This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

The aim of this study was to analyze the association between coaches’ experience and their perceptions on the implementation of a long-term athletic development model created in 2016 by the Portuguese Swimming Federation. Eighty-six swimming coaches were assembled in groups according to their experience level: “novice”, “intermediate”, and “experienced”, and they answered a questionnaire with the following items: awareness of the existing model acceptance usefulness for practice, and implementation of this model by their peers. Regardless of experience, ~67% of the (...) coaches were aware of the model. Among those, a large number showed acceptance and confidence in its usefulness for their daily practice. Most coaches showed concerns about the fact that their peers do not respect the model frameworks, declaring the search for their swimmers’ immediate success as the main cause for such behavior. The results also showed an association between experience and knowledge about the model’s existence [χ2 = 10.223, p < 0.01, V = 0.345], and experienced coaches exhibited better knowledge than their intermediate [χ2 = 9.555, p < 0.01, V = 0.393] or novice [χ2 = 5.926, p = 0.02, V = 0.314] counterparts. While there was an association between the coaches’ experience and knowledge about the LTAD model’s existence, this situation does not seem to influence the way coaches accept and understand the usefulness of the model for their daily practice. (shrink)

Transdisciplinary research knits together knowledge from diverse epistemic communities in addressing social-environmental challenges, such as biodiversity loss, climate crises, food insecurity, and public health. This paper reflects on the roles of philosophy of science in transdisciplinary research while focusing on Indigenous and other subaltern forms of knowledge. We offer a critical assessment of demarcationist approaches in philosophy of science and outline a constructive alternative of transdisciplinary philosophy of science. While a demarcationist focus obscures the complex relations between epistemic communities, transdisciplinary (...) philosophy of science provides resources for meeting epistemic and political challenges of collaborative knowledge production. (shrink)

La conception de l'essence de la philosophie qui vient d'être esquissée paraitrait se recommander pour plusieurs raisons:Elle présente la philosophie comme étant une science, en intention et potentiellement, au même sens du mot „science“ que par exemple la physique ou la biologie: mais une science dont le sujet propre de recherches est différent de celui des sciences naturelles; et d'ailleurs une science qui n'est pas encore très avancée, parce que son sujet propre, et la méthode de recherche qui lui est (...) appropriée n'ont généralement pas été discernés d'une façon adéquate.En faisant une distinction entre les problèmes pratiques à résoudre par la philosophie, et les problèmes de philosophie, qui sont théoriques, notre conception rend justice, d'une part à l'opinion que la réflection philosophique peut et doit contribuer à la sagesse dans la conduite des affaires pratiques, et d'autre part au fait que beaucoup des problèmes théoriques de la philosophie sont aussi abstrus, abstraits et techniques, et en apparence aussi dénués d'implications pratiques, que beaucoup des problèmes de physique théorique ou des mathématiques pures; mais la relation entre la théorie et la pratique est logiquement la même dans les deux cas. En conséquence même les questions philosophiques les plus abstraites, quand elles ne sont pas des pseudo-questions et sont bien posées, ont potentiellement une importance pratique de l'espèce particulière qui a été indiquée.La conception de la philosophie que nous avons ébauchée fait place, dans le domaine général de la philosophie, non seulement à la morale et aux autres branches de la philosophie dites normatives, mais aussi à la métaphysique et à l'épistémologie, tant que les hypothèses de ces dernières ne sont pas dogmatiques, mais peuvent être mises à l'épreuve consistant à voir si elles s'accordent avec les faits observables de l'espèce appropriée, aussi bien qu'à l'épreuve de cohérence interne et de cohérence réciproque ou mutuelle.La conception philosophique présentée spécifie quelle est l'espèce de faits pouvant servir de référence pour contrôler empiriquement la validité ou l'invalidité des spéculations philosophiques quand elles ne sont pas présentées comme des révélations d'oracle, et ainsi rend claire la forme particulière que la méthode scientifique, génératrice de connaissances, et non de simples croyances, doit assumer, lorsqu'elle est appliquée au sujet de recherches qui distingue la philosophie des autres sciences.Finalement, notre conception met en relief le fait que les mots (et en particulier les termes de valeur, et autres termes philosophiques) sont des outils créés par l'homme tout autant qu'une hache, un moteur électrique ou une maison; que les mots sont les moyens les plus typiques par lesquels les hommes s'influencent réciproquement, et enfin que les mots influencent les sentiments, les croyances et les actions, même quand ils sont mal compris ou employés à tort. En conséquence l'analyse ou la fixation de leur signification, qui permet de les appliquer avec discernement et sans malentendu aux faits, actions ou événements concrets, est une tâche de la plus haute importance pour l'homme vivant en société. (shrink)

