Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Corporate ethical values (CEVs) can be viewed outside the realm of organizational training, standard operating procedures, reward and punishment systems, formal statements, and as more representative of the real nature of the organization (Organ, 1988). Past researchers have empirically demonstrated the direct influence of CEVs on job performance. This study argues that employees' perception of organizational fairness will create perceptual distortion of CEVs. The results of the study indicate that perceived fairness moderates the influence of CEVs on two seminal outcomes, (...) namely, job performance and commitment. The study offers prescriptive and descriptive insights to both academe and industry to understand the influence of CEVs and fairness on the performance outcomes of employees. (shrink)

Extant research indicates a positive and significant relationship between corporate ethical values and employees’ job performance. Furthermore, past studies have empirically demonstrated that perceived fairness moderates the influence of corporate ethical values on employee performance. In other words, high congruity between employees’ and an organization’s ethical values will result in superior employee performance outcome. This research aims to develop a broader perspective on the complex relationship between CEV and employee outcomes. The article will first examine the direct influence of CEV (...) on organizational citizenship behaviors and alienation from work, and then the moderating role of perceived fairness. The researcher found a significant direct effect of CEV on both OCBs and AFW, but that perceived fairness does not moderate these relationships. A key implication of findings of this research is that although perception of fairness may suppress the impact of organizational ethical transgressions on employee performance in the short run, as earlier studies have demonstrated, but in the long term, implications of perceived fairness are multifold. (shrink)

Religion is an important cultural and individual difference variable. Yet, despite its obvious importance in consumers’ lives, religion in the United States has been under-researched. This study addresses that gap in the literature and investigates the influence of consumer religion in the buyer–seller dyad. Specifically, this study examines the influence of consumer religious commitment and a Christian consumer’s conservative beliefs in the United States on store loyalty when retailers make business decisions which are potentially reli- gious objectionable. This study uses (...) structural equation modeling and applies Anderson and Gerbing’s :411–423, 1988 ) two-step approach to exam- ine data obtained from a national sample of 531 consumers. The results from this study suggest that consumers evaluate seller’s actions and form ethical judgments. These judgments are a major explanatory variable in consumer store loyalty intentions. (shrink)

While many models of ethical decision-making in marketing have been presented in the literature, no recent attempts have been made to explicitly account for ethical decision-making from a marketing research perspective. We present an ethical framework for marketing research, the various philosophies of ethics, and a few enduring marketing ethical decision-making models, thus laying the foundation for a descriptive model for ethics in marketing research. The authors then develop an integrated model of ethical decision-making that incorporates the perspectives of all (...) parties involved in the process of making ethical marketing research decisions, the various philosophies, and external variables. The proposed model is compared with some of the models considered in the literature and illustrated with a marketing research application. (shrink)

Music education has long been linked to various cognitive and developmental benefits for students and enhances cognitive abilities, including concentration and academic achievement. The aim of this study examines the impact of music education on academic achievement, cognitive development, and overall classroom engagement. Specifically, it explores how music learning correlates with student educational performance. The study looks into a number of factors, including enhanced cognitive abilities, social-and emotional benefits, development of critical thinking skills, economic barriers, and time constraints.The study involved (...) 150 students’ data through an online survey, the framework includes hypothesis the development and statistical analysis employing through SPSS to perform statistical tests, including Pearson correlation and T-test. The result indicates a positive correlation between student educational performances in Group 1, with extensive music education, demonstrating higher proficiency and improved academics performance compared to Group 2. The study concludes that music education is a positive consequence on students' performance in academics that underscores the significant role of music education to enhance the integration into educational curriculum can lead to improved cognitive development. (shrink)

