The application of artificial intelligence and machine learning technologies in healthcare have immense potential to improve the care of patients. While there are some emerging practices surro...

This major study examines the most fundamental categories in terms of which we conceive of ourselves, critically surveying the concepts of substance, causation, agency, teleology, rationality, mind, body and person, and elaborating the conceptual fields in which they are embedded. The culmination of 40 years of thought on the philosophy of mind and the nature of the mankind Written by one of the world’s leading philosophers, the co-author of the monumental 4 volume _Analytical Commentary on the Philosophical Investigations_ Uses broad (...) categories, such as substance, causation, agency and power to examine how we think about ourselves and our nature Platonic and Aristotelian conceptions of human nature are sketched and contrasted Individual chapters clarify and provide an historical overview of a specific concept, then link the concept to ideas contained in other chapters. (shrink)

Philosophical and scientific investigations of the proprietary aspects of self—mineness or mental ownership—often presuppose that searching for unique constituents is a productive strategy. But there seem not to be any unique constituents. Here, it is argued that the “self-specificity” paradigm, which emphasizes subjective perspective, fails. Previously, it was argued that mode of access also fails to explain mineness. Fortunately, these failures, when leavened by other findings (those that exhibit varieties and vagaries of mineness), intimate an approach better suited to searching (...) for an explanation. Having an alternative in hand, one that shows promise of achieving explanatory adequacy, provides an additional reason to suspend the search for unique constituents. In short, a negative and a positive thesis are developed: we should cease looking for unique constituents and should seek to explain mineness in accord with the model developed here. This model rejects attempts to explain the phenomenon in terms of either a narrative or a minimal sense of self; it seeks to explain at a “molecular” level, one that appeals to multiple, interacting dimensions. The molecular-level model allows for the possibility that subjective perspective is distinct from a stark perspective (one that does not imply mineness). It proposes that the confounding of tacit expectations plays an important role in explaining mental ownership and its complement, disownership. But the confounding of tacit expectations is not sufficient. Because we are able to be aware of the existence of mental states that do not belong to self, we require a mechanism for determining degree of self-relatedness. One such mechanism is proposed here, and it is shown how this mechanism can be integrated into a general model of mental ownership. In the spirit of suggesting how this model might be able to help resolve outstanding problems, the question as to whether inserted thoughts belong to the patient who reports them is also considered. (shrink)

The pragmatic framework developed by H.P. Grice in “Logic and Conversation” explains how a speaker can mean something more than, or different from, the conventional meaning of the sentence she utters. But it has been argued that the framework cannot give a similar explanation for cases where these pragmatic effects impact the understood content of an embedded clause, such as the antecedent of a conditional, a clausal disjunct, or the clausal complement of a verb. In this paper, I (...) show that such an explanation is available. One of the central arguments of the paper is that in a significant subset of cases, local pragmatic effects are a consequence of a global pragmatic requirement. In these cases, local pragmatic effects are a consequence of ‘acting locally’ to resolve a potential global pragmatic violation. These cases do not require us to posit application of pragmatic principles to the contents of embedded clauses. The account does, though, require the assumption that interpreters can identify and reason about the contents of unasserted sub-parts of sentences, an assumption that I motivate in section 3. Building on this, in section 4 of the paper, I argue that once we have recognized that interpreters can, and do, reason independently about the contents of non-asserted clauses, it becomes unproblematic to assume that in some cases, Gricean conversational principles do apply directly to these contents, providing an alternative route to account for local pragmatic effects. In revisiting the ideas of this paper in my response to the commentaries, I consider in more detail the revisions to Grice’s broader program that are necessitated by these moves, in particular acknowledging the problematicity of Grice’s notion of what is said. I argue that the starting point for Gricean reconstructions should instead be merely what is expressed, which carries no pragmatic commitments regarding what is speaker meant. (shrink)

In this paper we argue that normative reasons are hyperintensional and put forward a formal account of this thesis. That reasons are hyperintensional means that a reason for a proposition does not imply that it is also a reason for a logically equivalent proposition. In the first part we consider three arguments for the hyperintensionality of reasons: an argument from the nature of reasons, an argument from substitutivity and an argument from explanatory power. In the second part we describe a (...) hyperintensional logic of reasons based on justification logics. Eventually we discuss the philosophical import of this proposal and highlight some limitations and possible developments. (shrink)