Background: Electroconvulsive therapy is one of the most effective treatments for major depressive disorder. Recently, there has been increasing attention to evaluate the effect of ECT on resting-state functional magnetic resonance imaging. This study aims to compare rs-fMRI of depressive disorder patients with healthy participants, investigate whether pre-ECT dynamic functional network connectivity network estimated from patients rs-fMRI is associated with an eventual ECT outcome, and explore the effect of ECT on brain network states.Method: Resting-state functional magnetic resonance imaging data were (...) collected from 119 patients with depression or depressive disorder, and 61 healthy participants, with an age mean of 52.25 years old. The pre-ECT and post-ECT Hamilton Depression Rating Scale were 25.59 ± 6.14 and 11.48 ± 9.07, respectively. Twenty-four independent components from default mode and cognitive control network were extracted, using group-independent component analysis from pre-ECT and post-ECT rs-fMRI. Then, the sliding window approach was used to estimate the pre-and post-ECT dFNC of each subject. Next, k-means clustering was separately applied to pre-ECT dFNC and post-ECT dFNC to assess three distinct states from each participant. We calculated the amount of time each subject spends in each state, which is called “occupancy rate” or OCR. Next, we compared OCR values between HC and DEP participants. We also calculated the partial correlation between pre-ECT OCRs and HDRS change while controlling for age, gender, and site. Finally, we evaluated the effectiveness of ECT by comparing pre- and post-ECT OCR of DEP and HC participants.Results: The main findings include depressive disorder patients had significantly lower OCR values than the HC group in state 2, where connectivity between cognitive control network and default mode network was relatively higher than other states, Pre-ECT OCR of state, with more negative connectivity between CCN and DMN components, is linked with the HDRS changes. This means that those DEP patients who spent less time in this state showed more HDRS change, and The post-ECT OCR analysis suggested that ECT increased the amount of time DEP patients spent in state 2.Conclusion: Our finding suggests that dynamic functional network connectivity features, estimated from CCN and DMN, show promise as a predictive biomarker of the ECT outcome of DEP patients. Also, this study identifies a possible underlying mechanism associated with the ECT effect on DEP patients. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

With the ascent of modern epidemiology in the Twentieth Century came a new standard model of prediction in public health and clinical medicine. In this article, we describe the structure of the model. The standard model uses epidemiological measures-most commonly, risk measures-to predict outcomes (prognosis) and effect sizes (treatment) in a patient population that can then be transformed into probabilities for individual patients. In the first step, a risk measure in a study population is generalized or extrapolated to a target (...) population. In the second step, the risk measure is particularized or transformed to yield probabilistic information relevant to a patient from the target population. Hence, we call the approach the Risk Generalization-Particularization (Risk GP) Model. There are serious problems at both stages, especially with the extent to which the required assumptions will hold and the extent to which we have evidence for the assumptions. Given that there are other models of prediction that use different assumptions, we should not inflexibly commit ourselves to one standard model. Instead, model pluralism should be standard in medical prediction. (shrink)

The present commentary addresses the main results obtained in the Butler and Klein [Butler, B. C., & Klein, R. . Inattentional blindness for ignored words: Comparison of explicit and implicit memory tasks. Consciousness and Cognition, 18, 811–819.] study and discusses them in relation to the Perceptual Load Theory of Lavie [Lavie, N. . Perceptual load as a necessary condition for selective attention. Journal of Experimental Psychology: Human Perception and Performance, 21, 451–68.]. The authors claim that the use of implicit indexes (...) of conceptual distractor processing in high-load situations would be an important addition to the load literature, which would benefit the research field regardless of their positive or negative findings. (shrink)

