Attention-deficit/hyperactivity disorder (ADHD) is currently defined as a cognitive/behavioral developmental disorder where all clinical criteria are behavioral. Inattentiveness, overactivity, and impulsiveness are presently regarded as the main clinical symptoms. The dynamic developmental behavioral theory is based on the hypothesis that altered dopaminergic function plays a pivotal role by failing to modulate nondopaminergic (primarily glutamate and GABA) signal transmission appropriately. A hypofunctioning mesolimbic dopamine branch produces altered reinforcement of behavior and deficient extinction of previously reinforced behavior. This gives rise to delay (...) aversion, development of hyperactivity in novel situations, impulsiveness, deficient sustained attention, increased behavioral variability, and failure to “inhibit” responses (“disinhibition”). A hypofunctioning mesocortical dopamine branch will cause attention response deficiencies (deficient orienting responses, impaired saccadic eye movements, and poorer attention responses toward a target) and poor behavioral planning (poor executive functions). A hypofunctioning nigrostriatal dopamine branch will cause impaired modulation of motor functions and deficient nondeclarative habit learning and memory. These impairments will give rise to apparent developmental delay, clumsiness, neurological “soft signs,” and a “failure to inhibit” responses when quick reactions are required. Hypofunctioning dopamine branches represent the main individual predispositions in the present theory. The theory predicts that behavior and symptoms in ADHD result from the interplay between individual predispositions and the surroundings. The exact ADHD symptoms at a particular time in life will vary and be influenced by factors having positive or negative effects on symptom development. Altered or deficient learning and motor functions will produce special needs for optimal parenting and societal styles. Medication will to some degree normalize the underlying dopamine dysfunction and reduce the special needs of these children. The theory describes how individual predispositions interact with these conditions to produce behavioral, emotional, and cognitive effects that can turn into relatively stable behavioral patterns. Key Words: catecholamine; clumsiness; dopamine; hyperkinesis; hyperkinetic disorder; impulsivity; monoamine; neuromodulator; overactivity; pollutants; reinforcement; reward; verbally governed behavior; soft signs; variability. (shrink)

The dynamic developmental theory (DDT) has benefited from the insights of the commentators, particularly in terms of the implications for the proposed steepened delay gradients in attention-deficit/hyperactivity disorder (ADHD). The introduction of modified memory processes as a basis for the delay gradients improved the links to aspects of ADHD. However, it remains unclear whether the hyperactive-impulsive and inattentive subtypes are separate subgroups or may be explained as different outcomes of the same genetic factors and thus explicable by the same principles. (...) The DDT suggests that altered reinforcement and extinction processes define an endophenotype in ADHD that can be related dimensionally to inattention, hyperactivity, and impulsivity. The relation between the suggested endophenotype, characterized by changes in basic learning mechanisms, and other endophenotypes characterized by delay aversion or response disinhibition, needs to be tested in future studies. (shrink)

It is traditionally believed that cerebral activation (the presence of low voltage fast electrical activity in the neocortex and rhythmical slow activity in the hippocampus) is correlated with arousal, while deactivation (the presence of large amplitude irregular slow waves or spindles in both the neocortex and the hippocampus) is correlated with sleep or coma. However, since there are many exceptions, these generalizations have only limited validity. Activated patterns occur in normal sleep (active or paradoxical sleep) and during states of anesthesia (...) and coma. Deactivated patterns occur, at times, during normal waking, or during behavior in awake animals treated with atropinic drugs. Also, the fact that patterns characteristic of sleep, arousal, and waking behavior continue in decorticate animals indicates that reticulo-cortical mechanisms are not essential for these aspects of behavior. (shrink)

In this new study of Rousseau, Levine presents a Kantian reading of the Social Contract. By attempting to reveal Rousseau’s anticipation of such Kantian themes as moral right and obligation the author’s purpose has been "to produce a Kantian reading of The Social Contract, a reading that emphasizes the many respects in which Rousseau anticipates Kant and motivates his investigations in moral philosophy". This purported similarity has been noted previously by thinkers such as Hegel and Cassirer. The book also develops (...) the theme that the solution to the conflict between moral autonomy and political authority is the main issue in The Social Contract. Because Rousseau apparently "grasped his conflict better than either Hobbes or Locke" he was able to anticipate Marx’s critique of the contractarian tradition. Consequently, Rousseau’s political philosophy underlies the "deep structure" of contemporary mentality, and continues to dominate our own sense of self, society, and being-in-the-world. While the main issues in Kant’s moral philosophy—autonomy/heteronomy, person/thing, rule of reason/heteronomous irrationalism—are present in ovo in Rousseau, the author warns us of crucial differences between the two thinkers, for example, in Kant the notion of our being forced to our own freedom is absent. But both thinkers share the belief that any conception of the state’s function as merely external coercion or coordination is sub-rational. Also, Kant’s conception of moral autonomy located in the de jure kingdom of political ends is anticipated in Rousseau’s attempt to direct society to the norm of the general will as its legitimate political end. In sum, Levine’s book, while drawing from the previous work of Althusser, avoids the usual Marxist concept manipulation, and gives us an interesting addition to Rousseau scholarship.—H.N.T. (shrink)

