While aging research and policy aim to promote ‘health’ at all ages, there remains no convincing explanation of what this ‘health’ is. In this paper, I investigate whether we can find, implicit within the sciences of aging, a way to know what health is and how to measure it, i.e. a theory of health. To answer this, I start from scientific descriptions of aging and its modulators and then try to develop some generalizations about ‘health’ implicit within this research. After (...) discussing some of the core aspects of aging and the ways in which certain models describe spatial and temporal features specific to both aging and healthy phenotypes, I then extract, explicate, and evaluate one potential construct of health in these models. This suggests a theory of health based on the landscape of optimized phenotypic trajectories. I conclude by considering why it matters for more candidate theories to be proposed and evaluated by philosophers and scientists alike. (shrink)

In psychiatry, pharmacological drugs play an important experimental role in attempts to identify the neurobiological causes of mental disorders. Besides being developed in applied contexts as potential treatments for patients with mental disorders, pharmacological drugs play a crucial role in research contexts as experimental instruments that facilitate the formulation and revision of neurobiological theories of psychopathology. This paper examines the various epistemic functions that pharmacological drugs serve in the discovery, refinement, testing, and elaboration of neurobiological theories of mental disorders. I (...) articulate this thesis with reference to the history of antipsychotic drugs and the evolution of the dopamine hypothesis of schizophrenia in the second half of the twentieth century. I argue that interventions with psychiatric patients through the medium of antipsychotic drugs provide researchers with information and evidence about the neurobiological causes of schizophrenia. This analysis highlights the importance of pharmacological drugs as research tools in the generation of psychiatric knowledge and the dynamic relationship between practical and theoretical contexts in psychiatry. (shrink)

Jonathan Bennett engages with the thought of six great thinkers of the early modern period: Descartes, Spinoza, Leibniz, Locke, Berkeley, and Hume. While not neglecting the historical setting of each, his chief focus is on the words they wrote. What problem is being tackled? How exactly is the solution meant to work? Does it succeed? If not, why not? What can be learned from its success or failure? For newcomers to the early modern scene, this clearly written work is (...) an excellent introduction to it. Those already in the know can learn how to argue with the great philosophers of the past, treating them as colleagues, antagonists, students, teachers. In this second volume, Bennett focuses on the work of Locke, Berkeley, and Hume. (shrink)

Jonathan Knowles argues against theories that seek to provide specific norms for the formation of belief on the basis of empirical sources: the project of naturalized epistemology. He argues that such norms are either not genuinely normative for belief, or are not required for optimal belief formation. An exhaustive classification of such theories is motivated and each variety is discussed in turn. He distinguishes naturalized epistemology from the less committal idea of naturalism, which provides a sense in which we (...) can achieve epistemic normativity without norms. (shrink)

Various influential ethical theories propose that we should strive to develop morally sound character traits, either because good actions are those that issue from good character traits, or because good traits are those that generally incline us toward actions that are good for some independent reason such as the intentions with which they are performed or the consequences of performing them. This proposal obviously raises questions about the nature and origins of character traits, and our degree of control over them. (...) For if we cannot develop our traits then this proposal should be abandoned, and if we can then we need to know how this is best achieved. (shrink)

The discovery of the engram, the physical substrate of memory, is a central challenge for the sciences of memory. Following the application of optogenetics to the neurobiological study of memory, scientists and philosophers claim that the engram has been found. In this paper, I evaluate the implications of applying optogenetic tools to the localization of the engram. I argue that conceptions of engram localization need to be revised to be made consistent with optogenetic studies of the engram. I distinguish between (...) challenges to vehicle and content localization. First, I consider the silent engram hypothesis. According to this hypothesis, optogenetic studies indicate that synaptic efficacy, the traditional engram-bearing vehicle, is important merely for retrieval. I argue that this interpretation rests upon a misunderstanding of accessibility. Second, I argue that optogenetic-based strategies and findings conflict with preservationist and constructivist views on memory storage. There is an enduring trace, but stored content may change over time and experience, resulting in doubt about what constitutes a single engram. (shrink)

Inclusive fitness theory was not originally designed to explain the major transitions in evolution, but there is a growing consensus that it has the resources to do so. My aim in this paper is to highlight, in a constructive spirit, the puzzles and challenges that remain. I first consider the distinctive aspects of the cooperative interactions we see within the most complex social groups in nature: multicellular organisms and eusocial insect colonies. I then focus on one aspect in particular: the (...) extreme redundancy these societies exhibit. I argue that extreme redundancy poses a distinctive explanatory puzzle for inclusive fitness theory, and I offer a potential solution which casts coercion as the key enabler. I suggest that the general moral to draw from the case is one of guarded optimism: while inclusive fitness is a powerful tool for understanding evolutionary transitions, it must be integrated within a broader framework that recognizes the distinctive problems such transitions present and the distinctive mechanisms by which these problems may be overcome. (shrink)

I begin by expressing my sincere thanks to my critics for taking time from their own impressive projects in epistemology to consider mine. Often, in reading their criticisms, I had the feeling of having received more help than I really wanted! But the truth of the matter is that we learn best by making mistakes, and I appreciate the conscientious attention to my work that my critics have shown.

