Research that is initiated, designed or funded by sponsor agencies based in countries with relatively high social and economic development, and conducted in countries that are relatively less developed, gives rise to many important ethical challenges. Although clinical trials of HIV vaccines began ten years ago in the US and Europe, an increasing number of trials are now being conducted or planned in other countries, including several that are considered “developing” countries. Safeguarding the rights and welfare of individuals participating as (...) research subjects in developing countries is a priority. In September, 1997, the Joint United Nations Programme on HIV/AIDS embarked on a process of international consultation; its purpose was further to define the important ethical issues and to formulate guidance that might facilitate the ethical design and conduct of HIV vaccine trials in international contexts. This paper summarises the major outcomes of the UNAIDS consultative process. (shrink)

The paper is a critical discussion of scholarship on the "Critique of Pure Reason" published during the past ten years. The emphasis is on Anglo-American authors. I identify and discuss three main trends in the field: a shift from the general discussion of transcendental arguments to the analysis and evaluation of particular proofs in Kant; a renewed interest in the doctrine of transcendental idealism and the distinction between things in themselves and appearances; and the emergence of an entire body of (...) literature on Kant's philosophy of mind, centered around the idea of a "transcendental psychology." The main body of the text is supplemented by extensive bibliographical information provided in the notes. (shrink)

Moral behaviour, based on social norms, is commonly regarded as a hallmark of humans. Hitherto, humans are perceived to be the only species possessing social norms and to engage in moral behaviour. There is anecdotal evidence suggesting their presence in chimpanzees, but systematic studies are lacking. Here, we examine the evolution of human social norms and their underlying psychological mechanisms. For this, we distinguish between conventions, cultural social norms and universal social norms. We aim at exploring whether chimpanzees possess evolutionary (...) precursors of universal social norms seen in humans. Chimpanzees exhibit important preconditions for their presence and enforcement: tolerant societies, well-developed social-cognitive skills and empathetic competence. Here, we develop a theoretical framework for recognizing different functional levels of social norms and distinguish them from mere statistical behavioural regularities. Quasi social norms are found where animals behave functionally moral without having moral emotions. In proto social norms, moral emotions might be present but cannot be collectivized due to the absence of a uniquely human psychological trait, i.e. shared intentionality. Human social norms, whether they are universal or cultural, involve moral emotions and are collectivized. We will discuss behaviours in chimpanzees that represent potential evolutionary precursors of human universal social norms, with special focus on social interactions involving infants. We argue that chimpanzee infants occupy a special status within their communities and propose that tolerance towards them might represent a proto social norm. Finally, we discuss possible ways to test this theoretical framework. (shrink)

It’s not clear what supervaluationists should say about propositional content. Does a vague sentence, e.g., ‘Harry is bald’, express one proposition, or a barrage of propositions, or none at all? Or is the matter indeterminate? The supervaluationist canon is not decisive on the issue; authoritative passages can be cited in favor of each of the proposals just mentioned. Furthermore, some detractors have argued that supervaluationism is incapable of providing any coherent account of propositional content. This paper considers each of the (...) proposals for how many propositions are expressed by a vague sentence: none, some, all, or it’s indeterminate. Most of these proposals turn out to be unworkable in the metalanguage. I conclude that orthodox supervaluationists—those who identify truth with supertruth—must either relax the standard requirement that propositions be bivalent, or else alter the standard relation between sentences and propositions in which a sentence inherits its truth-conditions from the proposition it expresses. The best option going forward for the orthodox supervaluationist is perhaps the most surprising—amend the requirement that propositions be bivalent. I argue that propositions having supervaluational truth-conditions are best suited to fill the propositional roles in the semantic theory of a vague language. These propositions admit of truth-value gaps, and gappy propositions are controversial, but I argue that they earn their keep. (shrink)

This article compares Kant and Fichte from the double stand- point of identity and difference with regard to two thinkers who were at first united by a master-student relation but who later on drifted apart from each other due to mutual defamation. At the center of the present discussion stands the relationship between spirit of freedom and system’s form which binds Kant and Fichte beyond methodological divergences and doctrinal differ- ences. The critical comparison between Kant and Fichte will be developed (...) in four steps: it will start with the general positioning of Kant within German Idealism, and then move on to Kant’s double critical enterprise of grounding an aprioristic doctrine of principles of nature and freedom; it will later on address the conception championed by Fichte of having pre- sented the “first system of freedom”, and from there it will focus on the manifestations of freedom within Fichte’s philosophical system, with Kant’s position as contrast. (shrink)

As Husserl already noticed, artworks themselves have a phenomenological character. This means, however, that to experience artworks as phenomena no “epoché” and no “phenomenological reduction” is necessary. The leading question of my essay is whether, and possibly how, this observation can be methodologically generalized for understanding phenomena. I discuss if, and possibly how, a phenomenological reflection on art allows and even demands a general conception of phenomenology that nevertheless does not confuse artworks with phenomena in general. My intention is to (...) show that and how phenomenality can be clarified with reference to its spatial character. Accordingly, works of architecture that are artworks will play a decisive role in my argument. (shrink)

