The study of the mammalian immune system offers many advantages to systems biologists. The cellular components of the mammalian immune system are experimentally tractable; they can be isolated or differentiated from in vivo and ex vivo sources and have an essential role in health and disease. For these reasons, the major effectors cells of the innate immune system, macrophages, have been a particular focus in international genome and transcriptome consortia. Genomescale analysis of the transcriptome, and transcription initiation has enabled the (...) construction of predictive models of transcription control in macrophages that identify the points of control (the major nodes of networks) and the ways in which they interact. (shrink)

ABSTRACT A belief is correct if and only if the believed proposition is true. Some philosophers argued that from this standard of correctness it is possible to derive the statement of a norm, a claim about what a subject ought to do. Many formulations of the standard in terms of an ‘ought’-claim have been suggested, but all resulted affected by some problem. My aim in this article is to suggest a new formulation of the standard in ‘ought’-terms based on an (...) analysis of the relations occurring between the notions of correctness and ‘ought’. My suggested formulation is that, for any subject S and proposition p, according to the standard of correctness, given that S believes that p, it ought to be that p. (shrink)

Davide Serpico describes his research at the Special Collection dedicated to the distinguished population geneticist John R. G. Turner at the University of Leeds’ Library.

This paper recognizes a specific correspondence between biological evolution and technological development and on this basis tries to set up a semioticapproach to the evolutionary phenomenon of exaptation. To do this, the existence of a historical-structural and pragmatic analogy between organs and tools is shown, which in turn implies on a communicative ground the dissolution of some of their traditional distinctive att ributes. Finally, a philosophical-analytical approach to natural and cultural functions is applied to define three types of exaptations.

Objectivism is the view that how an agent ought to act depends on all kinds of facts, regardless of the agent’s epistemic position with respect to them. One of the most important challenges to this view is constituted by certain cases involving specific conditions of uncertainty—so-called three-options cases. In these cases it seems overwhelmingly plausible that an agent ought to do what is recommendable given her limited perspective, even though the agent knows that this is not objectively the best course (...) of action. The standard objectivist response to this challenge relies on a distinction between what one ought to do and what would be blameworthy or unreasonable to do. This response is affected by several problems. In this paper I introduce and defend an alternative objectivist response to the challenge. My proposal admits that in the relevant cases the agent ought to do what is recommendable given her perspective, but maintains that this diagnosis of the cases is fully compatible with objectivism. I argue that this proposal has several advantages over alternative accounts of the cases. (shrink)

Aim of the present paper is to provide a formal characterization of various different notions of responsibility within groups of agents (Who did that? Who gets the blame? Who is accountable for that? etc.). To pursue this aim, the papers proposes an organic analysis of organized collective agency by tackling the issues of organizational structure, role enactment, organizational activities, task-division and task-allocation. The result consists in a semantic framework based on dynamic logic in which all these concepts can be represented (...) and in which various notions of responsibility find a formalization. The background motivation of the work consists in those responsibility-related issues which are of particular interest for the theory and development of multi-agent systems. (shrink)

Since the nineteenth and twentieth century, information has been pivotal both in the cultural tradition and then in the economic tradition. While the Fordism economic model and its specialisation requirements originated a simplistic zoning and single-use development approach to the design of a city. It, however, determined a fragmented growth of cities. Inevitably, the zoning as an urban strategy affected the architectural scale. Nevertheless, the idea of information, commercial goods and thereby people freely able to flow through the city allowed (...) architects and urban designer to conceive new types of urban infrastructures. For example, trains, which were designed on the model of urban “arteries and veins.” Over time, the persistence of urban and architectural segmentation has strengthened social and economic inequalities among urban society. In addition, information has played a more vital role in this strengthening process. The technological achievements of the twenty-first century such as information technologies have significantly affected cities. The new informational patterns have provided new ways of designing, and in turn how societies experience cities. These “quantified cities” consist of digital data that dynamically interacts with “quantified human beings.” Consequently, a renewed urban semiotics is established, which is built around an alternate sociological comprehension. Is this new urban semiotics able to heal an ill and divided urban body? The paper will investigate a new concept of “quantified city” based on the notion of “Hyper-Reality,” and its inhabitants who are entering in a “post-human” condition while living in a dynamic urban environment. In particular, the critical analysis will be used as a “tool” for redefining the perception of the city through inhabitants’ relational patterns which are technologically mediated. The more traditional notion of urbanisation is questioned with a focus on how the an urban society is embedded within the digital condition and the notion of a city. (shrink)

Volume 24, Issue 8, August 2024, Page 60-62.