In this article, the basic sociological approaches to theorizing human emotions are reviewed. In broad strokes, theorizing can be grouped into several schools of thought: evolutionary, symbolic interactionist, symbolic interactionist with psychoanalytic elements, interaction ritual, power and status, stratification, and exchange. All of these approaches to theorizing emotions have generated useful insights into the dynamics of emotions. There remain, however, unresolved issues in sociological approaches to emotions, including: the nature of emotions, the degree to which emotions are hard-wired neurological or (...) socially constructed, the relevance of analyzing the biology and evolution of emotions, the relationship between cognition and emotions, the number of distinctive emotional states produced by humans, and the relationship between emotions and rationality. (shrink)

It’s generally assumed that, if an agent x acts by ϕ-ing, then there occurs an event which is x’s ϕ-ing. But what about when an agent tries to do something? Are there such things as attempts? The standard answer is ‘Yes’. But in a series of articles, and now a book, David-Hillel Ruben has argued that the answer is ‘No’: what happens when x tries to ϕ isn’t that an attempt occurs; rather, what happens is simply that a certain subjunctive (...) conditional fact obtains; x tries to ϕ just in case, had all the necessary conditions for success obtained, x would have intentionally ϕ-ed. I defend the existence of attempts. Following Ruben, I frame the issue in terms of the logical form of trying sentences. Against Ruben’s view that such sentences express subjunctive conditionals, I argue that they express existential quantifications over attempts qua events. Thus, trying sentences are true only if attempts qua events exist. (shrink)

Third-party punishment (TPP) occurs when the perpetrator of a transgression is punished by an individual who is not the victim of the transgression and, therefore, not directly affected by it. As F...

A major work in moral philosophy by the noted Puritan divine.

ABSTRACTThis paper seeks to shed light on the often-overlooked account of divine and human freedom presented by Anne Conway in her Principles of the Most Ancient Modern Philosophy, partly through a...

This article examines the philosophical methodology of intuitions beginning with an argument developed by Max Deutsch and Herman Cappelen over the descriptive adequacy of what Cappelen calls “methodological rationalism”, and their own preferred view, “intuition nihilism”. Based on inadequacies in both accounts, it offers a descriptive take on intuition-deploying philosophical practice today via what it calls “Protean Crypto-Rationalism”. It then describes the epistemic profile of the appeal to intuition, listing four key aspects of the basic shape of intuition-deploying philosophical practice: (...) primacy of cases, flexibility of report format, freedom of stipulation, and interpretation-hungry. It also considers several sources of error for intuitions featured in at least the informal methodological lore of philosophy, namely: misconstruals, modal confusions, pragmatics/semantics confusion, and “tin ear”. Finally, it explores the problem of methodological ignorance and inferential demand, particularly the typical practices of philosophical inference that operate on the premises delivered by appeal to intuitions. (shrink)

The principle of exchange seems to be limited in its application, and it cannot serve as a link between utilitarianism and the idea of a market for interpersonal relations. Our preferences concern the inner states of other people as well as their overt behavior. The neglect of this aspect of our preferences is a result of the coupling of utilitarianism with behaviorism. The problem is thus behaviorism, not consequentialism. It might be argued that commensurability is wrong because it sanctions impure (...) practices - aside from any principle of exchange. In reply, it may be argued that the principle of purity is an intuitive one, which must be justified at a higher level. At the intuitive level, the purity principle competes with the view that practices are in some cases too pure already, and that blind purity cannot be maintained without educational deception. The apparent difficulty of making tradeoffs among different kinds of consequences is a problem in practice, not a problem in principle. The difficulty may indeed justify certain prescriptive rules, but a blanket prohibition against impure practices would seem to require considerable defense. (shrink)

I argue that the rationale behind the fine-tuning argument for design is self-undermining, refuting the argument’s own premise that fine-tuning is to be expected given design. In (Weisberg 2010) I argued on informal grounds that this premise is unsupported. White (2011) countered that it can be derived from three plausible assumptions. But White’s third assumption is based on a fallacious rationale, and is even objectionable by the design theorist’s own lights. The argument that shows this, the argument from divine indifference, (...) simultaneously exposes the fine-tuning argument’s self-undermining character. The same argument also answers Bradley’s (forthcoming) reply to my earlier objection. (shrink)

