There is a concern that physicians/researchers are inappropriately profiting from information derived from advance copies of high-impact clinical trial data distributed by medical conferences or journals. Despite these concerns, it has never been systematically evaluated, and little is known about the degree to which it exists. This is largely due to difficulties associated with directly verifying whether or not such activities have taken place and, furthermore, many medical conferences/journals today have taken the necessary actions to guard against this. One medical (...) association in particular, the American Society of Clinical Oncology, only began responding to such concerns several years ago. Their actions during that time serve as a compelling case study, with wide-ranging ramifications, and provide the unique opportunity to delve into this phenomenon.Up until 2008, ASCO selectively and discreetly distributed abstracts from all forthcoming presentations to ASCO members two weeks prior to it becoming publicly accessible during the conference. (shrink)

Proofs and Refutations is essential reading for all those interested in the methodology, the philosophy and the history of mathematics. Much of the book takes the form of a discussion between a teacher and his students. They propose various solutions to some mathematical problems and investigate the strengths and weaknesses of these solutions. Their discussion raises some philosophical problems and some problems about the nature of mathematical discovery or creativity. Imre Lakatos is concerned throughout to combat the classical picture of (...) mathematical development as a steady accumulation of established truths. He shows that mathematics grows instead through a richer, more dramatic process of the successive improvement of creative hypotheses by attempts to 'prove' them and by criticism of these attempts: the logic of proofs and refutations. (shrink)

The central question in this book is why it seems reasonable for the words of our language to divide up the world in ordinary ways rather than other imaginable ways. Hirsch calls this the division problem. His book aims to bring this problem into sharp focus, to distinguish it from various related problems, and to consider the best prospects for solving it. In exploring various possible responses to the division problem, Hirsch examines series of "division principles" which purport to express (...) rational constraints on how our words ought to classify and individuate. The ensuing discussion deals with a wide range of metaphysical and epistemological topics, including projectibility and similarity, alternative analyses of natural properties and things, the inscrutability of reference, and the relevance of such pragmatic notions as salience and economy. The final chapters of the book develop what Hirsch contends is the most promising response to the division problem: a theory in which constraints on classification and individuation are seen to derive from the necessary structure of "fine-grained" propositions and the necessary dependence of some concepts on others. (shrink)

Eli Alshanetsky considers how we make our thoughts clear to ourselves in the process of putting them into words and examines the paradox of those difficult cases where we do not already know what we are struggling to articulate.

To clarify the proper role of values in science, focusing on controversial expert responses to Covid-19, this article examines the status of (in)convenient hypotheses. Polarizing cases like health experts downplaying mask efficacy to save resources for healthcare workers, or scientists dismissing “accidental lab leak” hypotheses in view of potential xenophobia, plausibly involve modifying evidential standards for (in)convenient claims. Societies could accept that scientists handle (in)convenient claims just like nonscientists, and give experts less political power. Or societies could hold scientists to (...) a higher bar, by expecting them not to modify evidential standards to avoid costs only incidentally tied to error. (shrink)

This study focuses on women who define themselves as being undecided about becoming mothers. It addresses the question of how these women navigate their lives between two main conflicting cultural directives and perceptions: pronatalism and familism entwined in perception of linear time on one hand; and individualism and its counterpart, the notion of flexible liquid society, on the other. The research is based on group meetings designated for these women, which were facilitated by the first author. Ten women participated in (...) the study—of whom, most were heterosexual, half were single, and half were partnered. Data were collected using (1) questionnaires completed during individual interviews that preceded the group encounter; (2) transcripts of the discussions held during the ten group sessions; and (3) questions regarding the status of the women’s doubts about motherhood asked 4 years after participating in the group. Our findings expand the existing typology of women’s reproductive decision-making, and demonstrate how categories that are commonly perceived as binary intersect when one challenges the rigid classifications of “active decisions” and “passive decisions”; “motherhood” and “non-motherhood,” and “want to be a mother” and “do not want to be a mother.” The findings also suggest that after becoming mothers, women can change their maternal status from “non-mother” to “mother,” yet still continue to view themselves as indecisive regarding motherhood. Based on our findings, we will argue that while indecisiveness about motherhood derives from individualized neoliberal rhetoric, it simultaneously undermines that same rhetoric and contradicts the injunction to “know, to decide, to strive.” It opposes the expectation in post-feminist discourse, that women will make choices about their bodies and exert them, while also opposing the pronatalist rhetoric, and the temporal linear discourse positing that women should “move forward” toward motherhood along with the ticking of the “biological clock.” Whereas some women sought to resolve their indecisiveness, other women found that the indecisiveness leaves all options open in a manner that expands their boundaries of autonomy in a society that seeks to limit it. (shrink)