The practice of physical activity (PA) contributes to the prevention of chronic diseases such as obesity, metabolic syndrome or cardiovascular diseases, being also directly related to the individual’s physical fitness. Therefore, it is necessary to measure and monitoring the levels of PA in childhood and adolescence, since it may be useful to describe their current health status and the association with physical fitness, as well as to reveal putative consequences in the future. Within the educational field, it has been shown (...) that physical education (PE) classes are a favorable context for the creation of healthy physical-sports habits and self-determined motivation could be a key for explaining the level of PA practice. For this reason, the purpose of this research was to study the mediating role of integrated regulation (IR) on the relationship between PA and physical fitness in children and adolescents. A total of 325 students between 11 and 14 years old participated in the study. The level of PA was estimated through the specific Physical Activity Questionnaire for Children (PAQ-C), while motivation and IR were measured by using the Perceived Locus of Causality scale (PLOC-2). In addition, physical fitness was measured through the Eurofit fitness battery of tests, composed of three body composition measures and seven tests of different physical capacities. The physical fitness score showed no differences when genders were compared. After regression analysis, the resulti... (shrink)

Este artículo examina el reciente debate entre J. Habermas y C. Lafont sobre la ética del discurso. Se intenta mostrar que la propuesta de Lafont de interpretar la ética del discurso como una versión del realismo moral se enfrenta a problemas difíciles de resolver dentro del marco teórico de la ética discursiva. El artículo examina en primer lugar cómo la posición de Lafont extiende al terreno de la razón práctica varias objeciones importantes contra la teoría consensual de la verdad. A (...) continuación, se critican los argumentos con que Lafont avala su realismo moral, y se concluye examinando la distinción entre consensos racionales y compromisos de intereses desde una perspectiva estrictamente procedimental. This paper analyses the recent debate between J. Habermas and C. Lafont on discourse ethics. The aim is to show that Lafont's proposal of a realist interpretation of discourse ethics must face several problems which are difficult to resolve from within the theoretical frame of discourse ethics. First of all, the paper sets out how Lafont's position extends to the field of practical reason some important objections against Habermas¿s consensus theory of truth. Subsequently Lafont's arguments in support of moral realism are criticised, and the paper concludes with an analysis of the difference between rational agreements and compromises of interests from a procedural point of view. (shrink)

