Responsible Research and Innovation (‘RRI’) is a cross-cutting priority for scientific research in the European Union and beyond. This paper considers whether the way such research is organised and delivered lends itself to the aims of RRI. We focus particularly on international consortia, which have emerged as a common model to organise large-scale, multi-disciplinary research in contemporary biomedical science. Typically, these consortia operate through fixed-term contracts, and employ governance frameworks consisting of reasonably standard, modular components such as management committees, advisory (...) boards, and data access committees, to co-ordinate the activities of partner institutions and align them with funding agency priorities. These have advantages for organisation and management of the research, but can actively inhibit researchers seeking to implement RRI activities. Conventional consortia governance structures pose specific problems for meaningful public and participant involvement, data sharing, transparency, and ‘legacy’ planning to deal with societal commitments that persist beyond the duration of the original project. In particular, the ‘upstream’ negotiation of contractual terms between funders and the institutions employing researchers can undermine the ability for those researchers to subsequently make decisions about data, or participant remuneration, or indeed what happens to consortia outputs after the project is finished, and can inhibit attempts to make project activities and goals responsive to input from ongoing dialogue with various stakeholders. Having explored these challenges, we make some recommendations for alternative consortia governance structures to better support RRI in future. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

It is usually assumed that what Lewis says about the given in Mind and the World-Order (MWO) and An Analysis of Knowledge and Valuation (AKV) is essentially the same, and that both works are defenses of foundationalism. However, this assumption faces two problems: first, it is difficult to bring Lewis's diverse remarks on the given into coherence, especially when those in MWO are compared with those in AKV; and second, though AKV is a defense of foundationalism, there is much in (...) MWO that can be read as a critique of foundationalism. In this paper a different reading of Lewis is proposed, one that avoids these problems. This is developed by going farther back in Lewis, to his Harvard Ph.D. dissertation, The Place of Intuition in Knowledge (PIK). By tracing Lewis's discussion of the given from PIK through MWO up to AKV, it is shown that the phrase 'the given' is used to refer to two different doctrines, and that Lewis's position on foundationalism undergoes a fundamental change, roughly, from indifference to rejection to acceptance. (shrink)

Our lives are such that moral wrongdoing is sometimes inescapable for us. We have moral responsibilities to persons which may conflict and which it is wrong to violate even when they do conflict. Christopher W. Gowans argues that we must accept this conclusion if we are to make sense of our moral experience and the way in which persons are valuable to us. In defending this position, he critically examines the recent moral dilemmas debate. He maintains that what is (...) important in this debate is not whether there are irresolvable moral conflicts, but whether there are moral conflicts in which wrongdoing is unavoidable. Though it would be incoherent to conclude moral deliberation by deciding to perform incompatible actions, he argues that there is nothing incoherent in supposing that we have conflicting moral responsibilities. In this way, he shows that it is possible to capture the intuitions of those who have defended the idea of moral dilemmas while meeting the objections of those who have rejected this idea. Gowans carefully evaluates utilitarian and Kantian analyses of moral dilemmas. He argues that these approaches eliminate genuine moral conflict only by displacing persons as direct objects of moral concern. As an alternative, he develops a more concrete account in which moral responsibilities to persons are central. The book also includes discussions of Melville's Billy Budd, methodology in moral philosophy, moral pluralism, moral tragedy, and "dirty hands" in politics. (shrink)

The Neo-Aristotelian ethical naturalism of Philippa Foot and Rosalind Hursthouse purports to establish a naturalistic criterion for the virtues. Specifically, by developing a parallel between the natural ends of nonhuman animals and the natural ends of human beings, they argue that character traits are justified as virtues by the extent to which they promote and do not inhibit natural ends such as self-preservation, reproduction, and the well-being of one’s social group. I argue that the approach of Foot and Hursthouse cannot (...) provide a basis for moral universalism, the widely-accepted idea that each human being has moral worth and thus deserves significant moral consideration. Foot and Hursthouse both depict a virtuous agent as implicitly acting in accord with moral universalism. However, with respect to charity, a virtue they both emphasize, their naturalistic criterion (especially in the more elaborate form developed by Hursthouse) at best provides a warrant for a restricted form of charity that extends only to a limited number of persons. There is nothing in the natural ends of human beings, as Foot and Hursthouse understand these, that gives us a reason for having any concern for the well-being of human beings as such. (shrink)

