The rapid generation of new shapes observed in the living world is the result of genetic variation, especially in “morphological” developmental genes. Many of these genes contain coding tandem repeats. Fondon and Garner have shown that expansions and contractions of these repeats are associated with the great diversity of morphologies observed in the domestic dog, Canis familiaris.1 In particular, they found that the repeat variations in two genes were significantly associated with changes in limb and skull morphology. These results open (...) the possibility that such a mechanism contributes to the diversity of life. BioEssays 27:581–587, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

This book is a tribute to Kevin Kelly, who has been one of the most influential British theologians for a number of decades. On its own merits, however, it is groundbreaking collection of essays on key themes, issues and concepts in contemporary moral theology and Christian ethics. The focus is on perspectives to inform moral debate and discernment in the future. The main themes covered are shown in the list of contents below. Several of the of the contributors are from (...) the United States, three others live and work in Continental Europe and the rest are from various parts of the British Isles. Many of the authors are among the best known in their fields on both sides of the Atlantic. (shrink)

Social media platforms have been vested with hope for their potential to enable ‘ordinary citizens’ to make their judgments public and contribute to pluralized discussions about organizations and their perceived legitimacy :60–97, 2018). This raises questions about how ordinary citizens make judgements and voice them in online spaces. This paper addresses these questions by examining how Western citizens ascribe responsibility and action in relation to corporate misconduct. Empirically, it focuses on modern slavery and analyses online debates in Denmark on child (...) slavery in the cocoa industry. Conceptually, it introduces the notion of cosmopolitanism as a general disposition of care and responsibility towards distant others, conceived as a prerequisite for the critical evaluation of corporate responsibility in the Global South. The analysis of online debates shows that citizens debate child slavery in terms of individual consumer responsibility rather than corporate responsibility. Corporations are not considered potential agents of change. As a consequence, online citizen debates did not reflect a legitimacy crisis for the cocoa industry, as debates over responsibility were overwhelmingly concerned with the agency of the Western individual, the individual agency of the speakers themselves. Participants in debates understood their agency strictly as consumer agency. (shrink)

In attempting to provide protection to individuals and communities, childhood immunization has benefits that far outweigh disease risks. However, some parents decide not to immunize their children with some or all vaccines for reasons including lack of trust in governments, health professionals, and vaccine manufacturers. This article employs a theoretical analysis of trust and distrust to explore how twenty-seven parents with a history of vaccine rejection in two Australian cities view the expert systems central to vaccination policy and practice. Our (...) data show how perceptions of the profit motive generate distrust in the expert systems pertaining to vaccination. Our participants perceived that pharmaceutical companies had a pernicious influence over the systems driving vaccination: research, health professionals, and government. Accordingly, they saw vaccine recommendations in conflict with the interests of their child and “the system” underscored by malign intent, even if individual representatives of this system were not equally tainted. This perspective was common to parents who declined all vaccines and those who accepted some. We regard the differences between these parents—and indeed the differences between vaccine decliners and those whose Western medical epistemology informs reflexive trust—as arising from the internalization of countering views, which facilitates nuance. (shrink)

Universities around the world are undergoing a marketisation process in order to respond to consumer-oriented demands. Despite priority shifts, universities have remained traditionally hierarchical and elitist. Moreover, a new and growing generation of academic researchers has found it increasingly difficult to integrate in academia. Systems and patterns of behaviour breeding cultural narcissism, intended as a value and cultural system characterised by an investment in false self-projections backed by Machiavellian attainment, exist and appear to thrive in academic institutions. This organizational adaptation (...) for survival is now embedded in higher education and interlinked with mobbing, workplace bullying and academic misconduct. The problematics we are witnessing today in many academic settings (high rates of mental health issues, widespread research misconduct scandals and loss of credibility of academic research) are a by-product of an organizational narcissistic culture. Amidst economic shifts, it might seem reasonable to adopt measures aimed at increasing assets, invest in highly entrepreneurial academics who attract financial resources to universities and use any means to salvage the reputations of educational institutions. Yet these strategies might be promoting and perpetuating value systems that are undermining academic integrity, and therefore contributing to the scientific credibility crisis and failure of these institutions. (shrink)

