Platforms for sharing genomic and phenotype data have been developed to promote genomic research, while maximizing the utility of existing datasets and minimizing the burden on participants. The value of genomic analysis of trios or family members has increased, especially in rare diseases and cancers. This article aims to argue the necessity of protection when sharing data from both patients and family members. Sharing patients’ and family members’ data collectively raises an ethical tension between the value of datasets and the (...) rights of participants, and increases the risk of re-identification. However, current data-sharing policies have no specific safeguards or provisions for familial data sharing. A quantitative survey conducted on 10,881 general adults in Japan indicated that they expected stronger protection mechanisms when their family members’ clinical and/or genomic data were shared together, as compared to when only their data were shared. A framework that respects decision-making and the right of withdrawal of participants, including family members, along with ensuring usefulness and security of data is needed. To enable this, we propose recommendations on ancillary safeguards for familial data sharing according to the stakeholders, namely, initial researchers, genomic researchers, data submitters, database operators, institutional review boards, and the public and participants. Families have played significant roles in genetic research, and its value is re-illuminated in the era of genomic medicine. It is important to make progress in data sharing while simultaneously protecting the privacy and interests of patients and families, and return its benefits to them. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:A Short ReplyGianluca MoriWhile thanking Thomas Lennon for the interest he has shown in my work—and without going into details of interpretation which cannot bear discussion in this context—I would like to make a few remarks on factual questions raised by his response.1) Lennon's text (p. 338): "The text that Bayle and Mori erroneously take to be Saint-Evremond's is in fact from Jean-François Sarasin."While it is not certain (...) that Bayle and I "erroneously" take this text to be Saint-Evremond's, it is certain that Lennon erroneously takes it to be Sarasin's. In fact, the text quoted by Bayle is not taken from Sarasin's Discours sur Epicure, but, as Bayle explicitly points out ("Xénophanes," K, note 124), from a "Discours des ennuis et des déplaisirs." This "Discours" is chapter 5 of De l'usage de la vie, a text published in many editions of Saint-Evremond's works (see the Barbin 1692 in-4° ed., Seconde Partie, p. 326). The paternity of De l'usage de la vie is doubtful and controversial, but it possibly contains some passages taken from Saint-Evremond's unpublished manuscripts, especially in chapters 3-6, as reported by an important source quoted by Ternois in Saint-Evremond, Œuvres en prose, IV, 3-4, note 1.2) Lennon's text (pp. 338-39): "The significance of two of the other texts advanced by Mori is fully vitiated, for in them Bayle makes the same mistake."In my article, I did not fail to state that these texts (OD I, 158 and Dict., "Epicure," M) are taken from an apocryphal source. On page 329 I wrote: "[Bayle] mistakenly attributes to [Saint-Evremond] a text on Epicurus's morals [i.e., Sarasin's Discours] included in that volume." However, it was absolutely impossible, for seventeenth-century readers, to distinguish between Saint-Evremond's original and apocryphal texts: the author himself—as is widely known—did not want to clarify this point (with a few exceptions, including the Saint-Evremoniana, which, as we have seen, Bayle never attributed to Saint-Evremond). [End Page 343] And this is true for all editions: there is no significant difference between genuine and pirated editions, since no official edition, authorized and revised by the author, existed before Des Maizeaux's posthumous one. From this point of view, virtually nobody (before 1705) could "study" Saint-Evremond's texts. (On this connection it should be added that I never claimed that Bayle "studied" Saint-Evremond, but only that he read his available works and made up his mind on them, and particularly on the Conversation du Maréchal d'Hocquincourt—which should be at the core of the present debate—long before reading Cotolendi).3) Lennon's text (p. 336): "As Mori acknowledges elsewhere, Labrousse thinks Le Vassor was a left-wing Anglican who failed to understand Bayle's calvinist perspective."Concerning Le Vassor, I "acknowledge" Labrousse's opinion only to reject it with a detailed argument (Bayle philosophe, 262, note 341).Gianluca MoriUniversità del Piemonte OrientaleCopyright © 2004 The Journal of the History of Ideas, Inc.... (shrink)

