Driven by technological innovations, newborn screening (NBS) panels have been expanded and the development of genomic NBS pilot programs is rapidly progressing. Decisions on disease selection for NBS are still based on the Wilson and Jungner (WJ) criteria published in 1968. Despite this uniform reference, interpretation of the WJ criteria and actual disease selection for NBS programs are highly variable. A systematic literature search [PubMED search “Wilson” AND “Jungner”; last search 16.07.22] was performed to evaluate the applicability of the WJ (...) criteria for current and future NBS programs and the need for adaptation. By at least two reviewers, 105 publications (systematic literature search, N = 77; manual search, N = 28) were screened for relevant content and, finally, 38 publications were evaluated. Limited by the study design of qualitative text analysis, no statistical evaluation was performed, but a structured collection of reported aspects of criticism and proposed improvements was instead collated. This revealed a set of general limitations of the WJ criteria, such as imprecise terminology, lack of measurability and objectivity, missing pediatric focus, and absent guidance on program management. Furthermore, it unraveled specific aspects of criticism on clinical, diagnostic, therapeutic, and economical aspects. A major obstacle was found to be the incompletely understood natural history and phenotypic diversity of rare diseases prior to NBS implementation, resulting in uncertainty about case definition, risk stratification, and indications for treatment. This gap could be closed through the systematic collection and evaluation of real-world evidence on the quality, safety, and (cost-)effectiveness of NBS, as well as the long-term benefits experienced by screened individuals. An integrated NBS public health program that is designed to continuously learn would fulfil these requirements, and a multi-dimensional framework for future NBS programs integrating medical, ethical, legal, and societal perspectives is overdue. (shrink)

The concept of facticity denotes conditions of experience whose necessity is not logical yet whose contingency is not empirical. Although often associated with Heidegger, Fichte coins ‘facticity’ in his Berlin period to refer to the conclusion of Kant’s metaphysical deduction of the categories, which he argues leaves it a contingent matter that we have the conditions of experience that we do. Such rhapsodic or factical conditions, he argues, must follow necessarily, independent of empirical givenness, from the I through a process (...) of ‘genesis.’ I reconstruct Fichte’s argument by tracing the origin of his neologism, presenting his Jena critique of Kant’s rhapsodic appeal to the forms of judgment, and illustrating the Jena period’s continuity with the Berlin period’s genetic method, while noting a methodological shift whereby Fichte directs his critique against his own doctrine of intellectual intuition in order to eliminate its ‘factical terms.’. (shrink)

While the idea that philosophy requires self-transformation is historically pervasive, it exerts considerable influence on the post-Kantians who first aim to systematize Kant’s idealism by grounding it on a first principle. In the 1790s, Fichte and Schelling offer competing accounts of the self-transformation that they regard as essential to positing a first principle. Their accounts raise two central questions. First, what makes this kind of self-transformation possible? Second, are there different possible expressions of philosophical self-transformation? In what follows, I will (...) articulate the Fichtean and Schellingian answers to these central questions. For Fichte, the one who summons me to posit a first principle makes possible my philosophical self-transformation, although the latter has an exclusively idealist expression in that I can only genuinely posit the I as first principle, which is to say that philosophical self-transformation depends on mutual recognition and vindicates precisely one philosophical system (Section 1). For Schelling, a brute act of will makes possible my philosophical self-transformation, although the latter has either an idealist or a realist expression in that I can genuinely posit either the I or the not-I as first principle, which is to say that philosophical self-transformation does not depend on mutual recognition and vindicates one of two possible philosophical systems (Section 2). Thus, whereas Fichtean self-transformation is recognitive and non-pluralistic, Schellingian self-transformation is pluralistic and non-recognitive. I conclude with a discussion of how Jacobi poses a challenge to Fichte’s and Schelling’s answers to the two central questions (Section 3). (shrink)

This article aims to explicate the concept of emotional sharing against the background of interactive and situated approaches to affectivity, and to contextualize emotional sharing within the broader context of emotion research. It brings together research on situated affectivity with the debate on collective emotion. Emotional sharing is defined via four requirements and distinguished from other phenomena in the broad field of collective emotion, especially from mechanisms of emotional convergence and other forms of affective we-experience. The paper makes use of (...) the recently proposed concepts of affective scaffolding and affective arrangement to explore how emotional sharing is always enacted in sociorelational dynamics and embedded in socio-material contexts which enable, shape, and modulate the unfolding of emotional sharing and regulate who is likely to participate. (shrink)