Peano's axiomatizations of geometry are abstract and non-intuitive in character, whereas Peano stresses his appeal to concrete spatial intuition in the choice of the axioms. This poses the problem of understanding the interrelationship between abstraction and intuition in his geometrical works. In this article I argue that axiomatization is, for Peano, a methodology to restructure geometry and isolate its organizing principles. The restructuring produces a more abstract presentation of geometry, which does not contradict its intuitive content but only puts it (...) into a particular form. (shrink)

This paper aims to perform a multi-level analysis of the Irish public discourse on Covid-19. Despite widespread agreement that Ireland’s response was rapid and effective, the country’s journey through the pandemic has been no easy ride. In order to contain the virus, the Government’s emergency legislation imposed draconian measures including the detention and isolation of people deemed to be even “a potential source of infection” and a significant extension of An Garda Síochána’s power of arrest. In April 2020, journalists John (...) Waters and Gemma O’Doherty initiated judicial review proceedings before the High Court to challenge such legislation, which they defined as unconstitutional, “disproportionate” and based on “fraudulent science”. The proceedings attracted widespread media coverage in what soon became a debate on the legitimacy of emergency legislation and the notion of ‘fake news’ itself. After a brief survey of the legislative background to Ireland’s Covid response, the argumentative strategy is analysed through which the High Court eventually dismissed Mr Waters and Ms O’Doherty’s challenge. Focusing on the process of justification of the judicial decision, the paper provides a descriptive account of the argument structure of the Court’s decision. This sheds light on the pattern of multiple argumentation through which the Court interpreted relevant norms in the Constitution and at once re-established the primacy of “facts” informing political decision-making at a time of national emergency. (shrink)

Individuals sit on the board of directors and set organizational goals, individuals make the product, push new marketing campaigns, make tough decisions, create new products, and so on. What is the role of social responsibility (SR) in their thinking? Do individuals need to behave responsibly to live in a social environment? Could this be grounded in their cognition? Furthermore, is there room for SR in our cognitive processes? And then, how can this analysis help studies on socially responsible business? The (...) article presents how the distributed cognition approach provides a viable explanation for SR in human thinking. The exploitation of external – both social and nonsocial – resources shapes cognitive processes such that the idea of the “isolated brain” is definitely abandoned. Our social cognition uses responsibility as a support mechanism that sustains or discharges distributive processes. The article uses the notion of docility to keep cognition and social behavior together. The conclusion is that SR is (1) a mechanism that allows individuals to maintain cognitive advantages and (2) it emerges when the same social channel is exploited for extended periods of time. (shrink)

Selon une thèse populaire en épistémologie contemporaine, une croyance est justifiée si, et seulement si, elle est une connaissance. Les défenseurs de cette thèse soutiennent également que la connaissance est la norme fondamentale de la croyance et que la conformité à cette norme est à la fois nécessaire et suffisante pour la justification. Je conteste l’affirmation selon laquelle la simple conformité à une norme suffit à justifier une croyance. La justification exige la conformité pour des raisons suffisantes et «invaincues» (undefeated). (...) Une conséquence de ceci est le rejet de la thèse selon laquelle la conformité à la norme de la croyance est nécessaire et suffisante pour la justification épistémique. (shrink)

In Normative Reasons: Between Reasoning and Explanation (2022), Arturs Logins provides a novel reductivist account of normative reasons, what he calls the Erotetic View of Reasons. In this paper, I provide three challenges to this view. The first two concern the extensional adequacy of the Erotetic View. The view may fail to count as normative reasons all and only considerations that are such. In particular, the view seems to both overgenerate and undergenerate reasons. My third concern is that the view (...) may fail to capture the essential, practice-independent nature of reasons, as well as reasons’ constitutive and grounding role with respect to other normative properties. (shrink)