São muitas as abordagens do fenômeno religioso surgidas nos últimos dois séculos. Algumas recorrem aos métodos elaborados pelas ciências humanas, sobretudo a historiografia, a sociologia, a etnologia/antropologia, a psicologia e a fenomenologia. Outras tratam a religião numa perspectiva filosófica, como se pode ver nos grandes autores que, sobretudo a partir do século XIX, se consagraram à elaboração de uma filosofia da religião. Nas últimas décadas, com a renovação da filosofia hermenêutica, novas leituras da religião têm surgido, renovando profundamente esse campo (...) do saber. O texto aqui proposto apresenta alguns elementos da grande síntese do filósofo luxemburguês Jean Greisch, pouco conhecido no Brasil, mas cuja contribuição ao estudo da religião é original, privilegiando uma hermenêutica da passagem. Após uma breve apresentação de sua obra consagrada à filosofia da religião, serão apresentados os cinco “paradigmas” dos estudos da religião segundo ele: o especulativo, o crítico, o fenomenológico, o analítico e o hermenêutico, o último seguido pelo próprio autor. (shrink)

This thesis focuses on one of the mechanisms for solving the baryon asymmetry of the Universe (BAU) which is a long-standing open question in both particle physics and cosmophysics. Electroweak baryogenesis (EWBG) is one attractive hypothetical scenario to solve this mystery because it can be verified by collider experiments. The author aims to clarify the possibility of EWBG, and to show its verifiability using the Higgs physics and electric dipole moments (EDMs) of an electron, neutron, and proton. The thesis begins (...) with a review of the BAU and EWBG. Subsequently, the possibility of EWBG in one effective model is discussed, which can be applied to some motivated physics beyond the Standard Model. Numerical analyses of electroweak phase transition and sphaleron solution are presented, and the closed time path formalism is also explained to estimate the BAU. After essential calculations for investigation of the possibility of EWBG, the relationship between the BAU and EDMs is described. Through the discussion of the result, it is concluded that both EDMs and the Higgs physics verify the scenario completely. The whole discussion in this thesis causes us to accept the current situation that is ripe for verification of EWBG. (shrink)

In lowland South America, breath animates human and non-human bodies, pulsating through the materialities of organisms. Humans, however, should manage their bodies to recast and reconfigure breath in its most life-enhancing manifestations: singing and smoking. These are the specialized domains of those able to manage their vitalities in such a way as to produce potent effects in themselves and in the world around them, including influencing atmospheric conditions, the lives of animals and plants and the harming and healing of others. (...) In these relational onto-epistemologies, intersubjectivity, intercorporality and states of non-cognitive interaffection find new depths. Breath, properly managed, can make and unmake worldly forms, including bodies and the societies they come together in. Focusing on two Amerindian communities, the Warekena of northwestern Rio Negro, Brazil and the Shipibo-Konibo of the Ucayali valley in Eastern Peru, this article examines the interface between human and non-human subjectivities, and how resonant interaffective atmospheric conditions are induced to promote health. (shrink)