In this paper we address the issue of how to think about immunity. Many immunological writings suggest a straightforward option: the view that the immune system is primarily a system of defense, which naturally invites the talk of strong immunity and strong immune response. Despite their undisputable positive role in immunology, such metaphors can also pose a risk of establishing a narrow perspective, omitting from consideration phenomena that do not neatly fit those powerful metaphors. Building on this analysis, we argue (...) two things. First, we argue that the immune system is involved not only in defense. Second, by disentangling various possible meanings of ‘strength’ and ‘weakness’ in immunology, we also argue that such a construal of immunity generally contributes to the distortion of the overall picture of what the immune system is, what it does, and why it sometimes fails. Instead, we propose to understand the nature of the immune system in terms of contextuality, regulation, and trade-offs. We suggest that our approach provides lessons for a general understanding of the organizing principles of the immune system in health and disease. For all this to work, we discuss a wide range of immunological phenomena. (shrink)

In this conceptual article, we argue that defining corporate social responsibility and corporate social irresponsibility as opposite constructs produces a lack of clarity between responsible and irresponsible acts. Furthermore, we contend that the treatment of the CSR and CSI concepts as opposites de-emphasizes the value of CSI as a stand-alone construct. Thus, we reorient the CSI discussion to include multiple aspects that current conceptualizations have not adequately accommodated. We provide an in-depth exploration of how researchers define CSI and both identify (...) and analyze three important gray zones between CSR and CSI: the role of harm and benefit, the role of the actor and intentionality, and the role of rectification. We offer these gray zones as factors contributing to the present lack of conceptual clarity of the term CSI, as a concept in its own right, leading to difficulties that researchers and managers experience in categorizing CSI acts as distinct from CSR. (shrink)

Research on the concept of affordance generated different interpretations, which are due to different stories aimed at describing how this notion accounts for visually guided motor behaviors. On the one hand, _dispositional accounts of affordances_ explain how affordances emerge from the encounter of the agent’s perceptual-motor skills, with an object offering possible interactions, as _behavioral dispositional properties_. On the other hand, _cognitive neuroscience_ explains what neural mechanisms are required for agents to detect affordances, resulting from an internal _processing_. As the (...) literature recognized, it would be beneficial to connect these two stories. We propose an important step into this connection, showing how a _dispositional notion_ of affordance can be distinguished into two versions, the _Dispositional Account of Nomological Affordance Response_ and the _Dispositional Account of Probable Affordance Response_, and how to complement different aspects of _visuomotor processing_ for affordance extraction, discussed in _neuroscience_, with them. An important benefit of our proposal is that it suggests, for the first time, that we should not prefer one _dispositional_ account at the expense of the other. Indeed, we show that different _dispositional_ accounts can capture distinct aspects of the plethora of complex manifestations, at the neurocognitive level of visuomotor-processing, that affordances can display in humans, both in healthy and pathological subjects. (shrink)

Recently, the mechanistic framework of active inference has been put forward as a principled foundation to develop an overarching theory of consciousness which would help address conceptual disparities in the field (Wiese 2018 ; Hohwy and Seth 2020 ). For that promise to bear out, we argue that current proposals resting on the active inference scheme need refinement to become a process theory of consciousness. One way of improving a theory in mechanistic terms is to use formalisms such as (...) computational models that implement, attune and validate the conceptual notions put forward. Here, we examine how computational modelling approaches have been used to refine the theoretical proposals linking active inference and consciousness, with a focus on the extent and success to which they have been developed to accommodate different facets of consciousness and experimental paradigms, as well as how simulations and empirical data have been used to test and improve these computational models. While current attempts using this approach have shown promising results, we argue they remain preliminary in nature. To refine their predictive and structural validity, testing those models against empirical data is needed i.e., new and unobserved neural data. A remaining challenge for active inference to become a theory of consciousness is to generalize the model to accommodate the broad range of consciousness explananda; and in particular to account for the phenomenological aspects of experience. Notwithstanding these gaps, this approach has proven to be a valuable avenue for theory advancement and holds great potential for future research. (shrink)

The history of maternal-fetal therapy is a complex and compelling one. It can be argued that the science and ethics underpinning this field evolved together, with emerging technology spurring on th...