Scientific exploration and thus our knowledge about the outside world is subject to the conditions of our experience.These conditions are condensed here into an interface model which,besides being physical,has an additional interface structure not reducible to physics. We suggest that this structure can dynamically be characterized by separate modes.Their selection and operation presupposes free will and a rudimentary concept of time and space. Based on some analogies with quantum networks it is argued that the 'observed' gets 'dressed'as a consequence of (...) the observing. Interface dynamics and system dynamics supplement each other without over- determination. (shrink)

In what follows, the difference between Frege’s and Schröder’s understanding of logical connectives will be investigated. It will be argued that Frege thought of logical connectives as concepts, whereas Schröder thought of them as operations. For Frege, logical connectives can themselves be connected. There is no substantial difference between the connectives and the concepts they connect. Frege’s distinction between concepts and objects is central to this conception, because it allows a method of concept formation which enables us to form concepts (...) from the logical connectives alone. Schröder in contrast unifies the distinction between concepts and objects, but keeps the distinction between logical connectives and what they connect. It will be argued that Frege’s particular way of perceiving logical connectives is crucial for his foundational project. (shrink)

Frege ist bekannt für seinen Versuch, die Arithmetik aus der Logik herzuleiten. Doch welcher Begriff von Logik liegt diesem Projekt zugrunde? Wenn Logik die Grundlage der Arithmetik ist und die Arithmetik über Inhalte verfestigt, so muss die Logik selbst eine Wissenschaft mit eigenen Inhalten sein. Die Autorin zeigt, wie Frege logische Zeichen zu eigenständigen Begriffen aufwertet und dadurch eine inhaltliche Logikkonzeption überhaupt erst ermöglicht. In einem weiteren Schritt wird ein Kriterium vorgestellt, mit dessen Hilfe Frege logische Inhalte von den Inhalten (...) anderer Wissenschaften abgrenzt. Dabei wird jedoch deutlich, dass Frege bis in die 1890er Jahre braucht, um sich vollständig vom Kantischen Diktum zu lösen, die Logik sei nur ein negativer Probierstein der Wahrheit. Die Suche nach dem Grund, der Frege zu einer inhaltlichen Konzeption von Logik zwang, führt in die Geometriegeschichte des 19. Jahrhunderts. Vor ihrem Hintergrund werden schließlich die Anfangsparagraphen der Grundlagen der Arithmetik in einem neuen Licht interpretiert. (shrink)

Die Welt liegt in Scherben, so heisst es. Und sich mit einer Welt anzufreunden, die sich der Anfreundung entzieht, scheint paradox. Christina Thürmer-Rohr kreist in ihren Essays zu Feminismus, Pluralität, Dialog, Aussenseitertum, Vergänglichkeit und zum politischen Denken Hannah Arendts um den Widerstreit zwischen dem Heimatlichen und dem Unheimlichen - und um die Fiktionen vom »heilen« Geschlecht. Sie widerspricht dabei der Annahme, Fremdheit sei das Andere der Freundschaft, Freundschaft das Andere der Fremdheit. So entsteht eine Karte, auf der man sich (...) hin- und herbewegen kann, denn die Nachbarschaft der einzelnen Texte eröffnet Türen zu Lesarten, die nicht in den gewohnten Spuren bleiben, und führt zu unerledigten Fragen, die keine Ruhe lassen." --Back cover. (shrink)

This paper aims to show that Frege’s and Hilbert’s mutual disagreement results from different notions of Anschauung and their relation to axioms. In the first section of the paper, evidence is provided to support that Frege and Hilbert were influenced by the same developments of 19th-century geometry, in particular the work of Gauss, Plücker, and von Staudt. The second section of the paper shows that Frege and Hilbert take different approaches to deal with the problems that the developments in 19th-century (...) geometry posed for the traditional Kantian philosophy of mathematics. Frege maintains that Anschauung is a source of knowledge by which we acknowledge geometrical axioms as true. For Hilbert, in contrast, axioms provide one of several correct “pictures” of reality. Hilbert’s position is thereby deeply influenced by epistemological ideas from Hertz and Helmholtz, and, in turn, influenced the neo-Kantian Cassirer. (shrink)

C.S. Peirce's "A Neglected Argument for the Reality of God" [NA] has always baffled its readers. Its publishing editor needed to ask, "[W]hat, then, precisely, is your neglected argument?", and EP 2's editors observe that "[t]his is one of Peirce's most enigmatic writings". First-time readers will likely concur with the underwhelmed theologian who told Michael Raposa that NA "ought to remain neglected". Early Peirce scholars did neglect the essay, regarding it as an "anomalous sideshow to Peirce's more important concern with (...) the logic and methodology of science". No longer ignored, NA continues to bewilder: "N.... (shrink)

