The spatial organization of the genome is intimately linked to its biological function, yet our understanding of higher order genomic structure is coarse, fragmented and incomplete. In the nucleus of eukaryotic cells, interphase chromosomes occupy distinct.

Background Speech understanding may rely not only on auditory, but also on visual information. Non-invasive functional neuroimaging techniques can expose the neural processes underlying the integration of multisensory processes required for speech understanding in humans. Nevertheless, noise (from fMRI) limits the usefulness in auditory experiments, and electromagnetic artefacts caused by electronic implants worn by subjects can severely distort the scans (EEG, fMRI). Therefore, we assessed audio-visual activation of temporal cortex with a silent, optical neuroimaging technique: functional near-infrared spectroscopy (fNIRS). Methods (...) We studied temporal cortical activation as represented by concentration changes of oxy- and deoxy-hemoglobin in four, easy-to-apply fNIRS optical channels of 33 normal-hearing adult subjects and 5 post-lingually deaf cochlear implant (CI) users in response to supra-threshold unisensory auditory and visual, as well as to congruent auditory-visual speech stimuli. Results Activation effects were not visible from single fNIRS channels. However, by discounting physiological noise through reference channel subtraction, auditory, visual and audiovisual speech stimuli evoked concentration changes for all sensory modalities in both cohorts (p<0.001). Auditory stimulation evoked larger concentration changes than visual stimuli (p<0.001). A saturation effect was observed for the audiovisual condition. Conclusions Physiological, systemic noise can be removed from fNIRS signals by reference channel subtraction. The observed multisensory enhancement of an auditory cortical channel can be plausibly described by a simple addition of the auditory and visual signals with saturation. (shrink)

This article reviews the edited volume “Evolvability: A Unifying Concept in Evolutionary Biology?” through biological and philosophical lenses. The book provides diverse angles on evolvability, which is affected by various hierarchical levels, timescales, and types of variation, thus moving beyond a purely genomics perspective. Evolvability is important to biosemiotics because understanding the dynamics of topological genotype spaces could help one better comprehend the phenotypic spaces of meaning, as developmental codes and interrelations can influence the emergence of biological novelty over time. (...) This book is successful in provoking thought on evolvability's role as both a product and a driver of evolutionary innovations and explores the philosophical implications of how evolution has the capacity to generate novel forms of meaning. (shrink)

Background As health education robots may potentially become a significant support force in nursing practice in the future, it is imperative to adhere to the European Union’s concept of “Responsible Research and Innovation” (RRI) and deeply reflect on the ethical risks hidden in the process of intelligent robotic health education. Aim This study explores the perceptions of professional nursing professionals regarding the potential ethical risks associated with the clinical practice of intelligent robotic health education. Research design This study adopts a (...) descriptive phenomenological approach, employing Colaizzi’s seven-step method for data analysis. Participants and research context We conducted semi-structured interviews with 17 nursing professionals from tertiary comprehensive hospitals in China. Ethical considerations This study has been approved by the Ethics Committee of the Second Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Second Chinese Medicine Hospital. Findings Nursing personnel, adhering to the principles of RRI and the concept of “person-centered” care, have critically reflected on the potential ethical risks inherent in robotic health education. This reflection has primarily identified six themes: (a) threats to human dignity, (b) concerns about patient safety, (c) apprehensions about privacy disclosure, (d) worries about implicit burdens, (e) concerns about responsibility attribution, and (f) expectations for social support. Conclusions This study focuses on health education robots, which are perceived to have minimal ethical risks, and provides rich and detailed insights into the ethical risks associated with robotic health education. Even seemingly safe health education robots elicit significant concerns among professionals regarding their safety and ethics in clinical practice. As we move forward, it is essential to remain attentive to the potential negative impacts of robots and actively address them. (shrink)