The paper develops an interface between syntax-based logical models of awareness and dynamic epistemic logic. The framework is shown to be able to accommodate a variety of notions of awareness and knowledge, as well as their dynamics. This, it is argued, offers a natural formal environment for the analysis of epistemic phenomena typical of multi-agent information exchange, such as how agents become aware of relevant details, how they perform inferences and how they share their information within a group. Technically, the (...) logics presented are all simple refinements of the logic of public announcements. (shrink)

This paper will critically assess Popper’s evolutionary philosophy. There exists a rich literature on the topic with which we have many reservations. We believe that Popper’s evolutionary philosophy should be assessed in light of the intriguing theoretical insights offered, during the last 10 years or so, by the philosophy of biology, evolutionary biology and molecular biology. We will argue that, when analysed in this manner, Popper’s ideas concerning the nature of selection, Lamarckism and the theoretical limits of neo-Darwinism can be (...) appreciated in their full biological and philosophical value. (shrink)

This article describes the creation of a lightweight ontology of European Union (EU) criminal procedural rights in judicial cooperation. The ontology is intended to help legal practitioners understand the precise contextual meaning of terms as well as helping to inform the creation of a rule ontology of criminal procedural rights in judicial cooperation. In particular, we started from the problem that directives sometimes do not contain articles dedicated to definitions. This issue provided us with an opportunity to explore a phenomenon (...) typically neglected in the construction of domain-specific legal ontologies. Whether classical definitions are present or absent, laws and legal sources in general are typically peppered with a number of hidden definitions (in the sense that they are not clearly marked out as such) as well as incomplete definitions, which may nevertheless help legal practitioners (and legal reasoning systems) to reason on the basis of analogy or teleology. In this article we describe the theoretical basis for building an analogical lightweight ontology in the framework of an EU project called _CrossJustice_. We present our methodology for collecting the data, extracting the data fields and creating the ontology with WebProtégé, followed by our conclusions and ideas for future work. (shrink)

Certain mathematical problems prove very hard to solve because some of their intuitive features have not been assimilated or cannot be assimilated by the available mathematical resources. This state of affairs triggers an interesting dynamic whereby the introduction of novel conceptual resources converts the intuitive features into further mathematical determinations in light of which a solution to the original problem is made accessible. I illustrate this phenomenon through a study of Bertrand’s paradox.

Institutions are committed to a constant work aimed at classifying cultural heritages, in order to preserve selected objects from decay or disappearing. In this domain of policy, a significant role is played by architecture and by the preservation of the architectural heritage of cities. How is it possible, however, to determine the value in the field of architectural heritages? What are the criteria for evaluation and the degree of objectivity these classifications are based upon? Is architectural worth immanent to objects (...) or does it reside outside them? These are fundamental questions for the science of preservation and the legislation on cultural heritages. By closely examining a controversial case occurred in the European Union, e.g. England, the paper tackles analytically some of these issues, and it exploits also concepts borrowed from social ontology and ontology of art. (shrink)

When a law court makes a decision based on the individual deliberation of each judge, a case of judgment aggregation occurs. The possibility that the aggregation's outcome be logically inconsistent, even though it is based on consistent individual judgments, arises relatively easily and has been the subject of several investigations. In this paper I show that this paradoxical behaviour is the effect of decision procedures that are unable to discriminate between logically consistent and logically inconsistent individual judgments. The paradoxes can (...) be resolved by selecting procedures that are not affected by this limitation. (shrink)