Ausgehend von einer Kritik der Sprach- und Theorieauffassung allgemeiner Wissenschaftstheorie wird das Dilemma der Sprachwissenschaft Linguistik zwischen einem hypothetisch-deduktiven Theoretizismus und interaktionistischen Erfahrungsempirismus aufgezeigt. Sprach- und Sprechhandlungstheorien sind demnach ruckverwiesen auf materialistisch-hermeneutische Rekonstruktionen thematischer Situationsdefini- tionen in ihren handlungsrelevanten gesellschaftlichen Begrifflichkeiten.".

Background In February, 2015, the Supreme Court of Canada struck down the ban on medical assistance in dying. In June, 2016, the federal government passed Bill C-14, permitting MAiD. Current medical students will be the first physician cohort to enter a system permissive of MAiD, and may help to ensure equitable access to care. This study assessed medical student views on MAiD, factors influencing these views, and opportunities for medical education. Methods An exploratory cross-sectional survey was developed and distributed to (...) medical students across all years of a three-year Canadian undergraduate medical program. The investigators administered the survey to participants during academic sessions from November to December, 2015. Analysis of the results included summary descriptive statistics, Pearson’s chi-square test of independence to identify differences between participants by year of study, logistic regression to identify factors that influence students’ stances on MAiD, and Wilcoxon signed rank test to measure changes in student support for MAiD and comfort discussing MAiD. Results There were 405 participants for a response rate of 87%. The majority of students supported the Supreme Court’s decision, 61% would provide the means for a patient to end their life, and 38% would personally administer a lethal medication. Students who were more willing to provide the means for MAiD found medical education/clinical experience and patient autonomy to be important contributors to their stances on MAiD. Those students who were less willing to provide the means for MAiD found religious/spiritual beliefs and teachings, as well as concern about potential negative consequences, to be important contributors to their stances on MAiD. Educational training desired by participants included medicolegal, communication skills, technical skills, and religious. Conclusions Medical students generally supported and would provide the means for MAiD to patients. They also indicated a desire for directed medical education on MAiD. (shrink)

Language -- Image -- Time -- Body -- Dream -- Myth -- Baudelaire -- Rescue -- Remembrance.

In 1986, Elie Wiesel received the Nobel Peace Prize in recognition of his victory over “the powers of death and degradation, and to support the struggle of good against evil in the world.” Soon after, he and his wife, Marion, created the Elie Wiesel Foundation for Humanity. A project at the heart of the Foundation’s mission is its Ethics Prize—a remarkable essay-writing contest through which thousands of students from colleges across the country are encouraged to confront ethical issues (...) of personal significance. The Ethics Prize has grown exponentially over the past twenty years. “Of all the projects our Foundation has been involved in, none has been more exciting than this opportunity to inspire young students to examine the ethical aspect of what they have learned in their personal lives and from their teachers in the classroom,” writes Elie Wiesel. Readers will find essays on Bosnia, the genocide in Rwanda, sweatshops and globalization, and the political obligations of the mothers of Argentina’s Disappeared. Other essays tell of a white student who joins a black gospel choir, a young woman who learns to share in Ladakh, and the outsize implications of reporting on something as small as a cracked windshield. Readers will be fascinated by the ways in which essays on conflict, conscience, memory, illness, and God overlap and resonate with one another. These essays reflect those who are “sensitive to the sufferings and defects that confront a society yearning for guidance and eager to hear ethical voices,” writes Elie Wiesel. “And they are a beacon for what our schools must realize as an essential component of a true education.”. (shrink)

Nair-Collins and Joffe (2023) rightly call attention to an incompatibility between brain-based criteria for death, as defined by the Uniform Determination of Death Act (UDDA), and what the current...

In this book, Eli Hirsch focuses on identity through time, first with respect to ordinary bodies, then underlying matter, and eventually persons.

