The essay describes how the articles in the issue exemplify the value of virtue-related approaches for these questions, before ending with thoughts for further research.

Personnage central de la littérature mondiale, prix Nobel 2000, Gao Xingjian est également peintre, dramaturge, chorégraphe, cinéaste et photographe. En quête de l'art total, tel Leonardo, il développe avec une infinie rigueur la théorie de l'engagement du créateur dans le réel au delà de toute ingérence politique. Avec quelques-unes des grandes figures de la culture internationale il engage le débat sur l'éthique et l'esthétique au cours d'un mémorable colloque organisé à Marseille dans le cadre surréel d'une incroyable Année Gao. Tous (...) les textes de cet ouvrage de référence sont des jalons précieux pour qui veut discerner les grandes alternatives de l'histoire de l'art au croisement des siècles et des millénaires de l'histoire des hommes. (shrink)

The three‐dimensional architecture of the bacterial chromosome is intertwined with genome processes such as transcription and replication. Conspicuously so, that the structure of the chromosome permits accurate prediction of active genome processes. Although appreciation of this interplay has developed rapidly in the past two decades, our understanding of this subject is still in its infancy, with research primarily focusing on how the process of transcription regulates and is regulated by chromosome structure. Here, we summarize the latest developments in the field (...) with a focus on the interplay between chromosome structure and transcription in Escherichia coli (E. coli) as mediated by H‐NS—a model nucleoid structuring protein. We describe how the organization of chromosomes at the global and local scales is dependent on transcription, and how transcription is regulated by chromosome structure. Finally, we take note of studies that highlight our limited knowledge of structure‐function relationships in the chromosome, and we point out research tracks that will improve our insight in the topic. (shrink)

After 100+ years of studying syllogistic reasoning, what have we learned? Well, Riesterer and colleagues suggest that we have learned to throw away most of the data! If that seems like a bad idea to you then, be assured, that the authors agree with you. The sad fact is that the conclusion of “No Valid Conclusion” (NVC) is one of the most frequently selected responses in syllogistic reasoning but these “majority data” have been ignored by most researchers. Riesterer and colleagues (...) introduce heuristic rules for predicting NVC and provide directions to modelers on how to up their game. (shrink)

Estas páginas reúnen una serie de escritos personales, testimoniales o autobiográficos del filósofo, traductor, escritor y profesor José Gaos, uno de los pensadores de la lengua española más importantes e influyentes del siglo xx. Nace el presente libro de la necesidad práctica de tener un conjunto de textos suyos que contribuyan a dibujar su enérgico y rico perfil intelectual, filosófico y literario; y a la de explicar en cierto modo la fecundidad de la reflexión crítica diseminada en el orbe de (...) la lengua española, de la cual él mismo es en parte responsable, gracias a su misión y vocación intelectuales. El libro se abre con una introducción de Adolfo Castañón, académico de número de la Real Academia Mexicana de la Lengua, poeta, ensayista, editor, crítico literario y bibliófilo. En 2009 fue ganador del Premio Xavier Villaurrutia de 2008, máximo galardón para las letras mexicanas, por Viaje a México. Ensayos, crónicas y retratos, publicado por Iberoamericana Vervuert. El colofón corre a cargo de Ángeles Gaos de Camacho, quien evoca la imagen de su padre, en un emotivo monólogo. (shrink)

According to doxastic pragmatism, certain perceived practical factors, such as high stakes and urgency, have systematic effects on normal subjects’ outright beliefs. Upholders of doxastic pragmatism have so far endorsed a particular version of this view, which we may call threshold pragmatism. This view holds that the sensitivity of belief to the relevant practical factors is due to a corresponding sensitivity of the threshold on the degree of credence necessary for outright belief. According to an alternative but yet unrecognised version (...) of doxastic pragmatism, practical factors affect credence rather than the threshold on credence. Let’s call this alternative view credal pragmatism. In this paper, I argue that credal pragmatism is more plausible than threshold pragmatism. I show that the former view better accommodates a cluster of intuitive and empirical data. I conclude by considering the issue of whether our doxastic attitudes’ sensitivity to practical factors can be considered rational, and if yes, in what sense. (shrink)

According to evidentialist views, credence in a proposition p should be proportional to the degree of evidential support that one has in favor of p. However, empirical evidence suggests that our credences are systematically sensitive to practical factors. In this article, I provide a cost–benefit analysis of credences' practical sensitivity. The upshot of this analysis is that credences sensitive to practical factors fare better than practically insensitive ones along several dimensions. All things considered, our credences should be sensitive to practical (...) factors. (shrink)

