Comme tout hommage posthume réussi, le livre que nous recensons souffre de ce douloureux paradoxe : celui dont on honore la mémoire aurait adoré le lire. Il s’agit également de l’un des très rares hommages posthumes dont la liste des contributeurs comprend le nom du défunt lui-même. Joli pied de nez qu’aurait sans aucun doute apprécié l’apparemment très austère Angel d’Ors (1951-2012). Les quelque treize contributions réunies par Paloma Pérez-Ilzarbe et María Cerezo sont parfaitement représen...

The goal of this article is to shed light on Deep Brain Stimulation (DBS) postoperative suicidality risk factors within Treatment Resistant Depression (TRD) patients, in particular by focusing on the ethical concern of enrolling patient with history of self-estrangement, suicide attempts and impulsive–aggressive inclinations. In order to illustrate these ethical issues we report and review a clinical case associated with postoperative feelings of self-estrangement, self-harm behaviours and suicide attempt leading to the removal of DBS devices. Could prospectively identifying and excluding (...) patients with suicidality risk factors from DBS experimental trials—such as history of self-estrangement, suicide attempts and impulsive–aggressive inclinations—lead to minimizing the risk of suicidality harm? (shrink)

Following Wallace’s suggestion, Darwin framed his theory using Spencer’s expression “survival of the fittest”. Since then, fitness occupies a significant place in the conventional understanding of Darwinism, even though the explicit meaning of the term ‘fitness’ is rarely stated. In this paper I examine some of the different roles that fitness has played in the development of the theory. Whereas the meaning of fitness was originally understood in ecological terms, it took a statistical turn in terms of reproductive success throughout (...) the 20th Century. This has lead to the ever-increasing importance of sexually reproducing organisms and the populations they compose in evolutionary explanations. I will argue that, moving forward, evolutionary theory should look back at its ecological roots in order to be more inclusive in the type of systems it examines. Many biological systems can only be satisfactorily accounted for by offering a non-reproductive account of fitness. This argument will be made by examining biological systems with very small or transient population structures. I argue this has significant consequences for how we define Darwinism, increasing the significance of survival over that of reproduction. (shrink)

In her article, Pascale Hess raises the issue of whether her proposed model may be extrapolated and applied to clinical research fields other than stem cell-based interventions in the brain (SCBI-B) (Hess 2012). Broadly summarized, Hess’s model suggests prioritizing efficacy over safety in phase 1 trials involving irreversible interventions in the brain, when clinical criteria meet the appropriate population suffering from “degenerative brain diseases” (Hess 2012). Although there is a need to reconsider the traditional phase 1 model, especially with respect (...) to first-in-human clinical trials involving novel technologies, the question arises as to whether it is appropriate to advocate for a new model that prioritizes efficacy over safety across all phase 1 clinical research trials involving irreversible interventions in the brain. -/- . (shrink)

(2011). ACCE, Pharmacogenomics, and Stopping Clinical Trials: Time to Extend the CONSORT Statement? The American Journal of Bioethics: Vol. 11, No. 3, pp. 11-13.

Although being generally safe, the use of Deep Brain Stimulation has been associated with a significant number of patients experiencing postoperative psychological and neurological harm within experimental trials. A proportion of these postoperative severe adverse effects have lead to the decision to medically prescribe device deactivation or removal. However, there is little debate in the literature as to what is in the patient’s best interest when device removal has been prescribed; in particular, what should be the conceptual approach to ethically (...) guide the decision to remove or maintain implants. The purpose of this article is to examine the ethical issues raised when patients refuse brain device explantation despite medical prescription. In order to illustrate these issues, we report and discuss a clinical case involving a patient suffering from treatment resistant depression who experienced forms of postoperative self-estrangement, as well as suicidal attempts, but who resists giving consent to device explantation. (shrink)

Background: Informed consent for genetic tests is a well-established practice. It should be based on good quality information and in keeping with the patient’s values. Existing informed consent assessment tools assess knowledge and values. Nevertheless, there is no consensus on what specific elements need to be discussed or considered in the consent process for genetic tests.Methods: We performed a systematic review to identify all factors involved in the decision-making and consent process about genetic testing, from the perspective of patients. Through (...) public databases, we identified studies reporting factors that influence the decision to accept or decline genetic testing. Studies were included if they reported the perspective of patients or at-risk individuals. All articles were thematically coded.Results: 1989 articles were reviewed: 70 met inclusion criteria and 12 additional articles were identified through the references of included studies. Coding of the 82 articles led to the identification of 45 factors involved in decision-making and consent, which were initially divided into three domains: in favor of, against or with an undetermined influence on genetic testing. Each factor was also divided into three subdomains relating to the informed choice concept: knowledge, values or other. The factors in the “other” subdomain were all related to the context of testing (e.g. timing, cost, influence of family members, etc), and were present in all three domains.Conclusions: We describe the network of factors contributing to decision-making and consent process and identify the context of genetic testing as a third component to influence this process. Future studies should consider the evaluation of contextual factors as an important and relevant component of the consent and decision-making process about genetic tests. Based on these results, we plan to develop and test a more comprehensive tool to assess informed consent for genetic testing. (shrink)