İndividualizm və xüsusilə personalizm filosof-mütəfəkkirlərin diqqətini xüsusilə cəlb edən məsələlər sırasında olublar. İnsanın cəmiyyət ilə münasibətlərində öz xüsusiyyətləri, özgürlüyü və təkrar olunmazlığını qoruyub saxlamasını ifadə edən bu problemi müəyyən etməyin əhəmiyyətindən danışsaq, konkret bir şəxsə məxsus göstəricilərdən çıxış etməklə bütöv və hərtərəfli nəticə əldə etmək mümkündür. Qeyd olunan vəzifəni həyata keçirmək o qədər də asan deyildir. Çünki söhbət müəyyən bir şəxsi başqalarından ayırmaqdan başlayaraq, onun unikallığının formalaşması və mövcudluğunun müəyyən olunmasına qədər davam edən bir prosesi öyrənməkdən gedir. Dünyaya fərd kimi (...) gələn insan öz fəaliyyəti, özünüdərketməsi sayəsində şəxsiyyətin qabil ola biləcəyi bir varlığa çevrilə bilər. Məhz cəmiyyətin normal fəaliyyəti və inkişafı üçün onun hər bir üzvünün müəyyən qədər özünəməxsusluğu zəruridir. Və cəmiyyət üzvlərinin rəngarəngliyi, burada aydın ifadə olunmuş fərdiyyətlər, şəxsiyyətlərin mövcudluğu hər bir ictimai quruluşun, onun mədəniyyətinin həqiqi zənginliyini təmin edir. Buna görə də, insanların fərdi özünəməxsusluğuna malik olması sosial inkişafın qanunauyğunluğu kimi də qəbul edilir. Məqalədə Avropa personalistlərinin fikirlərinə istinadən belə proseslər izlənilib. (shrink)

The abstract notion of “the feminine”, —in French, le f minin, and in German, das Weibliche —as substantivum neutrum, remains together with its opposite, the masculine, connotative of an inherent disparity. It is meant neither as the biological affiliation of sex, nor as gender, the social response, or echo, of this biological affiliation. Rather, it is the spiritual attitude which is the norm for psychic manifestations in general, and is its subtle psychosomatic background. It is not necessarily connected with the (...) rude biological differentiation of sex, but rather appears as a quality in one or the other form; either as the individual, the social group or forms of activities, etc., without respect to the biological manifestations of the participants. What this paper attempts to demonstrate, is the way in which the above described notion of the feminine, functions in classical Asian cultures and philosophies. In the famous Yijing, for instance, this is seen as the hexagram correlated to the male Qian; in the philosophy of Yin and Yang, as Yin the Earth, in correlation with Yang, the Heaven; which are united in the famous Taiji diagram, a sophisticated development of Chinese Neo-Confucianism. The paper focuses on the Dao de jing, in which Lao Zi gives, as a counterbalance to the existing praxis, priority to the female principle. He remains, however, faithful to the Asian tradition, maintaining that the masculine and the feminine should remain equal, correlative, neither one nor the other vying for dominance. The correlative embrace, “When you know the male yet hold on to. the female” subsists in the mythical past where both principles are joined in androgynous unity. (shrink)

Les doctrines phénoménologiques, malgré la diversité de leurs formes, se rapprochent par le problème central vers lequel elles se dirigent, celui de l’apparaître et de l’être. Cette communication montre la nature, la nécessité et l’actualité de ce problème. L’être et l’apparaître sont en effet les pôles entre lesquels se déroulent la vie de l’âme, la vie du Tout, la vie de l’absolu. L’on doit donc se demander quels rapports ils ont l’un à l’autre, surtout dans une époque critique telle que (...) la nôtre où le processus d’expression de l’Absolu, dans le droit, la morale, la politique, la religion, paraît interrompu. (shrink)