Seeking to better understand how nonprofit organizations (NPOs) manage hybridity, we investigated what distinguishes NPOs that combine multiple logics in productive and unproductive ways. We collected and analyzed data from six case studies of NPOs delivering social services in Australia. Our findings reveal that organizational members of NPOs take a _perspective_ on their hybrid nature which comprises four elements: motivational framing, actor engagement, resourcing attitude, and governance orientation. NPOs that combine multiple logics in productive and unproductive ways, respectively, are distinguished (...) by (1) a compelling or confused motivational framing for combining logics; (2) actors having active and shared, or passive and isolated, engagement with multiple logics; (3) attitudes toward resourcing multiple logics that are either coherent or competitive; and (4) a governance orientation toward multiple logics as opportunities to leverage or problems to resist. Our findings contribute to the literature by deepening understanding of the interplay between complex constellations of multiple logics in NPOs, including religious and professional logics. We also develop a model of organizational perspectives on hybridity and their implications for distinguishing NPOs that productively harness tensions between logics. (shrink)

Seeking to better understand how nonprofit organizations (NPOs) manage hybridity, we investigated what distinguishes NPOs that combine multiple logics in productive and unproductive ways. We collected and analyzed data from six case studies of NPOs delivering social services in Australia. Our findings reveal that organizational members of NPOs take a perspective on their hybrid nature which comprises four elements: motivational framing, actor engagement, resourcing attitude, and governance orientation. NPOs that combine multiple logics in productive and unproductive ways, respectively, are distinguished (...) by (1) a compelling or confused motivational framing for combining logics; (2) actors having active and shared, or passive and isolated, engagement with multiple logics; (3) attitudes toward resourcing multiple logics that are either coherent or competitive; and (4) a governance orientation toward multiple logics as opportunities to leverage or problems to resist. Our findings contribute to the literature by deepening understanding of the interplay between complex constellations of multiple logics in NPOs, including religious and professional logics. We also develop a model of organizational perspectives on hybridity and their implications for distinguishing NPOs that productively harness tensions between logics. (shrink)

The COVID-19 pandemic has shaken the world. After liberalization in 1991, microfinance became a panacea for poor people without collateral and information asymmetry. The higher cost of microfinance and debt traps highlighted the need for the state to intervene in resource redistribution. In addition, national lockdowns and COVID-19 restrictions have made it difficult for emerging economies like India to achieve this sustainable development goal. The Reserve Bank of India introduced self-help group (SHG) bank linkage to ensure the financial inclusion of (...) the poor. The difference-in-difference method examined how SHGs affect entrepreneur households’ income. CMIE Consumer Pyramid dx data were used for analysis. The data establish that SHGs have increased the income of the households, and demographic factors such as education, income level and gender also impact the financial inclusion of the poor. (shrink)

Since the conceptualization of unethical pro-organizational behavior ten years ago, scholarly interest in exploring this phenomenon has multiplied. Given a burgeoning body of empirical research, a review of unethical pro-organizational behavior literature is warranted. This study, therefore, systematically reviews the extant literature on unethical pro-organizational behavior and presents a comprehensive theory-based review of the past developments in this field. We classify previous studies based on their underlying theoretical perspectives and discuss the antecedents and consequences of unethical pro-organizational behavior in work (...) context. We also explicate the boundary conditions under which the influence of these antecedents gets accentuated or alleviated. Overall, this study synthesizes past knowledge to elucidate why, how, and when unethical pro-organizational behavior unfolds in the workplace. Finally, the gaps in the extant theorization are identified and an agenda for future research is proposed. (shrink)

With its promise of personal improvement, physical well-being and spiritual enrichment, yoga is enjoying a resurgence in popularity at the turn of the third millennium. To unravel the mystery of the discipline, its philosophies and relevance in contemporary life, the original text of the Yoga Sutras of Patanjali must be explored. This book offers the first accessible translation and commentary on Patanjali's Yoga Sutras. An introductory section examines the multidimensional aspects of yoga as philosophy, psychology, science, and religion, as well (...) as exploring popular versions of yoga in the West. The core of the book offers a new translation of the entire text of the Yoga Sutras, in a language that is clear and comprehensible to students. Commentaries are presented to highlight the meaning of various statements and key themes are outlined via sectional summaries. A full glossary of key words and names is also provided. Concluding chapters look at yoga in contemporary life, revealing the popularity of yoga in the 21st century through Star Wars, and exploring yoga's connection to health and science, contrasting yoga's holistic view of healing with that of the limited view of present day medical science. Sample physical, breathing and meditation exercises are provided. An Introduction to Yoga Philosophy offers a comprehensive introduction to the Yoga Sutras text of Patanjali to all students and interested readers of Indian philosophy and religion, world religions, east-west psychology, and mysticism. (shrink)