The contributors to this issue focus on legal internationalism, including hybrid mixes with nationalist forms. They have provoked us as editors to think more about these sites and forms of engagement. Sankey shows how civic participation in the ECCC has played a key role in surfacing the gendered harms of separation and starvation. Turan highlights the problems with ICC exclusion of the experience of men and boys from sexual violence. Peroni expresses her hesitations over the Istanbul Convention given an association (...) between assumed vulnerability and migrant women, while admiring its uncoupling of violence and culture. Cruz’s interview with Wendy Brown contextualizes and expands on these themes as they consider, with other participants, the future of feminist theory in the context of neo-liberal capturing of rights and legal space. Thinking more about internationalism and commitment in this context also helps us hold a mirror up to ourselves as we reflect more critically on our own naming of FLS as an ‘international’ journal. Together these contributions, and the reviews of new work, play a role in fleshing out an editorial commitment to enacting the journal as a living thing that ‘hangs together somehow’ even as it is known differently in different places. (shrink)

Canadian children’s literature rarely depicts characters labelled with intellectual disabilities, yet when it does it often remains mired in stereotypes that recycle prevalent myths and misconceptions. Even as more recent literature attempts to push back against such stereotypes, it nevertheless predominantly remains caught in these dangerous representational repertoires. This article offers a brief history of Canadian literary depictions of intellectual disability and a critique of the Canadian publishing spheres. Through a critical analysis of Lorna Schultz Nicholson’s book Fragile Bones, we (...) discuss the limits of representation of intellectual disability in children’s fiction. We also offer a critique of the ableist publishing climate in Canada and suggest that structural barriers prevent disabled writers from entering the literary marketplace on an equal playing field. These barriers to publishing lead to the vast underrepresentation of disabled authors and the misrepresentation of disability in general and intellectual disability in particular in Canadian children’s literature. (shrink)

Although I am not supposed to have a favorite patient, she is one. Arissa is a three‐year‐old girl. Her parents, natives of Comoros, had illegally immigrated to the French department of Mayotte. When I first began treating her, I saw her as a time bomb. But we built a relationship, and when she deteriorated on my watch, I wanted to say, “Fight to the end!—she is my favorite patient!” But I thought that I did not have the necessary distance to (...) answer the question. (shrink)

An important milestone was crossed recently in the discipline of philosophy, but hardly anyone seems to have noticed. In 2004, for the first time since statistics have been gathered on such things, women earned more than 30 percent of the doctorates in philosophy in this country, 33.3 percent, up from 27.1 percent the year before. The highest percentage women had achieved previously in philosophy was 29.4 percent, in..

Difference and Habit: Deleuze anti-Hegelian critique of consciousness Since Antiquity, habit has been understood as a second nature, as something that we develop in a conscious or unconscious way, and which directs and structures both our cognitive and practical lives – our consciousness and our actions. For Hegel, habit effectuates the transition from nature to spirit or consciousness, thus forming the basis of morality. Habit thus constitutes an essential stage in the development of the mind and a crucial aspect of (...) Hegel’s philosophical anthropology. Habit also plays a crucial role in the thinking of the French philosopher Gilles Deleuze, who characterizes his philosophical project as anti-Hegelian or anti-dialectical. Even though many works examine the relationship between Deleuze and Hegel, almost none of these discuss the concept of habit of these authors, and the role that it plays in Deleuze’s so-called anti-Hegelianism. In this article, I address the concept of habit in Difference and Repetition, and the role it plays in Deleuze’s critique of Hegel. I also compare this concept with Hegel’s own conception of habit in his Anthropology. I show that Deleuze certainly does not understand repetition as second nature as Hegel does, because then it is impossible to account for the productive power of the unconscious or the sub-representative, and of real creativity. I distinguish my interpretation of habit in Deleuze from that of a number of other authors, who, in my view, do not draw all the conclusions from Deleuze’s interpretation of Hume. I then expound Deleuze’s original notion of habit and compare it with Hegel’s. (shrink)

ABSTRACTObjective: This study was designed to improve our understanding of prospective memory changes in ageing, and to identify the cognitive correlates of PM decline, using a virtual environment, to provide a more realistic assessment than traditional laboratory tasks.Design: Thirty-five young and 29 older individuals exposed to a virtual town were asked to recall three event-based intentions with a strong link between prospective and retrospective components, three event-based intentions with a weak link, and three time-based intentions. They also underwent retrospective episodic (...) memory, executive functions, binding in working memory, processing speed, and time estimation assessments.Results: Older individuals recalled fewer intentions than young adults. While age-related PM decline affected the recall of both prospective and retrospective components, the recall of the latter seemed more challenging for older individuals when the link was weak. This PM decline was linked to an age-related decline... (shrink)

Niedenthal et al. postulate that eye contact with the expresser of an emotion automatically initiates embodied simulation. Our commentary explores the generality of such an eye contact effect for emotions other than happiness. Based on the appraisal theory of emotion, we propose that embodied simulation may be reinforced by mutual or averted gaze as a function of emotional context.

