To reduce the global burden of the COVID-19 pandemic, there is an urgent need to develop a safe vaccine. Vaccine development usually takes many years as it goes through several different phases. To hasten COVID-19 vaccine development, it has been suggested that the final stage could be replaced with a human challenge trial (HCT). Volunteers would be intentionally infected with SARS-CoV-2 to see how the vaccine candidate works. To intentionally infect a healthy human being with a potentially deadly virus is (...) contrary to the highest ethical standards in medical research. This article highlights the benefits and risks of COVID-19 HCTs and summarises what research ethics committees (RECs) need to consider during the ethical assessment of such trials including risk reduction, strict containment measures, specific informed consent measures and avoiding high monetary inducements. (shrink)

In The Corporeal Turn, political theorist John Tambornino offers a thorough rethinking of ethical and political theory by emphasizing human embodiment, and the primacy of passion and need, in response to the neglect of these matters in much of contemporary thought. Tambornino calls for a 'corporeal turn' or, as he explains, sustained attention to human embodiment—something that is often occluded when priority is given to reason or language. Working through a diverse set of thinkers, exploring such themes as (...) necessity and freedom, need and desire, nature and convention, and public and private, and noting vivid instances of politicized embodiment, Tambornino takes seriously Nietzsche's claim that philosophy has largely been an interpretation and misunderstanding of the body. The result is nothing less than a new orientation to ethical and political theory—one that appreciates the complex relations of language, politics, culture and corporeality-and a powerful intervention into those domains. (shrink)

Assuming that there is moral progress, and assuming that the abolition of slavery is an example of it, how does moral progress occur? Is it mainly driven by specific individuals who have gained new moral insights, or by changes in the socio‐economic and epistemic conditions in which agents morally judge the norms and practices of their society, and act upon these judgements? In this paper, I argue that moral progress is a complex process in which changes at the level of (...) belief and changes at the level of institutions and social practices are deeply intertwined, and that changes in the socio‐economic and epistemic conditions of moral agency constitute the main motor of moral progress. I develop my view of moral progress by way of grappling with Michelle Moody‐Adams’ prominent philosophical account of it. My view is less intellectualistic and individualistic than hers, does not presuppose meta‐ethical moral realism, and blurs her distinction between moral progress in beliefs and moral progress in social practices. I point out the limits of humans to progress morally, which are partly grounded in our evolutionary history, and argue that moral progress is always of a ‘local’ nature. (shrink)

Artificial intelligence is shaping strategy, activities, interactions, and relationships in business and specifically in marketing. The drawback of the substantial opportunities AI systems and applications provide in marketing are ethical controversies. Building on the literature on AI ethics, the authors systematically scrutinize the ethical challenges of deploying AI in marketing from a multi-stakeholder perspective. By revealing interdependencies and tensions between ethical principles, the authors shed light on the applicability of a purely principled, deontological approach to AI ethics in marketing. To (...) reconcile some of these tensions and account for the AI-for-social-good perspective, the authors make suggestions of how AI in marketing can be leveraged to promote societal and environmental well-being. (shrink)

Originally presented as the author's thesis --Universit'at Bonn, 2012.

The essay brings a summation of human efforts seeking to understand our existence. Plato and Kant & cognitive science complete reduction of philosophy to a neural mechanism, evolved along elementary Darwinian principles. Plato in his famous Cave Allegory explains that between reality and our experience of it there exists a great chasm, a metaphysical gap, fully confirmed through particle-wave duality of quantum physics. Kant found that we have two kinds of perception, two senses: By the spatial outer sense we perceive (...) phenomena, objects in space. Our temporal inner sense lets us perceive our inner state, noumena . Kant's two senses are fully confirmed through bilateral brain duality of cognitive science. The bilateral brain serves inner, temporal sense, logic & noumena in the left hemisphere. The right brain half is for the outer, spatial sense, geometry & phenomena. We form a whole system, a bilateral interior cosmos, a kind of world model, expressing what may lie beyond the metaphysical gap. In the right brain we build a phenomenal cosmos, to resemble the outer environment. In the brain's left hemisphere a noumenal cosmos, a model of our private world including Saint Teresa of Avila's castillo interior. The cosmos is regularly updated with novel sense data integrated into our memory banks. This was recognized early by Helmholtz (1860s). Our lives, health & well-being depend on us keeping our interior cosmos in good order. This used to be seen as saving one's precious soul from perdition. While we endeavour to keep our phenomenal cosmos neat & orderly by protecting the environment from harm, our noumenal cosmos to be livable requires us to engage in ethical conduct. This bilateral cosmos is responsible for our common sense judgment power, that we depend on for being able to lead a good & benign life. The 200 million neurons of BA10 in the prefrontal lobe have global access to the interior cosmos, & apply massive feedback to identify environmental conditions rapidly. The global access also gives conscious presence of the individual to itself, all that is present in the interior cosmos, for total freedom of action. In the left brain private ego, we are guarded by faith in divine mercy, & guided to choose the best course of action, able to survive under the most adverse conditions. For this, we receive directions from the Holy Ghost in Saint Teresa's castillo interior. (shrink)