Est-il vrai que la notion chrétienne de création soit une notion complètement nouvelle par rapport à la philosophie grecque ? Telle est la question qu'on se pose dans l'article ci-dessus. Si d'habitude on est incliné à répondre à cette question par l'affirmative, c'est en admettant que, assez généralement, la philosophie grecque connaît l'idée d'une matière préexistante. C'est ainsi que les apologètes grecs du deuxième siècle, tels qu'Aristide et Théophile d'Antioche, se sont opposés à la philosophie grecque et spécialement à la (...) doctrine de Platon telle qu'ils l'ont comprise. L'auteur essaie de démontrer que, en fait, Platon n'a pas admis une matière préexistante dans le sens voulu par ses adversaires. Il n'a ni enseigné que les éléments préexistassent à l'œuvre créatrice du Démiurge , ni introduit sa notion d' espace dans le sens de matière, telle qu'Aristote, suivant sa propre terminologie, a voulu l'expliquer. C'est donc une erreur de dire que Platon ait admis une matière qui soit « coéternelle » et « du même âge », donc du même ordre que Dieu. Pour Platon, et pour Aristote également, le principe non déterminé ne saurait, comme tel, être du même orde que le premier Principe de l'être qui est comme tel un principe déterminant et déterminé. C'e'st une erreur, encore, de dire que, sur ce point comme sur beaucoup d'autres, Aristote était plus près de la vérité, donc du Christianisme, que Platon, le « Démiurge » du dernier n'étant pas une cause totale, tandis que le Premier Moteur d'Aristote était, dans un sens, vraiment une cause totale. Ce qui se voit clairement chez Platon, non seulement dans le Timée, mais aussi dans la République et dans le Philète , c'est qu'il est constamment et profondément préoccupé de fonder l'existence relative dans l'Existence absolue. Il a reconnu le rapport entre le monde visible et le Monde transcendant comme une relation de dépendance totale et essentielle. Or, si, dans son essence, la notion chrétienne de création n'est autre chose qu'une telle relation de dépendance, Platon, qui a fait de cette notion la base de toute sa philosophie, était par là-même près de la foi chrétienne. Aristote, d'autre part, bien qu'il ait dit une fois au moins que de son premier Principe tout l'univers dépend, a minimisé en fait le rapport entre le premier Principe et notre monde. Dans la notion chrétienne de création deux éléments se dissinguent : L'Etre Absolu, dont sort tout ce qui est relatif, se distingue dans son essence de tout ce qui n'est pas Lui. Le mode selon lequel l'être relatif sort de l'Absolu n'est pas celui d'une nécessité de nature, mais d'un acte de volonté. En partant de cette analyse, on peut déterminer exactement les degrés de différence ou d'affinité entre la notion chrétienne de création et les différents systèmes de philosophie grecque. En rapport avec la Stoa, la différence est dans la notion de Dieu : ne reconnaissant pas sa transcendance, on méconnaît l'opposition entre l'Absolu et l'être relatif. Quant à Aristote, il n'explique aucunement comment l'être relatif provient de l'Absolu : son premier Moteur n'est pas la cause de l'être, et les « formes » immanentes des objets naturels restent chez lui sans aucune explication. Sans doute, Platon explique davantage. Il est suivi par les Néoplatoniciens qui font provenir l'être relatif de l'Absolu, tout en connaissant une différence essentielle entre l'un et l'autre, mais n'admettant point d'acte de volonté de la part de l'Absolu. Platon qui, probablement, admettait un acte de volonté, se trouvait par là-même le plus près de la notion chrétienne de création. Il en différait, cependant, sur quelques points importants. Il n'enseigne qu'en partie une création directe : c'est que le Nous transcendant qui est le Démiurge, constitue des éléments le monde visible ; ces éléments, il ne les a pas trouvés comme tels, mais il les a faits de — « quelque chose » qu'on n'a pas le droit de nommre une chose. Il « fait » donc le monde dans son aspect intelligible. Mais il reste un aspect qui échappe à la pensée et qui, comme tel, ne saurait provenir du Principe Suprême qui domine la hiérarchie platonicienne de l'être. Ensuite, le Nous transcendant fait les âmes : l'âme du monde, les astres , les âmes humaines. Il ne fait ni les corps humains ni les êtres vivants d'un ordre inférieur à l'homme. Ceux-là, ils sont tous créés par les « dieux créés » et secondaires qui sont les Astres. Pour Platon, l'Esprit transcendant qui crée le monde n'est pas le Principe suprême. Il se trouve d'après ce qu'il paraît, à un degré plus bas dans la hiérarchie de l'être. Ce seront les penseurs chrétiens, ce sera tout d'abord Saint Athanase qui, en unifiant essentiellement le Père et son Logos, a réuni l'Un et le Nous transcendant qui est le Démiurge de Platon. Au lieu d'opposer au Platonisme la doctrine qu'il n'y a pas de matière préexistante, Dieu ayant « concréé » la matière, nous préférons de dire : Platon a éloigné la notion d'infini et d'indétermination de son principe suprême ; donc, il en a fait un autre principe, jamais du même ordre que l'Un, mais tout de même un principe fondamental. La notion chrétienne de Dieu, d'autre part, renferme et le caractère de l'Un et celui de l'Infini. (shrink)

Este artículo se propone examinar el modo en que la fenomenología de la donación puede lograr una vinculación exitosa con la hermenéutica. Siguiendo la indicación dada por el propio Marion, a través de una comparación de su planteo con el de Claude Romano, es posible establecer hasta qué punto la propuesta marioniana es capaz de responder a las exigencias hermenéuticas y fenomenológicas que la articulación demanda.