Surprise – these much-publicized rules are not the least bit reassuring to people who specialize in the study of ethics. While attention to ethics is certainly welcome, these ethical codes provide a too-easy cop-out, a way to neatly dispose of attention to nagging and pervasive problems. The typical professional code is little more than a checklist of rules that enables professionals of any stripe to give lip service to ethical behavior without engaging in continuing dialogue on ethical dilemmas. Neatly packaged (...) commandments short-circuit development of the reasoning tools to work through ethical challenges meaningfully and with long-lasting impact on the actual behavior in any field. (shrink)

This paper is dedicated to the first universities and mendicant schools, where thousands of students began to converge during the thirteenth century. Logic played an unpreceded role in basic and higher education. A “Parisian logical model” of education was shaped at the University of Paris, adopted by mendicant Orders in their schools of logic, diffused in all disciplines, and progressively spread in Southern Europe. Medieval education became heavily based upon logical, and even “logician” practices, with the “syllogization” of exegetical, disputational, (...) and evaluation practices.The notion of logical skill conveniently captures this unique situation for the discipline of logic, as well as the way medieval thinkers conceived of logic as a universal, transdisciplinary method, a natural operation of the mind, a modality of knowledge, the very form of teaching and graduating, a “habitus,” a technique and a science.The divisions of Aristotelian logic, the “artificial logic,” were for the first time naturalized and projected on the very structure of human mind, which was thereby “logicalized” and ascribed a “natural logic.” A strong anthropological dimension was bestowed on logic. The discipline of logic was deemed a necessary instrument in the philosophical “perfection” and the Christian “reparation” of man as an intellectual creature by a group of logically skilled, professional philosophers and theologians, whereas men deprived of logical education were described as “logically disabled,” and stuck into inferior forms of humanity.The world of medieval intellectual elites displayed a variety of social uses of logic, beyond academic circles, especially in the performance of pastoral duties. The possible historical records of the social usefulness of logic are explored: for students, the majority in medieval universities, who left university without a degree, but with a solid logical education, for ordinary mendicant friars, dedicated to preaching and confession, who frequented logical schools, and for members of the parish clergy sent to the faculties of arts. (shrink)

Antoine Arnauld is well known as a passionate defender of Jansenism, specifically Jansen’s view on the relation between freedom and grace. Jansen and, early in his career Arnauld, advance compatibilist views of human freedom. The heart of their theories is that salvation depends on both the irresistible grace of God and the free acts of created things. Yet, in Arnauld’s mature writings, his position on freedom seems to undergo a significant shift. And, by 1689, his account of freedom no longer (...) seems Jansenist. In this paper, we offer an interpretation of Arnauld’s mature view on freedom, with a focus on his claim that freedom requires a “power to the opposite.” In order to see what he means by this, we look to several under-examined texts in his corpus for clues about how he understands the related topics of “infallible determination,” habit, and primo-primi motus. We argue that Arnauld’s mature view on freedom should be understood as libertarian. (shrink)

2017 substantive revision of the original 2008 "Continental Rationalism" entry (and 2012 revision) that introduces women and non-European authors and new historiographical considerations.

A presence for decades in individuals’ everyday life practices and identity formation, the Walt Disney Company has more recently also become an influential element within the "big" curriculum of public and private spaces outside of yet in proximity to formal educational institutions. _Disney, Culture, and Curriculum_ explores the myriad ways that Disney’s curricula and pedagogies manifest in public consciousness, cultural discourses, and the education system. Examining Disney’s historical development and contemporary manifestations, this book critiques and deconstructs its products and perspectives (...) while providing insight into Disney’s operations within popular culture and everyday life in the United States and beyond. The contributors engage with Disney’s curricula and pedagogies in a variety of ways, through critical analysis of Disney films, theme parks, and planned communities, how Disney has been taught and resisted both in and beyond schools, ways in which fans and consumers develop and negotiate their identities with their engagement with Disney, and how race, class, gender, sexuality, and consumerism are constructed through Disney content. Incisive, comprehensive, and highly interdisciplinary, _Disney, Culture, and Curriculum_ extends the discussion of popular culture as curriculum and pedagogy into new avenues by focusing on the affective and ontological aspects of identity development as well as the commodification of social and cultural identities, experiences, and subjectivities. (shrink)

In this paper, we offer an introduction to case study research in the social sciences. We begin with a discussion of the definition of case study research. Next, we point to various purposes that case study research may serve in the social sciences and then turn to outline the main philosophical issues raised by case study research. Finally, we briefly present the papers in this special issue.