This paper undertakes a comparative legal study to analyze the challenges of privacy and personal data protection posed by Artificial Intelligence embedded in Robots, and to offer policy suggestions. After identifying the benefits from various AI usages and the risks posed by AI-related technologies, I then analyze legal frameworks and relevant discussions in the EU, USA, Canada, and Japan, and further consider the efforts of Privacy by Design originating in Ontario, Canada. While various AI usages provide great convenience, many issues, (...) including profiling, discriminatory decisions, lack of transparency, and impeding consent, have emerged. The unpredictability arising from the AI machine learning function poses further difficulties, which have only been partially addressed by legal frameworks in the aforementioned jurisdictions. However, analyzing the relevant discussions yielded several suggestions. The first priority is adopting PbD as the most flexible, soft-legal, and preferable approach toward AI-oriented issues. Implementing PbD will protect individual privacy and personal data without specific efforts, and achieve both the development of AI and the advancement of privacy and personal data protection. Technical measures that can adapt to an individual’s dynamic choices according to the “context” should be further developed. Furthermore, alternative technical measures, including those to solve the “algorithmic black box” or achieve differential privacy, warrant thorough examination. If AI surpasses human intelligence, a terminating function, such as a “kill switch” will be the last resort to preserve individual choice. Despite numerous difficulties, we must prepare for the coming AI-prevalent society by taking a flexible approach. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Bayle, Saint-Evremond, and Fideism:A Reply to Thomas M. LennonGianluca MoriIn a recent article published in this journal Thomas M. Lennon returns to the controversial question of Bayle's attitude towards religion. The point he debates is the particular use that, in expounding his conception of the relationship between faith and reason, Bayle makes of a passage from Saint-Evremond. In Lennon's view the correct interpretation of this point would show that (...) Bayle's fideism is to be "taken at face value" without any hint of irony and with no suspicion of dissimulation or insincerity.1 This would cast doubt on and greatly weaken the interpretation I proposed in my Bayle philosophe.2 My aim here is to respond briefly to Lennon's arguments and to clarify even more briefly what in my opinion is the right perspective in which to consider Bayle's position on this topic.The context in which Bayle quotes Saint-Evremond is to be found in the Eclaircissements he added to the second edition of his Dictionnaire historique et critique (1702) to counter the Dutch religious authorities' harsh criticism of the first edition. In particular the Walloon Consistory accused Bayle of taking a skeptical position that undermined the most important dogmas of Christian faith. In response Bayle wrote the Eclaircissement sur les Pyrrhoniens, a clumsy mosaic of quotations from the Scriptures and from patristic and profane texts, with which he sought to show that his skeptical fideism was not in the least heterodox but indeed the position that most closely reflected true Christianity. The quotation from Saint-Evremond, almost at the end of this text, is taken [End Page 323] from the Conversation du Maréchal d'Hocquincourt et du Père Canaye (written in about 1654).3 The final passage gives a clear idea of the general tone: after having disputed with a churchman the need to subject one's intellect to the yoke of faith, the marshal concludes by saying that he is ready to be crucified "without knowing why." Father Canaye replies: "No reason! That is the true religion. No reason! God has granted you a fine grace, mylord." So, and here Lennon obviously agrees (229), Saint-Evremond's is a text with no shadow of mystical inspiration, indeed strongly tending in the libertine direction, as is clear from the blatant way it pours scorn on the fideist approach.In my interpretation Bayle's use of this quotation does not at all demonstrate his atheism or unbelief, for in my view that question is undecidable. However, the quotation from Saint-Evremond is sufficient—and this is the onlyreason I mentioned it4 —to show that Bayle's approach to fideism is in no way innocent and naive as is sometimes claimed. On the contrary, his texts on this subject contain what amounts to provocations aimed at orthodox readers (to which they immediately reacted). This, together with other more important reasons, leads me to believe that Bayle's professions of Christian faith, though frequent, are generally far from being above suspicion: indeed, almost every line of them raises questions about their actual significance.The provocation contained in the quotation from Saint-Evremond appears in all its rhetorical weight if we associate this text with three other passages from Bayle's works. The first is from the Nouvelles de la république des lettres of December 1686, in which Bayle stresses the unedifying nature of the religious maxims contained in Saint-Evremond's Conversation (which, incidentally, he himself had just had printed in the collection Le Retour des pièces choisies).5 The second is taken from a letter by Jean d'Oulès to Bayle, written in 1696, in which the author deals with exactly the same passage from the Conversation that was later to be reproduced in the Eclaircissement. In this letter d'Oulès quotes the full passage which he considers to be a "naughty text" deliberately written to throw ridicule on the fanatical fideism of Pierre Jurieu.6 The third passage is from Bayle's Continuation des pensées diverses of 1704 in which, shortly after the death of Saint-Evremond, he publicly reveals the poet... (shrink)

Martin Heidegger’s understanding of art and Paul Ricoeur’s reading of the poetics of existence, developed through his hermeneutics of symbols, metaphor and narrative, open an immense vista to a theological thinking that desires to place primacy on the hearing of the symbolic language of poetry and literature. Beginning a few decades ago, various theologians have ventured along this trajectory, but theology still remains under the dominion of “theoria” and “praxis” and is not very open to “poiesis”. The study presented here (...) revisits the book of J.-P. Manigne on the Poetics of Faith from the 1970s, and the doctoral thesis of A. Thomasset on the Poetics of Morality, from the 1990s, showing how poetic reason provoked theological discourse in the second half of the 20th century. It is part of a research still in progress, devoted to other contributions of the beginning of the 21st century. (shrink)

人間であること、これを問う政治哲学の徹底。その先に見えるのは、果たして平和的共存の根源性か、戦いのそのとき、自分以外ではありえない人間の生々しさか。.