Appeals to the miraculous are common in healthcare, and arguments about end-of-life decision-making can quickly become theological. Assessments of hope have been recommended within the biopsychosocialspiritual model of medicine, but these assessments fail to account for the theological dimension of hope. Examples of failed assessments include recent efforts in palliative care and classic works, such as On Death and Dying by Elisabeth Kübler-Ross. To adequately address the patient’s and family members’ hopes without patronizing or harming the patient, assessments must be (...) done by a person trained in theology. (shrink)

In this paper, we provide an analysis of the concept of legal personality and discuss whether personality may be conferred on artificial intelligence systems (AIs). Legal personality will be presented as a doctrinal category that holds together bundles of rights and obligations; as a result, we first frame it as a node of inferential links between factual preconditions and legal effects. However, this inferentialist reading does not account for the ‘background reasons’ of legal personality, i.e., it does not explain why (...) we cluster different situations under this doctrinal category and how extra-legal information is integrated into it. We argue that one way to account for this background is to adopt a neoinstitutional perspective and to update the ontology of legal concepts with a further layer, the meta-institutional one. We finally argue that meta-institutional concepts can also support us in finding an equilibrium around the legal-policy choices that are involved in including (or not including) AIs among legal persons. (shrink)

This paper concerns an information extraction process for building a dynamic legislation network from legal documents. Unlike supervised learning approaches which require additional calculations, the idea here is to apply information extraction methodologies by identifying distinct expressions in legal text in order to extract network information. The study highlights the importance of data accuracy in network analysis and improves approximate string matching techniques to produce reliable network data-sets with more than 98% precision and recall. The applications and the complexity of (...) the created dynamic legislation network are also discussed and challenged. (shrink)

A chronicled approach to the notion of computer simulations shows that there are two predominant interpretations in the specialized literature. According to the first interpretation, computer simulations are techniques for finding the set of solutions to a mathematical model. I call this first interpretation the problem-solving technique viewpoint. In its second interpretation, computer simulations are considered to describe patterns of behavior of a target system. I call this second interpretation the description of patterns of behavior viewpoint of computer simulations. This (...) article explores these two interpretations of computer simulations from three different angles. First, I collect a series of definitions of computer simulation from the historical record. I track back definitions to the early 1960s and show how each viewpoint shares similar interpretations of computer simulations—ultimately clustering into the two viewpoints aforementioned. This reconstruction also includes the most recent literature. Second, I unpack the philosophical assumptions behind each viewpoint, with a special emphasis on their differences. Third, I discuss the philosophical implications of each viewpoint in the context of the recent discussion on the logic of scientific explanation for computer simulations. (shrink)

The goal of this article is to offer a new model for the study of ocularization in film grounded in the semiotic pragmatism of Charles Sanders Peirce. We first present a literature overview addressing the state of research regarding the theorization of ocularization in film studies. Second, we discuss Peirce’s three universal categories (Firstness, Secondness, and Thirdness) on which our model will be based. Third, we argue how the theme of ocularization in film, as outlined in the first part, can (...) be theorized anew through these categories. This will result in the introduction of a nine-field matrix that will allow us to systemize all kinds of instances of subjectivity in cinema. Lastly, we will demonstrate the empirical usefulness of this model by illustrating each of the matrix’ nine categories through a discussion of Steven Soderbergh’s film Kimi (2022). (shrink)

The truth-conditions of many utterances have components that do not correspond to any uttered morpheme. This happens because linguistic acts are always a supplement to whatever else is available to agents engaged in a conversation. Unarticulated constituents result from the informational trade-off between what is available in the situation of utterance and what needs to be linguistically articulated. Unarticulated constituents are constituents of propositions, that is, of classifying tools that are neutral with respect to the way in which what is (...) given in a situation interacts with the words uttered. (shrink)

A model of normative provisions and related axioms represented by using RDF/owl are presented as a contribution to implement the semantic web in the legal domain. In particular, a pattern able to implement the Hohfeldian legal fundamental relations between provisions using OWL-DL expressivity is proposed. Moreover, a query-based approach able to deal with relations between provision instances is described. An example of advanced access and reasoning over provisions using the proposed approach, as well as a prototype architecture of a provision (...) retrieval system, are shown. The main benefit is represented by the ability of the approach to keep the complexity of the problem within a description logic computational tractability. (shrink)

Liao and Carbonell explore how oppressive medical technologies constitute materiality insofar as they reflect past oppression, embody oppression in the present day, and carry oppression into the fu...

