The increased incidence of morbidity and mortality due to Clostridium difficile infection, had led to the emergence of fecal microbial transplantation (FMT) as a highly successful treatment. From this, a 32 strain stool substitute has been derived, and successfully tested in a pilot human study. These approaches could revolutionize not only medical care of infectious diseases, but potentially many other conditions linked to the human microbiome. But a second revolution may be needed in order for regulatory agencies, society and medical (...) practitioners to accept and utilize these interventions, monitor their long term effects, have a degree of control over their use, or at a minimum provide guidelines for donors and recipients. (shrink)

This article explores the theory of natural kind essentialism, as developed by Putnam and Kripke. It defends the theory against certain criticisms, but also suggests that it should not be treated as universally true. Rather, it comes down to how different people use language, offering reasons why some people's idiolects might behave in an essentialist way while others behave in the contrary way, but explaining how we can all still communicate perfectly well despite this.

ALTHOUGH the content of Alexander Gottlieb Baumgarten's Aesthetica seems to be familiar in German philosophical circles, it is relatively unknown outside Germany. Most of us are aware that it was Baumgarten who coined the name "aesthetics" for the new philosophical discipline his Aesthetica was intended to establish; but as for the content of that work, our acquaintance is likely to be indirect, through two remarks of Kant. Explaining his own use of "Transcendental Aesthetic" in the Critique of Pure Reason, Kant (...) criticizes Baumgarten's "abortive attempt... to bring the critical treatment of the beautiful under rational principles and so to raise its rules to the rank of a science". In the Critique of Judgment, it is generally assumed to be Baumgarten Kant has in mind when, arguing that judgments of beauty are not cognitive or "logical" judgments, he criticizes the view that beauty is perfection known confusedly or indistinctly. Combining Kant's remark with Leibniz's view that beauty is--or, more precisely, flows from--perfection, we might conclude that Baumgarten simply lowered beauty from the level of distinct to that of confused concepts and tried to deduce its rules from the concept of perfection. If this was indeed Baumgarten's project, we might well ask to be excused from pursuing the subject further. (shrink)

ABSTRACTIn his account of public reason Rawls assumes that some facts ought to be treated as ‘fixed’, or beyond reasonable disagreement. These include, for him, facts upon which there is a scientif...

This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be (...) preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

When perceiving a face, we can easily decide whether it belongs to a human or non-human primate. It is thought that face information is represented by neurons in the macaque temporal cortex. However, the precise encoding mechanisms used by these neurons remain unclear. Here we use face stimuli of humans, monkeys and monkey-human hybrids (morphs) to gain a better understanding of these mechanisms, in particular of the categorization of faces into different species, and how learning affects representation of these stimuli.

Nostalgia, a sentimental longing for one’s past, can serve as a resource for individuals coping with discomforting experiences. The experience of bereavement poses psychological and physical risks....

In his "Ontological proof", Kurt Gödel introduces the notion of a second-order value property, the positive property P. The second axiom of the proof states that for any property φ: If φ is positive, its negation is not positive, and vice versa. I put forward that this concept of positiveness leads into a paradox when we apply it to the following self-reflexive sentences: (A) The truth value of A is not positive; (B) The truth value of B is positive. Given (...) axiom 2, sentences A and B paradoxically cannot be both true or both false, and it is also impossible that one of the sentences is true whereas the other is false. (shrink)

Can we find propositions that cannot rationally be denied in any possible world without assuming the existence of that same proposition, and so involving ourselves in a contradiction? In other words, can we find transworld propositions needing no further foundation or justification? Basically, three differing positions can be imagined: firstly, a relativist position, according to which ultimately founded propositions are impossible; secondly, a meta-relativist position, according to which ultimately founded propositions are possible but unnecessary; and thirdly, an absolute position, according (...) to which such propositions are necessary. In this short essay I show that under the premise of modal logic S5 with constant domain there are ultimately founded propositions and that their existence is even necessary, and I will give some reasons for the superiority of S5 over other logics. (shrink)