This paper examines the situation of rurally rooted cross-border migrant workers from Myanmar during the Covid-19 pandemic. It looks at the circumstances of the migrants prior to the global health emergency, before exploring possibilities for a post-pandemic future for this stratum of the working people by raising critical questions addressed to agrarian movements. It does this by focusing on the nature and dynamics of the nexus of land and labour in the context of production and social reproduction, a view that (...) in the context of rurally rooted cross-border migrant workers necessarily requires interrelated perspectives on labour, agrarian, and food justice struggles. This requires a rethinking of the role of land, not as a factor in either production or social reproduction, but as a central component in both spheres simultaneously. The question is not ‘whether’ it is necessary and desirable to forge multi-class coalitions and struggles against external capital, while not losing sight of the exploitative relations within rural communities and the household; rather, the question is ‘how’ to achieve this. It will require a messy recursive process, going back and forth between theoretical exploration and practical politics. (shrink)

Two studies were conducted to assess the psychometric properties of scores from the Norwegian adaptation of the Big Five Inventory-2. In Study 1, the BFI-2 was translated to Norwegian and the scores from a convenience sample demonstrated good psychometric properties. BFI-2 scores from subsamples correlated in expected ways with self- and other ratings of the Big Five, and with self-ratings of empathic concern and perspective taking. In Study 2, after some minor improvements in translation, the psychometric properties of BFI-2 scores (...) were assessed in a new sample. Results from random intercept EFA of scores supported the proposed model. The psychometric properties of two shorter versions of the inventory, the BFI-2-S and BFI-2-XS, were also examined. Overall, the results suggest that the Norwegian adaptation of the BFI-2 provide reliable and valid scores. (shrink)

This article explores the relationship between utility and justice in the ancient Epicurean tradition, and as it developed in the seventeenth and eighteenth centuries following the revival of Epicureanism in the writings of Pierre Gassendi. It focuses on the significance of various allusions to a line from Horace, ‘utilitas, justi prope mater et aequi’, which appeared in writings of Hugo Grotius, David Hume, and Jeremy Bentham, and was used to give utility a prominence in modern hought that it had not (...) hitherto received. The article attempts to provide the context for Hume’s belief in the Enquiry concerning the Principles of Morals that the foundation of justice was utility and for Bentham placing utility at the foundation of his system. (shrink)

§ 1. The dates for Peisistratus’ reigns and exiles in the Athenaion Politeia, as given in the papyrus, which is the sole authority for the text, are as follows.

The avowed simplicity of thomasius' practical philosophy conceals its real complexity. His treatment of reason and will, Moral and political obligation, And freedom and authority particularly bears this out. The impact of his political philosophy was to transmute the operative ethos of absolutism by demonstrating that while absolute power was possible, Absolute authority was an absurdity.

A Buddhist philosopher on monotheism; text, translation with critical introduction of Nāgārjuna's Īśvarakartṛtva-nirākṛtiḥ-viṣṇoḥ-ekakartṛtva-nirākaraṇa.--History of materialism in India.--Theory of poetry in India.--Scientific achievements of ancient India.--Establishment of the existence of other minds; free translation of Dharmakīrti's Santānāntara-siddhi with Vinītadeva's Santānāntara-siddhi-ṭīkā.

In this article, F. Tony Carusi considers the politics of instrumentalism performed between educational policy and research that figures the teacher as the primary means to raise student achievement. By reducing teachers to a means toward an end, policy and research work together to collapse what teachers are into what teachers are for, and in doing so, they enable discourses that privilege the instrumental specifically as ontological. In contrast to this collapse, Carusi highlights here the resistance of the ontological to (...) the instrumental by considering what teachers are apart from what they are for. Thinking the ontological apart from the instrumental leads to a dark pedagogy in which the refusals and negations performed by teachers occur where the politics of instrumentalism that renders them as an “in-school factor” do not see. (shrink)

This chapter contains sections titled: Introduction Origins of the Contemporary Debate Historiographic Research and Writing Two Variants of Narrativist Philosophy of Historiography The Philosophical Approach The Transcendentalization of Narrativist Philosophy of Historiography Rhetorical Narrativist Philosophy Hayden White Conclusion Bibliography.