The present paper unravels ontological and normative conditions of personhood for the purpose of critiquing ‘Cognitivist Views’. Such views have attracted much attention and affirmation by presenting the ontology of personhood in terms of higher-order cognition on the basis of which normative practices are explained and justified. However, these normative conditions are invoked to establish the alleged ontology in the first place. When we want to know what kind of entity has full moral status, it is tempting to establish an (...) ontology that fits our moral intuitions about who should qualify for such unique normative standing. But this approach conflates personhood’s ontology and normativity insofar as it stresses the primacy of the former while implicitly presupposing the latter; it thereby suffers from a ‘Normative Fallacy’ by inferring from ‘ought’ to ‘is’. Following my critique of Cognitivism, I sketch an alternative conception, contending that, whereas the Cognitivist ontology of personhood presupposes the normative, a social ontology is constituted by it. In due consideration of evidence from developmental psychology, the social embeddedness of persons—manifested in the ability of taking a ‘second-person stance’—is identified as a key feature of personhood that precedes higher-order cognition, and is directly linked to basic normative concerns. (shrink)

Postmortem evidence of chronic traumatic encephalopathy (CTE) in the brains of American National Football League players who suffered concussions while playing have intensified concerns about the risks of concussion in sport.1 Concussions are frequently sustained by amateur and professional players of Australia’s three most popular football codes (Australian football, rugby league, and rugby union) and, to a lesser extent, other contact sports such as soccer. This raises major concerns about possible long-term neurological damage, cognitive impairment and mental health problems in (...) players of these sports. (shrink)

Michel Henry has renewed our understanding of life as immanent affectivity: life cannot be reduced to what can be made visible; it is – as immanent and as affectivity – radically invisible. However, if life (la vie) is radically immanent, the living (le vivant ) has nonetheless to relate to the world: it has to exist . But, since existence requires and includes intentional components, human reality – being both living and existing – implies that immanence and intentionality be related (...) to one another, even though they are conceived at the same time as radically distinct modes of appearing in Henry’s phenomenology of life. Following this line of thought, we are faced with at least two questions: First, what reality does immanent appearing have for us as existing and intentional beings? And second, from an ethical point of view, what does Henry’s opposition of “barbarism” and “second birth” mean in terms of existence? As will be shown, it follows from the standpoint of radical phenomenology itself that immanent affectivity has reality for us only insofar as it finds its expression or translation in the realm of the intentionally visible and that, with regard to ethics, both “barbarism” and its overcoming in “second birth” are effective only insofar as they are mediated through representations. Henry’s critique of representation and intentionality needs therefore to be revised, especially in the field of practical philosophy, where the essential role played by intentionality has to be acknowledged even by radical phenomenology. (shrink)

Participatory Technology Assessment initiatives have usually been analyzed as if they existed in a social and political vacuum. This article analyzes the linkages that occur, in both directions, between the microcosm set up by a pTA exercise and the real world outside. This dual-dynamics perspective leads to a new way of understanding the function and significance of pTA initiatives. Rather than viewing them as a means to create the ideal conditions for real public debate, they are viewed here as an (...) additional public arena in which sociotechnical controversies are played out. This perspective is developed from the analysis of an interactive technology assessment exercise conducted by the French National Institute for Agricultural Research, on the topic of genetically modified vines. (shrink)