The integrity of the patient–physician relationship depends on maintaining professional boundaries. While ethicists and professional organisations have devoted significant consideration to the subject of sexual boundary transgressions, the subject of non-sexual boundaries, especially outside the mental health setting, has been largely neglected. While professional organisations may offer guidance on specific subjects, such as accepting gifts or treating relatives, as well as general guidance on transparency and conflict of interest, what is missing is a principle-based method that providers can use to (...) assess non-sexual interactions with patients that transcend norms of practice. This paper attempts to offer an operational model for such assessment that considers not only the traditional emphasis on beneficence, but also incorporates concerns over entanglement and concordance. (shrink)

When research concludes, post-trial access to the trial intervention or standard healthcare can be crucial for participants who are ill such as those in resource-poor countries with inadequate healthcare, British participants testing ‘last-chance drugs’ unavailable on the National Health Service and underinsured US participants. Yet, many researchers are unclear about their obligations regarding the post-trial period, and many research ethics committees do not know what to require of researchers. Consequences include participants who reasonably expect but lack PTA to the trial (...) intervention, unplanned financial liabilities for NHS Trusts forced to fund this, negative press and potential to undermine public trust.1–3,iOne reason for the lack of clarity is controversy over whether and when participants should have access, after the study, to the study intervention. At one extreme is the view that continued access should be ensured when the intervention has benefited the participant or when it has proven safe and effective for the participant population, irrespective of the cost and burden of ensuring continued access. At the other extreme is the view that continued access need never be provided so long as non-availability of the study intervention post-trial was adequately disclosed when participants were invited to participate.6 There is also disagreement about when poststudy access to the study intervention should be considered beneficial for participants. The spectrum ranges from the view that the intervention should be regarded as beneficial for a proposed use only after the …. (shrink)

Opinions have varied wildly as to whether the roots of language run extremely deep in the human lineage, or, alternatively, whether this unprecedented capacity is a recent acquisition. The question has been exacerbated by the fact that language itself does not preserve, so that its possession by earlier hominids has had to be inferred from indirect material proxies. Here I argue that while most technological putative proxies from the Paleolithic are certainly evidence of highly complex cognitive states among our precursors, (...) virtually none of them can reliably be taken as witness to the specific symbolic cognitive style that human beings share today—and with which language is intricately intertwined. Symbolic reasoning can only be confidently inferred from explicitly symbolic objects. These latter only became integral to hominid societies within the tenure of anatomically modern Homo sapiens, and their appearance marked an extreme inflection in the tempo of change as seen in the archaeological record. I thus suggest that the neural capacity for symbolic reasoning and language was acquired during the major developmental reorganization that gave rise to the highly anatomically distinctive H. sapiens some 200 thousand years ago, but that that the new potential was not exploited until about 100 thousand years later, when it was released by what was necessarily a cultural stimulus. Most probably, this stimulus was the spontaneous invention of externalized structured language. This brings the origin of language into the realm of exaptation and emergence—both of them familiar evolutionary phenomena requiring no special explanation—and excludes the long-term fine-tuning of language and human reasoning by natural selection. (shrink)

Adaptive phenotypic plasticity allows organisms to cope with environmental variability, and yet, despite its adaptive significance, phenotypic plasticity is neither ubiquitous nor infinite. In this review, we merge developmental and population genetic perspectives to explore costs and limits on the evolution of plasticity. Specifically, we focus on the role of modularity in developmental genetic networks as a mechanism underlying phenotypic plasticity, and apply to it lessons learned from population genetic theory on the interplay between relaxed selection and mutation accumulation. We (...) argue that the environmental specificity of gene expression and the associated reduction in pleiotropic constraints drive a fundamental tradeoff between the range of plasticity that can be accommodated and mutation accumulation in alternative developmental networks. This tradeoff has broad implications for understanding the origin and maintenance of plasticity and may contribute to a better understanding of the role of plasticity in the origin, diversification, and loss of phenotypic diversity. (shrink)

Business Ethics, the Environment &Responsibility, Volume 31, Issue 4, Page 1136-1156, October 2022.