Most academic papers on ethics in pandemics concentrate on the duties of healthcare professionals. This paper will consider non-professional healthcare workers: do they have a moral obligation to work during an influenza pandemic? If so, is this an obligation that outweighs others they might have, e.g., as parents, and should such an obligation be backed up by the coercive power of law? This paper considers whether non-professional healthcare workers—porters, domestic service workers, catering staff, clerks, IT support workers, etc.—have an obligation (...) to work during an influenza pandemic. It uses data collected as part of a study looking at the attitudes of healthcare workers to working during a pandemic to suggest the philosophical arguments explored. These include: being in a position to do good, the ethics of work, competing obligations to family members and in particular to children and the obligations of citizens in a state of national emergency. We also look at whether compulsory measures are justified to support a national health service during a health emergency. We conclude that even if they are, compulsion should not be restricted to non-professionals who happen to be working in the health service at the time. Rather, compulsion involving a larger pool of people with the relevant skills and abilities is more equitable. (shrink)

This paper demonstrates the undecidability of a number of logics with quantification over public announcements: arbitrary public announcement logic, group announcement logic, and coalition announcement logic. In APAL we consider the informative consequences of any announcement, in GAL we consider the informative consequences of a group of agents all of which are simultaneously making known announcements. So this is more restrictive than APAL. Finally, CAL is as GAL except that we now quantify over anything the agents not in that group (...) may announce simultaneously as well. The logic CAL therefore has some features of game logic and of ATL. We show that when there are multiple agents in the language, the satisfiability problem is undecidable for APAL, GAL, and CAL. In the single agent case, the satisfiability problem is decidable for all three logics. (shrink)

In this new study of Dilthey, Professor Makkreel attempts to counteract the common tendency among Dilthey scholars to divorce his early psychological work from his later hermeneutical-historical position by showing their essential continuity. Makkreel also attempts to show the centrality of Dilthey’s aesthetic writings, and to reveal their implications for his theory of historical understanding. A disregard of these themes, the author claims, has encouraged a fragmentary interpretation of Dilthey’s philosophy. The thrust of the book is to provide a historical (...) and theoretical background for the development of hitherto disregarded aspects of Dilthey’s mature philosophy. In Part II, for example, Professor Makkreel examines Dilthey’s aesthetics as a model human science and explores the role of the poetic imagination by exposing its apparently unnoticed epistemological implications. One such implication is that Dilthey’s theory of the imagination involves a concept of articulation which relates it to poetry and history. It is not clear in the text, however, why this implication is "epistemological," or how Makkreel’s treatment of it exhibits any epistemic analysis. The book also discusses Dilthey’s later hermeneutics and philosophy of history which some commentators believe to have replaced Dilthey’s earlier psychology as the means of understanding human existence in time. Makkreel denies this interpretation, and he reinstates the importance of psychology at all stages of Dilthey’s thought. One chapter examines the interesting question of Husserl’s relation to Dilthey. It attempts to show to what extent Dilthey reformulated his previous psychological descriptions of the lived experience in the light of Husserl’s work. (shrink)

In Hegel’s Dialectic the English speaking world is presented with a collection of five newly translated essays from the pen of Hans-Georg Gadamer. These essays on various topics in Hegel will all be of interest to Hegel scholars.