The contemporary discussion on the subjective character of conscious experience is characterized by a stark contrast between higher-order intentionalism, according to which any state of awareness depends on the instantiation of intentional properties by mental states, and anti-intentionalism, according to which the inner awareness constitutive of subjective experience is fundamentally different from ordinary instances of external or introspective awareness, in that one’s experience is not given to the subject as an ordinary intentional object. The purpose of this paper is to (...) outline the most fundamental dimensions of variation among the different kinds of higher-order theories and to show, by providing a comprehensive analysis of the logical space available, that these seemingly incompatible views can be reconciled within an intentionalist framework. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:diacritics 30.2 (2000) 113-126 [Access article in PDF] Dissenting Words:A Conversation with Jacques Rancière 1 Davide Panagia:In your writings you highlight the political efficacy of words. In The Names of History, for instance, this emphasis is discussed most vividly in terms of what you refer to as an "excess of words" that marks the rise of democratic movements in the seventeenth century. Similarly, in On The Shores of (...) Politics, you begin your discussion with an excursus on the end of politics as the end of the promise. Finally, in Dis-agreement you speak of "the part of those who have no-part" as voicing a "wrong" for the sake of equality.In each of these instances, however, your treatment of words (and language more generally) is very different from those thinkers of the "linguistic turn" in political philosophy who expound on an ethics of deliberation as the first virtue of modern democracies. For that matter, your approach is quite different from those thinkers who focus on the aporias of language as such.Could you discuss this thematic of the proliferation of words in your thinking about democratic politics?Would it be fair to characterize your research on and exposition of democratic thinking as a "poetics of politics"?Rancière's Reply:In order to address your question adequately, it would be wise to enlarge the sense of "linguistic turn" you invoke. In its most generally accepted sense, the linguistic turn in philosophy consists in ascribing to linguistic processes certain phenomena and specifiable modes of relating objects attributed, in a previous instance, either to factual processes or lines of thought. This approach is not limited to the two figures you invoke in your question. The linguistic turn also has two stages of development that, from my experience, have been more noticeable in France than in the United States. The first phase, then, emerged with Lévi-Strauss and his structural approach to social relations founded on a linguistic model of relationality, subsequently reprised in Lacan's psychoanalytic notion that "the unconscious is structured like a language" that, in its turn, conjoins the energetic mental processes Freud discusses to linguistic practices. The primacy of "the linguistic" thus granted language all the properties of the Freudian unconscious [End Page 113] along with those of a Marxist notion of infrastructure. The Saussurian opposition between langue and parole provided a privileged status to a linguistic model whose role was that of a general law that unconsciously structures the behavior of individuals and societies. It is on the basis of these parameters that the structuralist moment of the linguistic turn was constituted. At one and the same time, the analysis of speech acts became first and foremost a "symptomatic" analysis of those procedures of misrecognition that linguistically structured both the behavior of individuals and social relations. When we "read" Le Capital with Althusser, the interpretive and methodological schema for linguistic phenomena operated like a kind of "policing of the enunciated": that is, a search for those unsuccessful (i.e., inadequate) modes of expression that exemplify such symptomatic procedures of misrecognition.The second phase of the linguistic turn constituted itself more ambiguously. For those who shared intellectual experiences similar to my own, this version involved a critique of the langue/infrastructure model; that is, a further and more favorable consideration of the value of the political and the linguistic games therein that, according to the Althusserian/Marxist model (and, indeed, with structuralism more generally), were to be treated as ideological artifacts. In a very real sense, it all began with the May '68 assertion that "we are all German Jews"--an entirely ideological statement, the validity of which, if analyzed at the level of its content, one finds to rest entirely on the capacity to overturn the political relationship between the order of designations and that of events by emphasizing the gap that separates subject and predicate. From there, an entire field of understanding speech acts as political gestures opened up: a field that reconfigured the division between words and things while rearranging the distinction between legitimate... (shrink)

The overall objective of this dissertation is to provide an analysis of the standard of correctness of belief. According to this standard, a belief is correct if and only if the believed proposition is true. My analysis consists in the investigation of a set of aspects and properties of the correctness standard of belief. The main point argued in this dissertation is that the correctness standard of belief is a standard of conformity to the satisfaction conditions of a representational function (...) constitutive of belief. Another relevant conclusionreached in my dissertation concerns the appropriate formulation of the standard in an ought-claim. I argued that the proper way of formulating the standard in an ought-claim is: "for any S, p: it ought to be the case that p, given that S believes that p". (shrink)