In these essays, we are concerned with virtue in journalism and the media but are mindful of the tension between the commercial foundations of publishing and broadcasting, on the one hand, and journalism's democratic obligations on the other. Adam outlines, first, a moral vision of journalism focusing on individualistic concepts of authorship and craft. Next, Craft attempts to bridge individual and organizational concerns by examining the obligations of organizations to the individuals working within them. Finally, Cohen discusses the importance of (...) resisting the powerful corporate logic that pervades the news media in the United States and calls on journalists to be courageous. (shrink)

Research has demonstrated that employee reactions to monitoring systems depend on both the characteristics of the monitoring system and how it is implemented. However, little is known about the role individual differences may play in this process. This study proposes that individuals have generalized attitudes toward organizational control and monitoring activities. We examined this argument by assessing the relationship between employees’ baseline attitudes toward a set of monitoring and control techniques that span the employment relationship. We further explore the effects (...) of employees’ generalized attitudes toward monitoring and their individual ethical orientations on their attitudinal reactions to an Internet monitoring system implemented in their workplace. Results of a longitudinal study indicate that as expected, prior beliefs and ethical orientation interact to affect employees’ reactions to monitoring systems. Implications for research and practice are discussed. (shrink)

From ancient conceptions of becoming a philosopher to modern discussions of psychedelic drugs, the concept of transformation plays a fascinating part in the history of philosophy. However, until now there has been no sustained exploration of the full extent of its role. Transformation and the History of Philosophy is an outstanding survey of the history, nature, and development of the idea of transformation, from the ancient period to the twentieth century. Comprising twenty-two specially commissioned chapters by an international team of (...) contributors, the volume is divided into four clear parts: -/- - Philosophy as Transformative: Ancient China, Greece, India, and Rome - Transformation Between the Human and the Divine: Medieval and Early Modern Philosophy - Transformation After the Copernican Revolution: Post-Kantian Philosophy - Treatises, Pregnancies, Psychedelics, and Epiphanies: Twentieth-Century Philosophy. -/- Each of these sections begins with an introduction by the editors. Transformation and the History of Philosophy is essential reading for students and researchers in the history of western and non-western philosophy, ethics, metaphysics, and aesthetics. It will also be extremely useful for those in related disciplines such as religion, sociology, and the history of ideas. (shrink)

Zermelo once wrote that he had anticipated Russell's contradiction of the set of all sets that are not members of themselves. Is this sufficient for having anticipated Russell's Paradox — the paradox that revealed the untenability of the logical notion of a set as an extension? This paper argues that it is not sufficient and offers criteria that are necessary and sufficient for having discovered Russell's Paradox. It is shown that there is ample evidence that Russell satisfied the criteria and (...) that Zermelo did not. (shrink)

Monitored Emergency Use of Unregistered and Experimental Interventions (MEURI) is an ethical framework developed by the WHO for using unproven interventions in public health emergencies outside the context of medical research. It is mainly intended for use when medical research would be impracticable, but there is still a need to systematically gather data about unproven interventions. As such, it is designed as something of a middle ground between clinical and research ethical frameworks. However, I argue that MEURI does not truly (...) lie at the intersection of clinical care and research. Due to its intent, structure and oversight requirements, it takes on most of the crucial features of research, to the point that it is best understood as a form of research. As a result, cases where MEURI could practicably be applied should instead make use of existing research frameworks. For those circumstances where research is truly impracticable, a more straightforward oversight system than MEURI is needed. While existing practices of compassionate use have some applicability, proposals to make use of clinical ethics committees to oversee unproven interventions may help achieve the right balance in acting in a patient’s best interests when the relevant evidence base is weak. (shrink)

Plutarch, in his work,_ Peri __Deisidaimon_ia_ __,_ presents a striking portrayal of superstition in the First Century. The Philosopher who also served for decades as a priest of Apollo portrays the pernicious effects of some supposed religious practices as worse than the outcome of atheism. His position constitutes a forceful explanation to ostensibly controversial socio-religious behaviours. This article discusses some of the priest’s concerns as well as his rebuff of religious attitudes that are borne out of what he describes as (...) misrepresentation of the gods or superstition. Plutarch’s essay is seen as illustrating a reason for a socio-religious situation in Africa, a continent that shares a similar religious background with the world of the writer. Specifically, with the example of the hard fight against street begging in some parts of Nigeria, the article shows how social reform programmes could fail when effects of traditional African beliefs and cultural practices remain potent. __. (shrink)

The Platonic Commentators.—After Cicero the Academy is no more than a few names to us for nearly five centuries. The nearest that we get to contact with it in this period is in the writings of Plutarch. He was himself a student there, and was well read in the books of Plato and the commentaries thereon.