Despite the various perceptual-motor deficits documented in strabismus, there is a paucity of studies evaluating visual illusions in patients with strabismus. The aim of this study was to examine how the illusionary perception occurs in children/adolescents with strabismus with referral for surgery to correct ocular deviations. A controlled cross-sectional study was carried out in which 45 participants with strabismus and 62 healthy volunteers aged 10–15 years were evaluated. The behavioral response to three geometric illusions [Vertical-Horizontal illusion, Müller-Lyer illusion and Ponzo (...) illusion] and respective neutral stimuli regarding the estimation of image size and response time were measured using the Method of Adjustment. To analyze the influence of secondary factors: type of ocular deviation ; amount of eye deviation; presence of amblyopia and stereopsis, a one-way ANOVA was performed. Among the tested illusions, children with strabismus showed greater susceptibility and response time to Ponzo’s illusory images. Children with strabismus and preserved stereopsis, on the other hand, showed similar susceptibility and response time to control group patients to the Ponzo illusion. Patients with amblyopia showed overcorrection in the estimate of non-illusory Ponzo images. Children with horizontal ocular deviation associated with vertical deviation showed higher susceptibility to vertical adjustment images for the Müller-Lyer illusion. Individuals with strabismus tended to overcorrect the length of the straight-line segment adjusted for non-illusory images when testing non-illusory images in the Müller-Lyer test, as well as for the neutral images in the Vertical-Horizontal test. The findings indicated impairment in the perception of geometric illusions and neutral figures, especially for the Ponzo illusion test by children with strabismus. As the behavioral response to illusory images may indirectly reflect the visual and morphofunctional alterations present in these individuals, we suggest that the investigation of visual illusory perception can be used as a new research strategy in the field of investigating the visual function in strabismus. (shrink)

C. S. Peirce claimed that the pragmatic method of clarifying ideas is "nothing but a particular application of an older logical rule, 'By their fruits ye shall know them.'"1 While Jesus spoke about discriminating between true and false religious teachers, Peirce was concerned with clarifying our intellectual concepts. Peirce's pragmatism asserts that we clearly understand the meaning of a concept if we can state the potentially practical and empirical consequences that would follow from the truth of a proposition involving that (...) concept. Robert C. Neville's semiotic and pragmatic theory of religious truth unites Jesus's and Peirce's concerns, proposing that religious truth consists in an adaptedness or fit between... (shrink)

Objectives:Social isolation is increasing in aging societies and several studies have shown a relation with worse cognition in old age. However, less is known about the association in the oldest-old (85+); the group that is at highest risk for both social isolation and dementia. Methods:Analyses were based on follow-up 5 to 9 of the longitudinal German study on aging, cognition, and dementia in primary care patients (AgeCoDe) and the study on needs, health service use, costs, and health-related quality of life (...) in a large sample of oldest-old primary care patients (AgeQualiDe), a multi-center population-based prospective cohort study. Measurements included the Lubben Social Network Scale (LSNS-6), with a score below 12 indicating social isolation, as well as the Mini-Mental Status Examination (MMSE) as an indicator of cognitive function. Results:Dementia-free study participants (n = 942) were M = 86.4 (SD = 3.0) years old at observation onset, 68.2% were women. One third (32.3%) of them were socially isolated. Adjusted linear hybrid mixed effects models revealed significantly lower cognitive function in individuals with smaller social networks (β = 0.5, 95% CI = 0.3-0.7, p <.001). Moreover, changes in an individual's social network size were significantly associated with cognitive changes over time (β = 0.2, 95% CI = 0.1-0.4, p =.003), indicating worse cognitive function with shrinking social networks. Conclusion:Social isolation is highly prevalent among oldest-old individuals, being a risk factor for decreases in cognitive function. Consequently, it is important to maintain a socially active lifestyle into very old age. Likewise, this calls for effective ways to prevent social isolation. (shrink)

This essay employs Charles Peirce’s triadic semiotics in order to develop a biosemiotic theory of life that is capable of illuminating the function of information in living systems. Specifically, I argue that the relationship between biological information structures , selecting environments, and the adapted bodily processes of living organisms is aptly modelled by the irreducibly triadic relationship between Peirce’s sign, object, and interpretant, respectively. In each instance of information-based semiosis, the information structure is a complex informational sign that represents the (...) informational object ; and the bodily, behavioral, mental, or intellectual processes that are organized by the informational sign to more or less accurately interpret the present environment constitute a complex informational interpretant—a living, interpreting organism. The essay begins by discussing the precise sense in which this biosemiotic theory is based upon Charles Peirce’s semiotic theory. Next, the theory is developed at length in relation to genetic information structures. Finally, I present a brief outline of how the theory applies to neural and linguistic information structures. The essay concludes with a reflection upon the anti-reductionist implications of the theory. (shrink)

The central thesis of this essay is that the relation imagined to hold between the Father, Son, and Holy Spirit corresponds quite closely with the triadic relationship that holds between object, sign, and interpretant, respectively, within C. S. Peirce’s conception of semiosis. Section 1 introduces Peirce’s conception of semiosis. Section 2 supports the main thesis through examination of descriptions of the Trinitarian relations in two classic Christian texts: The New Testament and The Catechism of the Catholic Church. Section 3 reviews (...) two alternative explanations of this surprising correlation: Andrew Robinson’s vestigia Trinitatis explanation and a naturalistic alternative. (shrink)