Le but de cet article est de montrer comment la lecture de Kant par Bergson, loin de se ramener à un mot d’ordre sommaire, comporte une reprise partielle, une critique précise, un refus ultime enfin, qui conduisent au cœur d’une relation profonde entre deux philosophies irréductibles. La reprise partielle de la distinction entre intelligence et intuition, et même entre matière et forme de l’intuition, doit être comprise autrement que comme un hommage ironique. Elle seule permet de comprendre l’unité que Bergson (...) revendique contre Kant, d’abord entre matière et forme de l’intuition, dans le cas du temps, puis entre intelligence et intuition même, à partir de L’évolution créatrice. À son tour, cette unité permet aussi de comprendre pourquoi l’intelligence reste à l’écart de l’intuition pratique dans le dernier grand livre de Bergson. « Gagnée » par l’intuition, l’intelligence ou l’entendement le sont donc bien en un double sens : non seulement surmontés, mais envahis par elle, jusqu’à une limite qui révèle au cœur d’un problème commun, une singulière différence.The purpose of this paper is to show how Bergson’s reading of Kant, far from any expeditive fightword, implies at the same time some reappropriation, a precise critique, and a final objection that together lead to the heart of a profound relationship between two irreducible doctrines. The partial endorsing of Kant’s distinction between intelligence and intuition, and even between matter and form of intuition itself, must not be understood only as a ironical hommage. On the contrary, it helps understanding the unity Bergson advocates against Kant, first between the matter and form of intuition, in the case of time, then between intuition and intelligence itself, after Creative Evolution. In its own turn, that unity helps understanding why intelligence is put aside of practical intuition in Bergson’s last great book. Intelligence or understanding are thus « won » in a double way : not only as surpassed, but also as penetrated by intuition, up to a last limit, which reveals a peculiar difference, at the heart of a common problem. (shrink)

Anticipatory policy for gene editing requires assessing public opinion about this new technology. Although previous surveys have examined respondents’ views on the moral acceptability of various hypothetical uses of CRISPR, they have not considered whether these scenarios are perceived as plausible. Research in construal level theory indicates that participants make different moral judgments about scenarios seen as likely or near and those seen as unlikely or distant. Therefore, we surveyed a representative sample of 400 Americans and Canadians about both the (...) likelihood and the permissibility of 23 commonly discussed uses of gene editing. Respondents with more knowledge of gene editing generally thought these applications would be more likely within the next 20 years. There was a strong positive relationship between the perceived likelihood and permissibility of most CRISPR applications. Our results suggest that ongoing public engagement efforts for gene editing could be improved by taking its perceived time-frames into account. (shrink)

From epileptic seizures to depressive symptoms, predictive neurotechnologies are used for a large range of applications. In this article we focus on advisory devices; namely, predictive neurotechnology programmed to detect specific neural events (e.g., epileptic seizure) and advise users to take necessary steps to reduce or avoid the impact of the forecasted neuroevent. Receiving advise from a predictive device is not without ethical concerns. The problem with predictive neural devices, in particular advisory ones, is the risk of seeing one’s autonomous (...) choice supplanted by the predictions instead of being supplemented by it. For users, there is a potential shift from being assisted by the system to being over-dependent on the technology. In other terms, it introduces ethical issues associated with epistemic dependency. In this article, we examine the notion of epistemic authority in relation to predictive neurotechnologies. Section 1 of our article explores and defines the concept of epistemic authority. In section 2, we illustrate how predictive devices are best conceived of as epistemic authorities and we explore the subject-device epistemic relationship. In section 3, we spell out the risk of harms interconnected with epistemic deferral. We conclude by stressing a set of preliminary measures to prepare users for the authoritative nature of predictive devices. (shrink)

When developing phylogenetic systematics, the entomologist Willi Hennig adopted elements from Nicolai Hartmann’s ontology. In this historical essay I take on the task of documenting this adoption. I argue that in order to build a metaphysical foundation for phylogenetic systematics, Hennig adopted from Hartmann four main metaphysical theses. These are (1) that what is real is what is temporal; (2) that the criterion of individuality is to have duration; (3) that species are supra-individuals; and (4) that there are levels of (...) reality, each of which may be subject to different kinds of law. Reliance on Hartmann’s metaphysics allowed Hennig to ground some of the main theoretical principles of phylogenetic systematics, namely that the biological categories—from the semaphoront to the highest rank—have reality and individuality despite not being universals, and that they form a hierarchy of levels, each of which may require different kinds of explanation. Hartmann’s metaphysics thereby provided a philosophical justification for Hennig’s phylogenetic systematics, both as a theory and as a method of classification. (shrink)

The article presents an overview of the intellectual trajectory of Alain Caillé, the founder and animator of the anti-utilitarian movement in the social sciences (MAUSS) in France. Going back to early influences of Claude Lefort, Karl Polanyi and Pierre Clastres, it shows the centrality of the symbolic constitution of the economy in the development of an intellectual front against rational choice. It also considers how Marcel Mauss’s famous Essay on the Gift has been developed into a ‘gift paradigm’ that aims (...) to unify the various social sciences into a comprehensive alternative to the interest paradigm. (shrink)