Fabvla misere mutila: this notice in the Oxford edition, reinforced in the critical apparatus, warns the reader against the transmitted text of the Heradidae. It tends to perpetuate the view which Wilamowitz, following up the hints of G. Hermann and A. Kirchhoff, propounded in 1882. The sweeping assurance of his famous article gave it a publicity which makes a detailed rehearsal superfluous. Wilamowitz throughout his life stuck to the opinion that ‘wir lesen die Herakliden in der Bearbeitung eines Regisseurs’. Dissentient (...) voices have been raised from time to time. M. Pohlenz in 1930 even proposed an interpretation of the Heradidae which quietly discarded the thesis of Wilamowitz. Nevertheless the latter appears still to hold the field at least in the English-speaking countries. If it is correct, the Heradidae of Euripides is beyond our reach. This conclusion has indeed, quite recently, been drawn by H. D. F. Kitto. (shrink)

The main aim of this paper is to discuss a recently discovered manuscript of Vāsudēvappāṭṭu and to comment on the characteristic features of the text: its devotional content, language and philosophy. Vāsudēvappāṭṭu is a bhakti song written in the Tamil-Maṇipravāḷa language and attributed to Pūntānam (1547–1640), one of the prominent devotional poets of Kerala, who is often praised as a talented and prolific writer and an ardent devotee of Kṛṣṇa. The first section of the paper investigates the linguistic features of (...) the work, the writing style, and the characteristics of the manuscript itself. The second part focuses on the content of the poem: its style, tone, and religious motives. Furthermore, the article suggests that Vāsudēvappāṭṭu belongs to the South-Indian pāṭṭu genre and discusses the work in the context of the pāṭṭu literature of Kerala. Moreover, to highlight the performative aspects of pāṭṭu, the authors have recorded a traditional recitation of Vāsudēvappāṭṭu, which can be found attached to this paper. The paper also considers the features of the manuscript and therefore contributes to current research on Keralan Bhakti literature and participates in ongoing debates on the production of pre-modern Indian texts and manuscriptology. (shrink)

There is a long history to the debate of nationalism. The Indian nationalism has emerged after a long people’s movement the truth to which is often denied by a range of forces who have ideological leanings towards the ideology of Hindutwa. This paper is an attempt to revisit the historical context in which Indian nationalism has emerged and evaluate it in reference to the contemporary time. It emphasizes on the relation between the nation and the state with special reference to (...) its impact on the universities. Further, the paper suggests that in order to uphold the idea of university and nation, an inclusive and secular idea of nation has to be espoused. Lastly, it suggests that a university needs to foster a non sectarian approach and broaden its vision for an internationalist outlook. (shrink)

It is usual to read nomina, with which three interpretations are possible. The stronger arrogates to himself the titles of moderation and justice. So in the excellent Rumanian translation of 1871 by Gavrilu J. Munteanu: ‘Cându are sâ decida pumnulu, celu mai tare si atribue titlu de moderatu şi de onestu.’.

The article aims to develop the philosophy of Emmanuel Levinas as a valuable new perspective in understanding the triune drama of the Resurrection. Firstly, the juxtaposition of Levinas’ thought and Christian theology will be argued for, followed by a development of von Balthasar’s Trinitarian theology of the Resurrection. Especially, Levinas’ non-phenomenological notion of “otherness” will be used to offer an understanding of the Risen Christ’s “Otherness” as communicating the non-phenomenality of Holy Saturday to the disciples. As a result, we discover (...) significant theological openings towards a vision of a Biblical God free from the constraints of ontological thinking and phenomenal experience. (shrink)

Since these notes were written, news has come of the finding at Troizen of an inscription purporting to bear a decree proposed by Themistokles in 480, which is relevant to Part II above, pp. 33–35. If this new evience is valid, it would appear to confirm the view expressed there to some extent.