Douglas Husak contends that both criminalization and punishment can serve preventive goals, so long as they respect retributive culpability constraints. This Essay draws on Husak’s work to argue that, while Husak is right to defend the legitimacy of criminal law as a preventive endeavor, preventive coercion is also permissible on consequentialist grounds alone, outside the culpability constraints of the criminal law. The Essay presents a unified consequentialist theory of preventive coercion, addresses deontological objections to ‘pure’ preventive detention, and argues that (...) a consequentialist approach to prevention might ultimately be more protective of liberty and equality interests than the deontological ‘mad or bad’ approach that currently dominates Anglo-American jurisprudence and legal theory. (shrink)

Business and Society Review, Volume 127, Issue 1, Page 23-48, Spring 2022.

This textbook provides a survey of the literature of social choice. It integrates the ethical aspects of the subject, with positive aspects of decision mechanisms that centre on the revelation of true preferences. The literature on the subject presently consists of a great many papers. This book draws them together in common notation and points out interpretations which are often missing in specialist papers. Applications in economics, electoral politics, and ethics are discussed. The book will be used by senior undergraduate (...) and graduate students of economics, political science and philosophy as a text book in the subject. (shrink)

The first half of this Editorial examines the implications of the close link between morality and religion in Islamic thinking. There is no separate discipline of ethics in Islam, and the comparative importance of reason and revelation in determining moral values is open to debate. For most Muslims, what is considered halāl (permitted) and harām (forbidden) in Islam is understood in terms of what God defines as right and good. There are three main kinds of values: (a) akhlāq, which refers (...) to the duties and responsibilities set out in the shari‘ah and in Islamic teaching generally; (b) adab, which refers to the manners associated with good breeding; and (c) the qualities of character possessed by a good Muslim, following the example of the Prophet Muhammad. Among the main differences between Islamic and western morality are the emphasis on timeless religious principles, the role of the law in enforcing morality, the different understanding of rights, the rejection of moral autonomy as a goal of moral education and the stress on reward in the Hereafter as a motivator of moral behaviour. The remainder of the Editorial is concerned with the two main aspects of moral education in Islam: disseminating knowledge of what people should and should not do, and motivating them to act in accordance with that knowledge. Ultimately, moral education is about inner change, which is a spiritual matter and comes about through the internalisation of universal Islamic values. (shrink)

In her article, Lee vouches for a reciprocity-based approach that supports an ethics of inclusion in precision medicine research and accounts for participants’ values and experiences of the...

BackgroundThis manuscript presents a framework to guide the identification and assessment of ethical opportunities and challenges associated with electronic patient records (EPR). The framework is intended to support designers, software engineers, health service managers, and end-users to realise a responsible, robust and reliable EPR-enabled healthcare system that delivers safe, quality assured, value conscious care.MethodsDevelopment of the EPR applied ethics framework was preceded by a scoping review which mapped the literature related to the ethics of EPR technology. The (...) underlying assumption behind the framework presented in this manuscript is that ethical values can inform all stages of the EPR-lifecycle from design, through development, implementation, and practical application.ResultsThe framework is divided into two parts: context and core functions. The first part ‘context’ entails clarifying: the purpose(s) within which the EPR exists or will exist; the interested parties and their relationships; and the regulatory, codes of professional conduct and organisational policy frame of reference. Understanding the context is required before addressing the second part of the framework which focuses on EPR ‘core functions’ of data collection, data access, and digitally-enabled healthcare.ConclusionsThe primary objective of the EPR Applied Ethics Framework is to help identify and create value and benefits rather than to merely prevent risks. It should therefore be used to steer an EPR project to success rather than be seen as a set of inhibitory rules. The framework is adaptable to a wide range of EPR categories and can cater for new and evolving EPR-enabled healthcare priorities. It is therefore an iterative tool that should be revisited as new EPR-related state-of-affairs, capabilities or activities emerge. (shrink)