The relation between categories and sentence frames as presented in ryle's "the concept of mind" is discussed. smart states, "it is important to note that the fact that two expressions 'a' and 'b' "will" go into the same blank in a sentence frame does "not" prove that they are of the same category." (staff).

Introduction - From the Illiad to the Studies on Hysteria: A chronology of the discovery of the unconscious mind - Freud's theories of the unconscious mind - Jung's collective unconscious - Lacan's linguistic paradigm.

Among the manuscripts of Ovid's Metamorphoses used by N. Heinsius and as yet unidentified or given up for lost is the so-called fragmentum Caesenas, the collation of which was not carried out by Heinsius himself but provided for him by the Hamburg jurist Lucas Langermann, who was a correspondent of Heinsius, Gronovius and Vossius, among others. According to M.D. Reeve, he was also responsible for adding these notes, using the siglum c, to Oxon. Bodl. Auct. S.V.5, which also includes the (...) collations—by another hand—of A and B. The variants provided by this fragment affect lines 9.235–11.169 and 13.1–403, although this does not imply that these were the exact limits of its content, as we shall see below. Some of these variants ended up in the notes of the editions by Heinsius himself and by those who continued his work, and it was D.A. Slater who rescued the collation of Bodl. Auct. S.V.5 from obscurity when he included the greater part of the readings of c among the rich store of information presented in his work. F. Munari included the fragment in his catalogue, clearly pointing to the uncertainty surrounding its dating while adding the information that it was not at that time to be found in Cesena. The succinct information offered by Slater is used by I. Marahrens for her dissertation and by W.S. Anderson for his edition. R.J. Tarrant, in turn, explicitly states that the fragment is now lost. In the following pages, however, I will attempt to show that this fragment is not lost, but still preserved in the Biblioteca Malatestiana in Cesena. (shrink)

This essay defends a view which is near enough to Putnam's characterization of metaphysical realism for it to be called by the same name. Indeterminacy of reference is conceded, in the sense that there may be multiple reference relations, but it is denied that this implied belief in unknowable noumena. It is enough for metaphysical realism as conceived here, that there be at least one reference relation. The essay also argues against defining truth epistemically. Even a Peircean ideal theory might (...) be false, in a contextual sense of might' stronger than that of the logically possible. (shrink)

This review is mainly expository. At one place, Following a suggestion of carnap's, It is suggested that advances in brain physiology might enable us to revive the notion of conventional truth.

In this paper we expand previous results obtained in [2] about the study of categorical equivalence between the category IRL 0 of integral residuated lattices with bottom, which generalize MV-algebras and a category whose objects are called c-differential residuated lattices. The equivalence is given by a functor ${{\mathsf{K}^\bullet}}$ , motivated by an old construction due to J. Kalman, which was studied by Cignoli in [3] in the context of Heyting and Nelson algebras. These results are then specialized to the case (...) of MV-algebras and the corresponding category ${MV^{\bullet}}$ of monadic MV-algebras induced by “Kalman’s functor” ${\mathsf{K}^\bullet}$ . Moreover, we extend the construction to ℓ-groups introducing the new category of monadic ℓ-groups together with a functor ${\Gamma ^\sharp}$ , that is “parallel” to the well known functor ${\Gamma}$ between ℓ and MV-algebras. (shrink)

Cattle production has the potential of being an important component of sustainable agriculture globally. The ability to transform feed not suitable for humans into high-quality food will be of great importance in the long-term for feeding a growing population. Other aspects such as preservation of landscape values and maintenance of rural communities are highly appreciated values, especially in the industrialized part of the world.To exploit the sustainable potential of cattle production systems, problems of pollution (such as ozone destruction, acid rain, (...) and nitrate leaching) and of health and welfare, which are associated with cattle production, are critically reviewed. The possibilities of integrating cattle production with other types of production are evaluated. Cattle can be used for single purposes such as dairy, beef, and draught, but dairy cows can also be used for restricted suckling combining dairy and beef production. In addition a mixture of species makes grazing more efficient, and a combination of cattle and mixed cropping can increase resource efficiency. (shrink)

