We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Drawing on writers as diverse as Saul Kripke, Stanley Cavell, G. E. M. Anscombe, Jonathan Lear, and Bernard Williams, I offer an interpretation of Wittgenstein's key notion of a form of life that explains why Wittgenstein was so enigmatic about it. Then, I show how Hilary Putnam's criticism of Wittgenstein's philosophy of mathematics and Richard Rorty's support of (what he takes to be) Wittgenstein's legacy in the philosophy of mind both require mistaken assumptions about Wittgenstein's idea of a form (...) of life. Finally, I consider the extent to which the idea of a form of life is subject to Donald Davidson's critique of the idea of a conceptual scheme. (shrink)

Ontological dualism is energetically resisted by a range of Christian scholars including philosophers such as Baker and Corcoran who defend accounts of human persons based on material constitution. Whilst Baker’s view fails to account for diachronic identity, Corcoran’s account of life after death makes use of Zimmerman’s problematic “Falling Elevator Model.” It is argued that Zimmerman’s recent reassessment of the model overestimates its value for materialists. In fact, the model generates either a fatal encounter with the nature of (...) identity, or absurdity. A lack of alternatives is illustrated by anticriterialist proposals. Thus it seems materialism and resurrection belief remain incompatible. (shrink)

Lynne Rudder Baker’s work was driven by commitments to quasi-naturalist materialism and the ontological distinctiveness of human persons. The incompatibility of these commitments is apparent in her constitution view. Baker's “Not-so-simple Simple View” of personal identity is inferior to the Simple View traditionally associated with substance dualism since CV’s underlying account of persons is vacuous. It also entails a dilemma: either indeterminate identity or the problem of the many. Finally, CV also fails to support Baker’s view that (...) human persons do not begin to exist prior to the acquisition of a capacity for conscious, intentional thought. (shrink)

Baker (Mind 114:223–238, 2005; Brit J Philos Sci 60:611–633, 2009) has recently defended what he calls the “enhanced” version of the indispensability argument for mathematical Platonism. In this paper I demonstrate that the nominalist can respond to Baker’s argument. First, I outline Baker’s argument in more detail before providing a nominalistically acceptable paraphrase of prime-number talk. Second, I argue that, for the nominalist, mathematical language is used to express physical facts about the world. In endorsing this line (...) I follow moves made by Saatsi (Brit J Philos Sci 62(1):143–154, 2011). But, unlike Saatsi, I go on to argue that the nominalist requires a paraphrase of prime-number talk, for otherwise we lack an account of what that ‘physical fact’ is in the case of mathematics that seemingly makes reference to prime numbers. (shrink)

Some Christian materialists have argued for the possibility of resurrection given that persons are constituted by bodies, and constitution is not identity. Baker's constitutionist view claims superiority over animalist alternatives but offers only circular accounts of both personal identity over time and personhood. Corcoran's alternative approaches these questions differently but makes use of Zimmerman's ‘Falling Elevator Model’ of resurrection, which is rendered incoherent by its reliance on contingent identity. A recent constitutionist revision of this model succeeds only in exchanging (...) incoherence for absurdity. Despite difficulties for such resurrection accounts, the idea of constitution as a sui generis relation remains attractive among philosophers and Christian materialists in particular. However, Wasserman's deflationary view combines with problems such as extensionality, indiscernibility and the explosion of reality to provide reason to worry that constitution might be just identity after all. If so, then the metaphysics of constitution cannot provide a convenient route between animalism and immaterialism when explaining the possibility of resurrection. (shrink)

ABSTRACT Our aim in this article is to offer a new justification for preferring theories that are more quantitatively parsimonious than their rivals. We discuss cases where it seems clear that those involved opted for more quantitatively parsimonious theories. We extend previous work on quantitative parsimony by offering an independent probabilistic justification for preferring the more quantitatively parsimonious theories in particular episodes of theory choice. Our strategy allows us to avoid worries that other considerations, such as pragmatic factors of computational (...) tractability and so on, could be the driving ones in the historical cases under consideration. _1_ Introduction _2_ Three Desiderata _2.1_ Limiting _2.2_ Robustness _2.3_ Breadth _2.3.1_ A limited success for Baker _2.3.2_ Rejecting Baker’s analysis _2.4_ The proposal _3_ Probabilistically Additive Hypotheses and a Bayesian Account: The Limpid Rationale Relativized and Reconsidered _3.1_ Neutrinos and beta decay _3.2_ Avogadro’s hypothesis _3.3_ Postulation of Neptune _4_ Conclusion. (shrink)

Neither full belief nor partial belief is more fundamental, ontologically speaking. A survey of some relevant cognitive psychology supports a dualist ontology instead. Beliefs come in two kinds, categorical and graded, neither more fundamental than the other. In particular, the graded kind is no more fundamental. When we discuss belief in on/off terms, we are not speaking coarsely or informally about states that are ultimately credal.

