狂信的な国粋主義者か、はたまた魂の尊厳を問うた求道者か。民俗学と国粋主義の親和性とは。多角的な視点からファシズムを再考する。.

Master Sorai's Responsals was to eighteenth-century Japan what The Prince was to Renaissance Italy. Like Machiavelli, Ogyu Sorai was a humanist scholar who served a prince and drew on his experiences as a house philosopher and on his vast knowledge of history and political affairs in his work. In 1720, when he began to write the letters that comprise this text, the Tokugawa regime was more than a hundred years old and beset with grave administrative and fiscal problems, about which (...) Sorai had much to say.Samuel Yamashita's impressive translation of this work offers modern readers a rare glimpse of the prevailing political discourse of the day and the specific concepts that rulers had at their disposal as they struggled to manage their domains, find talented men for their bureaucracies, create new sources of revenue, and keep their subjects well fed and happy.Sorai himself, of course, is a presence in the text. He is by tunes earnest, frank, impatient, utterly confident, and occasionally condescending. Unlike his Renaissance counterpart, he is something of an optimist: he was convinced that the introduction of archaic Chinese culture and institutions to Japan would solve its myriad problems.Well-versed in Chinese history, philosophy, religion, medicine, and belles lettres, Sorai holds forth on everything from archaic Chinese divination to Sung poetry and prose. He offers advice on how to become a Confucian gentleman, how to learn to read classical Chinese, and which books to read and which to avoid. He even discusses his belief in a sentient, Chinese-style "heaven," a topic not well understood by modern scholars. Long regarded as one of Sorai's best works, Master Sorai's Reponsals bristles with the sharp and clear opinions of the most influential thinker of Tokugawa Japan. (shrink)

Cellular pattern formations of some epithelia are believed to be governed by the direct lateral inhibition rule of cell differentiation. That is, initially equivalent cells are all competent to differentiate, but once a cell has differentiated, the cell inhibits its immediate neighbors from following this pathway. Such a differentiation repeats until all non-inhibited cells have differentiated. The cellular polygonal patterns can be characterized by the numbers of undifferentiated cells and differentiated ones. When the differentiated cells become large in size, the (...) polygonal pattern is deformed since more cells are needed to enclose the large cell. An actual example of such a cellular pattern was examined. The pupal wing epidermis of a butterfly Pieris rapae shows a transition of the equivalent-size cell pattern to the pattern involving large cells. The process of the transition was analyzed by using the method of weighted Voronoi tessellation that is useful for treatment of irregularly sized polygons. The analysis supported that the pattern transition of the early stage of the pupal wing epidermis is governed by the lateral inhibition rule. The differentiation takes place in order of largeness, but not smallness, of the apical polygonal area in the differentiating region of the pupal wing. (shrink)

I am honored to have been invited to participate in this Workshop on Comparative Studies of Building Molecular Biology, with a discussion of Japanese experiences in constructing a science — in this case, the discipline of molecular biology. As I understand it, the construction of a science must be equivalent to building a new culture. My having given this title to my paper suggests that I have enough knowledge about the subject to perhaps even extrapolate its course into the future (...) — which I do not. What I do have is a sincere admiration of my old friends and colleagues, in Japan and elsewhere, who together tried to build a new science of molecular biology in Japan. (shrink)

Intervention studies on sedentary older adults have demonstrated that commencing physical exercise at an older age has a positive effect on brain structure. Although this suggests that older athletes with lifelong sports training have larger gray matter volume in some brain regions compared to age-matched non-athletes, evidence in the literature is scarce. Moreover, it remains unclear whether a larger GMV is associated with training intensity or period of training in life. To address these gaps in the literature, we compared regional (...) brain GMV between 24 older athletes and 24 age-matched non-athletes. The period of sports training and the current training time of the athletes were assessed. Both groups were evaluated for physical activity intensity as well as cognitive and motor performance. Although no group differences were noted in cognitive and motor performance, athletes reported higher physical activity intensity than non-athletes. Whole-brain structural analysis revealed a significantly larger GMV in several brain regions in athletes. Notably, the GMV of the precuneus in athletes was positively correlated with earlier commencement of sports training and training duration but was negatively correlated with current training time. Our findings demonstrate that early-commenced and continued sports training predicts structural maintenance of the precuneus in old age. Our results also suggest that excessive training time in old age may have a negative impact on the GMV of the precuneus; thereby delineating how the precuneus is associated with lifelong sports training in older athletes. (shrink)

LANGUAGE NOTE | Document text in Chinese; abstract also in English. 世界衛生組織(WHO)在歷經自1976年伊波拉病毒病(EbolaHemorrhagicFever, 伊波拉出血熱)爆發以來，處理疫情爆發當中出現的種種倫理問題之後，於2016年出版“Guidance for Managing Ethical Issues in Infectious Disease Outbreaks”（中文暫譯：《傳染病爆發處理倫理議題之指引》）一書，其中整理出「正義、行善、效益、尊重自主、自由、團結、互惠」等七項倫理原則，於今面對新冠肺炎（COVID-19）的疫情上，各國防疫 政策，亦可作為應對。作為一名當代墨者，本文即以此為基礎，由醫療的角度，結合國內情況，企欲在墨學義理內作一生命倫理的反思，並試圖對後疫情時代給予具體作為之建議。 In response to various ethical problems that emerged after the 1976 Ebola hemorrhagic fever epidemic, WHO published the book Guidance for Managing Ethical Issues in Infectious Disease Outbreaks in 2016. The content of the book was organized around seven ethical principles, namely, justice, beneficence, benefit, respect for autonomy, freedom, reciprocity, and unity. These seven ethical principles can be used as (...) a framework for countries to develop policies for coping with the COVID-19 pandemic. Drawing from contemporary Mohism, this paper reflects on the situation in Taiwan through the lens of these seven ethical principles. It aims to arrive at a Mohist understanding of bioethics and proposes concrete actions for the post-epidemic era. (shrink)