Given the complexity of most phenomena, we have to delegate much epistemic work to other knowers and we must find reasons for relying on these specific knowers and not others. In our societies, these other knowers are often called experts and we rely on their epistemic authority more and more. For many complex phenomena such as climate change, genetically modified crops, and immunization, the experts that are called upon are scientific experts. For that reason, finding good reasons and justification for (...) deferring to their knowledge is of paramount societal importance. As we shall see, many have analyzed this epistemic dependence on scientific experts and have tried to show in what contexts are there good... (shrink)

La politesse n’est pas seulement chez Hume une dissimulation sociale de l’orgueil et une vertu artificielle exigée par la vie en société, elle permet une intensification de la sympathie entre les hommes. Bien qu’elle repose sur une convention, comme la vertu de justice, son exercice est si manifestement désirable que l’artifice prend ici le caractère de la spontanéité et de l’agrément. Ainsi, même si la pensée de Hume échappe à l’idéalisation humaniste d’une sociabilité à la fois vertueuse et naturelle, elle (...) se démarque également de la tradition augustinienne et mandevillienne par le rôle donné à la sympathie et par la valeur éthique accordée à l’orgueil justifié, à la pratique de la conversation, et à la facilité dans l’exercice de la sociabilité. (shrink)

Radical phenomenology is nonintentional phenomenology, and it opposes what Michel Henry has designated since The Essence of Manifestation "onto-phenomenological monism,"1 according to which appearing is always ecstatic, that is, transcendent. Contrary to monism, radical phenomenology maintains a dualism of appearing: underlying the intentionally given, life reveals itself in pure immanence. Nonetheless, this living self-affection can never appear to intentionality, although the second is grounded in the first: they are two modes of appearing that are essentially different. While the very essence (...) of appearing or manifestation lies in immanent self-affection, intentional appearing is derived from and second to .. (shrink)

Nicolas de Cues effectue au XVe siècle un geste métaphysique qui nous paraît décisif pour la métaphysique classique et particulièrement pour la philosophie de Leibniz : il élabore une métaphysique de la singularité créée à partir de l’affirmation de l’infinité du Principe. La puissance de l’infinité divine renforce la valeur de chaque créature singulière grâce à un dispositif d’expression de l’infini dans le fini. Cependant ce processus de singularisation universel ne va pas sans soulever des difficultés. Comment la singularité de (...) la créature peut-elle s’ouvrir à l’infini ? Comment les créatures singulières peuvent-elles former un monde commun et se rapporter à leur Principe sans abandonner leur puissance de distinction ? Nous exposerons trois temps de ce processus de singularisation : la déduction, par une métaphysique expressive de l’infini, de la singularité conçue comme contraction de l’Unité divine ; l’intégration cosmologique des êtres singuliers ainsi déduits ; enfin la destinée spirituelle de l’intériorisation mentale de l’ensemble du processus. (shrink)

The complexity of the physiological phenotype currently prevents us from identifying an integrative measure to assess how the internal state and environmental conditions modify life‐history strategies. In this article, it is proposed that shorter telomeres should lead to a faster pace‐of‐life where investment in self‐maintenance is decreased as a means of saving energy for reproduction, but at the cost of somatic durability. Inversely, longer telomeres would favor an increased investment in soma maintenance and thus a longer reproductive lifespan (i.e., slower (...) pace‐of‐life). Under this hypothesis, telomere dynamics could be such an integrative mediator, which will assemble the information about oxidative stress levels, inflammation status and stress reactivity, and relate this information to the potential lifespan of the organism and its pace‐of‐life strategy. The signaling function of telomere dynamics can also reach over generations, a phenomenon in which the telomere lengths of gametes would provide a channel through which offspring would receive information about their environment early in their development, hence increasing the possibilities for developmental plasticity. -/- . (shrink)

"Of all the theorists of the first Critical Theory, Horkheimer was the one who most explicitly expressed his interest in moral theory. He concludes his research with the impossibility of any moral system possessing its own foundations. Habermas challenged Horkheimer's judgment that it was impossible to establish the completeness of a moral system without a transcendent foundation, and proposed communicational reason as an immanent foundation.