Photographers John Shimon and Julie Lindemann use antique cameras, modern lens technology, artificial light, and contemporary pop culture to create portraits of the people in their native state amidst backyards, living rooms, parking lots, and the landscape of Wisconsin. These recent photographs are juxtaposed with portraits from the Milwaukee Art Museum’s permanent collections, including daguerreotype portraits, ambrotypes, and tintypes of anonymous people taken by nineteenth-century photographers, as well with photographs by such well-known artists as Alfred Stieglitz, Sally Mann, Larry (...) Clark, Walker Evans, Nan Goldin, Eugene von Beuenchenhein, and Francis Ford. The pairings of new and old illustrate the legacy of portraiture and the significance of “posing” before the lens, and each image is enriched by its proximity to another, unmasking sitter, photographer, and viewer. Unmasked & Anonymous: Shimon & Lindemann Consider Portraiture includes more than sixty color and black-and-white photographs plus essays by Shimon, Lindemann, and Milwaukee Art Museum curator Lisa Hostetler. (shrink)

En dialogue avec ses amis et partenaires de travail, Dominique Malaquais, réinterroge sa manière d’entrer en relation avec les artistes et de donner à connaître leur travail. De nombreuses précautions doivent être prises pour affirmer l’art africain dans toutes ses dimensions. Un regard nouveau sur la grande ville en découle nécessairement. Les livres accumulés pendant cette quête, qu’ils y aient trait ou non, seront donnés à une institution amie, Chimurenga, à Cape Town, et transmettront ce travail.

This essay introduces the notion of a digital concordance as a reading and research tool to explore intertextual passages online, and illustrates how a digital concordance of highly allusive texts can change how we read and research such texts. I take as example the digital concordance on Intertextual Dante, a project on Digital Dante developed in collaboration with the Center for Digital Research and Scholarship at Columbia University, which in the first phase highlights the Ovidian intertextuality in Dante’s Divina Commedia. (...) The essay traces the history of the scholarship on Dante’s Ovid, identifying its strengths and limitations, especially of the concordances in print. Since the intertextual passages in the Commedia require a reading not restricted to the obviously corresponding verses, but attentive to the broader textual contexts, I show how the digital concordance on Intertextual Dante greatly facilitates such a contextualized reading. The visualization of the corresponding passages and the search options help the study of intertextuality in the Commedia, as illustrated with examples from the site. (shrink)

Moral distress has been identified as an occupational hazard for clinicians caring for vulnerable populations. The aim of this systematic review was (i) to summarize the literature reporting on prevalence of, and factors related to, moral distress among nurses within acute mental health settings, and (ii) to examine the efficacy of interventions designed to address moral distress among nurses within this clinical setting. A comprehensive literature search was conducted in October 2022 utilizing Nursing & Allied Health, Embase, CINAHL, PsychInfo, and (...) PubMed databases to identify eligible studies published in English from January 2000 to October 2022. Ten studies met inclusion criteria. Four quantitative studies assessed moral distress among nurses in acute mental health settings and examined relationships between moral distress and other psychological and work-related variables. Six qualitative studies explored the phenomenon of moral distress as experienced by nurses working in acute mental health settings. The quantitative studies assessed moral distress using the Moral Distress Scale for Psychiatric Nurses (MDS-P) or the Work-Related Moral Stress Questionnaire. These studies identified relationships between moral distress and emotional exhaustion, depersonalization, cynicism, poorer job satisfaction, less sense of coherence, poorer moral climate, and less experience of moral support. Qualitative studies revealed factors associated with moral distress, including lack of action, poor conduct by colleagues, time pressures, professional, policy and legal implications, aggression, and patient safety. No interventions targeting moral distress among nurses in acute mental health settings were identified. Overall, this review identified that moral distress is prevalent among nurses working in acute mental health settings and is associated with poorer outcomes for nurses, patients, and organizations. Research is urgently needed to develop and test evidence-based interventions to address moral distress among mental health nurses and to evaluate individual and system-level intervention effects on nurses, clinical care, and patient outcomes. (shrink)

Dans la production industrielle qui entoure actuellement l'œuvre de Hannah Arendt en France, certains ouvrages se distinguent tant par leur qualité que par leur originalité. C'est le cas de celui de Françoise Collin qui aborde la pensée de Hannah Arendt à travers le prisme de la natalité. Ce qui intéresse F. Collin dans l'œuvre arendtienne, qui irrigue ses propres travaux depuis une quinzaine d'années, c'est la capacité de préserver l'agir en commun dans un monde durablement marqué par...

