This article explores the relation between innovation and resources that are governed as commons by looking at the governance of potato genetic resources, especially in the context of the emergence ofhybrid diploid potato breedingthat will enable potato propagation through true seeds. As a new breeding tool, hybrid diploid potato breeding may not only revolutionize traditional potato breeding practices, it may also strongly affect current governance modes of potato genetic resources as a commons. Contrary to conventional accounts of the commons that (...) treat technological innovation mainly as an exogenous factor, we argue that technological innovation can better be understood as an endogenous factor. In particular, we develop aco-production frameworkof innovation and the commons that draws attention to the different ways in which innovation, commons and its governance interact. Using this framework, we demonstrate that the constitution of potato genetic resources as a commons cannot be understood without considering the various ways in which technological innovation affects resources and mediate how these are governed. While reversely, technological innovations themselves are also enabled and constrained by users who govern potato genetic resources as a shared resource. We argue that changes in the governance of genetic resources can be understood as a change from one socio-technical constellation to another, whereby innovations, resources, and institutions are continuously co-produced. (shrink)

In this book, authors from a variety of disciplines examine how the interpretative disciplines deal with the lack or loss of certainty for their signs and texts.

Contributors consider the limits of our knowledge of a world of unlimited knowability by examining philosophical thought from the Classical Greeks to the present.

BET proteins such as Brd3 and Brd4 are chromatin‐associated factors, which control gene expression programs that promote inflammation and cancer. The Nrf2 transcription factor is a master regulator of genes that protect the organism against xenobiotic attack and oxidative stress. Nrf2 has demonstrated anti‐inflammatory activity and can support cancer cell malignancy. This review describes the discovery, mechanism and biomedical implications of the regulatory interplay between Nrf2 and BET proteins. Both Nrf2 and BET proteins are established drug targets. Small molecules that (...) either activate or suppress these proteins are currently tested in clinical trials. The crosstalk between Nrf2 and BET proteins may have important, and until now overlooked, implications for the therapeutic effects of these drugs. Based on the information covered in this review, it should be possible to design combinatorial treatment strategies for cancer and inflammatory diseases, which may improve the efficacy of targeting a Nrf2 or BET proteins individually. (shrink)

Irrespective of the short academic history of Christian spirituality, a vast number of academic and popular publications ensued and is still dynamically growing. Many definitions have been proposed to define (Christian) spirituality. Spirituality is also no longer connected only to religion, although in this research the focus will fall on Christian spirituality. This research intends to partake in the continuing academic dialogue to define Christian spirituality. Christian spirituality is interpreted from the perspective of the divine-human conversation. This research consists of (...) three sections. In the first section, a working definition of Christian spirituality is formulated. In the second section, various aspects that constitute spiritualities are distinguished and discussed. In the last section, the constituents of Christian spirituality are pointed out and are reviewed from a conversational perspective. The focus will be on ‘the experience of the divine’ when living a life that resonates with the Christian life. (shrink)

Het verhaal van de natuurkunde is ook een persoonlijk verhaal, want achter de feiten gaan altijd mensen schuil. Van Einstein, die Beethoven op zijn viool probeert te spelen, tot Van Swinden, die jarenlang in het planetarium in Franeker werkt. Cees Andriesse, die 'Titan kan niet slapen' schreef, een biografie over Christiaan Huygens, heeft veel gevoel voor deze verhalen. In deze nieuwe geschiedenis van de natuurkunde wordt dan ook ruim aandacht besteed aan de zoektocht en wederwaardigheden van grote figuren, maar ook (...) van collega's uit de tijd dat Andriesse in Groningen werkte. De wetenschap draait om onmiskenbare relaties tussen harde feiten; die gaan spreken onder de pen van Andriesse, die oog heeft voor de ontdekkers en zichtbaar maakt hoe zijn eigen begrip is ontstaan. Het is hem niet te doen om de mechanisering van de natuurkunde, maar om de historisering daarvan. Dit boek biedt een nieuw perspectief op grote ontdekkingen, waarbij zowel God, als literatuur als psychologie een rol spelen. (shrink)

A wide-ranging analysis of the economic world order and its ecological and theological dimensions, this unique and challenging work confronts us with the ...