Digital platforms are increasingly criticized for being disembedded, raising ethical concerns about their minimal links with the economic, political, and cultural environments in which they operate. Many ‘local digital platforms’ argue that their connection with and responsibility to their territory sets them apart from traditional digital platforms. However, more research is needed to better understand how local platforms claim different forms of territorial embeddedness to address the ethical challenges of the platform economy. In this article, we analyze these claims and (...) abductively develop a typology of digital platforms’ links to their local environments based on eleven sub-dimensions, drawing on the concept of territorial embeddedness. According to our framework, territorial embeddedness is multifaceted, and platforms can be characterized by a continuum from weak to strong embeddedness. This renewed conceptualization offers a deeper understanding of local platforms’ territorial embeddedness. In addition, our framework allows for a critical examination of how local platforms respond to ethical challenges of the platform economy. Our research thus brings a fresh perspective to the polarized debate between platform capitalism and cooperativism. (shrink)

La publication de cet Aristoteles-Lexikon, sous la direction d’Otfried Höffe, fournit au lecteur germaniste un instrument de travail pratique et accessible, qui témoigne de la vitalité des études aristotéliciennes outre-Rhin, puisque pas moins de vingt-huit chercheurs, dans différentes universités, ont contribué à cet ouvrage. Plutôt que d’un index, c’est-à-dire d’une liste de citations regroupées par termes, sans prétention interprétative, il s’agit d’un dictionnaire visant à éclairer les co...

La philosophie de Nietzsche a longtemps servi de ligne de démarcation entre deux courants majeurs de la pensée critique contemporaine: l'École de Francfort, inspirée par Hegel et Marx, et le poststructuralisme français d'obédience nietzschéenne. C'est à une réévaluation originale de ce grand partage que le présent ouvrage se consacre. La pensée de Nietzsche est en fait une référence incontournable non seulement pour les théoriciens français de mai 68 (Foucault, Deleuze, Guattari), mais aussi pour la dialectique de l'Aufklärung d'Adorno et Horkheimer, (...) en passant par l'oeuvre de Canguilhem qui traite de la question des normes vitales et sociales à partir d'une lecture hétérodoxe de Nietzsche et de l'héritage français du comtisme. Il s'agit de comprendre comment une même pensée a pu irriguer des courants aussi différents et comment une philosophie apparemment conservatrice a pu nourrir et contribuer à l'élaboration des philosophies sociales critiques du XXe siècle."--Page 4 of cover. (shrink)

We resolve a useful formulation of the question how a statistician can coherently incorporate the information in a consulted expert’s probability assessment for an event into a personal posterior probability assertion. Using a framework that recognises the total information available as composed of units available only to each of them along with units available to both, we show: that a sufficient statistic for all the information available to both the expert and the statistician is the product of their odds ratios (...) in favour of the event; that the geometric mean of their two probabilities specifies a contour of pairs of assertions in the unit-square that yield the same posterior probability; that the information-combining function is parameterised by an unknown probability for the event conditioned only on the unspecified information common to both the statistician and the expert; and that an assessable mixing distribution over this unspecified probability allows an integrable mixture distribution to represent a computable posterior probability. The exact results allow the identification of the subclass of coherent probabilities that are externally Bayesian operators. This subclass is equivalent to the class of combining functions that honour the principles of uniformity and compromise. (shrink)

Dans le courant du XVII e siècle se multiplient en Chine les discours sur l’amitié. En partie liés à la déliquescence des structures traditionnelles et notamment familiales qui servaient de base au fonctionnement social de l’empire, ils proposent de réévaluer le lien amical dans l’organisation politique. He Xinyin (1517-1579) est à cet égard l’un des penseurs les plus innovants et radicaux. À travers la lecture de quelques essais majeurs recueillis dans le recueil de ses œuvres complètes, l’article entend expliciter la (...) réévaluation de l’amitié et sa dimension subversive chez cet auteur et montrer comment une telle redéfinition a pu instiller dans la culture chinoise du XVII e siècle et au-delà de nouveaux rapports subjectifs où l’individu émerge comme une entité cardinale dans les rapports sociaux ainsi que les idées de liberté d’expression. (shrink)

Les concepts scientifiques, même usés, même désuets, ne sont jamais définitivement périmés. Ils peuvent toujours faire retour dans les conjonctures théoriques ultérieures. Cela tient à la nature très particulière du concept, irréductible aux descriptions positivistes : issus de l’expérience et ayant vocation à en rendre raison, les concepts représentent autant d’arrachements à l’expérience et de survols explicatifs de l’expérience. Des épistémologues antipositivistes du xxe siècle ont été attentifs à de telles caractéristiques philosophiques. On expose ici leur modèle de la conceptualisation (...) scientifique et on le met au travail sur un cas, le concept de tendance, dont on montre il survit à la période de sa première formulation et il mérite de revenir dans les débats psychophysiologiques contemporains. (shrink)