Steven Pinker presents four ideals of Enlightenment in his popular book Enlightenment Now: The Case for Reason, Science, Humanism, and Progress. He argues his case brilliantly and convincingly through cogent arguments in a language comprehensible to the reader of the present century. Moreover, whether it is reason or science or humanism or progress, he defends his position powerfully. He justifies his views by citing 75 graphs on the upswing improvement made by humanity in terms of prosperity, longevity, education, equality of (...) men and women, health, political freedom and medical breakthroughs. Though Pinker makes an excellent case for the positive contributions of Enlightenment; however he ignores the negative aspects that are responsible for causing a great schism between the white race and others who are black and brown. The paper highlights some of these negative comments made by such Enlightenment thinkers as Montesquieu, Voltaire, Chambers, Down and Down and others. Through their literary and scientific writings, these scholars and researchers downgraded the black and brown races, thus causing a rift that led to slavery, colonialism and apartheid. The paper reveals these negative aspects ignored by Pinker in his otherwise well-researched book on Enlightenment. Since Pinker presents a one-sided case by including only the positive contributions of Enlightenment, I recommend that he should write a sequel to his present work outlining the negative aspects responsible for numerous political, social and environmental problems facing humanity today. By using dialectical logic in place of logic of contraries, he might be able to synthesize both the positive and negative aspects of Enlightenment. He can then argue that humanity might be propelled to make progress more efficiently at a faster pace toward humanism and world peace. (shrink)

This volume is a critical investigation into the contemporary phenomenon of the dissensus of the globe and the planet, and the new terrains of consciousness that need to be negotiated towards a possibility for transformation. It examines the possibilities of alternate, sustainable modes of being and existing in a world which requires a unified, ethical, biopolitical worldview. The book explores themes like philosophical posthumanism and planetary concerns; disruption of cultural and intellectual inequality; bodily movement through nomadic subjectivity; dystopic spatialities of (...) game(re)play; globalization, and speculative imaginaries of the body; and theory of multiplicity. It also discusses impact of COVID on human beings, role of the neoliberal media, the question of rights of robots and cyborgs in sci-fi movies, and representation of refugees in literature. This book will be of interest to scholars and researchers of English literature, political philosophy, cultural studies, literary cultures, post-colonial studies, critical theory, and social anthropology. (shrink)

This book presents a critical analysis of sense-making practices through an exploration of acoustic, creative, and artistic spaces. It studies how local cultures of sight, hearing, smell, taste, and touch are impacted by global discourses and media, such as television, popular music, digital media, and literature. The authors look at sense-making practices and spatial discourses through an interconnected discussion on thought and experience that seeks to present a multidimensional cartography of the global, the local, and the glocal, to closely analyze (...) the phenomenon of globalization. The volume is an investigation of the possibilities of alternate, sustainable modes of being and existing in a world which requires a unified, ethical, biopolitical worldview that challenges the disparity of its fragments while speculating on their synesthetic conditionality. A unique contribution, the book will be of interest to scholars and researchers of English literature, media studies, cultural studies, literary cultures, post-colonial studies, globalization studies, philosophy, critical theory, sociology, and social anthropology. (shrink)

The activation of leukocytes by bacterial cell wall lipopolysaccharide (LPS) contributes to the pathogenesis of septic shock. It is well established that, in the presence of plasma LPS‐binding protein (LBP), LPS binds with high affinity to CD14. The binding of LPS to CD14 has been associated with the activation of cells, although available evidence indicates that CD14 itself does not transduce intracellular signalling. The physiological function of this interaction is to promote host defense mechanisms of cells to combat the infection (...) and clear LPS from the circulation. At higher concentrations of LPS, however, the activation of cells can take place in the absence of LBP and CD14, presumably through a distinct low‐affinity signalling LPS receptor. On the evidence published by us and others, we propose that in neutrophils, and possibly other leukocytes, L‐selectin can act as a low‐affinity LPS receptor. (shrink)

Pt. 1. Purva paksha (examination of my opponents' positions) -- pt. 2. Uttara paksha (my response).