J. C. Dannhauer estimait nécessaire d'adjoindre une " nouvelle cité " à l'Organon aristotélicien, et J. Clauberg de donner un prolongement à la méthode cartésienne pour prendre en compte le caractère intersubjectif de notre accès à la connaissance. Admettre le fait que nous ne cheminons jamais seuls sur la voie qui nous y conduit ne contredit pourtant pas le geste plus classique de Descartes, ou de Malebranche par exemple, qui met l'accent sur la nécessité de se déprendre de ce que (...) l'" on " pense : il en est le pendant. Descartes s'adresse lui-même dans ses ouvrages à des lecteurs, et l'on sait que la lettre préface des Principes de la philosophie ne dédaigne pas leur indiquer précisément, quoique succinctement, la méthode correcte à laquelle doit obéir leur lecture pour en saisir le sens. À cet égard, et dans un contexte qui est également constitué par les débats théologiques de l'époque relatifs à l'interprétation de l'Écriture, l'apport de Dannhauer et de Clauberg tient au fait qu'ils ont élaboré cette partie de la logique visant à déterminer le sens des textes et plus largement des discours d'autrui, et qu'ils qualifient, avant Schleiermacher, d'herméneutique. À partir de contributions destinées à clarifier leur projet d'une herméneutique générale, cet ouvrage propose la première traduction de la remarquable troisième partie de la Logica de Clauberg consacrée à l'herméneutique qu'il appelle " analytique ". (shrink)

Excluding only pure nominalists and "imagists" he includes in the classical theory "almost everyone who lived before the second decade of the twentieth century." This of course covers most of the other general types of theory found in the epistemology textbooks: that concepts are in the mind, that they are also in the thing, and finally that they are fundamentally prior to the thing. These types may be exemplified by Locke, Aristotle, and Plato, respectively. The controversy between these three schools (...) Price feels can for his purposes be regarded as a "domestic difference within the classical tradition." His subsidiary discussions of these differences he confines almost entirely to the first two. The Platonic theory he handles very lightly and gingerly; "it is a sufficiently difficult task in these days to convince people that there is any sense in talking of universals at all, even in the mild and moderate Aristotelian way". (shrink)

Rights have two properties which prima facie appear to be inconsistent. The first is that they are conditional in the sense that one some occasions it is always justifiable for someone to act in a way which appears to be inconsistent with someone else's rights, such as when the defence of necessity applies. The second is that rights are indefeasible in the sense that they are not subject to being defeated our outweighed by utilitarian or policy considerations. If we view (...) rules and the rights which they establish as being subject to a ceteris paribus clause, the form of which generates out the exceptions, the conditionality of rights becomes reconcilable with their nondefeasibility. Such a view of rules and rights would entail that the goals of the law and their orderings be considered as a part of the law. When so viewed, propositions about goals and their orderings become legitimate premises for legal reasoning, furnishing solutions to hard cases in the law of torts, without resort to balancing of interests or judicial discretion. (shrink)

Book reviewed in this article:F.H. Bradley, Collected Works Volumes 1–5.

This paper is written in an analytic style, but it is meant to deprive analysis of an important prop. The title needs a short introduction. The mistake is to take ‘real’ as governed in its separate uses by criteria; and this paper is meant to show that this is a mistake and that Ausin makes it. In the course of the argument I try to develop my own account and, although I am not altogether satisfied with it, the result gives (...) something to build upon. I believe the mistake is by no means confined to Austin, but that it is connected with a particular conception of philosophy. (shrink)

I do not approach the question of free will as a scientist, like Colin Blakemore, or a lawyer, like David Hodgson, or philosopher, like Daniel Dennett, but as a priest -- someone who feels responsible for my own actions and who is called upon to counsel and absolve such as come to me with their shame and their guilt. Should I say that their sense of responsibility is illusory? Or should I encourage them to accept responsibility, and then to deal (...) with it in the various ways -- religious, psychological and practical -- that are open to them? (shrink)