Rousseau a bien compris, mieux que ses contemporains peut-être, le paradoxe de la communication propre aux Lumières, prises entre le développement du savoir et la constitution d'une opinion publique. Avec l'accélération de la circulation des discours et des écrits, comment parler et agir philosophiquement sans se perdre? Comment concilier la culture du secret, issue de la tradition littéraire du libertinage érudit, et la publicité, qui ouvre de plus en plus grands les horizons de la sphère publique? Masano Yamashita examine (...) ici l'articulation entre les stratégies rhétoriques de l'adresse au lecteur chez Rousseau et sa conception proprement philosophique de la communication. Elle met en lumière l'originalité et la lucidité de Rousseau face aux difficultés liées à cette société de l'information d'Ancien Régime. Rousseau cherche les conditions de possibilité d'une parole émancipée et pleinement publique. Au moyen d'une philosophie incarnée mettant en scène une figure de lecteur, il met à l'épreuve l'idée d'un sujet universel, la constitution d'un espace public, le sens de l'exercice de la philosophie, les enjeux politiques et éthiques des actes de discours. La réception des textes et le rapport au public constituent ainsi pour Rousseau un enjeu philosophique. Entre exigence de transparence et désir d'expérimenter les diverses facettes du moi public, se dessine la conception originale que Rousseau se fait de l'homme des Lumières. Masano Yamashita montre que la réflexion de Rousseau sur les manières de vivre dans un espace public, social comme littéraire, débouche sur une véritable vie philosophique. (shrink)

This study compared 30 older musicians and 30 age-matched non-musicians to investigate the association between lifelong musical instrument training and age-related cognitive decline and brain atrophy. Although previous research has demonstrated that young musicians have larger gray matter volume in the auditory-motor cortices and cerebellum than non-musicians, little is known about older musicians. Music imagery in young musicians is also known to share a neural underpinning [the supramarginal gyrus and cerebellum] with music performance. Thus, we hypothesized that older musicians would (...) show superiority to non-musicians in some of the abovementioned brain regions. Behavioral performance, GMV, and brain activity, including functional connectivity during melodic working memory tasks, were evaluated in both groups. Behaviorally, musicians exhibited a much higher tapping speed than non-musicians, and tapping speed was correlated with executive function in musicians. Structural analyses revealed larger GMVs in both sides of the cerebellum of musicians, and importantly, this was maintained until very old age. Task-related FC analyses revealed that musicians possessed greater cerebellar-hippocampal FC, which was correlated with tapping speed. Furthermore, musicians showed higher activation in the SMG during MWM tasks; this was correlated with earlier commencement of instrumental training. These results indicate advantages or heightened coupling in brain regions associated with music performance and imagery in musicians. We suggest that lifelong instrumental training highly predicts the structural maintenance of the cerebellum and related cognitive maintenance in old age. (shrink)

In bacteria, PriA protein, a conserved DEXH‐type DNA helicase, plays a central role in replication restart at stalled replication forks. Its unique DNA‐binding property allows it to recognize and stabilize stalled forks and the structures derived from them. Cells must cope with fork stalls caused by various replication stresses to complete replication of the entire genome. Failure of the stalled fork stabilization process and eventual restart could lead to various forms of genomic instability. The low viability of priA null cells (...) indicates a frequent occurrence of fork stall during normal growth that needs to be properly processed. PriA specifically recognizes the 3′‐terminus of the nascent leading strand or the invading strand in a displacement (D)‐loop by the three‐prime terminus binding pocket (TT‐pocket) present in its unique DNA binding domain. Elucidation of the structural basis for recognition of arrested forks by PriA should provide useful insight into how stalled forks are recognized in eukaryotes. (shrink)

ヨーロッパの“美”と日本の“うつくしさ”の邂逅―それは単に比較文明の問題ではない。両者の邂逅に、西洋形而上学が形而上学=美学の歴史であった所以が立ち現われるなか、“あるがまま”という“うつくしさ”の存 在論が、ヨーロッパの存在論の忘れられた根底と呼び合う。.

In this paper I argue that an encounter with a tick can produce both fear and wonder. I make a distinction between the legitimate danger of tick borne-diseases and the non-danger of our entanglement with the nature revealed by the tick’s bite in order to highlight the goodness of the tick and the possibilities for post-human existences beyond narratives of conquest and control. Ultimately, I argue that wonder is a helpful mechanism for thinking through the goodness of the tick by (...) allowing an ungrounding of our assumptions about climate change, hospitality, and the danger of non-human agencies. (shrink)