One of the hardest parts of being a leader is handling disagreements about values. The skills required to do this are increasingly important in polarized societies where there is pressure for businesses and organizations to have a sense of purpose and "do the right thing." Our book helps readers address these challenges. To do this, we don''t give a simplistic cookie-cutter recipe for what is right and wrong. Rather, we guide readers on a journey to rigorously explore their values and (...) better understand the values of others. We discuss the human psychology that drives conflicts over values as well as the philosophical frameworks that have guided people for millennia. We provide strategies, based in research from psychology and the behavioral sciences, whichthat readers can use to implement their values in their lives and their organizations. Topics covered include moral intuitions, self-serving biases, situational pressures, social norms, the role of business in society, consequentialism/utilitarianism, motives, perspective-taking, justice, fairness, and liberty. (shrink)

The thesis of the paper is that the root cause of clash or reconciliation among civilizations is housed in the drama of consciousness! Two models of consciousness that highlight this drama are put forward here. First is Jean Gebser’s view, which asserts that the history of human civilization is nothing more than the manifestations of the development of consciousness. This development has taken place through five distinct stages: the archaic, magical, mythic, mental and integrative. Clash in civilizations is due to (...) the fixation on the first four stages whereas reconciliation is possible through the use of the integrative stage. The second is the Tantric Yoga view of consciousness in terms of the seven chakras or wheels of consciousness. These chakras are spread out in the body like seven colors of the rainbow—starting with the base of the spine to the genitals, the belly button, the heart, the throat, the forehead and ending in the crown of the head. Clash in civilizations is due to the fixation on the first three levels (chakras) of consciousness whereas reconciliation is possible through the use of the upper fourwheels of consciousness (chakras), which are focused at developing universal consciousness. Since religion and civilization are intimately connected and several of the prominent civilizational clashes have been due to the religious differences, religious consciousness will be taken as the paradigm of this paper.How can humanity move from clash towards reconciliation? Such a possibility is suggested by both Gebser and Tantric Yoga whose theories point towards the development of an integrative universal consciousness: an encompassing consciousness that will transcend as well as incorporate all limited religious consciousness perspectives in its fold! The views of Vivekananda, a scholar-monk of India, on “one religion/one spirituality” are of particular interest in this context. They indicate an approach, which might lead to a possible future solution thus paving a path towards one-world-spiritual-peaceful order! (shrink)

The author examines the relationships between civilization and organized religion. A new theory of religion spawning civilization instead of vice versa is discussed, as well as the influence of the great organized religions on the development of modern cultures and civilizations. The history of the various large organized religions, including their origins, spread and mindsets are all examined, and the major differences between the Abrahamic and Indic religions are remarked upon as well.

Clinical Pharmacology is a specialty with many attributes and our association with the subject has allowed us to acquire, apply and disseminate myriad aspects of research and practice. Though clinical pharmacologists are conspicuous by virtue of their small number, recent years have shown a growing need for the course. In the review below we navigate through several aspects of the subject as we encountered them from time to time. From critical appraisal of literature, to application of knowledge of drugs, to (...) clinical practice; moving on to clinical and basic research, to drug development process, to policy making - these are but a few of the many fields which constitute the scope of clinical pharmacology. The importance of the subject lies in allowing a trainee to develop a broad overview of the entire process, from drug generation to drug distribution to drug utilization, a process meant for the greater common goal of better health for all. We foresee a bright future for the subject though with a slight skepticism thrown in. In the present article, we make use of personal experiences and reference from literature to help you get a broad view of what clinical pharmacology means to us. (shrink)