The study presented in this article is based on field observations over one year on a critical care unit in Norway. Data were analysed according to Glaser’s grounded theory and generated a theory of hidden and emerging drama in the context of ambiguity while the nurses routinized the handling of complex technology. To the untrained eye the unit presented a picture of calm competence, while under the surface one finds hidden drama full of difficult interacting clinical and ethical problems. The (...) nurses identified six ethical dilemmas: (1) end of life issues; (2) whether there should be an age limit for coronary surgery; (3) distributing limited resources; (4) resource allocation in terms of better staffing; (5) situations in which is it more harmful than beneficial to continue treatment; and (6) transferring patients to other facilities. The six problems overlap and have clinical as well as ethical components, but it was the ethical dimensions that the nurses identified and discussed. The significance for nursing is the importance of well-educated and well-qualified nurses and how they find viable solutions to complex ethical and clinical problems. (shrink)

In this thought-provoking book, Eli Foster Ritter explores the relationship between moral and civil law, arguing that they are different aspects of the same fundamental system of justice. With insightful analysis and persuasive argumentation, Ritter challenges readers to reconsider their assumptions about the nature of law and the role it plays in society. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in (...) the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Can politics be thought?, asks Alain Badiou in the title of a recent book. The question itself reveals an experienced lack: that of politics. A lack which the so-called “return of the subject,” far from resolving, would stigmatize. The “return of the subject,” as he asserts, is merely the counterface of the break of politics, its reduction to an “ethics of tolerance” from which all its properly political traces have previously been erased. If politics cannot be associated with the “return (...) of the subject,” this is because politics does not relate to any subject but rather to the very impossibility of conceiving of it. Thus, the attempt to reactivate politics becomes inextricably linked to the endeavor of rethinking, or better said, unthinking the subject. As this article shows, this project articulates a specially dynamic current of thought in the last years, which we may call, generically, “poststructuralist Marxist.” That project not only gave a new impulse to Marxist thinking, articulating a space of reflection which delimitates this current from that one with which it borders—deconstructionism—and from which it can interpellate the entire philosophical tradition. Ultimately, it comes to condense an issue whose relevance far exceeds the ambit of Marxist thinking: how politics is possible in a post-metaphysical and post-subjective context. Being and Event, by Alain Badiou, is, no doubt, the most systematical attempt to answer that question. It allows us to observe the main contributions of these current to contemporary philosophical thinkings, revealing, at the same time, the kind of aporias that that issue poses to it. (shrink)

Einstein Versus Bohr is unlike other books on science written by experts for non-experts, because it presents the history of science in terms of problems, conflicts, contradictions, and arguments. Science normally "keeps a tidy workshop." Professor Sachs breaks with convention by taking us into the theoretical workshop, giving us a problem-oriented account of modern physics, an account that concentrates on underlying concepts and debate. The book contains mathematical explanations, but it is so-designed that the whole argument can be followed with (...) the math omitted. Professor Sachs' story begins with classical and nineteenth century physics, describes the early discoveries in particle theory, and introduces the "old" quantum theory, which evolved into the quantum mechanics of the Copenhagen School. Such important ideas as the Einstein Photon Box experiment and the Einstein-Podolsky-Rosen Paradox, and Schrodinger's Cat Paradox are clearly expounded, followed by a completely fresh explanation of relativity in conceptual terms, showing how apparent paradoxes can be removed by Einstein's own interpretation, especially that of his later years. Professor Sachs gives a detailed comparison of the fundamentals of the quantum and relativity theories, suggesting how the contradictions might be resolved. In an epilogue, he makes suggestions, with reference to religious notions, Taoism, and Buber's theory of I-Thou, for generalizing Einstein's approach beyond physics. (shrink)

In this paper I want to argue that a unified set of concerns constituting a new dimension—a realignment of our sense of language, self, and world—emerges in the progress of the Tractatus as we turn to inquire into the inner connection between language and such notions as world, limits, life, and ipseity. The most elusive step in that progress, and the one most necessary to recognize as part of the argument of the Tractatus, is the transition from an understanding of (...) language in terms of logic, sense, and meaning to a perspective in which language becomes the primary locus of significance or meaningfulness. It is also the pivot from the logical to the ethical concerns of the book. An ethics that appeals to the notion of meaningfulness is elaborated in terms of the dimension of existence, namely in terms of the very possibility of agreement of disagreement with what has ultimate reality. (shrink)