Bd. 1. Kants Theorie der Erfahrung (3 v.) -- Bd. 2. Kants Begründung der Ethik -- Bd. 3. Kants Begründung der Ästhetik -- Bd. 4. Kommentar zu Immanuel Kants Kritik der reinen Vernunft -- [Bd.] 5. Das Prinzip der Infinitesimal-Methode und seine Geschichte -- Bd. 6. System der Philosophie, 1. Teil -- Bd. 7. System der Philosophie, 2. Teil -- Bd. 8. System der Philosophie, 3. Teil, 1. Bd. -- Bd. 9. System der Philosophie, 3. Teil, 2. Bd. -- Bd. (...) 12. Kleinere Schriften I, 1865-1869 -- Bd. 15. Kleinere Schriften IV, 1907-1912. (shrink)

Impressions, energy radiated by phenomena in the momentary environmental scene, enter sensory neurons, creating in afferent nerves a data stream. Following Kant, by our inner sense the mind perceives its own thoughts as it ties together sense data into an internalized scene. The mind, residing in the brain, logically a Language Machine, processes and stores items as coded grammatical entities. Kantian synthetic unity in the linguistic brain is able to deliver our experience of the scene as we appear to see (...) it. Uniquely, the brain records its own history, synthesizing a Movie-in-the-Brain, called the Noumenal Cosmos. Attempting thereby to represent the actual Universe, this makes for a sovereign brain that governs itself. The brain is domicile of an Ego, with its selfhood at stake at all times. Yet, it can know itself only by its actions, in which it appears as an actor in its own movie. Phenomena enter garbled, as confused apparitions, and must be put in good form using top–down feedback control by Ego, so that each movie frame makes rational sense within the overall context of the Noumenal Cosmos. A stack of frames is processed typically in 40 Hz rhythm with 300 ms process time each, for about 12 in the stack at any time. Successive neural centers are processing the stack in the brain assembly line, based on data from increasingly global receptive fields. Ego stitches together the movie frames, but only the top frame is in consciousness for 25 ms. The top frame contains the whole scene where the Ego makes an appearance as the actor that imposes Kantian synthetic unity on the scene, merely an assembly of grammatical texts, in a system-internal coded process language, fitting the scene into the Noumenal Cosmos. But Ego observes Ego only to the extent permitted by the objectivity rule, only what it does and thinks, not its true face. From the Noumenal Cosmos, the Ego receives grammatical messages in the internal sense code. They are integrated into a whole in the reaction of the Ego to the momentary scene. The voluntary nature of Ego’s decisions is explained, based on its ability to code in advance its own actions sequentially in time, as it sees fit with a view to an orderly Noumenal Cosmos, records of code being arranged spatially in neural structures. (shrink)

From the earliest times, American ethics, the rules for the moral \& intellectual life of the West, used to be founded upon the two principles of self-reliance and good neighborliness. Here we consider the underlying functions of neural brain circuits, organic structures that have evolved adaptively by Darwinian rules subject to selection pressure. In the left brain resides our self-reliant private Ego, making plans, launching initiatives. Your public Ego dwells in the right brain, looking around, meeting with your friendly neighbor. (...) A main component is our bilateral interior cosmos, providing us with all the detailed information about our environment as well as the universe at large. (shrink)

System der Philosophie ist ein unveränderter, hochwertiger Nachdruck der Originalausgabe aus dem Jahr 1874. Hansebooks ist Herausgeber von Literatur zu unterschiedlichen Themengebieten wie Forschung und Wissenschaft, Reisen und Expeditionen, Kochen und Ernährung, Medizin und weiteren Genres. Der Schwerpunkt des Verlages liegt auf dem Erhalt historischer Literatur. Viele Werke historischer Schriftsteller und Wissenschaftler sind heute nur noch als Antiquitäten erhältlich. Hansebooks verlegt diese Bücher neu und trägt damit zum Erhalt selten gewordener Literatur und historischem Wissen auch für die Zukunft bei.