La mort de Françoise Collin laisse un grand vide sur la scène féministe francophone et internationale. Certes, elle n’était pas qu’une féministe et refusait de se laisser réduire à la posture de la « militante », mais c’est principalement dans ce domaine qu’elle a agi et laissé une empreinte. Elle s’illustre d’abord dans le domaine de la littérature. Déjà, pendant ses études secondaires en pleine Seconde Guerre mondiale, elle avait découvert dans celle-ci une ouverture vers la liberté. Elle s...

"Towards the Death of Humanity" is the endless demonstration of the disastrous side effects left on our environment, on life on this planet, on health and most of all on human dehumanization by a century of tremendous scientific and technological realizations and their material values. It illustrates how these unhealthy side effects are highly linked to the hasty and thoughtless decisions of scientists, intellectuals and governments to replace the humanities and the traditional methods of teaching with their own methods of (...) science, technology and their essentially material values. Unfortunately totally deprived of the smallest bit of humanity, this method of education has killed the rudiments of humanity acquired during the course of history, has dehumanized the people, their institutions and their societies. These side effects originate in the age-old desire of intellectuals and scientists to take hold of the power of religion over man and to satisfy their morbid need to build a new world, re-designed following Hegel' belief that the matter is eternal and God. Although these ideologies have lost all their legitimacy today because science has recently demonstrated that the matter is not eternal, scientists and intellectuals keep on teaching the falseness of their materialistic social system as if the logic of their reasoning were the only truth. This work promotes certain guidelines that individuals must follow to make the lucid and effective compromises needed to try and solve these destructive problems affecting man and society before the end of History. (shrink)

Les nombreux débats conflictuels entourant l’application du principe de grève de masse au sein du Parti social-démocrate allemand témoignent de la lente agonie des idéaux marxistes au sein de ce parti de masse. La fragile victoire des idéaux prônés par la faction radicale du Parti contre ceux des réformistes, entre 1900 et 1906, connaît un retour de balancier sans appel après la première révolution russe. De 1906 à 1910, la logique légalo-parlementaire allait progressivement devenir la seule voie légitime aux yeux (...) des dirigeants du Parti. Ce changement de tactique et de stratégie visant à conquérir le pouvoir, sera grandement contesté par plusieurs militants influents du Parti. Le conflit intellectuel entre Rosa Luxemburg et Karl Kautsky, qui éclata publiquement en 1910 alors que les mouvements contestataires en Allemagne étaient très forts, nous permet de comprendre, par l’analyse du discours de ces penseurs marxistes, les raisons qui conduisirent le SPD à ne pas appliquer la grève de masse. Ceci, alors qu’une motion favorable à ce principe avait été votée en 1905 lors du Congrès d’Iéna. Du point de vue pseudo-sérendipien qui était le sien, Luxemburg croyait fermement que la temporalité était favorable à l’application de la grève de masse. L’interprétation temporelle et électoraliste de Kautsky l’amènera plutôt à critiquer les effets pseudo-sérendipiens, non contrôlés par le SPD, entourant ce type d’action politique. (shrink)

The diversity of bone proteoglycan (PG) structure and localisation (pericellular, extracellular in the organic bone matrix) reflects a broad spectrum of biological functions within a unique tissue. PGs play important roles in organizing the bone extracellular matrix, taking part in the structuring of the tissue itself as active regulators of collagen fibrillogenesis. PGs also display selective patterns of reactivity with several constituents including cytokines and growth factors, such as transforming growth factor‐β or osteoprotegerin thereby modulating their bio‐availability and biological activity (...) in the bone tissue. In this review, the complex PG composition in bone will be addressed together with the specific role played by PGs (or their GAGs chains) in bone biology, as regulatory molecules for bone resorption and their involvement in bone tumor development. These roles have been determined after modulation of PG expression or mutations in their corresponding genes, which revealed specific roles for these compounds in bone pathologies (e.g. perlecan or glypican‐3 mutations observed respectively in chondrodysplasia or dysmorphic syndrome). Finally, the potential therapeutic interest of PGs is discussed based on recent data, more particularly on bone tumor‐associated osteolysis as these molecules are involved both in bone resorption and tumor development. BioEssays 29:758–771, 2007. © 2007 Wiley Periodicals, Inc. (shrink)