The schism referred to in 1 John 2:18 had already taken place within the Johannine community, with specific reference to the divisions between members, about the identity of Jesus Christ. The author nonetheless uses different semantically related verbs for communicating the ‘message’ (1:5; 3:11) about Jesus’ identity, each one with a particular nuance: through ‘speech, declaring’ [ἀπαγγέλλειν, 1:2, 3]; ‘proclaiming’ [ἀναγγέλλειν, 1:5]; ‘confessing’ [ὁμολογεῖν, 1:9; 2:23, 4:2, 3, 15]; ‘testifying’ [μαρτυρεῖν, 1:2; 4:14; 5:6–11] and through ‘writing’ [γράφειν, 1:4; 2:1, 7, (...) 8, 12, 13 (2x), 14 (3x), 21, 26; 5:13]. In the last chapter of 1 John (1 Jn 5:5–12), the author’s testimony (in writing) that there is eternal life in Jesus Christ who is the Son of God culminates when he incorporates the fundamental testimonies of the Father, the Spirit and the water and blood to endorse this. The intention of this research is to determine conceivable spiritual experiences fostered among those early Christians when this message about Jesus as the Son of God, the Christ, was communicated to them through these activities (declaring, proclaiming, confessing, testifying) and confirmed via the testimonies of the Father, the Spirit and the water and blood. (shrink)

Im Zentrum des Cusanischen Denkens steht seit seinen Anfängen durchgängig die Auslotung der menschlichen Mittel und Formen, einen adäquaten und genauen Begriff des Absoluten oder des Unendlichen zu gewinnen. Die Studie widmet sich der Analyse der wesentlichen Ausarbeitungen eines Gottesbegriffs durch Nikolaus von Kues aus den Jahren 1459 bis 1464, die als Vollendung seines Denkweges angesehen werden können, weil sie durch konzeptuelle Neuerungen ein spekulatives und argumentatives Niveau erreichen, das eine genuin philosophische und damit christliche Vorgaben überhöhende Logik der Unendlichkeit (...) ermöglicht. (shrink)

v. 1. International perspectives on business ethics -- v. 2. New theoretical directions -- v. 3. Behavioral business ethics -- v. 4. Managing business ethics.

Foundational Texts in Modern Criminal Law presents essays in which scholars from various countries and legal systems engage critically with formative texts in criminal legal thought since Hobbes. It examines the emergence of a transnational canon of criminal law by documenting its intellectual and disciplinary history and provides a snapshot of contemporary work on criminal law within that historical and comparative context. Criminal law discourse has become, and will continue to become, more international and comparative, and in this sense global: (...) the long-standing parochialism of criminal law scholarship and doctrine is giving way to a broad exploration of the foundations of modern criminal law. The present book advances this promising scholarly and doctrinal project by making available key texts, including several not previously available in English translation, from the common law and civil law traditions, accompanied by contributions from leading representatives of both systems. (shrink)

Jonathan Wolff is Professor of Philosophy at University College London. He is the author of Robert Nozick (1991), An Introduction to Political Philosophy (1996) and Why Read Marx Today (2002). He is currently working on a number of topics at the intersection of political philosophy and public policy.

We identify a normative paradox of responsible management education. Business educators aim to promote social values and develop ethical habits and socially responsible mindsets through education, but they attempt to do so with theories that have normative underpinnings and create actual normative effects that counteract their intentions. We identify a limited conceptualization of freedom in economic theorizing as a cause of the paradox. Economic theory emphasizes individual freedom and understands this as the freedom to choose from available options. However, conceptualizing (...) individuals as profit-maximizing actors neglects their freedom to reflect on the purposes and goals of their actions. We build on the work of pragmatist philosopher John Dewey, who distinguishes between habitualized and creative problem-solving behaviors, conceptualizes knowledge construction as a process of interdependent scientific social inquiry, and understands actors as having the freedom to determine what kind of people they wish to be. We apply pragmatist theory to business education and suggest equipping students with a plurality of theories, supplementing neoclassical economics with other economic perspectives and views from other disciplines on economic behavior. Moreover, we suggest putting students into learning situations that require practical problem solution through interdependent social inquiry, encouraging ethical reflection. In doing so, we contribute by linking the problematic conceptions of freedom identified in economic theorizing to the debate on responsible management education. We conceptualize a pragmatist approach to management education that explicitly re-integrates the freedom to discursively reflect on the individual and societal purpose of business activity and thereby makes existing tools and pedagogies useful for bringing potential freedom back into business. (shrink)