Although the idiom “genesis and structure” is usually associated with the rise of structuralism in the late 1950s and early 1960s, the two notions are arguably among the most persistent methods in the history of modern philosophy. This article outlines the emergence of “genetic epistemology” in the seventeenth century, when the seemingly antithetical character of the conceptual pair was reworked into a productive epistemological theory, especially in Descartes, Hobbes, Spinoza, and Leibniz, who increasingly used diachronic (genetic) narratives to explain the (...) synchronic (structural) features in their theories. Against Cassirer, I argue that it was Descartes rather than Hobbes who first presented structural issues genetically. In Descartes’ natural philosophy, his frequent claims that showing how a thing is produced reveals its true nature foreshadow precisely what Hobbes and Isaac Barrow later describe as causal definitions of geometric figures, in which the process of ideal generation by motion is what constitutes the very essence of a figure. I link this method to the historicizing discourse on origins in the Enlightenment and conclude by suggesting that there is a trace of Platonic idealism in genetic epistemology. (shrink)

This paper offers a critical examination of Kierkegaard's account of friendship, and considers whether he accounts sufficiently for the transformative possibilities of friendship. Part I gives a brief discussion of ethical friendship in Either/Or, then turns to Works of Love and its critique of friendship. Kierkegaard does, however, retrieve and affirm friendship insofar as it is transformed by Christian neighbor love. The author then proceeds to consider whether this transformed friendship can also be genuinely transformative. Part II draws on Kierkegaard's (...) analysis of the leveling effects of modern culture, and argues that friendship can play an important role in resisting this threat by helping to initiate and preserve religious actuality. The author of the article contends that Kierkegaard needs to be pushed further on this point, since his writings remain ambivalent regarding such a possibility. Similarly, Part III examines Kierkegaard's openness to a concept of transformative Christian friendship. To this end, the article considers the possibility of friendship with Christ. Then, drawing on John 15, the Christological basis for friendship is taken into consideration. Finally, through Kierkegaard's account of Christ's friendship with Peter, the author of the article concludes that a charitable reading of Kierkegaard points us toward transformative friendship, even though it seems also clear that the Danish thinker does not venture far enough in that direction himself. /// O presente artigo analisa criticamente o pensamento de Kierkegaard sobre a amizade, interrogando-se particularmente até que ponto ele dará ou não suficiente atenção às possibilidades transformativas da mesma. Começando com uma breve discussão da amizade ética na obra Alternativa, o artigo passa depois a uma análise de Obras do Amor e à crítica da amizade que nela se faz. Mostra-se, assim, que Kierkegaard retoma e afirma a amizade na medida em que ela é transformada pelo amor ao próximo. A questão seguinte tem a ver com a possibilidade de esta amizade transformada poder também ela mesma ser genuinamente transformativa. Num segundo momento, o autor do artigo toma em consideração a análise que Kierkegaard faz dos efeitos niveladores da cultura moderna, argumentando que a amizade pode desempenhar um papel importante na resistência a esta ameaça ajudando a iniciar e a preservar a actualidade religiosa da mesma. O autor considera que Kierkegaard precisa de ser confrontado no que se refere a esta questão dado que os seus escritos permanecem ambivalentes a propósito desta possibilidade. De igual modo, num terceiro momento do artigo, o autor analisa a abertura de Kierkegaard ao conceito cristão de uma amizade transformativa. Para este fim, é considerada sobretudo a possibilidade da nossa amizade com Cristo. Neste contexto, o artigo aborda, nomeadamente em referência ao capítulo 15 do Evangelho de S. João, a base Cristo-lógica da amizade. Por fim, o artigo faz referência à amizade de Cristo com Pedro e conclui que uma leitura benevolente de Kierkegaard não pode deixar de nos apontar para uma visão transformativa da amizade, ainda que o pensador dinamarquês não pareça ir suficientemente longe nesta direcção. (shrink)

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Name der Zeitschrift: Das Mittelalter Jahrgang: 23 Heft: 2 Seiten: 241-253.