Kant has long been taxed with an inability to explain the detailed normative content of our lives by making universalizability the sole arbiter of our values. Korsgaard addresses one form of this critique by defending a Kantian theory amended by a seemingly attractive conception of practical identities. Identities are dependent on the contingent circumstances of each person's world. Hence, obligations issuing from them differ from Kantian moral obligations in not applying to all persons. Still, Korsgaard takes Kantian autonomy to mean (...) the normativity of all obligations is rooted in universalizability. The wealth of values informing our lives is thus said to be accommodated within a Kantian framework.After briefly explaining Korsgaard’s understanding of practical identities and their role in her reformation of Kant's moral philosophy, I argue that she gives an inadequate explanation of how the obligations that arise from a person’s practical identities derive their authority from the person's will. I then consider how her position might be developed to meet this objection in accordance with her allegiance to “constructivism” and I argue that the epistemic commitments of people’s actual identities makes it unlikely that such a development could preserve Kantian autonomy as she interprets it. (shrink)

Raymond Aron's vision of liberalism reflects the paradox that ideologies both fuel and restrict democratic debate. This may be related to the history of French liberalism developed by Albert Thibaudet in the inter-war period. This article considers Aron's use of Thibaudet's ideas in his wartime writings. It suggests that these represented a significant step forward from his pre-war approach to pluralism and set certain parameters for his post-war political thought. It is also suggested that Thibaudet's writings led Aron to study (...) the ideas of the nineteenth-century intellectual Ernest Renan. These contributed to his understanding of international relations. While Aron was to lose interest in Renan and Thibaudet, his wartime debt to them represents an important stage in his intellectual evolution and ties him to a distinctively French (if little known) tradition of pluralist thought. (shrink)

What the Old Testament says about wealth and poverty cannot be taken as prescriptive for any modern society, but its emphasis on the fate of the powerless prompts us to ask how our society deals with those unable to protect themselves from the depredations of others.

(No abstract is available for this citation).

The essays in this volume illuminate a central topic in ethical theory: moral dilemmas. Some contemporary philosophers dispute the traditional view that a true moral dilemma -- a situation in which a person has two irreconcilable moral duties -- cannot exist. This collection provides the historical background to the ongoing debate with selections from Kant, Mill, Bradley, and Ross. The best recent work on the question is represented in essays by Donagan, Foot, Hare, Marcus, Nagel, van Fraassen, Williams, and others.

Philosophy of the Buddha is a philosophical introduction to the teaching of the Buddha. It carefully guides readers through the basic ideas and practices of the Buddha, including kamma , rebirth, the not-self doctrine, the Four Noble Truths, the Eightfold Path, ethics, meditation, non-attachment, and Nibbâna . The book includes an account of the life of the Buddha as well as comparisons of his teaching with practical and theoretical aspects of some Western philosophical outlooks, both ancient and modern. Most distinctively, (...) Philosophy of the Buddha explores how Buddhist enlightenment could enable us to overcome suffering in our lives and reach our full potential for compassion and tranquillity. This is one of the first books to introduce the philosophy of the Buddha to students of Western philosophy. Christopher W. Gowans' style is exceptionally clear and appropriate for anyone looking for a comprehensive introduction to this growing area of interest. (shrink)