Evidence is univocal, not equivocal. Its implications don't depend on our beliefs or values, the evidence says what it says. But that doesn't mean there's no room for rational disagreement between people with the same evidence. Evaluating evidence is a lot like polling an electorate: getting an accurate reading requires a bit of luck, and even the best pollsters are bound to get slightly different results. So, even though evidence is univocal, rationality's requirements are not "unique." Understanding this resolves several (...) puzzles to do with uniqueness and disagreement. (shrink)

Many philosophers accept a response constraint on normative reasons: that p is a reason for you to φ only if you are able to φ for the reason that p. This constraint offers a natural way to cash out the familiar and intuitive thought that reasons must be able to guide us, and has been put to work as a premise in a range of influential arguments in ethics and epistemology. However, the constraint requires interpretation and faces putative counter-examples due (...) to Julia Markovits, Mark Schroeder, and others. This paper develops and motivates an interpretation of the response constraint that avoids the putative counter-examples. (shrink)

In the original publication of the article, the Acknowledgement section was not included. The section is given below.

The knowability paradox derives from a proof by Frederic Fitch in 1963. The proof purportedly shows that if all truths are knowable, it follows that all truths are known. Antirealists, wed as they are to the idea that truth is epistemic, feel threatened by the proof. For what better way to express the epistemic character of truth than to insist that all truths are knowable? Yet, if that insistence logically compels similar assent to some omniscience claim, antirealism is in jeopardy. (...) Response to the paradox has drifted toward a common theme, a theme I will argue is a non-starter in resolving the paradox. Seeing this point will also make clear the philosophical inadequacy of simply viewing the paradox as a refutation of a wide range of antirealisms. (shrink)

A major work in moral philosophy by the noted Puritan divine.

Theodore Sider has recently produced an argument which he takes to show that three-dimensionalism is incompatible with the possibility of time travel. I wish to argue that there is indeed a problem for the three-dimensionalist who wishes to countenance time travel, but that Sider has misdiagnosed it. I show why his putative challenge fails, and furthermore that if it were to succeed this would be as problematic for a wide class of four-dimensionalist positions, including Sider’s own, as it would be (...) for three-dimensionalism. Finally, I present the problem that the possibility of time travel genuinely poses for the three-dimensionalist. (shrink)

ABSTRACT We tested a model in which individualist and collectivist orientations mediate the association between cultural background and students’ self-reported plagiarism. A sample of 430 Jewish and non-Jewish undergraduates at a college in northern Israel completed a questionnaire to assess individualist and collectivist orientation and demographics, and answered a question regarding whether they had committed plagiarism during their studies. The results partly supported the model; individualism, but not collectivism, mediated the association between cultural background and admitting plagiarism. The model and (...) some unexpected results offer new insights into the role of culture in academic behavior and raise further questions. (shrink)

This book explores the contributions to the philosophy of mind made by the Tibetan Buddhist thinker Phya pa Chos kyi seng ge (1109–1169) in his seminal text, the “Dispeller of the Mind’s Darkness.” This study, which includes a critical edition and English translation of those portions of the “Dispeller” devoted to explicating the nature of mental episodes and their objects, contributes to a deeper understanding of Tibetan intellectual history, while also facilitating a wider appreciation of both Phya pa’s theory of (...) mind and its significance within the global history of philosophy. (shrink)

"--Daniel Callahan, cofounder of the Hastings Center "Doctors and people who have no choice but to trust doctors--which means all of us--need to read this book.

This essay considers the prospects of modeling spacetime as a phenomenon that emerges in the low-energy limit of a quantum liquid. It evaluates three examples of spacetime analogues in condensed matter systems that have appeared in the recent physics literature, indicating the extent to which they are viable, and considers what they suggest about the nature of spacetime.

Introduction : ethical economics? -- The sovereign consumer -- Two myths about economic growth -- The politics of pay -- Happiness -- Pricing life and nature -- New worlds of money : public services and beyond -- Conclusion.

Jonathan Bennett engages with the thought of six great thinkers of the early modern period: Descartes, Spinoza, Leibniz, Locke, Berkeley, and Hume. While not neglecting the historical setting of each, his chief focus is on the words they wrote. What problem is being tackled? How exactly is the solution meant to work? Does it succeed? If not, why not? What can be learned from its success or failure? For newcomers to the early modern scene, this clearly written work is (...) an excellent introduction to it. Those already in the know can learn how to argue with the great philosophers of the past, treating them as colleagues, antagonists, students, teachers. In this second volume, Bennett focuses on the work of Locke, Berkeley, and Hume. (shrink)

We argue that differences in the institutional setting of Europe and the US is the critical factor in understanding policymaking in Europe and the United States, and particularly the influence of nongovernmental organizations (NGOs). To test this relationship between institutional differences, corporate social responsibility (CSR), and NGO activism, we investigate 12 cases involving US and European companies in each of three industries. We conclude that different institutional structures and political legacies in the US and Europe are important factors in explaining (...) the influence of NGOs on business and in the policymaking process, regardless of the timeliness of corporate strategy or NGO influence. (shrink)

Bevir?s view that theories are prior to theorists, just in so far as they are prior to any observations which one might make and, by extension, any facts which one might invoke in support of any particular interpretative conclusions, is problematic when applied to intellectual history, for although it is in one sense true that all facts are ineluctably constituted by some or other underlying theory, it is also true that, in a vast number of important situations, all human beings (...) share the same basic theory. The most important implication of this shared stock of concepts, observations and facts, is that we shall often be able to see numerous aspects of a long?dead author?s world in much the same way as he or she saw it. (shrink)