Seit Beginn der frühen Neuzeit ist das naturwissenschaftliche Verfahren maßgeblich durch ein neues Konzept geprägt: das Konzept des experimentellen, gestalterischen Eingriffs in die Natur. Es geht nun nicht mehr darum, eine Geschichte der "freien und ungebundenen Natur" (Bacon) zu erzählen, die in ihrem eigenen Lauf belassen und als vollkommene Bildung betrachtet wird. Es geht vielmehr darum, der "gebundenen und bezwungenen Natur" (Bacon) vermittels der experimentellen Tätigkeit des Menschen die Geheimnisse zu entreißen. Diese technisch-praktische Konzeption grenzt sich explizit von den klassischen (...) kontemplativen Wissenschaftsvorstellungen der Antike ab. Wie es Kant paradigmatisch in Bezug auf Bacon formuliert hat, ist diese "Revolution der Denkart" maßgeblich durch ein gewandeltes Verständnis des Verhältnisses des Menschen zur Natur geprägt. Der Mensch als Experimentator hat für Kant nicht mehr die "Qualität eines Schülers", der sich passiv von der Natur belehren läßt und an ihrem "Leitbande" (Kant) gegängelt wird. Seine neu gewonnene Autorität verleiht ihm vielmehr den Status eines Richters, der nun die Natur nötigen kann, auf gestellte Fragen zu antworten. Die Laborforschung der modernen Naturwissenschaft ist von den Formen der alten Naturwissenschaft so weit entfernt, daß sie den Vorwurf auf sich zog, sie untersuche Artefkakte, aber nicht Natur. Die grundlegenden Theorien über Natur können in der Regel nur unter den künstlichen Bedingungen des Labors aufgestellt werden. Daraus darf aber nicht geschlossen werden, die anhand von Laborphänomenen aufgestellten und getesteten Theorien handelten nicht von der Natur außerhalb der Labore. Aber ihrer exakten und detaillierten Anwendung auf Prozesse außerhalb der Labore stehen eine Fülle von Schwierigkeiten entgegen. Insofern markiert das Labor sehr wohl eine Grenze exakter Naturforschung, die für den Umgang der wissenschaftlich-technischen Zivilisation mit der Natur wichtige Konsequenzen hat. (shrink)

This book presents, in method, logical form, and philosophical content, a counterproposal to mainstream personal identity theory. The lotter's purported conflation of logical questions, i.e. reidentification with characterization, leads to an implausible reductionism about selves. A self-constituting narrative is the basis for identity, and contra reductionism, the ontological primitive of a person. As a dynamic valuational and intentional system, the narrative meaningfully constructs the autobiographical past through memory and both causally directs and emotively anticipates the experiences and form of future (...) selves. Schechtman's account, in contrast to mainstream theories, rightly connects identity to those four features that weigh heavily in our values, viz. survival, self-concern, responsibility, and compensation. Though bold and original, the account dispels a couple of important issues along with its rejection of mainstream theory. These issues, encountered most notably through fission cases, are taken up in the evaluation with a “narrative split”. (shrink)

Das traditionelle Selbstverstandnis des Menschen in der westlichen Kultur ist gekennzeichnet von dem Dualismus von Natur und Kultur oder Korper und Geist. Demgegenuber fassen neuere Konzeptionen des "verkorperten Geistes" (embodied mind) zunehmend die Wechselwirkungen von biologischer, anthropologischer und kultureller Evolution ins Auge. Damit dynamisiert sich der traditionelle Gegensatz von Natur und Kultur zu einem Prozess, in dem die beiden Momente ineinander verschrankt sind und sich wechselseitig bestimmen. Auf dieser Basis lasst sich die Kontinuitat der menschlichen Evolution als stufenformige Transformation der (...) gesamten korperlichen Struktur des Lebewesens Mensch begreifen. Der Band vereint geistes-, kultur- und naturwissenschaftliche Perspektiven auf unterschiedlichen Ebenen und Zeitskalen der menschlichen Entwicklung und tragt damit zur Grundlegung des neuen Forschungsgebiets einer Interdisziplinaren Anthropologie bei. (shrink)