Moral relativism is an important topic in metaethics. It is also widely discussed outside philosophy (for example, by political and religious leaders), and it is controversial among philosophers and nonphilosophers alike. This is perhaps not surprising in view of recent evidence that people's intuitions about moral relativism vary widely. Though many philosophers are quite critical of moral relativism, there are several contemporary philosophers who defend forms of it. These include such prominent figures as Gilbert Harman, Jesse J. Prinz, J. David (...) Velleman and David B. Wong. The term ‘moral relativism’ is understood in a variety of ways. Most often it is associated with an empirical thesis that there are deep and widespread moral disagreements and a metaethical thesis that the truth or justification of moral judgments is not absolute, but relative to the moral standard of some person or group of persons. Sometimes ‘moral relativism’ is connected with a normative position about how we ought to think about or act towards those with whom we morally disagree, most commonly that we should tolerate them. (shrink)

ABSTRACT While a great deal of scholarly attention has been given to the publication of serialized novels in early Victorian Britain, there has been hardly any consideration of the no less widespread practice of issuing scientific works in parts and numbers. What scholarship there has been has insisted that scientific part-works operated on entirely different principles from the strategies for maintaining readerly interest that were being developed by serial novelists like Charles Dickens. Deploying the methods of book history, this essay (...) examines the reporting of Richard Owen's celebrated paleontological reconstructions from the 1830s and 1840s in the serialized formats of the Proceedings of the Zoological Society, his own History of British Fossil Mammals, and, in particular, the Penny Cyclopaedia. It argues that Owen, along with his close friend William John Broderip, clearly recognized the affective possibilities of the serial format and that they exploited the Penny Cyclopaedia's sequential mode of publication to evoke suspense and expectation in their anonymous but collaboratively authored accounts of Owen's paleontological researches. (shrink)

Can moral disagreements be rationally resolved? Can universal human rights be defended in face of moral disagreements? The problem of moral disagreement is one of the central problems in moral thinking. It also provides a stimulating stepping-stone to some of the perennial problems of philosophy, such as relativism, scepticism, and objectivity. _Moral Disagreements_ is the first anthology to bring together classic and contemporary readings on this key topic. Clearly divided into five parts; The Historical Debate; Voices from Anthropology; Challenges to (...) Moral Objectivity; Defenses of Moral Objectivity; and New Directions, the anthology presents readings from the following key thinkers: * Sextus, Empiricus, Chagnon, Wong, MacIntyre * Aquinas, Shweder, Brink, Rawls * Montaigne, Turner, Nussbaum, Narayan * Hume, Mackie, Gewirth * Nietzsche, Williams, Berlin. A distinctive feature of the anthology is that it brings philosophers into dialogue with well-known anthropologists. Also included is a comprehensive introduction by Christopher Gowans, introducing the problem of moral disagreement to those coming to the topic for the first time. (shrink)

The first book of its kind, Buddhist Moral Philosophy: An Introduction introduces the reader to contemporary philosophical interpretations and analyses of Buddhist ethics. It begins with a survey of traditional Buddhist ethical thought and practice, mainly in the Pali Canon and early Mahāyāna schools, and an account of the emergence of Buddhist moral philosophy as a distinct discipline in the modern world. It then examines recent debates about karma, rebirth and nirvana, well-being, normative ethics, moral objectivity, moral psychology, and the (...) issue of freedom, responsibility and determinism. The book also introduces the reader to philosophical discussions of topics in socially engaged Buddhism such as human rights, war and peace, and environmental ethics. (shrink)