Dirk Westerkamp offers a systematic approach to German idealism's philosophy of language. He argues for the ongoing relevance of its semantical holism and shows how its encounter with rational realism amounts to a philosophically as well as linguistically fruitful discussion on the relation between language and thought, language and world, and language and subjectivity. Its ultimate aim is the pursuit of truth"--From publisher's website.

Places the development of Anaximander's thought within social, political, cosmological, astronomical, and technological contexts.

This article explains problems and opportunities created by standardized ethics initiatives (e.g., the UN Global Compact, the Global Reporting Initiative, and SA 8000) from the perspective of stakeholder theory. First, we outline differences and commonalities among currently existing initiatives and thus generate a common ground for our discussion. Second, based on these remarks, we critically evaluate standardized ethics initiatives by drawing on descriptive, instrumental, and normative stakeholder theory. In doing so, we explain why these standards are helpful tools when it (...) comes to ‘managing’ stakeholder relations but also face considerable limitations that can eventually hamper their successful expansion. We suspect that this discussion is necessary to conduct meaningful empirical research in the future and also to provide managers with a more clear-cut picture about a successful application of such initiatives. Third, we outline possible ways to cope with the identified problems and thus demonstrate how standard-setting institutions can improve the initiatives they offer. (shrink)

Since the publication of W. V. Quine's classic paper “Epistemology Naturalized” there have been many discussion on the virtues and vices of naturalistic epistemology. Within these discussions not much attention has been paid to a basic question: What makes an epistemology naturalistic? I give an answer by providing a logical geography of competing naturalistic positions. Then I defend naturalistic epistemology against the charge of the so-called causal fallacy. Finally I give a critical appraisal of different naturalistic theories of knowledge and (...) introduce cooperative naturalism as the most promising research strategy. (shrink)

Proclus' interpretation of the Timaeus confronts the question of whether the living being that is the Platonic cosmos perceives itself. Since sense perception is a mixed blessing in the Platonic tradition, Proclus solves this problem by differentiating different gradations of perception. The cosmos has only the highest kind. This paper contrasts Proclus' account of the world's perception of itself with James Lovelock's notion that the planet Earth, or Gaia, is aware of things going on within itself. This contrast illuminates several (...) key differences between contemporary theories of perception and the neoplatonic world view. In particular, it argues that the neoplatonists had a radically different view of these matters because they assigned the property of truth not only to representations, but to objects as well. (shrink)

The Ontological Dilemma of Normative Ethics. This paper pursues two goals. The first is to show that normative ethics is confronted with the following dilemma: to be coherent, this discipline is ontologically committed to acknowledge the existence of objective values, but, to be scientifically respectable, it is committed to repudiate such values. The second goal is to assess the possible solutions to this dilemma. To this end, the following strategies are discussed: Kant’s constructive objectivism, Jürgen Habermas’ “epistemic ersatzism”, Franz von (...) Kutschera’s “confirmation pragmatism”, and David Brink’s “objectivist tour de force”. The paper’s conclusion is that the dilemma cannot be solved because it rests on a clash of intuitions none of which can be given up. (shrink)