Prior research on sustainability in business often assumes that decisions on social and environmental investments are made for instrumental reasons, which points to causal relationships between corporate financial performance and corporate social and environmental commitment. In other words, social or environmental commitment should predict higher financial performance. The theoretical premise of sustainability, however, is based on a systems perspective, which implies a tighter integration between corporate financial performance and corporate commitment to social and environmental issues. In this paper, we describe (...) the important theoretical differences between an instrumental and integrative logic in managing business sustainability. We test the presence of each logic using data from 738 firms over 13 years and find evidence of integrative logic applied in business. (shrink)

Background: The use of race as a category in medical research is the focus of an intense debate, complicated by the inconsistency of presumed independent variables, race and ethnicity, on which analysis depends. Interpretation is made difficult by inconsistent methods for determining the race or ethnicity of a participant. The failure to specify how race or ethnicity was determined is common in the published literature.Hypothesis: Criteria by which they assign a research participant to racial or ethnic categories are not reported (...) by published articles.Methods: Methods were reviewed for assigning race and ethnicity of research participants in 268 published reports reporting associations among race , health outcome and genotype.Results: Of the 268 published reports reviewed, it was found that 192 did not explain their methods for assigning race or ethnicity as an independent variable. This was despite the fact that 180 of those reports reached conclusions about associations among genetics, health outcome and race or ethnicity.Conclusions: More attention needs to be given to the definition of race and ethnicity in genetic studies, especially in those diseases where health disparities are known to exist. (shrink)

It has been argued recently that knowledge is the norm of practical reasoning. This norm can be formulated as a bi-conditional: it is appropriate to treat p as a reason for acting if and only if you know that p. Other proposals replace knowledge with warranted or justified belief. This paper gives counter-examples of both directions of any such bi-conditional. To the left-to-right direction: scientists can appropriately treat as reasons for action propositions of a theory they believe to be false (...) but good approximations to the truth for present purposes. Cases based on a variant of Pascal’s Wager and actions performed by a skeptic also illustrate the point. To the right-to-left direction: in certain circumstances, it can be unreasonable for a scientist to reason from propositions of a theory she knows to be true. (shrink)

One challenge for moderate invariantists is to explain why we tend to deny knowledge to subjects in high stakes when the target propositions seem to be inappropriate premises for practical reasoning. According to an account suggested by Williamson, our intuitive judgments are erroneous due to an alleged failure to acknowledge the distinction between first-order and higher-order knowledge: the high-stakes subject lacks the latter but possesses the former. In this paper, I provide three objections to Williamson’s account: i) his account delivers (...) counterintuitive verdicts about what it is appropriate for a high-stakes subject to do; ii) the high-stakes subject doesn’t need iterated knowledge in order to be regarded as appropriately relying on the relevant proposition in practical reasoning; iii) Williamson’s account doesn’t provide a good explanation of why the high-stakes subject would be blameworthy if she were relying on the relevant proposition in her practical reasoning. (shrink)

Quantum mechanics and experience -- The wave function: ontic vs epistemic -- The nomological view -- Reality of the wave function -- Origin of the Schrödinger equation -- The ontology of quantum mechanics (I) -- The ontology of quantum mechanics (II) -- Implications for solving the measurement problem -- Quantum ontology and relativity.

According to pragmatic encroachment, whether an epistemic attitude towards p has some positive epistemic status (e.g., whether a belief is epistemically rational or justified, or it amounts to knowledge) partially depends on practical factors such as the costs of being wrong or the practical goals of the agent. Pragmatic encroachment comes in many varieties. This survey article provides an overview of different kinds of pragmatic encroachment. It focuses on three dimensions under which kinds of pragmatic encroachment differ: the type of (...) epistemic status affected by practical factors, the type of practical factors affecting the epistemic status, and the type of normative considerations encroaching on the epistemic status. (shrink)

It has been suggested that a reporting channel administered by a third-party may represent a stronger procedural safeguard of anonymity and avoids the appearance of impropriety. This study examines whistleblowing intentions among lower-tier employees, specifically examines whether an externally-administered reporting channel increases whistleblowing intentions compared to an internally-administered one. In contrast to the findings of an earlier study by Kaplan et al. :273–288, 2009), our results suggest that whistle-blowing intentions are higher when the reporting channel is administered externally than when (...) it is administered internally. We also find that an externally-administered reporting channel mitigates the negative effect of bystanders on whistleblowing intentions. Implications are discussed. (shrink)