The paper attempts to show that Kant's criticism of eudaemonism does not affect Plato's moral theory, because the kind of eudaemonism which Plato embraces is different from that rejected by Kant. Whereas the target of Kant's criticism is the view that virtuous actions are an instrumental means to becoming happy, Plato regards virtue as a constitutive part of happiness and is, thus, committed to what Gregory Vlastos has called a "noninstrumentalist form of eudaemonism".

In this theoretical study we explore the concept of intentional-ity. Intentionality is the specific reference that mental phenomena have with respect to objects, also termed the 'aboutness' of cognitive acts. We discuss intentionality on the basis of self-organized pattern formation, a ubiquitous phenomenon in complex open systems. Dynamical systems theory provides an understanding of how emergent variables originate from microscopic variables. Control parameters comprise those external parameters and gradients that drive the systems they represent environmental inuences. The relationship between pattern (...) formation and control parameters therefore addresses the functioning of a system in its environment. Our hypothesis is that self-organizing systems exhibit intentionality-like capabilities in their responses to environmental inuences. This is modelled using differential calculus, by which we demonstrate how pattern formation reduces control parameters in an efficient manner. These ideas are applied to the complex system brain, using the Wilson-Cowan equations of axonal pulse rates in neural networks. (shrink)

L'écologie cherche à connaître les conditions d'existence des organismes par rapport à leur milieu physique et biotique.D'une part elle étudie les exigences des organismes envers le milieu et leurs adaptations à celui-ci; d'autre part, elle recherche comment le milieu influe sur les organismes. Or, puisque chaque être vivant fait partie du milieu des autres et que sa présence et son activité modifient le milieu physique et biotique pour lui-même comme pour les autres, l'écologie est amenée à considérer en général les (...) interactions entre les facteurs constitués par les organismes ainsi que par les agents inorganiques.Toutefois, la complexité de ces interactions est telle qu'à leur analyse physico-chimique s'opposent des difficultés partiellement insurmontables. La raison en est que les multiples facteurs écologiques n'agissent pas isolément, mais en combinaison dans l'espace et dans le temps. Il en résulte des états d'équilibre relatif dont seule l'expérience multiséculaire de la nature nous révèle l'aboutissement avec certitude. Aussi bien l'écologiste qui veut en tenir compte commence-t-il ses recherches par le relevé qualitatif et quantitatif des groupements biologiques spontanés. Le chercheur les reconnaît à la constance relative de leur composition, dans les divers endroits où ils sont réalisés, constance résultant de l'équilibre relatif entre les facteurs. C'est exactement pour de tels groupements queMöbius à créé le terme de biocénose. Ainsi la biocénotique peut être considérée comme la propédeutique d'une écologie justement conçue; elle ne serait que préparatoire et provisoire si la Science pouvait un jour entièrement éclaircir le jeu des forces écologiques.Enfin en essayant de bien situer l'écologie dans le cadre des disciplines biologiques voisines, il est utile d'avoir présent à l'esprit l'ébauche suivante d'un nouveau système de la biologie:Dans mes „Analyses et synthèses biocénotiques” , j'ai discuté la conception d'Agrell, qui se base sur des stations-types préétablies. Depuis,Agrell a consacrédeux articles polémiques à soutenir que ses „Bestandestypen” s'identifient aux groupements écologiques tels que je le conçois.Il n'en est rien.Dans l'idée d'Agrell, tous les relevés provenant d'un même type de stations font a priori partie d'un même „Bestandestyp”. La conséquence en est que certaines espèces en réalité vicariantes, c'est-à-dire ne cohabitant jamais -Tetracanthella wahlgreni etFolsomia brevicauda, par exemple — se trouvent réunies, sur le papier, dans une même „communauté”. Au contraire, dans mon système, les relevés faits dans un certain type de stations sont classés tantôt dans un groupement , tantôt dans un autre , d'après leur composition faunistique servant d'indicateur. Cette différence explique amplement les discordances qu'Arell relève entre mes indices d'abondance-fréquence et les siens, discordance prouvant une fois de plus que les „Bestandestypen” et les groupements ne sont pas la même chose.Agrell qualifie de résidu l'un de mes groupements. Or, rien n'est plus résiduel queson Bestandestyp 2, qui représente l'ensemble de 7 stations sur 10, celles qui restent après avoir retranché les 3 stations de milieux extrêmes.Agrell reproche à ma méthode de laisser inclassables certains relevés dépourvusd'espèces vicariantes. Cela n'est-il pas préférable au classement de force de relevés, fragmentaires et aux calculs hasardeux basés sur des unités hétérogènes?Enfin,Agrell estime que le choix des espèces caractéristiques est subjectif. J'ai: montré qu'il ne l'est ni plus ni moins que celui des caractères spécifiques en taxonomie.Oekologie, Ethologie, Biogeographie und Biocoenotik werden noch häufig miteinander verwechselt. Diese Disziplinen lassen sich an Hand des Schemas unterscheiden, das in vorstehenden Schlussfolgerungen wiedergegeben ist. Dieses Schema ist zugleich ein Beitrag zu einem neuen, dreidimensionalen System der Biologie.Speziell wird auf den methodischen Unterschied zwischen Oekologie und Biocoenotik eingegangen. Die Biocoenotik kann als eine unentbehrliche Vorstufe der Oekologie angesehen werden, insofern sie die natürliche Vergemeinschaftung der Organismen als ein grossartiges, von der Natur selbst eingesetztes Experiment betrachtet. Ihre Aufgabe ist es, dass Ergebnis dieses Experiments zu beschreiben. Die Lebensgemeinschaften, die sie dabei unterscheidet, sind gekennzeichnet durch ihre häufig wiederkehrende, einigermassen konstante Zusammensetzung, entsprechend den relativen Faktoren-Gleichgewichten, welche sich im Laufe der Jahrhunderte einstellen. Die Lebensgemeinschaften sind aber viel leichter zu erfassen als die Faktoren-Gleichgewichte und deren biologische Bedeutung. Ihre Abgrenzung erfolgt, — wie in der Taxonomie diejenige der Arten — auf Grund objektiver Diskontinuitäten. Letztere gründen sich in der Biocoenotik auf die sich ökologisch ersetzenden Arten. Sie sind die Prüfsteine für die Grundeinheiten der Biocoenotik: die Biocoenosen.] Soweit die Organismen einer Biocoenose aufeinander einwirken, stellen sie gleichzeitig einen Konnex dar; und soweit sie in ihren Ansprüchen oder Anpassungen übereinstimmen, gehören sie auch zum gleichen Lebensformen-Typ. Es ist praktisch, drei Grössenordnungen von Biocoenosen zu unterscheiden: Synusien, Assoziationen und Biome. (shrink)