It is widely assumed that if ontological disputes turn out to be verbal they ought to be dismissed. I dissociate the semantic question concerning the verbalness of ontological disputes from the pragmatic question on whether they ought to be dismissed. I argue that in the context of ontological disputes ontologists ought to be taken to communicate views with conflicting ontological commitments even if it turns out that on the correct view of semantics they fail to literally-express their disagreement. I argue, (...) that is, against dismissing ontological disputes on grounds of verbalness. This serves to discharge the ongoing debate on the verbalness of ontological disputes from the metaontological consequences typically associated with it. (shrink)

Este manifesto, escrito a quatro mãos no contexto de um colóquio sobre Bergson organizado no Japão, visa inicialmente responder a uma simples questão: que significa, hoje, trabalhar à maneira de Bergson? Não se trata de uma pergunta sobre a dedicação para com o corpus bergsoniano ou quanto a certos temas que o seu pensamento permite renovar a compreensão, mas sim sobre o método que ele próprio recomenda. Este método foi aplicado diligentemente por Bergson no curso de suas investigações, particularmente quanto (...) ao seu trato com as ciências positivas, tanto as da vida quanto às do universo material em sentido amplo. No que diz respeito à função da imaginação metafísica, este manifesto refaz os passos de Bergson quanto a um empirismo não especulativo e verdadeiramente contemporâneo à inteligência científica. (shrink)

This article concerns the ways in which authors from various fields conceptualise the ethical issues arising in the conduct of research. We reviewed critically and systematically the literature concerning the ethics of conducting research in order to engage in a reflection about the vocabulary and conceptual categories used in the publications reviewed. To understand better how the ethical issues involved in conducting research are conceptualised in the publications reviewed, we 1) established an inventory of the conceptualisations reviewed, and 2) we (...) critically assessed them. We found that the publications reviewed mostly showed examples of descriptive ethics, in that most authors describe ethical issues without reflecting much on them, which could be explained both by 1) a lack of ethical education in research contexts, and 2) by the fact that we do not know what researchers know (or do not) about ethical issues. Additionally, the definitions identified in the publications are scarce and at times imprecise, but this seems more to point out the ethical vocabulary’s difficulties in certain contexts. Further, very few authors offer proper conceptualisations of the ethical issues arising in conducting research. When dealing with vast arrays of ethical issues to conceptualise, perhaps one ought to remember that some typologies already exist that could guide further reflection and help understand other realities for which the current ethical vocabulary may be lacking. We believe that combining the reviewed typologies, both with other well-developed typologies and critical reflection, could help support better ethical practice in conducting research. (shrink)

English summary: The Spitzer Manuscript is one of the oldest Sanskrit manuscripts found on the Silk Road. The work preserved in it is unique; no further manuscripts of it have been discovered so far, nor is it transmitted in Tibetan or Chinese translations. The present volume contains an introduction which summarizes previous research and discusses grammatical, lexical and palaeographical aspects of the work, together with an outline of its content. It is followed by a complete facsimile edition of the fragments (...) accompanied by transliterations. These are supplemented by transcriptions of some fragments which are no longer available, recovered from the estate of the Indologist Dr. Moritz Spitzer. A concordance juxtaposes the earlier and present-day arrangements of the fragments, and an extensive character table documents the peculiarities of the Ku'a'a-Brahma script used in the manuscript. A complete word index and a study which aims at reconstructing the last part of the manuscript conclude the volume. As well as Buddhist scholastics the work also deals with a number of non-Buddhist topics, such as a theory of Vaise'ika qualities completely unknown from other sources it contains, inter alia, the oldest list of books of the Mahabharata and an enumeration of the sixty-four arts and sciences. The last part of the work is devoted to dialectics. German description: Das Spitzer-Manuskript ist eine der altesten Sanskrithandschriften, die an der Seidenstrasse gefunden wurde. Das in ihm erhaltene Werk ist ein Unikum; bis jetzt wurden keine weiteren Manuskripte dieses Werkes entdeckt und es ist auch nicht in tibetischer oder chinesischer Ubersetzung uberliefert. Der vorliegende Band enthalt eine Einleitung, die den Forschungsstand zusammenfasst, grammatische, lexikalische und palaographische Aspekte des Werks diskutiert und eine Inhaltsubersicht bietet. \nHierauf folgt eine vollstandige Faksimileausgabe der Fragmente zusammen mit ihren Transliterationen. Diese werden erganzt durch Transkriptionen einiger verloren gegangener Fragmente, die dem Nachlass des Indologen Dr. Moritz Spitzer entnommen wurden. Eine Konkordanz stellt die heutige und fruhere Anordnung der Fragmente gegenuber; eine ausfuhrliche Zeichentabelle dokumentiert die Besonderheiten der Ku'a'a-Brahma -Schrift des Manuskripts. Ein vollstandiger Wortindex und eine Studie, die die Rekonstruktion des letzten Teils des Manuskripts zum Ziel hat, beschliessen den Band. Neben Themen der buddhistischen Scholastik behandelt das Werk auch eine Zahl nicht-buddhistischer Themen, wie eine Vaise'ika-Theorie der Eigenschaften, die aus anderen Quellen nicht bekannt ist; ferner enthalt es u. a. die alteste Liste der Bucher des Mahabharata und eine Aufzahlung der vierundsechzig Kunste und Wissenschaften. Der letzte Teil des Werkes ist der Dialektik gewidmet. (shrink)