Medical analogies are commonly invoked in both Indian Buddhist dharma and Hellenistic philosophy. In the Pāli Canon, nirvana (or, in Pāli,nibbāna) is depicted as a form of health, and the Buddha is portrayed as a doctor who helps us attain it. Much later in the tradition, Śāntideva described the Buddha’s teaching as ‘the sole medicine for the ailments of the world, the mine of all success and happiness.’ Cicero expressed the view of many Hellenistic philosophers when he said that philosophy (...) is ‘a medical science for the mind.’ He thought we should ‘hand ourselves over to philosophy, and let ourselves be healed.’ ‘For as long as these ills [of the mind] remain,’ he wrote, ‘we cannot attain to happiness.’ There are many different forms of medical analogy in these two traditions, but the most general form may be stated as follows: just as medicine cures bodily diseases and brings about physical health, so Buddhist dharma or Hellenistic philosophy cures mental diseases and brings about psychological health—where psychological health is understood as the highest form of happiness or well-being. Insofar as Buddhist dharma involves philosophy, as it does, both renditions of the analogy may be said to declare that philosophy cures mental diseases and brings about psychological health. This feature of the analogy—philosophy as analogous to medical treatment—has attracted considerable attention. (shrink)

Buddhist thought flourished in India for well over a thousand years after the life of the Buddha around the fifth century BCE. During this time there were many diverse developments, but for the purpose of the overview in this chapter, two central traditions will be featured. The first centers on the original teaching of the Buddha as represented in a set of texts written in Pāli called the “Three Baskets”. The second tradition is rooted in a set of texts written (...) in Sanskrit called the “Perfection of Wisdom Sūtras” that began to emerge a few centuries later, around the beginning of the new millennium. These texts constitute the historical heart of Mahāyāna Buddhism. This chapter demonstrates that in both traditions Buddhist thought in India was fundamentally concerned with ethical values. (shrink)

I argue that the Buddha did not discuss the free will and determinism problem because he only considered issues relating to overcoming suffering and his teaching about this did not raise the problem. As represented in the Nikāyas, the heart of his teaching was an empirically based account of the causes of suffering and how to modify these to end suffering. It was primarily a practical teaching about how to achieve this goal, more a craft knowledge than a philosophical theory (...) of causality. Similarly, the no-self teaching was more about living selflessly than about developing a theoretical analysis of agency. (shrink)

"The book defends the thesis that the concept of self-cultivation philosophy is an informative interpretive framework for comprehending and reflecting on several philosophical outlooks in India, the Greco-Roman world and China. On the basis of an understanding of human nature and the place of human beings in the world, self-cultivation philosophies maintain that our lives can and should be substantially transformed from what is judged to be a problematic, untutored condition of human beings, our existential starting-point, into what is put (...) forward as an ideal state of being. We are to do this by undertaking a set of therapeutic or spiritual exercises guided by some philosophical analysis. The self-cultivation philosophies in India are expressed in: the Bhagavad Gītā; the Sāṃkhya and Yoga philosophies of Īśvarakṛṣṇa and Patañjali; and teaching of the Buddha and his followers Buddhaghosa and Śāntideva. The philosophies originating in Greece, with subsequent development in the Roman period, are the most prominent Hellenistic approaches: the Epicureanism of Epicurus, Lucretius and Philodemus; the Stoicism of Chrysippus, Epictetus and Seneca; and Pyrrho and the Pyrrhonism of Sextus Empiricus. The self-cultivation philosophies from China are the early Confucian outlooks of Confucius, Mencius and Xunzi; the classical Daoist perspectives of the Daodejing and the Zhuangzi; and the Chan tradition of Bodhidharma, Huineng and Linji"--. (shrink)

It is often observed that there is little or no moral philosophy in classical Indian Buddhist thought. This is sometimes believed to be surprising since obviously there is an ethical teaching in Buddhism and clearly there are other forms of Buddhist philosophy. In my view, there is something that can plausibly be called moral philosophy in Indian Buddhism, but it is not quite what many people have expected because they have approached the issue from a specific understanding of philosophy that (...) is too limited. I propose to defend this interpretation by reshaping Mark Siderits’ concept of fusion philosophy. The fusion I will propose reveals a form of moral philosophy that may be called self-cultivation philosophy. I will argue that this was a common activity in ancient Chinese, Greek and Indian cultures—including especially early Buddhist thought and practice. (shrink)