In the mid fourth century b.c. some Roman gentes drew on a Pythagorean tradition. In this tradition, Numa's role of Pythagoras’ disciple connected Rome with Greek elites and culture. The Marcii, between 304 and 300 b.c., used Numa's figure, recently reshaped by the Aemilii and the Pinarii for their propaganda, to promote the need for a plebeian pontificate. After the approval of the Ogulnium plebiscite, the needs for this kind of propaganda fell away. When Marcius Censorinus became censor, Numa's pontificate (...) was no longer relevant for promoting the gens. For this reason, the Marcii used another genealogy for similar propagandistic effect: the figure of Marsyas, a symbol of plebeian ideals. (shrink)

Cet article a déjà paru dans Maria do Carmo Ribeiro & Arnaldo Sousa Mello, Evolucão da paisagem urbana cidade e periferia, Braga, Centro de Investigação Transdisciplinar « Cultura, Espaço e Memória » – Instituto de Estudos Medievais – Universidade Nova de Lisboa, 2014, pp.175-204. Il est disponible en ligne sur la base des Archives ouvertes. Nous remercions Hélène Noizet et Davide Gherdevich de nous avoir autorisé à le republier ici. Comme la plupart des villes, Paris connaît une dynamique - (...) Géographie – Nouvel article. (shrink)

In _Rancière’s Sentiments _Davide Panagia explores Jacques Rancière’s aesthetics of politics as it informs his radical democratic theory of participation. Attending to diverse practices of everyday living and doing—of form, style, and scenography—in Rancière’s writings, Panagia characterizes Rancière as a sentimental thinker for whom the aesthetic is indistinguishable from the political. Rather than providing prescriptions for political judgment and action, Rancière focuses on how sensibilities and perceptions constitute dynamic relations between persons and the worlds they create. Panagia traces this approach (...) by examining Rancière’s modernist sensibilities, his theory of radical mediation, the influence of Gustave Flaubert on Rancière’s literary voice, and how Rancière juxtaposes seemingly incompatible objects and phenomena to create moments of sensorial disorientation. The power of Rancière’s work, Panagia demonstrates, lies in its ability to leave readers with a disjunctive sensibility of the world and what political thinking is and can be. (shrink)

Prologue : narratocracy and the contours of political life -- From nomos to nomad : Kant, Deleuze, and Rancière on sensation -- The piazza, the edicola, and the noise of the utterance -- Machiavelli's theory of sensation and Florence's vita festiva -- The viewing subject : Caravaggio, Bacon, and the ring -- "You're eating too fast!" slow food's ethos of convivium -- Epilogue : "the photographs tell it all" : on an ethics of appearance.

An increasingly popular view in contemporary epistemology holds that the most fundamental norm governing belief is knowledge. According to this norm one shouldn’t believe what one doesn’t know. A prominent argument for the knowledge norm appeals to the claim that knowledge is the most general condition of epistemic assessment of belief, one entailing all other conditions under which we epistemically assess beliefs. This norm would provide an easy and straightforward explanation of why we assess beliefs along all these various epistemic (...) dimensions. This article argues that this line of argument is ultimately unsuccessful. I show that the main premise of the argument actually supports the opposite conclusion: the norm of belief requires a condition weaker than knowledge. Furthermore, I argue that if we hold on to the assumption that knowledge is the most general condition of belief’s epistemic assessment, the fundamental norm of belief is factive: one is not permitted to believe a proposition p if it is not true that p. (shrink)

In this paper we show that axiomatic extensions of H. Wansing’s connexive logic $$\textsf{C}$$ ( $$\textsf{C}^{\perp }$$ ) are algebraizable (in the sense of J.W. Blok and D. Pigozzi) with respect to sub-varieties of $$\textsf{C}$$ ( $$\textsf{C}^{\perp }$$ )-algebras. We develop the structure theory of $$\textsf{C}$$ ( $$\textsf{C}^{\perp }$$ )-algebras, and we prove their representability in terms of twist-like constructions over implicative lattices (Heyting algebras). As a consequence, we further clarify the relationship between the aforementioned classes. Finally, taking advantage of (...) the above machinery, we provide some preliminary remarks on the lattice of axiomatic extensions of $$\textsf{C}$$ ( $$\textsf{C}^{\perp }$$ ) as well as on some properties of their equivalent algebraic semantics. (shrink)