In the first section of this paper I consider the practice of volume-measurement in baking, and I distinguish between two measurement schemes that can be extracted from this practice. In the second section I argue that the ascription of propositional content to utterances bears intuitive affinity to one of these schemes, that extant accounts of propositions are in the mold of the other scheme, and that therefore an alternative conception of propositions is called for.

In this essay, I defend philosophical wandering not only as an approach to doing philosophy, but also as an important force to incite critical reflection in cultural life. I argue that philosophical wanderers have an embodied, errant praxis, supporting wisdom whenever they engage with others. For these philosophers reflection is not given in a series of systematic assertions, nor through phenomenological description, nor analytic dissection. Rather, reflective life is the force that enhances the performative element of philosophy as an exercise (...) in being obnoxious to bring people within a culture to particular kinds of critical awareness and action. I conclude by suggesting that this mode of philosophy has a correlate mode of truth, “incited reflectivism,” different from coherentism, foundationalism, warranted assertibility, and other theories that have been previously defended as the standard for “truth.”. (shrink)

The causal compatibility question asks whether a given causal structure graph — possibly involving latent variables — constitutes a genuinely plausible causal explanation for a given probability distribution over the graph’s observed categorical variables. Algorithms predicated on merely necessary constraints for causal compatibility typically suffer from false negatives, i.e. they admit incompatible distributions as apparently compatible with the given graph. In 10.1515/jci-2017-0020, one of us introduced the inflation technique for formulating useful relaxations of the causal compatibility problem in terms of (...) linear programming. In this work, we develop a formal hierarchy of such causal compatibility relaxations. We prove that inflation is asymptotically tight, i.e., that the hierarchy converges to a zero-error test for causal compatibility. In this sense, the inflation technique fulfills a longstanding desideratum in the field of causal inference. We quantify the rate of convergence by showing that any distribution which passes the nth-order inflation test must be On−1/2$\begin{array}{} \displaystyle {O}{\left(n^{{{-}{1}}/{2}}\right)} \end{array}$-close in Euclidean norm to some distribution genuinely compatible with the given causal structure. Furthermore, we show that for many causal structures, the (unrelaxed) causal compatibility problem is faithfully formulated already by either the first or second order inflation test. (shrink)

In the first section of this paper I present the measurement-theoretic fallacy of 'over-assignment of structure': the unwarranted assumption that every numeric relation holding among two (or more) numbers represents some empirical, physical relation among the objects to which these numbers are assigned as measures (e.g., of temperature). In the second section I argue that a generalized form of this fallacy arises in various philosophical contexts, in the form of a misguided, over-extended application of one conceptual domain to another. Three (...) examples are given: (i) the reduction of arithmetic into set theory, (ii) the ascription of full-blown intentional states to (at least some) non-overtly intentional creatures, such as Wittgenstein's builders, and (iii) the analysis of some modal notions as involving quantification over possible worlds (or their substitutes). The discussion of the third example gives rise to a novel account of possible-worlds talk. (shrink)