The title accurately reflects the two chief philosophic aims of the book: the construction of a theory of inquiry, and of a theory of reality. The author’s intent, announced at the outset, is "to develop a systematic philosophy with the ultimate goal of disclosing the significance of man in the universe." He calls his approach a "pragmatic synthesis," since, he explains, it is a pragmatic defense of the "warrant" and the integration of ordinary and scientific beliefs with propositions affirming emergence, (...) potentiality, and internal relations drawn variously from "emergentism, Aristotelianism, and absolute idealism." He expresses much indebtedness to Dewey and James; he is also inspired by Lester F. Ward. (shrink)

At last an English edition of Georg Simmel’s Philosophie des Geldes has appeared. Simmel first published this work in Germany in 1900. A second and enlarged edition was published in 1907. The Philosophy of Money is the first complete English translation of the second edition.

Max Weber's dominant scholarly concern was the development of rationalism in the West. He exemplified his interest in this theme in his two great works, Economy and Society and The Economic Ethics of the World Religions. In Wolfgang Schluchter's new book, The Rise of Western Rationalism: Max Weber's Developmental History, the author presents an analysis and re-evaluation of Weber's sociology of Western rationalism. He also wants to show Weber's relation to the sociological school of neo-evolutionism. By an examination of Weber's (...) relation to the neo-evolutionary thought of such men as Habermas and Parsons, Schluchter attempts to show that Weber's developmental historical sociology, if properly understood and formulated, is still the best explanatory model of Western rationalism in contemporary sociology. (shrink)

The Global Ethics Observatory, launched by the United Nations Educational, Scientific, and Cultural Organization in December 2005, is a system of databases in the ethics of science and technology. It presents data on experts in ethics, on institutions and on teaching programmes in ethics. It has a global coverage and will be available in six major languages. Its aim is to facilitate the establishment of ethical infrastructures and international cooperation all around the world.

The objective of the new series, "Molecular Biology, Biochemistry and Biophysics", of which this brochure forms the first volume, is to produce more than another compilation of data. It is hoped that the new series will help the individual "specialist" keep abreast of important developments in the natural sciences at the molecular and subcellular level in fields complementary to his own. The predominant aim is not so much to increase the ever-growing body of information in an encyclopedic fashion but rather (...) to give, in addition to a well rounded factual presentation of subjects which have reached a degree of maturation, a leitmotiv developed by the individual authors from a more personal point of view. The reader should thus be able to use these mono graphs not only for acquisition of knowledge but as a source of further motiva tion in his own work. This latter and more consequential aim of the monograph series is one of the reasons for presenting here a most unusual talk which should enable the reader to sit back and view his own efforts in the context of science and creative attempts as a whole. The lecture is the virtually unknown inaugural address of the Dutch physical chemist JACOBUS HENRICUS VAN'T HOFF. As is shown in his short biography presented on pages 3 and 4 the principal thoughts of the molecular biologist of today are akin to his own and he clearly recognized the universality of molecular life processes. (shrink)

Le volume s'enquiert des liens entre l'affectivite et l'activite philosophique. Sur le mode historique et/ou problematique il s'agit de traiter de questions telles que: Y a-t-il une ou des tonalites affectives specifiques a la philosophie: etonnement, angoisse, ennui, serenite, melancolie,...? L'activite philosophique est-elle associee a un deni de l'affectivite et sous quelles formes: nihilisme, detachement, refoulement...? Quel rapport le philosophe noue-t-il a l'ambivalence de l'affect (indecidabilite, double bind,...)? Qu'en est-il de la reception thematique de l'affectivite en philosophie: une philosophie ou (...) une phenomenologie de l'affectivite est-elle possible? Quel statut philosophique pour des sciences nouvelles - les neurosciences -qui pretendent etudier objectivement et techniquement l'affectivit. (shrink)

Professors A. D. Ritchie and F. H. George both miss the question: What is the use of saying that machines think? Does the extension in the use of the word “think” to cover the complicated activity of modern machines enable us to explain better the nature of such activity? Extensions in usage are common and necessary in science.

One problem of interpreting research on subconscious processing is the possibility that participants are weakly conscious of the stimuli. Here, we compared the fMRI BOLD response in healthy adults to clearly visible single letters with the response to letters presented in the absence of any behavioural evidence of visibility . No letter catch trials served as a control condition. Forced-choice responses did not differ from chance when letter-to-background contrast was low, whereas they were almost 100% correct when contrast was high. (...) A comparison of fMRI BOLD signals for supraliminal and subliminal letters with the control trials revealed a signal increase in left BA 37 . Comparison of supraliminal with subliminal letters showed a significant increase in the right inferior frontal gyrus . Finally, a comparison of subliminal with supraliminal letters showed increases in the left middle temporal gyrus and the right extrastriate cortex. (shrink)