What contribution can political philosophers make to policy questions, such as the best configuration of the welfare state? On one view, political philosophers set out abstract theories of justice that can guide policy makers in their attempt to transform existing institutions. Yet it rarely seems the case that such a model is used in practice, and it therefore becomes unclear how political philosophy can contribute to policy debates. Following a suggestion from Margaret MacDonald, I consider the view that political philosophers (...) can contribute by drawing attention to relatively neglected values. I develop this view to add the possibility that political philosophers can try to correct a situation in which a particular value, though important, can come to be too highly emphasised. I illustrate the account by considering the rise of the value of ‘responsibility’ in the welfare state, and ultimately the damage that has been done to society to disadvantaged groups by the over-insistence on the importance of responsibility. (shrink)

Many healthcare agencies are producing evidence-based guidance and policy that may determine the availability of particular healthcare products and procedures, effectively rationing aspects of healthcare. They claim legitimacy for their decisions through reference to evidence-based scientific method and the implementation of just decision-making procedures, often citing the criteria of ‘accountability for reasonableness’; publicity, relevance, challenge and revision, and regulation. Central to most decision methods are estimates of gains in quality-adjusted life-years, a measure that combines the length and quality of survival. (...) However, all agree that the QALY alone is not a sufficient measure of all relevant aspects of potential healthcare benefits, and a number of value assessment frameworks have been suggested. I argue that the practical implementation of these procedures has the potential to lead to a distorted assessment of value. Undue weight may be ascribed to certain attributes, particularly those that favour commercial or political interests, while other attributes that are highly valued by society, particularly those related to care processes, may be omitted or undervalued. This may be compounded by a lack of transparency to relevant stakeholders, resulting in an inability for them to participate in, or challenge, the decisions. The makes it likely that costly new technologies, for which inflated prices can be justified by the current value frameworks, are displacing aspects of healthcare that are highly valued by society. (shrink)

This paper considers the conception of the Triune God, soteriology and eschatology in Anne Conway’s metaphysics. After outlining some of the key features of her thought, including her account of a timeless God who is nevertheless intimately present in creation, I will argue that her conception of the Trinity offers a distinctive role for Christ and the Holy Spirit to play in her philosophical system. I also propose an interpretation of Conway’s eschatology, in which time is understood as grounded in (...) a never-ending soteriological process of the overall movement of creatures towards perfection and a state of spirituality. (shrink)

We should understand the concept of self-legislation that is central to Kant's moral philosophy not in terms of the enactment of statute, but in terms of the way in which judges make law, by setting down and refining precedent through particular judgements. This paper presents a descriptive model of agency based on self-legislation so understood, and argues that we can read Kant's normative ethics as based on this view of agency. It is intended to contribute to contemporary debates in moral (...) psychology and to exegetical discussion of Kant. (shrink)

The COVID-19 pandemic has been unprecedented, in every sense of the word. At the time of writing, there have been nearly 80 million confirmed cases of coronavirus and nearly 2 million deaths worldw...

It is argued that both neuroscience and physics point towards a similar re-assessment of our concepts of space, time and 'reality', which, by removing some apparent paradoxes, may lead to a view which can provide a natural place for consciousness and language within biophysics. There are reasons to believe that relationships between entities in experiential space and time and in modern physicists' space and time are quite different, neither corresponding to our geometric schooling. The elements of the universe may be (...) better described not as 'particles' but as dynamic processes giving rise, where they interface with each other, to the transfer, and at least in some cases experience, of 'pure'or 'active'information, the mental and physical just reflecting different standpoints. Although this analy-sis draws on general features of quantum dynamics, it is argued that purely quantum level events (and their 'interpretations') are unlikely to be relevant to the understanding of consciousness. The processes that might be able to give rise, within brain cells, to an experience like ours are briefly reviewed. It is suggested that the elementary signals that are integrated to generate a spatial experience may have features more in common with words than pixels. It is further suggested that the laws of integration of words in language may provide useful clues to the way biophysical integration of signals in neurons relates to integration of elements in experiential space. (shrink)

Medical interventions that cure or prevent medical conditions are central to medicine; and thus, understanding them is central to our understanding of medicine. My purpose in this paper is to explore the conceptual foundations of medicine by providing a singular analysis of the concept of a ‘preventive or curative medical intervention’. Borrowing a general account of prevention from Phil Dowe, I provide an analysis of prevention, cure, risk reduction, and a preventive or curative intervention, before turning to preventive and curative (...) medical interventions. The resulting counterfactual-mechanistic account holds that preventive and curative medical interventions reduce the probability of a medical condition in an actual population compared to their counterfactual omission, commonly by disrupting an etiological or constitutive mechanism for the condition. (shrink)

This study provides an account of Augustine's understanding of prayer and its importance to his theology by drawing on his practices as monk and bishop.

This book defines Christian epistemological orthodoxy against such heterodox systems as Kantian phenomenology, Barthian Neoorthodoxy, Ayerian Logical Positivism, and Whiteheadian Process Thought and their respective trajectories.