The present article is devoted to the second part of chapter 10 of Aristotle’s De interpretatione (20 a 16-40), which mainly deals with the logical relations between statements whose predicate is finite (i. e., of the affirmative form “is P”) and statements whose predicate is infinite (i. e., of the negative form “is not-P”). I attempt to show that this part of the chapter contains both a section the text of which is corrupt (20 a 20-23) and a section which (...) is misplaced (20 a 37-40). In the former section the likely false reading of the manuscripts τῇ δὲ … ἡ ἀντι- κειμένη ὅτι … (“while from ‘…’ the opposite [statement follows] that …”) should be corrected into ἡ δὲ … τῇ ἀντικειμένῃ ὅτι … (“while ‘…’ [follows] from the opposite [statement] that …”), and the latter section should be placed immediately after the former, with which it is intimately connected. (shrink)

Origin of the Yellowstone hotspot & Columbia River Basalts has remained uncertain until now. Here, we present evidence of meteorite impact origin. The hotspot is shallow, only 200 km deep, invalidating a theory of mantle plume origin. The hotspot track runs from the Yellowstone National Park in NW Wyoming to the volcanic Modoc Plateau in NE California. We present evidence of apparent remnants of an impact crater existing in the Modoc, a large multi-ring structure at least 160 km diameter. Much (...) of the complex crater has become obliterated by later Cascadia and Sierra orogenies. The crater has a tall 4,100 foot central uplift cone, locally known as Chalk Mountain, consisting of diatomaceous earth, presumably the rebound cone of a meteorite impact. This falsifies a theoretical prohibition of cosmic impact volcanism. Based on recent insights into explosive volcanism a plausible mechanism is proposed for how meteorite impacts can lead to resurgent calderas of the Yellowstone type, & of apparent LIP origin from thin crust ET impacts, invalidating theoretical constructs of mantle plumes. We mention chaotic terrains, including plutons, arising antipodal to impacts. (shrink)