En 1887, Nietzsche écrivait: «Lévénement le plus actuel, à savoir que Dieu est mort, commence à jeter ses premières ombres sur l'Europe». Ceux qui regardent le monde avec attention, avec une certaine suspicion même, remarquent que le soleil s'est couché, que la confiance de jadis s'est transformée en doute, que notre monde quotidien est devenu plus sombre, plus étrange, «vieux». Cependant cet evenement ne s'est pas encore annonce publiquement, continue Nietzsche, et on ne mesure pas encore les implications de la (...) mort de Dieu: une longue suite de démolitions, de destructions, de déclins, de renversements. II y aura une «logique de terreur», comme on ne l'aura pas encore vu sur la surface de la terre. (shrink)

Gesprekken tussen filosoof en ecoloog Johan Braeckman en moraalfilosoof Dirk Verhofstadt over de evolutietheorie van Darwin, religie, irrationalieit, humanisme en atheïsme."--Publisher information.

We show that the Bohmian approach in terms of persisting particles that move on continuous trajectories following a deterministic law can be literally applied to QFT. By means of the Dirac sea model – exemplified in the electron sector of the standard model neglecting radiation – we explain how starting from persisting particles, one is led to standard QFT employing creation and annihilation operators when tracking the dynamics with respect to a reference state, the so-called vacuum. Since on the level (...) of wave functions, both formalisms are mathematically equivalent, this proposal provides for an ontology of QFT that includes a dynamics of individual processes, solves the measurement problem and explains the appearance of creation and annihilation events. (shrink)

INTRODUCTION This book is devoted to the formulation and the development of a paradigmatic-phenomenological theory of cognition. ...

In his Encomium of Agatha Patriarch Methodius suggests that a figure appearing to the saint in her prison could be either the Apostle Peter, an angel in the guise of Peter, or Christ impersonating an angel in the guise of Peter. This article has two aims : to show that Methodius offered these alternatives because he was acutely aware of the problems arising from attempts to identify agents from their outward appearances ; and to demonstrate that Methodius could accept the (...) concepts of angelic and divine impersonation without jeopardising the real presence of the saints in dreams and visions because he held the 'Origenist' belief that exemplary human beings can be transformed into 'angels' and 'gods' and therefore concluded that saints could act as their own impersonators. (shrink)

Drawing on letters, orations and disputations, this book argues that during the seventeenth century, the Amsterdam Athenaeum, despite the revolutionary debates of the time, and despite the intellectual liberalism characteristic of Amsterdam, remained traditional in its teaching.

There has recently been a wave of attempts to make sense of the role of de se thoughts in linguistic communication. A majority of the attempts assume a Perryan or a Lewisian view of de se thought. Views with these assumptions, I suggest, come in four varieties: uncentering (Egan 2007, Kölbel 2013, Moss 2012), recentering (Heim 2004, Weber 2012), multicentering (Kindermann 2014, Ninan 2010, Torre 2009), and no centering (Kaplan 1989, Perry 1979). I argue first that all four varieties of (...) centering are committed to what I call a shifting operation on the hearer's part. I argue second that, against common assumption, there is no real choice to make between the views. By showing that attempts to establish an advantage for some view over the others fail across the board, I make the case for neutralism regarding the varieties of centering – the claim that coverage of the empirical data is exactly the same for each view, and that the views are broadly equal in simplicity and elegance. (shrink)

ABSTRACT:Based on theoretical insights of discourse ethics as developed by Jürgen Habermas, we delineate a proposal to further develop the institutionalization of social accounting in multinational corporations (MNCs) by means of “Social Accountability 8000” (SA 8000). First, we discuss the cornerstones of Habermas's discourse ethics and elucidate how and why this concept can provide a theoretical justification of the moral point of view in MNCs. Second, the basic conception, main purpose, and implementation procedure of SA 8000 are presented. Third, we (...) critically examine SA 8000 from a Habermasian perspective, and discuss advantages and drawbacks of the initiative. Fourth, to address the drawbacks, we introduce a “discourse-ethically” extended version of SA 8000. We show that this approach is theoretically well-founded and able to overcome some of the current deficits of the certification initiative. We demonstrate that the extended version of SA 8000 can be successfully applied on a cross-cultural basis, and that our findings have significant implications for other international ethics initiatives. (shrink)