This article analyses Valla’s historiographical stance in the light of his dialectical assumptions about possibility, verisimilitude, and truth. I argue that, at variance with most humanists, Valla believed that historical truth should satisfy the requirements of logical necessity, being therefore incompatible with verisimilar reconstructions of past events. However, Valla also realized that a critical method of assessment grounded in verisimilitude was indispensable to the analysis of doubtful accounts and traditions. In order to explore these matters, Valla developed a genre distinct (...) from history proper and closer to the forensic, inquisitorial tradition. While history had to deal with necessary truths, the aim of ‘historical inquisitio’ was to draw probable conclusions from pieces of conjectural evidence. According to Valla’s dialectical principles, these conclusions were not absolutely true but could be considered true thanks to the notion of intellectual acumen, which allowed Valla to take a leap from the field of possibility or verisimilitude to that of truth and necessity. (shrink)

>Engelhardt’s After God gives a comprehensive perspective on the deepest and hardest issues in both moral philosophy and bioethics of our time. Although the book is an intelligent critique of contemporary moral philosophy in favor of a kind of traditionalism rooted in the perspective of the Orthodox Church, containing numerous forceful arguments, I ultimately disagree with Engelhardt on several main points stemming from his pessimistic view of our current culture and society. I have neither the pretense to open new perspectives, (...) nor to put forward new arguments, and I am aware that I might be wrong. I simply want to present a different position on the quest for meaning. (shrink)

This article presents an approach in doing philosophy with children through thought experiments, by focusing on that one about founding an utopia. Describing the group work practice and the role of philosophers in the dialogic learning process provided by the mental simulation concerning utopia, the author presents some elementary observations on the central role played by thought experiments both in philosophy and in the natural sciences, and stresses a variety of interesting implications in doing philosophy with children through thought experiments. (...) Finally, the author argues that mental simulation can be an engaging introduction to doing philosophy with children, which are enabled in this way to envision conflicting possibilities and face with something like Wittgenstein’s “puzzle pictures”. (shrink)

This article characterizes Florence Nightingale's nursing reform as the cleaning of the Victorian home which she found unheimlich. She laid strong emphasis on an improvement in the hygiene of the house as a significant part of nursing, and, by establishing the nurse as a new occupation, gave the surplus of unmarried women a decent means of escape from the stifling domesticity in which they had been helplessly trapped. Her nursing at once reformed and reinforced the traditional role of woman as (...) a domestic figure, for she created the nurse as a mother figure in charge of the home space. In the Crimean War, Nightingale successfully nursed the idea of England as Home by attending to the dying soldiers at the front. Her crusade to nurse the unhomely space into a home, however, dismissed one uncanny place inside the imperial Home that needed urgent nursing, that is, Ireland, which had been suffering from the Great Famine and its aftermath. Nightingale confronted Irish Sisters of Mercy, who came to the Crimea to save the lives and souls of the Irish soldiers. These Irish nuns not only embodied the memories of the Famine which they had recently relieved, but also threatened Nightingale's single female authority by representing Ireland as a nation through their equally motherly presence. The service of the Irish nuns in the Crimean War was erased from the myth of the Lady with the Lamp. Nightingale could establish herself as an authoritative female subject and assumed the voice of England only by suppressing another female voice which challenged England's competence in Home management. (shrink)

The aim of this paper is to examine whether it is morally wrong to ban only male citizens from leaving a country in wartime, and if it is, why it is the case. Following Russia’s invasion of Ukraine, President Volodymyr Zelensky declared martial law and ordered general mobilization, at the same time prohibiting male citizens aged 18 to 60 from crossing the border. The justifiability of the ban is in dispute, and opponents have made a case in both legal and (...) moral dimensions. In the moral dimension, there are arguments based on consequentialism, individual freedom, and fairness or non-discrimination. In this paper, I focus on the third argument and argue that the ban unfairly and morally wrongfully discriminates against male Ukraine citizens on the basis of their gender. First, I define discrimination and apply it to our case. Second, moving from the descriptive definition of discrimination to its moral wrongness, I argue that the male-only ban is unfair and morally unjustified. Third, I argue that the ban can also be deemed morally wrong from one of the prominent views in the field of the ethics of discrimination, namely the deliberative freedom view. (shrink)

Au 13e jour du tournoi de Kyushu, le dernier tournoi de la saison 2005, Kotooushu1, un jeune lutteur bulgare de 22 ans, a glorieusement assuré sa promotion au rang d’Oozeki..

This article analyses Lorenzo Valla’s dialectics in order to uncover an epistemological theory of truth undergirding Valla’s production. Based on the analysis of Valla’s Retractatio totius dialecticae, I argue that Valla rejects the notion of one-sided possibility, and considers both possibility and contingency as incompatible with necessity and absolute truth. This assumption inevitably hinders inquiries in fields of knowledge that deal with inherently possible or particular data. Analysing Valla’s philological works, this article shows that, in specific cases, Valla tries to (...) overcome this obstacle thanks to the notion of intellectual acumen, a faculty that transcends the rules of logical inference and puts the inquirer in contact with truth. (shrink)